2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. TLR9-IN-2

TLR9-IN-2 (Compound 20) is a selective inhibitor of Toll-like receptor 9 (TLR9) with IC50 values for TLR9, TLR7, and TLR8 of 25, 1400, and > 50,000 nM respectively. TLR9-IN-2 can be used for the study of fibrosis, autoimmune and inflammatory diseases.

For research use only. We do not sell to patients.

TLR9-IN-2

TLR9-IN-2 Chemical Structure

CAS No. : 2972638-16-5

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TLR9-IN-2 Related Antibodies

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Description

TLR9-IN-2 (Compound 20) is a selective inhibitor of Toll-like receptor 9 (TLR9) with IC50 values for TLR9, TLR7, and TLR8 of 25, 1400, and > 50,000 nM respectively. TLR9-IN-2 can be used for the study of fibrosis, autoimmune and inflammatory diseases[1].

IC50 & Target[1]

TLR9

25 nM (IC50)

TLR7

1400 nM (IC50)

TLR8

> 50,000 nM (IC50)

Molecular Weight

509.71

Formula

C28H39N5O2S
CAS No.
SMILES

O=S(C(C=C1)=CC=C1C2=NC3=C(C)C=C(C4CCN(C5CCN(C(C)C)CC5)CC4)N=C3N2C)(C)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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TLR9-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLR9-IN-22972638-16-5Toll-like Receptor (TLR)Toll-like receptor 9 inhibitorimidazopyridine derivativesfibrotic diseasesidiopathic pulmonary fibrosisnonalcoholic steatohepatitisselectivity over TLR7/8mitochondrial DNACpG motifsMyD88 signaling pathwayfibrosis treatmentInhibitorinhibitorinhibit

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