2. PROTAC Autophagy Apoptosis
  3. E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis
  4. Thalidomide-O-amide-C5-NH2 hydrochloride

Thalidomide-O-amide-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

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Thalidomide-O-amide-C5-NH2 hydrochloride

Thalidomide-O-amide-C5-NH2 hydrochloride Chemical Structure

CAS No. : 2716130-28-6

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Other Forms of Thalidomide-O-amide-C5-NH2 hydrochloride:

Thalidomide-O-amide-C5-NH2 hydrochloride Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

Thalidomide-O-amide-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1][2].

IC50 & Target[1]

Cereblon

 

Molecular Weight

452.89

Formula

C20H25ClN4O6
CAS No.
SMILES

O=C(NCCCCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (110.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2080 mL 11.0402 mL 22.0804 mL
5 mM 0.4416 mL 2.2080 mL 4.4161 mL
View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2080 mL 11.0402 mL 22.0804 mL 55.2010 mL
5 mM 0.4416 mL 2.2080 mL 4.4161 mL 11.0402 mL
10 mM 0.2208 mL 1.1040 mL 2.2080 mL 5.5201 mL
15 mM 0.1472 mL 0.7360 mL 1.4720 mL 3.6801 mL
20 mM 0.1104 mL 0.5520 mL 1.1040 mL 2.7601 mL
25 mM 0.0883 mL 0.4416 mL 0.8832 mL 2.2080 mL
30 mM 0.0736 mL 0.3680 mL 0.7360 mL 1.8400 mL
40 mM 0.0552 mL 0.2760 mL 0.5520 mL 1.3800 mL
50 mM 0.0442 mL 0.2208 mL 0.4416 mL 1.1040 mL
60 mM 0.0368 mL 0.1840 mL 0.3680 mL 0.9200 mL
80 mM 0.0276 mL 0.1380 mL 0.2760 mL 0.6900 mL
100 mM 0.0221 mL 0.1104 mL 0.2208 mL 0.5520 mL
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Thalidomide-O-amide-C5-NH2 hydrochloride Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-O-amide-C5-NH22716130-28-6E3 Ligase Ligand-Linker ConjugatesAutophagyApoptosisInhibitorinhibitorinhibit

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