2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Tedisamil dihydrochloride

Tedisamil dihydrochloride  (Synonyms: KC-8857 dihydrochloride)

Cat. No.: HY-126704A
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Tedisamil (KC-8857) (dihydrochloride) is an antiarrhythmic compound with important biological activities. Tedisamil (dihydrochloride) exhibits a significant slowing effect on heart rate, which is achieved by inhibiting the transient outward potassium current (I(to)) in the atrium. Tedisamil (dihydrochloride) inhibits multiple potassium currents, including IK, K(ATP), and PKA-activated chloride channels, thereby prolonging the cardiac action potential and QT interval, and increasing cardiac reentry. Tedisamil (dihydrochloride) has antiarrhythmic effects on ventricular arrhythmias and atrial flutter in animal models.

For research use only. We do not sell to patients.

Tedisamil dihydrochloride

Tedisamil dihydrochloride Chemical Structure

CAS No. : 132523-84-3

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Tedisamil dihydrochloride Related Antibodies

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Description

Tedisamil (KC-8857) (dihydrochloride) is an antiarrhythmic compound with important biological activities. Tedisamil (dihydrochloride) exhibits a significant slowing effect on heart rate, which is achieved by inhibiting the transient outward potassium current (I(to)) in the atrium. Tedisamil (dihydrochloride) inhibits multiple potassium currents, including IK, K(ATP), and PKA-activated chloride channels, thereby prolonging the cardiac action potential and QT interval, and increasing cardiac reentry. Tedisamil (dihydrochloride) has antiarrhythmic effects on ventricular arrhythmias and atrial flutter in animal models[1].

Molecular Weight

361.39

Formula

C19H34Cl2N2
CAS No.
SMILES

[C@@H](CN1CC2CC2)(C3)C4(CCCC4)[C@@H](C1)CN3CC5CC5.Cl.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tedisamil dihydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tedisamil132523-84-3KC-8857KC8857KC 8857Potassium ChannelKcsAInhibitorinhibitorinhibit

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