TRIB2 Protein, Human (sf9, His-GST)

TRIB2 protein regulates MAP kinase activation by interacting with MAPK kinase, acting as a regulator without intrinsic kinase activity. Emphasizing its role in fine-tuning the MAP kinase signaling pathway. TRIB2 Protein, Human (sf9, His-GST) is the recombinant human-derived TRIB2 protein, expressed by Sf9 insect cells , with C-His, N-GST labeled tag.

The TRIB2 protein exerts regulatory control over the activation of MAP kinases by interacting with MAPK kinases, despite lacking intrinsic kinase activity itself. This interaction underscores TRIB2's role as a modulator rather than a direct kinase, suggesting its involvement in fine-tuning MAP kinase signaling pathways. Additionally, TRIB2 engages in a specific interaction with COP1, further expanding its potential regulatory influence within cellular processes. The functional implications of these interactions highlight TRIB2 as a key player in orchestrating cellular signaling cascades and warrant further exploration into its intricate regulatory mechanisms.

Human

Sf9 insect cells

C-His;N-GST

Q92519 (M1-N343)

28951  [NCBI]

Approximately 66 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.