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withaferin A

" in MedChemExpress (MCE) Product Catalog:

15

Inhibitors & Agonists

3

Peptides

11

Natural
Products

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N2065
    Withaferin A
    5+ Cited Publications

    		 NF-κB Ferroptosis Inflammation/Immunology Cancer
    Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.
    Withaferin A
  • HY-N2065R
    Withaferin A (Standard)

    		Reference Standards NF-κB Ferroptosis Inflammation/Immunology Cancer
    Withaferin A (Standard) is the analytical standard of Withaferin A. This product is intended for research and analytical applications. Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.
    Withaferin A (Standard)
  • HY-N10352
    4-epi-Withaferin A

    		Others Cancer
    4-epi-Withaferin A (compound 28) is the analogue of Withaferin A. 4-epi-Withaferin A enhances cytotoxicity and cytoprotective heat-shock-inducing activity (HSA). 4-epi-Withaferin A has the potential for the research of protein aggregation-associated diseases by stimulating cellular defense mechanisms .
    4-epi-Withaferin A
  • HY-138146
    4-Dehydrowithaferin A

    4-oxo withaferin A

    		 Drug Derivative Cancer
    4-Dehydrowithaferin A is the analogue of withaferin A. Withaferin A is a withanolide isolated from Withania somnifera. 4-Dehydrowithaferin A has the potential for the research of multiple myeloma .
    4-Dehydrowithaferin A
  • HY-N10357
    3-Ethylthio withaferin A

    		Others Others
    3-Ethylthio withaferin A is a derivative of Withaferin A. Withaferin A is a NF-kB inhibitor.
    3-Ethylthio withaferin A
  • HY-N10353
    4-Methyl withaferin A

    		Others Inflammation/Immunology Cancer
    4-Methyl withaferin A is a withaferin A-analogue with anti-tumor activity .
    4-Methyl withaferin A
  • HY-N10358
    3-(2-Hydroxyethyl) thio withaferin A

    		NF-κB Others
    3-(2-Hydroxyethyl) thio withaferin A is a Withaferin A derivative. Withaferin A, a steroidal lactone, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding .
    3-(2-Hydroxyethyl) thio withaferin A
  • HY-N10356
    4,27-Dimethyl withaferin A

    		Others Neurological Disease
    4,27-Dimethyl withaferin A is a synthetic analog of withanolide natural products. 4,27-Dimethyl withaferin A has the potential for the research of neurodegenerative diseases (extracted from patent WO2015077780A1) .
    4,27-Dimethyl withaferin A
  • HY-N5046
    27-O-Acetyl-withaferin A

    		Others Inflammation/Immunology
    27-O-Acetyl-withaferin A is found in Withania aristata .
    27-O-Acetyl-withaferin A
  • HY-N10354
    27-Methyl withaferin A

    		Apoptosis Cancer
    27-Methyl withaferin A (comppund 26) is an apoptosis inducer with anticancer effects. 27-Methyl withaferin A shows antiproliferative effects against HeLa, A-549 and MCF-7 human tumor cell lines with IC50 values of 3.2 μM, 4.2 μM and 1.4 μM, respectively .
    27-Methyl withaferin A
  • HY-N10351
    27-O-(tert-Butyldimethylsilyl)withaferin A

    		Apoptosis Cancer
    27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an apoptosis inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells .
    27-O-(tert-Butyldimethylsilyl)withaferin A
  • HY-N10355
    27-TBDMS-4-Dehydrowithaferin A

    		Apoptosis Cancer
    27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells apoptosis. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent .
    27-TBDMS-4-Dehydrowithaferin A
  • HY-P10928
    BCY17901 TFA

    		Transferrin Receptor Neurological Disease Cancer
    BCY17901 TFA is a potent irreversible transferrin receptor 1 (TfR1) inhibitor (Ki=12 nM). BCY17901 TFA inhibits TfR1-mediated endocytosis and iron transport, and suppresses the proliferation of tumor cells dependent on iron metabolism. BCY17901 TFA can be used in the research of solid tumors (such as breast cancer, glioblastoma) and neurodegenerative diseases .
    BCY17901 TFA
  • HY-P10928A
    BCY17901

    		Transferrin Receptor Neurological Disease Cancer
    BCY17901 is a potent irreversible transferrin receptor 1 (TfR1) inhibitor (Ki=12 nM). BCY17901 inhibits TfR1-mediated endocytosis and iron transport, and suppresses the proliferation of tumor cells dependent on iron metabolism. BCY17901 can be used in the research of solid tumors (such as breast cancer, glioblastoma) and neurodegenerative diseases .
    BCY17901
  • HY-P10319
    RI-STAD-2

    		PKA Cardiovascular Disease Cancer
    RI-STAD-2 is a high-affinity interfering peptide that regulates the subunit RI of protein kinase A (PKA). RI-STAD-2 interferes with the binding of AKAPs and PKA-RI by simulating the interaction between AKAPs' α-helix domain and PKA-RI's dimerization/anchoration (D/D) domain, thereby affecting PKA activity and intracellular localization. RI-STAD-2 can be used to study the role of AKAPs interaction with PKA-RI in pathological processes such as cardiovascular disease and cancer .
    RI-STAD-2

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