2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. TN-101

TN-101 is an orally active NLRP3 inhibitor (IC50 = 29.8 nM). TN-101 can be used for the study of obesity.

For research use only. We do not sell to patients.

TN-101

TN-101 Chemical Structure

CAS No. : 2771020-68-7

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

TN-101 Related Antibodies

Top Publications Citing Use of Products

View All NOD-like Receptor (NLR) Isoform Specific Products:

View All Isoforms
NLRP3 NLRP1 NOD1 NOD2

  • Biological Activity

  • Purity & Documentation

  • Customer Review

Description

TN-101 is an orally active NLRP3 inhibitor (IC50 = 29.8 nM). TN-101 can be used for the study of obesity[1].

IC50 & Target

NLRP3

29.8 nM (IC50)

In Vitro

TN-101 (2 h) can effectively inhibit the secretion of IL-1β (IC50 = 5.58 nM) by THP-1 cells, under Lipopolysaccharides (HY-D1056) (LPS)/Nigericin (HY-127019) stimulation[1].
TN-101 (0.3 nM-6 μM, 1 h) can dose-dependently inhibit the secretion of IL-1β (IC50 = 5.97 nM) and IL-18 (IC50 = 12.2 nM) in THP-1 cells induced by Palmitic acid (HY-N0830)-BSA complex[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TN-101 Related Antibodies
In Vivo

TN-101 (1-10 mg/kg, p.o., twice daily, 15-28 days) does not affect the body weight of Diet-induced obese (DIO) mice, indicating that only NLRP3 inhibitors that can enter the central nervous system and reach effective doses can induce sustained weight loss in DIO mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet-induced obese (DIO) and Normal chow (NC)-fed lean mice[1].
Dosage: 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration: P.o., twice daily for 15 days
Result: Showed no effect on the weight of DIO and NC lean mice.
Animal Model: Diet-induced obese (DIO) and Normal chow (NC)-fed lean mice[1].
Dosage: 1 mg/kg
Administration: P.o., twice daily for 28 days
Result: Showed no effect on the weight of DIO and NC lean mice.
Molecular Weight

458.27

Formula

C18H20FIN2O3
CAS No.
SMILES

O[C@]1(C[C@H](C1)NC(CN2C[C@@]3(C4=C(C2=O)C=CC(I)=C4)C[C@H]3F)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

TN-101 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TN-1012771020-68-7TN101TN 101NOD-like Receptor (NLR)ObesityNLRP3 inflammasomeHypothalamic inflammationTN-783Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
TN-101
Cat. No.:
HY-179132
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.