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trivalent

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23

Inhibitors & Agonists

5

Biochemical Assay Reagents

2

Inhibitory Antibodies

2

Isotope-Labeled Compounds

1

Click Chemistry

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-141438
    SIM1
    1 Publications Verification

    		 PROTACs Epigenetic Reader Domain Cancer
    SIM1 is a potent von Hippel-Lindau (VHL)-based trivalent PROTAC capable of degradation for all BET family members, with preference for BRD2 degradation (IC50=1.1 nM; Kd=186 nM). SIM1 shows sustained anti-cancer activity .
    SIM1
  • HY-119594
    Melarsoprol

    		Parasite Apoptosis Infection Neurological Disease Cancer
    Melarsoprol, a melaminophenylarsine-type trivalent organic arsenical, is an important agent for African trypanosomiasis. Melarsoprol inhibits the growth of lymphoid leukemic cell by inducing apoptosis. Melarsoprol crosses the blood-brain barrier .
    Melarsoprol
  • HY-P99796
    Ozoralizumab

    ATN-103

    		 TNF Receptor Inflammation/Immunology
    Ozoralizumab (ATN-103) is an anti-TNFα humanized antibody. Ozoralizumab is a humanized trivalent nanobody compound that consists of two anti-human TNFα nanobodies and an anti-human serum albumin (HSA) nanobody. Ozoralizumab can be used in research of arthritis .
    Ozoralizumab
  • HY-P99397
    Sonelokimab

    ALX 0761; M 1095

    		 Interleukin Related MMP Inflammation/Immunology
    Sonelokimab (ALX 0761) is a trivalent bispecific nanobody composed of camel derived humanized IL-17F antibodies, IL-17A/F antibodies, and serum albumin VHH antibodies. Sonelokimab can prolong the plasma half-life by binding to human serum albumin. Sonelokimab can be used for research on rheumatoid arthritis and psoriasis .
    Sonelokimab
  • HY-W105699
    EDTA tetrasodium tetrahydrate

    Ethylenediaminetetraacetic acid tetrasodium tetrahydrate

    		 Biochemical Assay Reagents Others
    EDTA tetrasodium tetrahydrate is a metal chelator (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. EDTA tetrasodium tetrahydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. EDTA tetrasodium tetrahydrate can also decrease the formation of disulfide bonds .
    EDTA tetrasodium tetrahydrate
  • HY-160291
    Trivalent GalNAc-DBCO

    		Others Others
    Trivalent GalNAc-DBCO can be used for oligonucleotide coupling .
    Trivalent GalNAc-DBCO
  • HY-158378
    Trivalent hydroxyarsinothricn

    R-AST-OH

    		 Glutaminase Cancer
    Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible kidney-type glutaminase (KGA) inhibitor. Trivalent hydroxyarsinothricn binds to the glutamine binding site and forms a covalent bond with an active site cysteine residue. Trivalent hydroxyarsinothricn selectively kills triple-negative breast cancer (TNBC) cells and is not cytotoxic to the control cell line. KGA is the enzyme that controls glutamine metabolism and is correlated with tumor malignancy .
    Trivalent hydroxyarsinothricn
  • HY-138502
    Melarsomine

    		Parasite Infection
    Melarsomine is a trivalent arsenical compound used as an adulticide. Melarsomine can be used for the reserach of canine heartworm disease and other helminth infections .
    Melarsomine
  • HY-138502A
    Melarsomine dihydrochloride

    		Parasite Infection
    Melarsomine dihydrochloride is a trivalent arsenical compound used as an adulticide. Melarsomine dihydrochloride can be used for the reserach of canine heartworm disease and other helminth infections .
    Melarsomine dihydrochloride
  • HY-163057
    2,2',2''-Nitrilotris(NH-EG8-Lys-2,4-dinitroaniline)

    		Others Inflammation/Immunology
    2,2',2''-Nitrilotris(NH-EG8-Lys-2,4-dinitroaniline) is a trivalent hapten. 2,2',2''-Nitrilotris(NH-EG8-Lys-2,4-dinitroaniline) can aggregate with monoclonal anti-2,4-DNP IgG (IgGDNP) .
    2,2',2''-Nitrilotris(NH-EG8-Lys-2,4-dinitroaniline)
  • HY-Y0682S1
    Ethylenediaminetetraacetic acid-d16

    EDTA-d16

    		 Isotope-Labeled Compounds Neurological Disease
    Ethylenediaminetetraacetic acid-d16 is the deuterium labeled Ethylenediaminetetraacetic acid . Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds .
    Ethylenediaminetetraacetic acid-d16
  • HY-Y0682S
    Ethylenediaminetetraacetic acid-d12

    EDTA-d12

    		 Isotope-Labeled Compounds Neurological Disease
    Ethylenediaminetetraacetic acid-d12 is the deuterium labeled Ethylenediaminetetraacetic acid . Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds .
    Ethylenediaminetetraacetic acid-d12
  • HY-Y0682
    Ethylenediaminetetraacetic acid
    Maximum Cited Publications
    13 Publications Verification

    EDTA

    		 Biochemical Assay Reagents Bacterial SOD Cardiovascular Disease Neurological Disease Cancer
    Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research .
    Ethylenediaminetetraacetic acid
  • HY-W105700
    Ethylenediaminetetraacetic acid sodium hydrate
    5+ Cited Publications

    EDTA sodium hydrate

    		 Biochemical Assay Reagents Bacterial SOD Cardiovascular Disease Neurological Disease Cancer
    Ethylenediaminetetraacetic acid (EDTA) sodium hydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid sodium hydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid sodium hydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid sodium hydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid sodium hydrate can be used for coronary artery disease and neural system disease research .
    Ethylenediaminetetraacetic acid sodium hydrate
  • HY-Y0682B
    Ethylenediaminetetraacetic acid tetrasodium
    5+ Cited Publications

    EDTA tetrasodium

    		 Biochemical Assay Reagents Bacterial SOD Cardiovascular Disease Neurological Disease Cancer
    Ethylenediaminetetraacetic acid (EDTA) tetrasodium is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid tetrasodium has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid tetrasodium decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid tetrasodium can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid tetrasodium can be used for coronary artery disease and neural system disease research .
    Ethylenediaminetetraacetic acid tetrasodium
  • HY-B1009
    Ethylenediaminetetraacetic acid trisodium salt
    Maximum Cited Publications
    13 Publications Verification

    EDTA trisodium salt; Trisodium EDTA

    		 Ferroptosis Bacterial SOD Cardiovascular Disease Neurological Disease Cancer
    Ethylenediaminetetraacetic acid trisodium salt (EDTA trisodium salt; Trisodium EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid trisodium salt has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid trisodium salt decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid trisodium salt can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research .
    Ethylenediaminetetraacetic acid trisodium salt
  • HY-Y0682R
    Ethylenediaminetetraacetic acid (Standard)

    		Biochemical Assay Reagents Bacterial SOD Cardiovascular Disease Neurological Disease Cancer
    Ethylenediaminetetraacetic acid (Standard) is the analytical standard of Ethylenediaminetetraacetic acid. This product is intended for research and analytical applications. Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research [4] .
    Ethylenediaminetetraacetic acid (Standard)
  • HY-Y0682A
    Ethylenediaminetetraacetic acid disodium dihydrate
    5+ Cited Publications

    EDTA disodium dihydrate

    		 Biochemical Assay Reagents Bacterial SOD Cardiovascular Disease Neurological Disease Cancer
    Ethylenediaminetetraacetic acid (EDTA) disodium dehydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid disodium dehydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid disodium dehydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid disodium dehydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid disodium dehydrate can be used for coronary artery disease and neural system disease research .
    Ethylenediaminetetraacetic acid disodium dihydrate
  • HY-148118A
    Tri-GalNAc(OAc)3 TFA

    		LYTACs Cancer
    Tri-GalNAc(OAc)3 TFA is a trivalent N-acetylgalactosamine (GalNAc) derivative that can be used to synthesize GalNAc-LYTAC. Tri-GalNAc is a specific ligand targeting the asialoglycoprotein receptor (ASGPR), mediating the endocytosis and transport of cell surface proteins (such as EGFR, HER2) to lysosomes for degradation by lysosomal targeting chimeras (LYTACs). Tri-GalNAc significantly reduces the level of target proteins and inhibits downstream signaling pathways (such as EGFR-mediated Akt and MAPK signals). Tri-GalNAc(OAc)3 TFA can be used for hepatocyte targeting studies, and can degrade carcinogenic membrane proteins and inhibit tumor cell proliferation in liver cancer cell models .
    Tri-GalNAc(OAc)3 TFA
  • HY-148118
    Tri-GalNAc(OAc)3

    		LYTACs Cancer
    Tri-GalNAc(OAc)3is a trivalent N-acetylgalactosamine (GalNAc) derivative that can be used to synthesize GalNAc-LYTAC. Tri-GalNAc is a specific ligand targeting the asialoglycoprotein receptor (ASGPR), mediating the endocytosis and transport of cell surface proteins (such as EGFR, HER2) to lysosomes for degradation by lysosomal targeting chimeras (LYTACs). Tri-GalNAc significantly reduces the level of target proteins and inhibits downstream signaling pathways (such as EGFR-mediated Akt and MAPK signals). Tri-GalNAc(OAc)3can be used for hepatocyte targeting studies, and can degrade carcinogenic membrane proteins and inhibit tumor cell proliferation in liver cancer cell models .
    Tri-GalNAc(OAc)3
  • HY-Y0682AR
    Ethylenediaminetetraacetic acid disodium dihydrate (Standard)

    		Biochemical Assay Reagents Bacterial SOD Cardiovascular Disease Neurological Disease Cancer
    Ethylenediaminetetraacetic acid (disodium dihydrate) (Standard) is the analytical standard of Ethylenediaminetetraacetic acid (disodium dihydrate). This product is intended for research and analytical applications. Ethylenediaminetetraacetic acid (EDTA) disodium dehydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid disodium dehydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid disodium dehydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid disodium dehydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid disodium dehydrate can be used for coronary artery disease and neural system disease research [4] .
    Ethylenediaminetetraacetic acid disodium dihydrate (Standard)
  • HY-111297
    BMVC4

    		Biochemical Assay Reagents Cancer
    BMVC4 is a G-quadruplex (G4) stabilizer of the human telomeric sequence d[AG3(T2AG3)3]. Screening by circular dichroism (CD) spectroscopy revealed that BMVC4 is more suitable as the core molecule of G4 stabilizers than BMVC. The results showed that BMVC4-12C and BMVC4-8C3O are better candidates for G4 stabilizers and are worthy of further study. A simple and rapid screening method based on Cu2+-induced G4 unfolding can be used to find better G4 stabilizers for potential anticancer applications. CD results showed that the trivalent cations of 9-substituted BMVC derivatives are more suitable as G4 stabilizers than the divalent cations of BMVC. In addition, by monitoring the disappearance of the 291 nm CD band of human telomeres after Cu2+ addition, it was found that the core molecule of G4 stabilizer BMVC4 has better stability.
    BMVC4
  • HY-159102
    PVP-037.2

    		Toll-like Receptor (TLR) Inflammation/Immunology
    PVP-037.2 is a TLR7/8 agonist. PVP-037.2 can serve as an adjuvant to enhance vaccine-induced TH1 type immune responses, increasing the production of antigen-specific antibodies IgG1 and IgG2c .
    PVP-037.2

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