2. Protein Tyrosine Kinase/RTK
  3. SHP2
  4. SHP244

SHP244 is a conformational inhibitor targeting the "latch allosteric site" (site 2) of the SHP2 protein with an IC50 value for SHP2WT of 60 μM. SHP244 has no significant effect on the level of p-ERK alone. SHP244 combined with RMC-4550 (HY-116009) ("tunnel site" site 1 inhibitor) can reduce p-ERK and inhibit the rebound of p-ERK, thereby reducing drug resistance. SHP244 can be used to study drug resistance in FGFR-driven cancers.

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SHP244

SHP244 Chemical Structure

CAS No. : 902891-37-6

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SHP244 Related Antibodies

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Description

SHP244 is a conformational inhibitor targeting the "latch allosteric site" (site 2) of the SHP2 protein with an IC50 value for SHP2WT of 60 μM. SHP244 has no significant effect on the level of p-ERK alone. SHP244 combined with RMC-4550 (HY-116009) ("tunnel site" site 1 inhibitor) can reduce p-ERK and inhibit the rebound of p-ERK, thereby reducing drug resistance. SHP244 can be used to study drug resistance in FGFR-driven cancers[1].

Molecular Weight

432.86

Formula

C23H17ClN4O3
CAS No.
SMILES

O=C1C2=C(N3C(C4=C(O)C(OC)=CC=C4)=NN=C3N1CC5=C(Cl)C=CC=C5)C=CC=C2
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SHP244 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SHP244902891-37-6SHP 244SHP-244SHP2Src homology phosphatase 2PTPN11binding modelsdrug discoveryprotein tyrosine phosphataseSHP2 inhibitorsstructural landscapeInhibitorinhibitorinhibit

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