2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. U 93385

U93385 is a 5-HT₁A receptor agonist. U93385 exhibits no significant α₂ adrenergic, D₂ dopamine, or other receptor activities. U93385 has a heart rate regulating effect, stimulating the vagus nerve to induce bradycardia. U93385 can be used to study the 5-HT₁A receptor-mediated vagal nerve tolerance mechanism.

For research use only. We do not sell to patients.

U 93385

U 93385 Chemical Structure

CAS No. : 147145-16-2

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U 93385 Related Antibodies

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Description

U93385 is a 5-HT₁A receptor agonist. U93385 exhibits no significant α₂ adrenergic, D₂ dopamine, or other receptor activities. U93385 has a heart rate regulating effect, stimulating the vagus nerve to induce bradycardia. U93385 can be used to study the 5-HT₁A receptor-mediated vagal nerve tolerance mechanism[1].

IC50 & Target[2]

5-HT1A Receptor

 

In Vivo

U 93385 (0.01-3 mg/kg, i.v., single dose, cumulative administration or intravenous infusion) results in a 20-30% decrease in heart at administration of a single dose but fails to lower heart rate in the spinal cat by cumulative dosing and infusion[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Spinal cord transection model established in cats (2.5-4 kg)[1]
Dosage: 0.3, 1.0, 3.0 mg/kg (single dose); 0.01, 0.03, 0.1, 0.3, 1.0, 3.0 mg/kg (cumulative dose); 1 mg/kg (infusion)
Administration: Intravenous injection (i.v.), single dose, cumulative administration or intravenous infusion
Result: Dose-dependently reduced bradycardia and arterial blood pressure at single dose.
Failed to lower heart rate in animals pretreated in this cumulative manner.
Molecular Weight

258.36

Formula

C16H22N2O
CAS No.
SMILES

NC(C1=C2[C@@]3([H])[C@](CCC2=CC=C1)([H])N(CCC)CC3)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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U 93385 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

U 93385147145-16-2U93385U-933855-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorSerotonin5-HTIA receptor agonistBradycardiaHeart rateVagus nerveInhibitorinhibitorinhibit

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