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  4. BRD0418

BRD0418 is a diversity-oriented synthesis (DOS) molecule that regulates the expression of tribbles pseudokinase 1. BRD0418 has the effect of causing hot lipoprotein metabolism from fat production to clearance. BRD0418 can be used in the study of coronary artery disease (CAD) .

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BRD0418

BRD0418 Chemical Structure

CAS No. : 1565827-99-7

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Based on 1 publication(s) in Google Scholar

BRD0418 Related Antibodies

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Description

BRD0418 is a diversity-oriented synthesis (DOS) molecule that regulates the expression of tribbles pseudokinase 1. BRD0418 has the effect of causing hot lipoprotein metabolism from fat production to clearance. BRD0418 can be used in the study of coronary artery disease (CAD) [1].

Molecular Weight

488.57

Formula

C29H32N2O5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C[C@@H]1C[C@@]2([C@@]([H])(OC3=CC=C(C=C23)N(C)C)[C@@H](O1)CO)[H])NCC4=CC=C(C=C4)OC5=CC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (102.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0468 mL 10.2339 mL 20.4679 mL
5 mM 0.4094 mL 2.0468 mL 4.0936 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.22%

SDS (251 KB)

COA (251 KB) HNMR (307 KB) LCMS (89 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0468 mL 10.2339 mL 20.4679 mL 51.1697 mL
5 mM 0.4094 mL 2.0468 mL 4.0936 mL 10.2339 mL
10 mM 0.2047 mL 1.0234 mL 2.0468 mL 5.1170 mL
15 mM 0.1365 mL 0.6823 mL 1.3645 mL 3.4113 mL
20 mM 0.1023 mL 0.5117 mL 1.0234 mL 2.5585 mL
25 mM 0.0819 mL 0.4094 mL 0.8187 mL 2.0468 mL
30 mM 0.0682 mL 0.3411 mL 0.6823 mL 1.7057 mL
40 mM 0.0512 mL 0.2558 mL 0.5117 mL 1.2792 mL
50 mM 0.0409 mL 0.2047 mL 0.4094 mL 1.0234 mL
60 mM 0.0341 mL 0.1706 mL 0.3411 mL 0.8528 mL
80 mM 0.0256 mL 0.1279 mL 0.2558 mL 0.6396 mL
100 mM 0.0205 mL 0.1023 mL 0.2047 mL 0.5117 mL
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BRD0418 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD04181565827-99-7BRD 0418BRD-0418CaMKCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesHepG2 cellscoronary artery diseasetribbles pseudokinase 1 (TRIB1)Inhibitorinhibitorinhibit

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