tribbles pseudokinase 1 (TRIB1)

By Targets:	Apoptosis (1) CaMK (1) CDK (1) EGFR (1) IFNAR (2) IKK (1) Interleukin Related (2) Isotope-Labeled Compounds (1) JAK (3) Mixed Lineage Kinase (3) PROTACs (1) RIP kinase (1) ROR (1) Small Interfering RNA (siRNA) (3) STAT (1) VEGFR (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Inflammation/Immunology (4) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-123494

BRD0418	CaMK	Cardiovascular Disease Neurological Disease
BRD0418 is a diversity-oriented synthesis (DOS) molecule that regulates the expression of tribbles pseudokinase 1. BRD0418 has the effect of causing hot lipoprotein metabolism from fat production to clearance. BRD0418 can be used in the study of coronary artery disease (CAD) ^[1].

HY-18710

BMS-066	IKK JAK	Inflammation/Immunology
BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor, with IC₅₀s of 9 nM and 72 nM, respectively.

HY-141676

HyT36	EGFR	Others
HyT36 is a low molecular weight hydrophobic tag that promotes the degradation of fusion protein and pseudokinase Her3 ^[1] .

HY-156466

QL-1200186	STAT Interleukin Related IFNAR	Inflammation/Immunology
QL-1200186 is a selective, orally active, allosteric inhibitor targeting the tyrosine kinase TYK2 pseudokinase domain JH2 (IC₅₀=0.06 nM, TYK2 JH2), with 164-fold selectivity over TYK1 JH2 (IC₅₀=9.85 nM，TYK1 JH2). QL-1200186 first stabilizes the TYK2 JH2 conformation, inhibits the activity of the JH1 catalytic domain, and blocks the IFNα, IL-12/IL-23-mediated JAK-STAT signaling pathway. QL-1200186 can inhibit the production of Th1/Th17 cell-related cytokines (such as IFNγ, IL-23), reduce immune cell activation, and has no significant effect on JAK1/2/3 kinase activity. QL-1200186 can significantly improve skin inflammation in the Imiquimod (HY-B0180)-induced psoriasis mouse model and reduce the Psoriasis Area and Severity Index (PASI) score. QL-1200186 can be used in the study of autoimmune diseases such as psoriasis and systemic lupus erythematosus (SLE) ^[1].

HY-112292A

GW806742X hydrochloride 20+ Cited Publications	Mixed Lineage Kinase VEGFR	Cancer
GW806742X hydrochloride, an ATP mimetic and a potent *MLKL (Mixed Lineage Kinase* Domain-Like protein)** inhibitor, binds the MLKL pseudokinase domain with a K_d of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 (IC₅₀=2 nM). GW806742X hydrochloride retards MLKL membrane translocation and inhibits necroptosis ^[1] .

HY-112292

GW806742X 20+ Cited Publications	Mixed Lineage Kinase VEGFR	Others
GW806742X, an ATP mimetic and a potent *MLKL (Mixed Lineage Kinase* Domain-Like protein)** inhibitor, binds the MLKL pseudokinase domain with a K_d of 9.3 μM. GW806742X has activity against VEGFR2 (IC₅₀=2 nM). GW806742X retards MLKL membrane translocation and inhibits necroptosis ^[1] .

HY-RS15015

TRIB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TRIB1 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TRIB1 Human Pre-designed siRNA Set A TRIB1 Human Pre-designed siRNA Set A

HY-RS29392

Trib1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Trib1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Trib1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Trib1 Rat Pre-designed siRNA Set A Trib1 Rat Pre-designed siRNA Set A

HY-RS22878

Trib1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Trib1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Trib1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Trib1 Mouse Pre-designed siRNA Set A Trib1 Mouse Pre-designed siRNA Set A

HY-18709

Tyk2-IN-3	JAK	Inflammation/Immunology
Tyk2-IN-3 is a Tyk2 pseudokinase inhibitor, with an IC₅₀ of 485 nM.

HY-148366

NecroIr2	Mixed Lineage Kinase RIP kinase CDK	Cancer
NecroIr2 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin (HY-17394)-resistant lung cancer cells (A549R). NecroIr2 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP). NecroIr2 activates receptor-interacting *serine-threonine kinase* 3 (RIPK3*) and mixed lineage kinase* domain-like pseudokinase (MLKL), and regulates CDK4 expression ^[1].

HY-117287

Deucravacitinib Maximum Cited Publications 31 Publications Verification BMS-986165	JAK Interleukin Related IFNAR Isotope-Labeled Compounds	Inflammation/Immunology
Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases, which selectively binds to TYK2 pseudokinase (JH2) domain (IC₅₀=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain. Deucravacitinib inhibits IL-12/23 and type I IFN pathways. Deucravacitinib, the FDA's world first de novo deuterium, is available for study in moderate to severe plaque psoriasis ^[1] .

HY-170995

PROTAC ROR1 degrader-1	PROTACs ROR Apoptosis	Cancer
PROTAC ROR1 degrader-1 (Compound 11d) is a PROTAC degrader for pseudokinase *ROR1* that degrades *ROR1* in NSCLC cells with a DC₅₀s of 40-80 nM. PROTAC ROR1 degrader-1 causes the cleavage of PARP and induces apoptosis in NCI-H23 ^[1]. (Pink: ligand for target protein ROR1 ligand-1 (HY-170996); Black: linker (HY-W014787); Blue: ligand for VHL E3 ligase (S,R,S)-AHPC (HY-125845))

Species:	Human (4)
Tag:	His (2) GST (4)
Source:	Sf9 insect cells (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P74491

	TRIB3 Protein, Human (sf9, GST) tribbles homolog 3; TRB-3; SINK; C20orf97; NIPK; SKIP3	Human	Sf9 insect cells
	TRIB3 protein is an inactive kinase that centrally regulates the integrated stress response (ISR) and inhibits DDIT3/CHOP transcriptional activity. It causes DDIT3/CHOP-dependent cell death during endoplasmic reticulum (ER) stress, particularly in programmed neuronal cell death. TRIB3 Protein, Human (sf9, GST) is the recombinant human-derived TRIB3 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P703032

	TRIB1 Protein, Human (sf9, GST) Pseudouridylate synthase 1 homolog; tRNA pseudouridine synthase 1; tRNA pseudouridine(38-40) synthase; tRNA pseudouridylate synthase I; tRNA-uridine isomerase I	Human	Sf9 insect cells
	TRIB1 Protein, Human (sf9, GST) is the recombinant human-derived TRIB1, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P74492

	TRIB2 Protein, Human (sf9, His-GST) tribbles homolog 2; TRB-2; TRIB2; TRB2	Human	Sf9 insect cells
	TRIB2 protein regulates MAP kinase activation by interacting with MAPK kinase, acting as a regulator without intrinsic kinase activity. Emphasizing its role in fine-tuning the MAP kinase signaling pathway. TRIB2 Protein, Human (sf9, His-GST) is the recombinant human-derived TRIB2 protein, expressed by Sf9 insect cells , with C-His, N-GST labeled tag.

HY-P701725

	VRK3 Protein, Human (sf9, His, GST) VRK3; Inactive serine/threonine-protein kinase VRK3; Serine/threonine-protein pseudokinase VRK3; Vaccinia-related kinase 3	Human	Sf9 insect cells
	Despite its inactive kinase state, VRK3 protein crucially regulates ERK activity by enhancing the phosphatase activity of DUSP3. The interaction with DUSP3 is pivotal as it dephosphorylates and inactivates ERK in the nucleus. VRK3, also interacting with the small GTPase RAN, forms a network of molecular interactions, positioning it as a key modulator in signaling pathways controlling ERK activity and nuclear cellular processes. VRK3 Protein, Human (sf9, His, GST) is the recombinant human-derived VRK3 protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.

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HY-117287

Deucravacitinib 30+ Cited Publications
Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases, which selectively binds to TYK2 pseudokinase (JH2) domain (IC₅₀=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain. Deucravacitinib inhibits IL-12/23 and type I IFN pathways. Deucravacitinib, the FDA's world first de novo deuterium, is available for study in moderate to severe plaque psoriasis ^[1] .

Deucravacitinib

30+ Cited Publications

Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases, which selectively binds to TYK2 pseudokinase (JH2) domain (IC₅₀=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain. Deucravacitinib inhibits IL-12/23 and type I IFN pathways. Deucravacitinib, the FDA's world first de novo deuterium, is available for study in moderate to severe plaque psoriasis ^[1] .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82429

	TRIB3 Antibody (YA2174) C20orf97; NIPK; SINK; SKIP3; TRB3; Trib3; tribbles homolog 3; tribbles pseudokinase 3; tribbles3	WB	Human
	TRIB3 Antibody (YA2174) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TRIB3.

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Cat. No.	Product Name		Classification

HY-RS15015

TRIB1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TRIB1 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS29392

Trib1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Trib1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Trib1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS22878

Trib1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Trib1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Trib1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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