Search Result
Results for "
valine
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
32
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-P0108
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-
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- HY-W013751
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N-Fmoc-glycyl-L-valine
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Drug Intermediate
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Others
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Fmoc-Gly-Val-OH (N-Fmoc-glycyl-L-valine) is a glycyl valine derivative, can be used for the synthesis of drugs or other compounds .
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- HY-N0717A
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- HY-N0717
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(S)-valine
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Bacterial
Arginase
Akt
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Infection
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L-Valine (Valine) is a new nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase .
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- HY-N0717R
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(S)-valine (Standard)
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Arginase
Akt
Bacterial
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Others
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L-Valine (Standard) is the analytical standard of L-Valine. This product is intended for research and analytical applications. L-Valine (Valine) is a new nonlinear semiorganic material. L-Valine standrd causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine standrd inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase .
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- HY-W012889
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- HY-N0717AS
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- HY-W142140
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N-Methylvaline
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Amino Acid Derivatives
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Others
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N-Methyl-DL-valine is a valine derivant, is metabolized to cysteine, alanine, tyrosine, tryptophan, citric acid, and succinic acid in the sprout. N-Methyl-DL-valine involves in the modification of monomethyl auristatin F (MMAF), an anti-tubulin agent, makes it hydrophobic functionalization and increases cell permeability .
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- HY-W012889R
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Amino Acid Derivatives
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Others
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DL-Valine (Standard) is the analytical standard of DL-Valine. This product is intended for research and analytical applications. DL-Valine is a valine derivative .
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- HY-N0717S8
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- HY-W002300
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- HY-W048283
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- HY-W013905
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- HY-W016785
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- HY-N0717S
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(S)-valine-15N
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Endogenous Metabolite
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Others
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L-Valine- 15N is the 15N-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1][2].
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- HY-42709
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- HY-N0717S5
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-
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- HY-20561
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-
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- HY-W008733
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-
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- HY-20561A
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- HY-W015465
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-
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- HY-N0717S4
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(S)-valine-1-13C
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Endogenous Metabolite
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Others
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L-Valine-1- 13C is the 13C-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].
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- HY-118535
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- HY-W012889S2
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-
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- HY-41060
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- HY-I1124R
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Isotope-Labeled Compounds
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Others
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L-Valine-d8 (Standard) is the analytical standard of L-Valine-d8. This product is intended for research and analytical applications. L-Valine-d8 is a deuterated form of L-Valine. L-Valine-d8 can be used in the labelled synthesis of L-valineamide-d8 intermediate . L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid .
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- HY-W012889S4
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- HY-W012889S
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- HY-N0717S6
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(S)-valine-13C5
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Endogenous Metabolite
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Others
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L-Valine- 13C5 is the 13C-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].
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- HY-N0717S9
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(S)-valine-15N,d8
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Isotope-Labeled Compounds
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Others
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L-Valine- 15N,d8 is the deuterium and 15 N labeled L-Valine[1]. L-Valine (Valine) is a new nonlinear semiorganic material[2].
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- HY-W002300S
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- HY-W012889S3
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- HY-147180
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Biochemical Assay Reagents
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Others
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Dansyl-DL-valine cyclohexylammonium is a salt form of Dansyl-DL-valine. Dansyl-DL-valine cyclohexylammonium can be used as analyte in chromatographic separation and separation column for the separation of enantiomers and diastereomers for dansyl amino acids, aromatic carboxylic acids, and isoxazolines .
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- HY-W048828
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-
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- HY-W048831
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- HY-I1111
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- HY-78733
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- HY-I1124
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L-valine-2,3,4,4,4,5,5,5-d8
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Isotope-Labeled Compounds
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Others
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L-Valine-d8 is a deuterated form of L-Valine. L-Valine-d8 can be used in the labelled synthesis of L-valineamide-d8 intermediate[1]. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[2].
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- HY-N0717S7
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- HY-W011722
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- HY-N0717S1
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(S)-valine-13C5,15N
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Endogenous Metabolite
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Others
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L-Valine- 13C5, 15N is the 13C- and 15N-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].
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- HY-W142140A
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N-Methylvaline hydrochloride
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Amino Acid Derivatives
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Cancer
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N-Methyl-DL-valine (N-Methylvaline) hydrochloride is a valine derivant, is metabolized to cysteine, alanine, tyrosine, tryptophan, citric acid, and succinic acid in the sprout. N-Methyl-DL-valine hydrochloride involves in the modification of monomethyl auristatin F (MMAF), an anti-tubulin agent, makes it hydrophobic functionalization and increases cell permeability .
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- HY-W142823S
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- HY-143790S
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- HY-136614
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L-valine β-naphthylamide
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Aminopeptidase
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Others
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H-Val-βNA (L-Valine β-naphthylamide) can be used as an aminopeptidase and a Valine arylamidase substrate .
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- HY-W074978
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3-Fluorovaline
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Bacterial
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3-Fluoro-DL-valine (3-Fluorovaline) is an unnatural amino acid that has the activity of inhibiting the growth of certain bacteria. 3-Fluoro-DL-valine can also be used in peptide synthesis, providing a variety of options for the synthesis of specific bioactive peptides. The unique structure of 3-Fluoro-DL-valine makes it a potential application prospect in compound research and development.
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- HY-N0717S2
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- HY-N0717S3
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- HY-P3545
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Angiotensin Receptor
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Cardiovascular Disease
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5-Valine-angiotensin I is an Ang I peptide belonging to angiotensin I. 5-Valine-angiotensin I induces muscle contraction, can be used for renin-angiotensin system studies. Angiotensin I is a putative neurotransmitter, is the precursor of angiotensin II and of angiotensin fragment 1-7, which are involved in regulation of fluid volume and the release of aldosterone .
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- HY-P4008
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dVDAVP
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Vasopressin Receptor
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Endocrinology
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[Deamino-4-valine, 8-D-arginine]-Vasopressin (dVDAVP) is a highly potent and specific antidiuretic agent possessing protracted effects .
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- HY-79709
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Amino Acid Derivatives
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Others
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N-(Methoxycarbonyl)-D-valine methyl ester is an amino acid derivative that can be used for compound synthesis .
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- HY-129263
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Ile-Val
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Ser/Thr Protease
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Cancer
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L-Isoleucyl-L-valine (Ile-Val) is a dipeptide that induces the bovine trypsinogen-trypsin transition .
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- HY-133246A
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Daclatasvir Impurity A TFA
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HCV
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Infection
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Monodes(N-carboxymethyl)valine Daclatasvir TFA (Daclatasvir Impurity A TFA) is the TFA salt form of Monodes(N-carboxymethyl)valine Daclatasvir (HY-133246). Monodes(N-carboxymethyl)valine Daclatasvir TFA is the main degradation product of Daclatasvir (HY-10466). Daclatasvir is a potent HCV NS5A protein inhibitor .
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- HY-79708A
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Methyl (R)-2-amino-3-methylbutanoate hydrochloride; Methyl D-valinate hydrochloride; NSC 22921
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Amino Acid Derivatives
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Others
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O-Methyl-D-valine (hydrochloride) is a valine derivative .
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- HY-119414
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L-N,N-Dimethylvaline
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Drug Intermediate
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Others
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N,N-Dimethyl-L-valine (L-N,N-Dimethylvaline) is a synthetic intermediate useful for pharmaceutical synthesis.
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- HY-41061
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Apoptosis
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Cancer
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D-Boc Valine methyl ester is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis .
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- HY-133246
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Daclatasvir Impurity A
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HCV
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Infection
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Monodes(N-carboxymethyl)valine Daclatasvir (Daclatasvir Impurity A) is the main degradation product of Daclatasvir. Daclatasvir is a potent HCV NS5A protein inhibitor .
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- HY-145898
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14-D-valine-TPL
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c-Myc
Molecular Glues
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Cancer
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WBC100 (14-D-Valine-TPL) is a potent, selective, and orally active c-Myc molecule glue degrader. WBC100 is a c-Myc degrader and targets ubiquitin E3 ligase CHIP mediated 26S proteasome pathway. WBC100 is used for c-Myc overexpressing tumors research .
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- HY-41051
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N-tert-Butoxycarbonyl-N-methyl-L-valine; N-tert-Butoxycarbonyl-N-methylvaline
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Amino Acid Derivatives
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Others
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(2S)-2-[[(tert-Butoxy)carbonyl](methyl)amino]-3-methylbutanoic acid is a valine derivative .
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- HY-N1461R
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Endogenous Metabolite
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Metabolic Disease
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L-Valine (Standard) is the analytical standard of L-Valine. This product is intended for research and analytical applications. L-Valine (Valine) is a new nonlinear semiorganic material .
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- HY-41309
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- HY-W018850
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- HY-W008544
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- HY-W012446
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- HY-75949
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- HY-W018238
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- HY-I1107
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- HY-42757B
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- HY-W037443
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- HY-W010077
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- HY-W013774
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- HY-W012519
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- HY-W009119
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- HY-W014418
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- HY-Y1030
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tert-Butyl (S)-2-amino-3-methylbutanoate hydrochloride
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Amino Acid Derivatives
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Others
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tert-Butyl L-valinate hydrochloride is a valine derivative .
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- HY-W099254
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- HY-W142126
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- HY-W013185
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- HY-W142133
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- HY-W013769
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- HY-123230S1
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- HY-126584
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- HY-W014100
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- HY-113380
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- HY-W004861
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- HY-W012707
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- HY-W010386
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- HY-41048
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- HY-W099255
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- HY-W022593
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- HY-171265
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Antibody-Drug Conjugates (ADCs)
EGFR
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Others
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MRG003 is an Antibody-Drug Conjugate (ADC) that consists of an anti-EGFR humanized IgG1 monoclonal antibody Becotatug (HY-P990049) and MMAE (HY-15162). These two parts are connected through a valine-citrulline (valine-citrulline) linker, where the linker and MMAE constitute the ADC's Drug-Linker conjugate VcMMAE (HY-15575) .
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- HY-N5182
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Others
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Others
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Chymostatin B is a subtype of chymostatin characterized by a valine residue. Chymostatin inhibits chymotrypsin, papain, and other serine/cysteine endopeptidases .
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- HY-W013207
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- HY-W008753
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N-Cbz-L-valine
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Biochemical Assay Reagents
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Others
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Z-L-Val-OH is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-114516
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Others
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Metabolic Disease
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Fructosylvaline (Fructose Valine) is a model fructosyl-amine (Amadori compound) for glycated hemoglobin. Fructosylvaline can be used as a nitrogen source to cultivate microbial strains .
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- HY-114657
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Neprilysin
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Others
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Benproperine is a new neprilysin B inhibitor composed of N-acyl-L-prolyl-L-valine, whose N-acyl moiety is α-isobutylsuccinic acid β-hydroxamic acid.
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- HY-W037443S
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- HY-P4583
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Cathepsin
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Others
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Suc-Val-Pro-Phe-SBzl (succinyl-valine-proline-phenylalanine thiobenzyl ester) is an inhibitor of CatG enzymes with IC50 values of 111-225 mM.
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- HY-W018849
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- HY-119737
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Acetolactate Synthase (ALS)
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Metabolic Disease
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Chlorsulfuron blocks the biosynthesis of the amino acids valine and isoleucine in plants. Chlorsulfuron completely alleviates herbicide-induced growth inhibition. The site of action of Chlorsulfuron is the enzyme acetolactate synthase .
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- HY-W007035
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- HY-I1111S4
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- HY-I1111S3
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- HY-W008064
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Fmoc-L-Citrulline
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Amino Acid Derivatives
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Cancer
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Fmoc-Cit-OH (Fmoc-L-Citrulline) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize a degradable ADC linker composed of a valine-citrulline (Val-Cit) motif .
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- HY-113380R
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Endogenous Metabolite
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Metabolic Disease
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(S)-b-aminoisobutyric acid (Standard) is the analytical standard of (S)-b-aminoisobutyric acid. This product is intended for research and analytical applications. (S)-b-aminoisobutyric acid is a non-protein amino acid originating from the catabolism of thymine and valine.
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- HY-I0102
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Amino Acid Derivatives
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Others
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(2S)-Methyl 2-(2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoate is a valine derivative .
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- HY-I1111S1
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- HY-I0115
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Amino Acid Derivatives
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Others
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(S)-2-((S)-2-Cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoic acid is a valine derivative .
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- HY-13598
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CKD-516
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Microtubule/Tubulin
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Cancer
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Valecobulin (CKD516) is a valine proagent of (S516) and a vascular disrupting agent (VDA). Valecobulin is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors .
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- HY-129724
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ACTH-(11-13)
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Melanocortin Receptor
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Metabolic Disease
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α-MSH(11-13) (ACTH-(11-13)) is the 11-13 amino acid (lysine-proline-valine) sequence of α-MSH (HY-P0252), which reduces fever in rabbits .
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- HY-I1111S2
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- HY-B0511
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Vitamin B7; Vitamin H; D-Biotin
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Endogenous Metabolite
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Metabolic Disease
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Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .
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- HY-CE00185
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(2S)-Methylmalonyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(2S)-Methylmalonyl-CoA ((2S)-Methylmalonyl-coenzyme A) is the (S)-enantiomer of Methylmalonyl-CoA (HY-126791). Methylmalonyl coenzyme A (Methylmalonyl-CoA) is a catabolite of valine, isoleucine, methionine, threonine, odd-chain fatty acids, and cholesterol.
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- HY-15575
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VcMMAE
Maximum Cited Publications
58 Publications Verification
MC-Val-Cit-PAB-MMAE; mc-vc-PAB-MMAE
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Drug-Linker Conjugates for ADC
Microtubule/Tubulin
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Cancer
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VcMMAE (mc-vc-PAB-MMAE) is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
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- HY-126791
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Isosuccinyl coenzyme A; Methylmalonyl coenzyme A
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Endogenous Metabolite
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Others
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Methylmalonyl coenzyme A (Methylmalonyl-CoA) is a catabolite of valine, isoleucine, methionine, threonine, odd-chain fatty acids, and cholesterol. Methylmalonyl coenzyme A tetralithium is converted to succinyl-CoA by enzymatic reaction of methylmalonyl-CoA mutase (MCM) with coenzyme vitamin B12 .
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- HY-160610A
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Others
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Others
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Carbamoyl phosphate dilithium salt is an antisickling agent and plays a significant role in the urea cycle. Carbamoyl phosphate dilithium salt carbamylates the amino-terminal valine residues of hemoglobin S in erythrocytes, which interferes with the sickling phenomenon. Carbamoyl phosphate dilithium salt exhibits toxicity due to the lithium cation .
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- HY-13598A
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CKD-516 hydrochloride
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Microtubule/Tubulin
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Cancer
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Valecobulin hydrochloride (CKD-516 hydrochloride) is a valine proagent of S516 (HY-130233) and a vascular disrupting agent (VDA). Valecobulin hydrochloride is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors .
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- HY-119737R
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Acetolactate Synthase (ALS)
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Metabolic Disease
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Chlorsulfuron (Standard) is the analytical standard of Chlorsulfuron. This product is intended for research and analytical applications. Chlorsulfuron blocks the biosynthesis of the amino acids valine and isoleucine in plants. Chlorsulfuron completely alleviates herbicide-induced growth inhibition. The site of action of Chlorsulfuron is the enzyme acetolactate synthase .
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- HY-126791A
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Isosuccinyl coenzyme A tetralithium; Methylmalonyl coenzyme tetralithium
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Endogenous Metabolite
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Others
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Methylmalonyl-CoA (Methylmalonyl coenzyme A) tetralithium is a catabolite of valine, isoleucine, methionine, threonine, odd-chain fatty acids, and cholesterol. Methylmalonyl-CoA tetralithium is converted to succinyl-CoA by enzymatic reaction of methylmalonyl-CoA mutase (MCM) with coenzyme vitamin B12 .
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- HY-B0511A
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Vitamin B7 sodium; Vitamin H sodium; D-Biotin sodium
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Endogenous Metabolite
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Metabolic Disease
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Biotin (Vitamin B7) sodium is a water-soluble B vitamin and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin sodium is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .
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- HY-W008599
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Amino Acid Derivatives
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Others
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(S)-2-Amino-3-methyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)butanamide 2,2,2-trifluoroacetate is a valine derivative .
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- HY-P2768
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LDH, EC 1.4.1.9
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Endogenous Metabolite
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Metabolic Disease
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Leucine dehydrogenase, Microorganism (EC 1.4.1.9) can be purified from Bacillus spheroides. Leucine dehydrogenase catalyzed the oxidative deamination of L-leucine, L-valine, L-isoleucine, L-norvaline, L-alpha-aminobutyrate, and L-norleucine, and the reductive amination of their keto analogues .
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- HY-B0511R
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Vitamin B7 (Standard); Vitamin H (Standard); D-Biotin (Standard)
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Endogenous Metabolite
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Metabolic Disease
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Biotin (Standard) is the analytical standard of Biotin. Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .
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- HY-164729
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Antibody-Drug Conjugates (ADCs)
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Cancer
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FZ-AD005 is a DLL3 target ADC compound containing a novel anti-DLL3 antibody, FZ-A038, and a valine–alanine (Val–Ala) dipeptide linker. FZ-AD005 can used in the research of small cell lung cancer .
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- HY-15575S
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MC-Val-Cit-PAB-MMAE-d8; mc-vc-PAB-MMAE-d8
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Drug-Linker Conjugates for ADC
Microtubule/Tubulin
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Cancer
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VcMMAE-d8 is an isotope of VcMMAE (HY-15575). VcMMAE-d8 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc) .
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- HY-P1767
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PACAP Receptor
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Cardiovascular Disease
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Prepro VIP (81-122), human is a prepro-vasoactive intestinal polypeptide (VIP) derived peptide, corresponding to residues 81-122. Peptide histidine valine 42 (PHV-42) has been designated to correspond exactly to Prepro VIP (81-122), which reduces both the force and frequency of spontaneous contractions of isolated rat uterus .
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- HY-117259
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ALZ-801
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Amyloid-β
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Neurological Disease
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ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound . ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease .
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- HY-158992S
-
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Isotope-Labeled Compounds
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Others
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SP-(Val- 13C5, 15)-EKNQ-(Leu- 13C6, 15)-TIDFINIVKDPVPHNEYKT TFA is a 13C- and 15N-labeled peptide containing 13C5, 15N-labeled valine (Val) and 13C6, 15N-labeled leucine (Leu).
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- HY-20336
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Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate
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ADC Linker
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Others
Inflammation/Immunology
Cancer
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Mc-Val-Cit-PABC-PNP is a cathepsin cleavable linker for antibody-drug conjugates (ADCs) which couples the antibody element to the effecting compound. Mc-Val-Cit-PABC-PNP can be used in the synthesis of ADCs .
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- HY-W110242A
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Endogenous Metabolite
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Cardiovascular Disease
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(S)-CPP sodium serves as an inhibitor of the branched-chain α-ketoacid dehydrogenase complex (BCKDC) kinase, commonly referred to as BDK or keto acid dehydrogenase kinase. As a negative regulator of BCKDC activity, the inhibition of BDK by (S)-CPP (with an IC50 of 6.3 μM) results in the activation of the complex and a notable decrease in plasma levels of leucine/isoleucine and valine in wild-type mice.
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- HY-B0511S3
-
Vitamin B7-13C5; Vitamin H-13C5; D-Biotin-13C5
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
Biotin- 13C5 (Vitamin B7- 13C5) is 13C labeled Biotin. Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .
|
-
- HY-101511
-
|
P-glycoprotein
|
Cancer
|
TTT-28 is a synthesized thiazole-valine peptidomimetic, a novel selective inhibitor of ABCB1 (P-gp/MDR1) with high efficacy and low toxicity, which reverses the ATP-binding cassette sub-family B member 1 (ABCB1)-mediated multidrug resistance (MDR) by selectively blocking the efflux function of ABCB1 .
|
-
- HY-113126
-
|
Endogenous Metabolite
ATP Synthase
|
Neurological Disease
Metabolic Disease
|
3-Hydroxyisobutyric acid is an intermediate in the metabolic pathways of L-valine and thymine, and can be found in urine. 3-Hydroxyisobutyric acid is a secreted mediator of endothelial cell fatty acid transport and insulin resistance. 3-Hydroxyisobutyric acid can also inhibit key enzymes of energy metabolism in the cerebral cortex of young rats. The levels of 3-Hydroxyisobutyric acid are closely related to various diseases such as 3-hydroxyisobutyric aciduria, diabetes, and ketoacidosis .
|
-
- HY-113126A
-
|
Endogenous Metabolite
ATP Synthase
|
Neurological Disease
Metabolic Disease
|
3-Hydroxyisobutyric acid sodium is an intermediate in the metabolic pathways of L-valine and thymine, and can be found in urine. 3-Hydroxyisobutyric acid sodium is a secreted mediator of endothelial cell fatty acid transport and insulin resistance. 3-Hydroxyisobutyric acid sodium can also inhibit key enzymes of energy metabolism in the cerebral cortex of young rats. The levels of 3-Hydroxyisobutyric acid sodium are closely related to various diseases such as 3-hydroxyisobutyric aciduria, diabetes, and ketoacidosis .
|
-
- HY-117259S
-
ALZ-801-d6
|
Isotope-Labeled Compounds
Amyloid-β
|
Neurological Disease
|
Valiltramiprosate-d6 (ALZ-801-d6) is deuterium labeled Valiltramiprosate. ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound . ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease .
|
-
- HY-164992
-
MRG002; Trastuzumab MMAE
|
Antibody-Drug Conjugates (ADCs)
EGFR
Microtubule/Tubulin
|
Cancer
|
Trastuzumab vedotin (MRG002) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab vedotin is composed of a humanized anti-HER2 antibody Trastuzumab (HY-P9907), an enzymatically cleavable peptide-linker Valine-citrulline, a tubulin inhibitor Monomethyl auristatin E (MMAE; HY-15162). Trastuzumab vedotin can be used for the research of HER2-positive breast cancer .
|
-
- HY-151661
-
L-azidovaline (CHA)
|
ADC Linker
|
Others
|
N3-L-Val-OH (CHA) is a click chemistry containing an azide group, a valine derivative. N3-L-Val-OH (CHA) can also be used as a synthetic intermediate for Valaciclovir (Valacyclovir) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-165098
-
β-Aminoisobutyric acid sodium salt; BAIBA sodium salt
|
Endogenous Metabolite
|
Cardiovascular Disease
Metabolic Disease
|
3-Aminoisobutyric acid (β-Aminoisobutyric acid) sodium salt has anti-inflammatory and antioxidant effects. 3-Aminoisobutyric acid sodium salt increases the expression of brown adipocyte-specific genes in white adipose tissue and fatty acid β-oxidation in hepatocytes. 3-Aminoisobutyric acid sodium salt attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK–PPARδ-dependent pathway in mice. 3-Aminoisobutyric acid sodium salt is a catabolic metabolite of thymine and valine in skeletal muscle .
|
-
- HY-W012974
-
β-Aminoisobutyric acid; BAIBA
|
Endogenous Metabolite
|
Cardiovascular Disease
Metabolic Disease
|
3-Aminoisobutyric acid (β-Aminoisobutyric acid) has anti-inflammatory and antioxidant effects. 3-Aminoisobutyric acid increases the expression of brown adipocyte-specific genes in white adipose tissue and fatty acid β-oxidation in hepatocytes. 3-Aminoisobutyric acid attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK-PPARδ-dependent pathway in mice. 3-Aminoisobutyric acid is a catabolic metabolite of thymine and valine in skeletal muscle .
|
-
- HY-B1119
-
|
Bacterial
Fungal
Antibiotic
Apoptosis
|
Infection
Cancer
|
Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
|
-
- HY-P99238
-
|
ADC Antibody
|
Inflammation/Immunology
Cancer
|
Rolinsatamab is a IgG1κ type chimeric antibody targeting to PRLR (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 (HY-101127) via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (S239C). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (S239C) .
|
-
- HY-P99829
-
PF-06647020; ABBV-647; h6M24-vc0101
|
Antibody-Drug Conjugates (ADCs)
Microtubule/Tubulin
|
Cancer
|
Cofetuzumab pelidotin (PF-06647020) is a PTK7-targeting ADC comprising a humanized anti-PTK7 mAb (hu6M024, IgG1) joined to an auristatin microtubule inhibitor payload, auristatin-0101 (Aur0101; HY-12522), by a cleavable valine-citrulline (vc)-based linker. Cofetuzumab pelidotin has a DAR of 4. Cofetuzumab pelidotin binds to cell-surface PTK7 with an EC50 of 1153 pM by flow cytometry. Cofetuzumab pelidotin has the potential for solid tumors research .
|
-
- HY-W012974R
-
β-Aminoisobutyric acid (Standard); BAIBA (Standard)
|
Endogenous Metabolite
AMPK
PPAR
|
Cardiovascular Disease
Metabolic Disease
|
3-Aminoisobutyric acid (Standard) is the analytical standard of 3-Aminoisobutyric acid. This product is used for research and analytical applications. 3-Aminoisobutyric acid (β-Aminoisobutyric acid) exhibits anti-inflammatory and antioxidant effects. It increases the expression of brown fat cell-specific genes in white adipose tissue and enhances fatty acid β-oxidation in hepatocytes. 3-Aminoisobutyric acid alleviates insulin resistance and inflammation induced by palmitic acid or a high-fat diet in mice via the AMPK–PPARδ-dependent pathway. 3-Aminoisobutyric acid is a catabolite of thymine and valine in skeletal muscle .
|
-
- HY-W653962
-
|
Isotope-Labeled Compounds
Apoptosis
Antibiotic
Fungal
Bacterial
|
Infection
Cancer
|
Triclosan- 13C6 is 13C labeled Triclosan. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
|
-
- HY-W747491
-
|
Isotope-Labeled Compounds
Antibiotic
Apoptosis
Bacterial
Fungal
|
Cancer
|
Triclosan- 13C12 is 13C labeled Triclosan. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
|
-
- HY-B1119R
-
|
Bacterial
Fungal
Antibiotic
Apoptosis
|
Infection
Cancer
|
Triclosan (Standard) is the analytical standard of Triclosan. This product is intended for research and analytical applications. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
|
-
Cat. No. |
Product Name |
Type |
-
- HY-W008753
-
N-Cbz-L-valine
|
Biochemical Assay Reagents
|
Z-L-Val-OH is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P0108
-
-
- HY-W013751
-
N-Fmoc-glycyl-L-valine
|
Drug Intermediate
|
Others
|
Fmoc-Gly-Val-OH (N-Fmoc-glycyl-L-valine) is a glycyl valine derivative, can be used for the synthesis of drugs or other compounds .
|
-
- HY-W012889
-
-
- HY-W002300
-
-
- HY-W048283
-
-
- HY-W013905
-
-
- HY-42709
-
-
- HY-20561
-
-
- HY-W142140
-
N-Methylvaline
|
Amino Acid Derivatives
|
Others
|
N-Methyl-DL-valine is a valine derivant, is metabolized to cysteine, alanine, tyrosine, tryptophan, citric acid, and succinic acid in the sprout. N-Methyl-DL-valine involves in the modification of monomethyl auristatin F (MMAF), an anti-tubulin agent, makes it hydrophobic functionalization and increases cell permeability .
|
-
- HY-W012889R
-
|
Amino Acid Derivatives
|
Others
|
DL-Valine (Standard) is the analytical standard of DL-Valine. This product is intended for research and analytical applications. DL-Valine is a valine derivative .
|
-
- HY-W008733
-
-
- HY-20561A
-
-
- HY-W015465
-
-
- HY-118535
-
-
- HY-41060
-
-
- HY-W048828
-
-
- HY-W048831
-
-
- HY-I1111
-
-
- HY-78733
-
-
- HY-W011722
-
-
- HY-P3545
-
|
Angiotensin Receptor
|
Cardiovascular Disease
|
5-Valine-angiotensin I is an Ang I peptide belonging to angiotensin I. 5-Valine-angiotensin I induces muscle contraction, can be used for renin-angiotensin system studies. Angiotensin I is a putative neurotransmitter, is the precursor of angiotensin II and of angiotensin fragment 1-7, which are involved in regulation of fluid volume and the release of aldosterone .
|
-
- HY-P4008
-
dVDAVP
|
Vasopressin Receptor
|
Endocrinology
|
[Deamino-4-valine, 8-D-arginine]-Vasopressin (dVDAVP) is a highly potent and specific antidiuretic agent possessing protracted effects .
|
-
- HY-79709
-
|
Amino Acid Derivatives
|
Others
|
N-(Methoxycarbonyl)-D-valine methyl ester is an amino acid derivative that can be used for compound synthesis .
|
-
- HY-79708A
-
Methyl (R)-2-amino-3-methylbutanoate hydrochloride; Methyl D-valinate hydrochloride; NSC 22921
|
Amino Acid Derivatives
|
Others
|
O-Methyl-D-valine (hydrochloride) is a valine derivative .
|
-
- HY-P4670
-
|
Peptides
|
Others
|
L-Valine p-nitroanilide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
-
- HY-P4698
-
NSC 35938
|
Peptides
|
Metabolic Disease
|
Tri-valine (NSC 35938) is a polypeptide that can be separated from Creatine kinase (HY-P2799), β-enolase, Triosephosphate isomerase (HY-P2931) and glyceraldehyde 3-phosphate dehydrogenase .
|
-
- HY-41051
-
N-tert-Butoxycarbonyl-N-methyl-L-valine; N-tert-Butoxycarbonyl-N-methylvaline
|
Amino Acid Derivatives
|
Others
|
(2S)-2-[[(tert-Butoxy)carbonyl](methyl)amino]-3-methylbutanoic acid is a valine derivative .
|
-
- HY-41309
-
-
- HY-W018850
-
-
- HY-W008544
-
-
- HY-W012446
-
-
- HY-75949
-
-
- HY-W018238
-
-
- HY-I1107
-
-
- HY-42757B
-
-
- HY-W037443
-
-
- HY-W010077
-
-
- HY-W013774
-
-
- HY-W012519
-
-
- HY-W009119
-
-
- HY-W014418
-
-
- HY-Y1030
-
tert-Butyl (S)-2-amino-3-methylbutanoate hydrochloride
|
Amino Acid Derivatives
|
Others
|
tert-Butyl L-valinate hydrochloride is a valine derivative .
|
-
- HY-W099254
-
-
- HY-W142126
-
-
- HY-W013185
-
-
- HY-W142133
-
-
- HY-W013769
-
-
- HY-126584
-
-
- HY-W014100
-
-
- HY-P4659
-
|
Peptides
|
Others
|
H-Val-Arg-OH is a dipeptide consisting of valine and arginine, used in biochemical research .
|
- HY-W004861
-
- HY-W012707
-
- HY-W010386
-
- HY-41048
-
- HY-W099255
-
- HY-W022593
-
- HY-W013207
-
- HY-P4666
-
|
Peptides
|
Others
|
Valylhistidine is a dipeptide consisting of valine and histidine (Val-His). Valylhistidine forms a dipeptide complex with Cu(II) that mimics superoxide dismutase, but lacks activity .
|
- HY-P4583
-
|
Cathepsin
|
Others
|
Suc-Val-Pro-Phe-SBzl (succinyl-valine-proline-phenylalanine thiobenzyl ester) is an inhibitor of CatG enzymes with IC50 values of 111-225 mM.
|
- HY-W018849
-
- HY-W008064
-
Fmoc-L-Citrulline
|
Amino Acid Derivatives
|
Cancer
|
Fmoc-Cit-OH (Fmoc-L-Citrulline) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize a degradable ADC linker composed of a valine-citrulline (Val-Cit) motif .
|
- HY-I0102
-
|
Amino Acid Derivatives
|
Others
|
(2S)-Methyl 2-(2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoate is a valine derivative .
|
- HY-I0115
-
|
Amino Acid Derivatives
|
Others
|
(S)-2-((S)-2-Cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoic acid is a valine derivative .
|
- HY-P4313
-
|
Peptides
|
Others
|
Asp-Val is a dipeptide formed from L-alpha-aspartyl and L-valine residues. Asp-Val has a role as a metabolite. Asp-Val can be isolated from an enzymatic hydrolysate of food proteins .
|
- HY-W008599
-
|
Amino Acid Derivatives
|
Others
|
(S)-2-Amino-3-methyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)butanamide 2,2,2-trifluoroacetate is a valine derivative .
|
- HY-135158
-
|
Peptides
|
Others
|
Prolylvaline (Pro-Val) is a proline-valine dipeptide that can be used to bind fluorescein isothiocyanate (FITC). Prolylvaline has specific imprinting effects in Tetrahymena, inducing negative imprinting. Using protozoan organisms, proline dipeptides containing different partner amino acids can be distinguished from dipeptides with opposite amino acid positions .
|
- HY-P1767
-
|
PACAP Receptor
|
Cardiovascular Disease
|
Prepro VIP (81-122), human is a prepro-vasoactive intestinal polypeptide (VIP) derived peptide, corresponding to residues 81-122. Peptide histidine valine 42 (PHV-42) has been designated to correspond exactly to Prepro VIP (81-122), which reduces both the force and frequency of spontaneous contractions of isolated rat uterus .
|
- HY-158992S
-
|
Isotope-Labeled Compounds
|
Others
|
SP-(Val- 13C5, 15)-EKNQ-(Leu- 13C6, 15)-TIDFINIVKDPVPHNEYKT TFA is a 13C- and 15N-labeled peptide containing 13C5, 15N-labeled valine (Val) and 13C6, 15N-labeled leucine (Leu).
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P99238
-
|
ADC Antibody
|
Inflammation/Immunology
Cancer
|
Rolinsatamab is a IgG1κ type chimeric antibody targeting to PRLR (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 (HY-101127) via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (S239C). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (S239C) .
|
-
- HY-P99829
-
PF-06647020; ABBV-647; h6M24-vc0101
|
Antibody-Drug Conjugates (ADCs)
Microtubule/Tubulin
|
Cancer
|
Cofetuzumab pelidotin (PF-06647020) is a PTK7-targeting ADC comprising a humanized anti-PTK7 mAb (hu6M024, IgG1) joined to an auristatin microtubule inhibitor payload, auristatin-0101 (Aur0101; HY-12522), by a cleavable valine-citrulline (vc)-based linker. Cofetuzumab pelidotin has a DAR of 4. Cofetuzumab pelidotin binds to cell-surface PTK7 with an EC50 of 1153 pM by flow cytometry. Cofetuzumab pelidotin has the potential for solid tumors research .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-N0717AS
-
|
D-Valine-d8 is the deuterium labeled D-Valine. D-Valine is the enantiomer of L-Valine (HY-N0717). L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid.
|
-
-
- HY-N0717S
-
|
L-Valine- 15N is the 15N-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1][2].
|
-
-
- HY-N0717S4
-
|
L-Valine-1- 13C is the 13C-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].
|
-
-
- HY-W012889S
-
|
DL-Valine-d8 is the deuterium labeled DL-Valine[1].
|
-
-
- HY-N0717S6
-
|
L-Valine- 13C5 is the 13C-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].
|
-
-
- HY-N0717S8
-
|
L-Valine-d is the deuterium labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].
|
-
-
- HY-N0717S5
-
|
L-Valine-2- 13C is the 13C-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].
|
-
-
- HY-W012889S2
-
|
DL-Valine-d is the deuterium labeled DL-Valine[1].
|
-
-
- HY-I1124R
-
|
L-Valine-d8 (Standard) is the analytical standard of L-Valine-d8. This product is intended for research and analytical applications. L-Valine-d8 is a deuterated form of L-Valine. L-Valine-d8 can be used in the labelled synthesis of L-valineamide-d8 intermediate . L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid .
|
-
-
- HY-W012889S4
-
|
DL-Valine-d2 is the deuterium labeled DL-Valine[1].
|
-
-
- HY-N0717S9
-
|
L-Valine- 15N,d8 is the deuterium and 15 N labeled L-Valine[1]. L-Valine (Valine) is a new nonlinear semiorganic material[2].
|
-
-
- HY-W002300S
-
|
Boc-L-Valine-d8 is the deuterium labeled Boc-L-Valine[1].
|
-
-
- HY-W012889S3
-
|
DL-Valine-d-1 is the deuterium labeled DL-Valine[1].
|
-
-
- HY-I1124
-
1 Publications Verification
|
L-Valine-d8 is a deuterated form of L-Valine. L-Valine-d8 can be used in the labelled synthesis of L-valineamide-d8 intermediate[1]. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[2].
|
-
-
- HY-N0717S7
-
|
L-Valine-1- 13C, 15N is the 13C- and 15N-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].
|
-
-
- HY-N0717S1
-
|
L-Valine- 13C5, 15N is the 13C- and 15N-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].
|
-
-
- HY-W142823S
-
|
N-(3-Indolylacetyl)-L-valine-d4 is deuterium labeled N-(3-Indolylacetyl)-L-valine .
|
-
-
- HY-143790S
-
|
N-2-(Hydroxyethyl)-L-valine-d4 is the deuterium labeled N-2-(Hydroxyethyl)-L-valine[1].
|
-
-
- HY-N0717S2
-
|
L-Valine- 13C5, 15N,d8 is the deuterium, 13C-, and 15-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].
|
-
-
- HY-N0717S3
-
|
L-Valine- 13C5, 15N,d2 is the deuterium, 13C-, and 15-labeled L-Valine. L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid[1].
|
-
-
- HY-123230S1
-
|
Trifloxystrobin-d3 is the deuterium labeled DL-Valine[1].
|
-
-
- HY-W037443S
-
|
Methyl L-valinate-d8 is the deuterium labeled Methyl L-valinate[1]. Methyl L-valinate is a valine derivative[2].
|
-
-
- HY-I1111S4
-
|
Fmoc-L-Val-OH- 15N is a 15N-labeled Fmoc-L-Val-OH (HY-I1111). Fmoc-L-Val-OH is a valine derivative .
|
-
-
- HY-I1111S3
-
|
Fmoc-L-Val-OH- 13C5 is a 13C-labeled Fmoc-L-Val-OH (HY-I1111). Fmoc-L-Val-OH is a valine derivative .
|
-
-
- HY-I1111S1
-
|
Fmoc-L-Val-OH-1- 13C is a 13C-labeled Fmoc-L-Val-OH (HY-I1111). Fmoc-L-Val-OH is a valine derivative .
|
-
-
- HY-I1111S2
-
|
Fmoc-L-Val-OH- 13C5, 15N is a 15N-labeled and 13C-labled Fmoc-L-Val-OH (HY-I1111). Fmoc-L-Val-OH is a valine derivative .
|
-
-
- HY-15575S
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VcMMAE-d8 is an isotope of VcMMAE (HY-15575). VcMMAE-d8 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc) .
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- HY-158992S
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SP-(Val- 13C5, 15)-EKNQ-(Leu- 13C6, 15)-TIDFINIVKDPVPHNEYKT TFA is a 13C- and 15N-labeled peptide containing 13C5, 15N-labeled valine (Val) and 13C6, 15N-labeled leucine (Leu).
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- HY-B0511S3
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Biotin- 13C5 (Vitamin B7- 13C5) is 13C labeled Biotin. Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .
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- HY-117259S
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Valiltramiprosate-d6 (ALZ-801-d6) is deuterium labeled Valiltramiprosate. ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound . ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease .
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- HY-W653962
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Triclosan- 13C6 is 13C labeled Triclosan. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
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- HY-W747491
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Triclosan- 13C12 is 13C labeled Triclosan. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
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Classification |
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- HY-151661
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L-azidovaline (CHA)
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Azide
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N3-L-Val-OH (CHA) is a click chemistry containing an azide group, a valine derivative. N3-L-Val-OH (CHA) can also be used as a synthetic intermediate for Valaciclovir (Valacyclovir) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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Product Name |
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Classification |
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- HY-N0717
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(S)-valine
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Freeze-drying Protective Agents
Solubilizing Agents
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L-Valine (Valine) is a new nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase .
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