Search Result
Results for "
thiol reaction
" in MedChemExpress (MCE) Product Catalog:
42
Biochemical Assay Reagents
2
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-D1262
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thiol-green 2
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Fluorescent Dye
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Others
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BODIPY-TS (Thiol-green 2) is a fast response and thiol-specific turn-on probe. BODIPY-TS utilizes the thiosulfonate scaffold as a thiol recognition unit. BODIPY-TS has low toxicity, and features high selectivity, low detection limit, and quantitative reaction to thiols . Ex: 490 nM; Em: 515 nM.
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- HY-108715A
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RT-AM
4 Publications Verification
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Fluorescent Dye
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Neurological Disease
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RT-AM is a pro-agent real thiol. Real Thiol is a reversible reaction-based fluorescent probe which can quantitatively monitor the real-time glutathione dynamics in living cells.
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- HY-138525
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PROTAC Linkers
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Cancer
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Azido-PEG4-Thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG4-Thiol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-129846
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Biochemical Assay Reagents
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Others
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IBTP iodide is a lipophilic cation and can be accumulated by mitochondria and yields stable thioether adducts in a thiol-specific
reaction. IBTP iodide can be used for specific labeling of mitochondrial protein thiols .
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- HY-W1048549J
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HOOC-PEG-thiol (MW 40000)
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Biochemical Assay Reagents
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Others
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HOOC-PEG-SH (MW 40000) (HOOC-PEG-Thiol (MW 40000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
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- HY-W1048549H
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HOOC-PEG-thiol (MW 1000)
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Biochemical Assay Reagents
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Others
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HOOC-PEG-SH (MW 1000) (HOOC-PEG-Thiol (MW 1000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
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- HY-174949B
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FMOC-NH-PEG-thiol (MW 3400)
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Biochemical Assay Reagents
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Others
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FMOC-NH-PEG-SH (MW 3400) (FMOC-NH-PEG-Thiol (MW 3400)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
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- HY-174949C
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FMOC-NH-PEG-thiol (MW 5000)
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Biochemical Assay Reagents
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Others
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FMOC-NH-PEG-SH (MW 5000) (FMOC-NH-PEG-Thiol (MW 5000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
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- HY-174949D
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FMOC-NH-PEG-thiol (MW 10000)
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Biochemical Assay Reagents
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Others
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FMOC-NH-PEG-SH (MW 10000) (FMOC-NH-PEG-Thiol (MW 10000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
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- HY-174949
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FMOC-NH-PEG-thiol (MW 1000)
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Biochemical Assay Reagents
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Others
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FMOC-NH-PEG-SH (MW 1000) (FMOC-NH-PEG-Thiol (MW 1000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
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- HY-174949A
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FMOC-NH-PEG-thiol (MW 2000)
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Biochemical Assay Reagents
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Others
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FMOC-NH-PEG-SH (MW 2000) (FMOC-NH-PEG-Thiol (MW 2000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
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- HY-W440727
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Liposome
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Cancer
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Cholesterol-PEG-Vinylsulfone (MW 2000) is a thiol reactive polyPEG via thiol-ene reaction to form a thioether bond. It can self-assemble in water and is used to prepare liposome as drug vehicle for targeted delivery into tissues.
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- HY-D0042
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NBD-Cl
1 Publications Verification
NBD chloride
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Fluorescent Dye
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Others
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NBD-Cl is a nonfluorescent reagent which becomes highly fluorescent after reaction with thiol or amino groups .
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- HY-108715
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Fluorescent Dye
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Neurological Disease
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Real Thiol is a reversible reaction-based fluorescent probe which can quantitatively monitor the real-time glutathione dynamics in living cells.
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- HY-136129
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ADC Linker
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Cancer
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N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-W011500
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Tris(2-carboxyethyl)phosphine hydrochloride
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Drug Derivative
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Others
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TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry .
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- HY-136386
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Reactive Oxygen Species (ROS)
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Others
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N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group, but cannot enter the glutathione metabolic pathway .
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- HY-W800714
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Biochemical Assay Reagents
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Others
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SPDP-Gly-Gly-methoxy is a linker with SPDP and methyl ester moiety. The SPDP is an amine and thiol reactive crosslinker. It is also membrane permeable, allowing it to participate in intracellular crosslinking reactions.
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- HY-W011500S
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Isotope-Labeled Compounds
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Others
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TCEP-d16 (hydrochloride) is the deuterium labeled TCEP hydrochloride . TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry .
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- HY-W023557
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3-Methylmaleimide; 2-Methylmaleimide
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Drug Intermediate
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Others
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Citraconimide is a 3-methylmaleimide derivative. Citraconimide has thiol affinity and can undergo highly regioselective addition with a variety of alkyl thiols. Citraconimide derivatives show growth inhibitory activity against HeLa cells. Citraconimide can be modified by N-substitution, halogenation and other reactions for use in bioactive molecule design and drug development research .
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- HY-W440905
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Biochemical Assay Reagents
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Others
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DSPE-PEG-Vinylsulfone, MW 2000 is a phospholipid PEG which can self-assemble to form lipid bilayer in water. The polymer can be used to encapsulate therapeutics, such as nucleic acid (mRNA/DNA) or protein, in drug delivery system. The vinyl sulfone is reactive with thiol molecule via thiol-ene reaction for bioconjugation. Reagent grade, for research use only.
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- HY-W440907
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Biochemical Assay Reagents
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Others
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DSPE-PEG-Vinylsulfone, MW 5000 is a viniyl sulfone PEG lipid which can be used for bioconjugation with cysteine or other thiol molecule through thiol-ene reaction. The polymer is a self-assembling reagetn which forms lipid bilayer in water and can be used as drug carrier to delivery therapeutic agents, such as mRNA or DNA vaccine. Reagent grade, for research use only.
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- HY-156392
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PROTAC Linkers
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Cancer
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TCO4-PEG7-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG7-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
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- HY-156391A
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PROTAC Linkers
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Cancer
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TCO4-PEG2-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG2-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
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- HY-156391
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PROTAC Linkers
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Cancer
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TCO4-PEG2-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG2-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
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- HY-W872575A
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PROTAC Linkers
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Cancer
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TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
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- HY-W872575
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PROTAC Linkers
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Cancer
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TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
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- HY-E70264
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Endogenous Metabolite
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Metabolic Disease
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16:0 Coenzyme A triammonium is palmitoyl-CoA, which can serve as a reaction substrate to transfer the palmitoyl group to the free thiol group of the target protein through palmitoylation catalyzed by protein acyl transferases (PATs) .
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- HY-W700621
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Tris(2-carboxyethyl)phosphine hydrochloride-d12
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Isotope-Labeled Compounds
Others
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Others
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TCEP-d12 (hydrochloride) (Tris(2-?carboxyethyl)?phosphine hydrochloride-d12) is deuterium labeled TCEP (hydrochloride). TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry .
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- HY-D2091
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Fluorescent Dye
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Others
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PE-VF647 Maleimide is a double-dye dye that can undergo thiol reaction. It contains maleimide groups that can react with thiol groups to form covalent bonds. PE-VF647 Maleimide contains two dyes, PE and VF, with excitation wavelengths (Ex) of 495 nm and 566 nm, respectively. PE-VF594 Maleimide has an emission wavelength (Em) of 665 nm.
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- HY-W615173
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Biochemical Assay Reagents
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Others
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NHS ester-C2-NHCO-C2-NHS is a heterobifunctional PEG linker, featuring a terminal NHS ester that can be used to label amine compounds and maleimide group for reactions with thiol groups.
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- HY-W800711
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Biochemical Assay Reagents
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Others
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SPDP-Gly-Pro-NHS ester is a linker with SPDP and NHS ester moieties. The SPDP is an amine and thiol reactive crosslinker. It is also membrane permeable, allowing it to participate in intracellular crosslinking reactions. The NHS ester is amine reactive and forms stable amide bonds.
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- HY-167324
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Biochemical Assay Reagents
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Others
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PLLA4000-PEG2000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA4000-PEG2000-SPDP can be used in drug delivery research .
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- HY-167333
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Biochemical Assay Reagents
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Others
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PLLA2000-PEG1000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA2000-PEG1000-SPDP can be used in drug delivery research .
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- HY-167335
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Biochemical Assay Reagents
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Others
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PLLA1000-PEG3000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA1000-PEG3000-SPDP can be used in drug delivery research .
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- HY-167338
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Biochemical Assay Reagents
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Others
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PLLA10000-PEG5000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA10000-PEG5000-SPDP can be used in drug delivery research .
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- HY-167341
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Biochemical Assay Reagents
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Others
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PLLA10000-PEG1000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA10000-PEG1000-SPDP can be used in drug delivery research .
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- HY-167336
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Biochemical Assay Reagents
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Others
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PLLA1000-PEG2000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA1000-PEG2000-SPDP can be used in drug delivery research .
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- HY-167331
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Biochemical Assay Reagents
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Others
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PLLA2000-PEG3000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA2000-PEG3000-SPDP can be used in drug delivery research .
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- HY-167332
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Biochemical Assay Reagents
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Others
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PLLA2000-PEG2000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA2000-PEG2000-SPDP can be used in drug delivery research .
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- HY-167321
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Biochemical Assay Reagents
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Others
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PLLA5000-PEG1000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA5000-PEG1000-SPDP can be used in drug delivery research .
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- HY-167328
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Biochemical Assay Reagents
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Others
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PLLA3000-PEG2000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA3000-PEG2000-SPDP can be used in drug delivery research .
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- HY-167320
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Biochemical Assay Reagents
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Others
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PLLA5000-PEG2000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA5000-PEG2000-SPDP can be used in drug delivery research .
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- HY-167327
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Biochemical Assay Reagents
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Others
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PLLA3000-PEG3000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA3000-PEG3000-SPDP can be used in drug delivery research .
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- HY-167326
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Biochemical Assay Reagents
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Others
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PLLA3000-PEG5000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA3000-PEG5000-SPDP can be used in drug delivery research .
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- HY-167334
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Biochemical Assay Reagents
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Others
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PLLA1000-PEG5000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA1000-PEG5000-SPDP can be used in drug delivery research .
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- HY-167318
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Biochemical Assay Reagents
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Others
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PLLA5000-PEG5000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA5000-PEG5000-SPDP can be used in drug delivery research .
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- HY-167323
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Biochemical Assay Reagents
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Others
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PLLA4000-PEG3000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA4000-PEG3000-SPDP can be used in drug delivery research .
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- HY-167322
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Biochemical Assay Reagents
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Others
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PLLA4000-PEG5000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA4000-PEG5000-SPDP can be used in drug delivery research .
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- HY-167339
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Biochemical Assay Reagents
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Others
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PLLA10000-PEG3000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA10000-PEG3000-SPDP can be used in drug delivery research .
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- HY-167330
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Biochemical Assay Reagents
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Others
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PLLA2000-PEG5000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA2000-PEG5000-SPDP can be used in drug delivery research .
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- HY-167325
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Biochemical Assay Reagents
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Others
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PLLA4000-PEG1000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA4000-PEG1000-SPDP can be used in drug delivery research .
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- HY-167340
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Biochemical Assay Reagents
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Others
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PLLA10000-PEG2000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA10000-PEG2000-SPDP can be used in drug delivery research .
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- HY-167337
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Biochemical Assay Reagents
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Others
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PLLA1000-PEG1000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA1000-PEG1000-SPDP can be used in drug delivery research .
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- HY-167319
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Biochemical Assay Reagents
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Others
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PLLA5000-PEG3000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA5000-PEG3000-SPDP can be used in drug delivery research .
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- HY-167329
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Biochemical Assay Reagents
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Others
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PLLA3000-PEG1000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA3000-PEG1000-SPDP can be used in drug delivery research .
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- HY-131468
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AMD473; ZD0473
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DNA/RNA Synthesis
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Cancer
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Picoplatin (AMD473) is a platinum-based antineoplastic agent. Picoplatin is specifically to circumvent thiol-mediated drug resistance by sterically hindering its reaction with glutathione (GSH) while still retaining the ability to form cytotoxic lesions with DNA .
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- HY-D2092
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Fluorescent Dye
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Others
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PE-VF680 Maleimide is a double-dye dye that can undergo thiol reaction. It contains maleimide groups that can react with thiol groups to form covalent bonds. Ex/Em=495-566/701 nm. PE-VF680 Maleimide contains two dyes, PE and VF, with excitation wavelengths (Ex) of 495 nm and 566 nm, respectively. PE-VF594 Maleimide has an emission wavelength (Em) of 701 nm.
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- HY-D1590
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Fluorescent Dye
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Others
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ODIPY Green 8-P2M is a novel thiol-reactive fluorescence probe based on the BODIPY fluorophore, the fluorescence is strongly quenched by d-PeT and then can be restored after reaction with thiol, resulting in an extremely high signal-to-noise ratio. ODIPY Green 8-P2M can be useful for detecting extremely low concentrations of protein in the gel after SDS-PAGE .
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- HY-118112
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Biochemical Assay Reagents
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Others
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4-N-Maleimidobenzoicacid-NHS is a PEG linker that finds utility in bioconjugation endeavors and protein labeling ventures. Specifically designed for selective reaction with thiol groups, the maleimide group establishes covalent linkages, thereby facilitating the coupling of proteins, peptides, or diverse molecules to thiol-bearing biomolecules. The NHS ester is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic conditions to form a covalent bond.
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- HY-W190925
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Biochemical Assay Reagents
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Others
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APN-C3-biotin is a heterobifunctional linker containing an APN moiety with exquisite chemoselectivity for cysteine and Biotin. The superior stability of APN-cysteine conjugates in aqueous media, human plasma, and living cells makes this new thiol-click reaction a promising methodology for applications in bioconjugation.
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- HY-174965H
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DBCO-PEG-thiol (MW 10000)
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Biochemical Assay Reagents
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Others
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DBCO-PEG-SH (MW 10000) (DBCO-PEG-Thiol (MW 10000)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 10000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
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- HY-174965E
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DBCO-PEG-thiol (MW 5000)
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Biochemical Assay Reagents
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Others
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DBCO-PEG-SH (MW 5000) (DBCO-PEG-Thiol (MW 5000)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 5000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
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- HY-136386R
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Reference Standards
Reactive Oxygen Species (ROS)
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Others
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N-Acetyl-D-cysteine (Standard) is the analytical standard of N-Acetyl-D-cysteine. This product is intended for research and analytical applications. N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group, but cannot enter the glutathione metabolic pathway .
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- HY-174965D
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DBCO-PEG-thiol (MW 3400)
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Biochemical Assay Reagents
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Others
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DBCO-PEG-SH (MW 3400) (DBCO-PEG-Thiol (MW 3400)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 3400) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
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- HY-174965C
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DBCO-PEG-thiol (MW 2000)
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Biochemical Assay Reagents
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Others
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DBCO-PEG-SH (MW 2000) (DBCO-PEG-Thiol (MW 2000)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 2000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
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- HY-174965
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DBCO-PEG-thiol (MW 400)
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Biochemical Assay Reagents
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Others
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DBCO-PEG-SH (MW 400) (DBCO-PEG-Thiol (MW 400)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 400) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174965B
-
|
DBCO-PEG-thiol (MW 1000)
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-PEG-SH (MW 1000) (DBCO-PEG-Thiol (MW 1000)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 1000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174965A
-
|
DBCO-PEG-thiol (MW 600)
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-PEG-SH (MW 600) (DBCO-PEG-Thiol (MW 600)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 600) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-W800713
-
|
|
Biochemical Assay Reagents
|
Others
|
|
SPDP-Gly-Pro-acid is a linker with SPDP and carboxylic acid moieties. The SPDP is an amine and thiol reactive crosslinker. It is also membrane permeable, allowing it to participate in intracellular crosslinking reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-W615327
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bis-sulfone NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact.
|
-
- HY-173390
-
|
|
Drug Intermediate
Biochemical Assay Reagents
|
Others
|
|
BCN-E-BCN is a strained cycloalkyne-based probe designed for detecting protein sulfenylation, the primary intermediate in protein oxidation. This structurally constrained cycloalkyne compound specifically recognizes sulfenic acid groups formed during thiol oxidation, while remaining completely unreactive toward other oxidative states (such as free thiols, sulfinic, or sulfonic acid groups). Researchers can leverage its efficient conjugation with azide-bearing tags through copper-free click chemistry to amplify detection signals. Compared to conventional detection methods, BCN-E-BCN demonstrates superior reaction kinetics and enhanced sensitivity. With these advantages, BCN-E-BCN shows great promise as an effective tool for protein oxidation research .
|
-
- HY-W800833
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Benzyl N-[2-(prop-2-enamido)ethyl]carbamate is a short aliphatic linker featuring a Cbz-protected amine and an acrylamide. Acrylamide is a Michael acceptor which is a good Michael acceptor which can be used in thiol-based bioconjugation or polymerization. Meanwhile, the Cbz protecting group can be removed using Pd-C hydrogenation to reveal a free amine that can participate in a wide variety of reactions such as couplings or reductive amination.
|
-
![Benzyl N-[2-(prop-2-enamido)ethyl]carbamate](//file.medchemexpress.eu/product_pic/hy-w800833.gif)
- HY-123189
-
|
|
Dopamine Receptor
|
Neurological Disease
|
|
LY 171859 is a D2 receptor agonist with significant reductase activity. LY 171859 exhibits enzymatic activity in the cytoplasm of liver, lung, and kidney, and also contains significant reductase activity in rat and human blood. LY 171859 has higher hepatic reductase activity in guinea pigs, followed by hamsters, rabbits, rats, and mice. The substrate of LY 171859 shows an apparent Km of 5.6 μM. The reduction reaction of LY 171859 is NADPH-dependent with an apparent Km of 14.8 μM. Only the A-side hydrogen of NADPH is incorporated in the reduction product of LY 171859. The reaction of LY 171859 is inhibited by cyanide and thiol reagents, and phenobarbital does not induce its activity in rats .
|
-
- HY-W190952
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bis-sulfone-PEG4-NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. The hydrophilic PEG spacer increases solubility in aqueous media.
|
-
- HY-W878827
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bis-sulfone-PEG12-NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. The hydrophilic PEG spacer increases solubility in aqueous media.
|
-
- HY-W800719
-
|
|
Biochemical Assay Reagents
|
Others
|
|
N-Boc-N'-(PEG1-t-butyl ester)-L-Lysine-amido-Mal is the amino acid, lysine, with a maleimide at its C-terminus, a Boc-protecting group on its α-amine, and an amido-PEG1-t-butyl ester on its ε-amine. Maleimide is a thiol-reactive covalent group used to conjugate cysteine residues, while the Boc and the t-butyl ester can be later deprotected to perform further reactions.
|
-
- HY-W440955
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Stearic acid-PEG-CH2CO2H, MW 3400 is a lipophilic thiol-reactive PEG polymer. The stearic acid can be used to encapsulate hydrophobic therapeutic agents while the PEG chain increases overall water solubility and biocompatibilty. Reaction between carboxylic acid (-COOH) and amine (-NH2) vai condensation in the presence of activator, such as HATU or EDC, generates a stable amide linkage. Reagent grade, for research use only.
|
-
- HY-W800627
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bis-sulfone-PEG8-NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. The hydrophilic PEG spacer increases solubility in aqueous media.
|
-
- HY-W073382
-
|
Bis–sulfone Acid
|
Biochemical Assay Reagents
|
Others
|
|
4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid (Bis-sulfone Acid) is a strong covalent linker featuring a free carboxylic acid and two tosyl groups. Each tosyl group can be displaced by thiol or amine nucleophiles via a Michael addition, and the inclusion of two on this molecule allow this reaction to proceed twice. This may be used to “staple” two reduced cysteine residues on a given protein to reform disulfide bridges. The carboxylic acid is free to react to form amides or esters.
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-
- HY-D1871
-
|
|
Fluorescent Dye
|
Others
|
|
Cy3 maleimide chloride is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing maleimide functional groups. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The alkyne functional group of Cy3 maleimide chloride can undergo a "thiol-acrylamide" reaction with molecules containing sulfur-oxygen functional groups to form covalent bonds. Cy3 maleimide chloride can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
|
-
- HY-W011696
-
|
cis-1-Amino-9-octadecene, 80-90%
|
Biochemical Assay Reagents
|
Others
|
|
Oleylamine, 80-90% (cis-1-Amino-9-octadecene, 80-90%) is a multifunctional reagent for metal ion coordination and nanoparticle surface modification. Oleylamine, 80-90% is a solvent, surfactant and reducing agent in the synthesis of metal oxide nanoparticles. Oleylamine, 80-90% can regulate nanoparticle morphology, magnetization and water proton relaxation rate through thiol-ene "click" reaction, and increase the colloidal stability of nanoparticles in organic reagents. Oleylamine, 80-90% is mainly used in the research and application of nanomaterial synthesis, biomedical imaging (MRI contrast agents, fluorescent probes), cancer cell targeting and drug delivery .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-D1262
-
|
thiol-green 2
|
Fluorescent Dyes/Probes
|
|
BODIPY-TS (Thiol-green 2) is a fast response and thiol-specific turn-on probe. BODIPY-TS utilizes the thiosulfonate scaffold as a thiol recognition unit. BODIPY-TS has low toxicity, and features high selectivity, low detection limit, and quantitative reaction to thiols . Ex: 490 nM; Em: 515 nM.
|
-
- HY-D0042
-
NBD-Cl
1 Publications Verification
NBD chloride
|
Dyes
|
|
NBD-Cl is a nonfluorescent reagent which becomes highly fluorescent after reaction with thiol or amino groups .
|
-
- HY-108715
-
|
|
Fluorescent Dyes/Probes
|
|
Real Thiol is a reversible reaction-based fluorescent probe which can quantitatively monitor the real-time glutathione dynamics in living cells.
|
-
- HY-D1871
-
|
|
Fluorescent Dyes/Probes
|
|
Cy3 maleimide chloride is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing maleimide functional groups. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The alkyne functional group of Cy3 maleimide chloride can undergo a "thiol-acrylamide" reaction with molecules containing sulfur-oxygen functional groups to form covalent bonds. Cy3 maleimide chloride can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
|
-
- HY-D2091
-
|
|
Protein Labeling
|
|
PE-VF647 Maleimide is a double-dye dye that can undergo thiol reaction. It contains maleimide groups that can react with thiol groups to form covalent bonds. PE-VF647 Maleimide contains two dyes, PE and VF, with excitation wavelengths (Ex) of 495 nm and 566 nm, respectively. PE-VF594 Maleimide has an emission wavelength (Em) of 665 nm.
|
-
- HY-D2092
-
|
|
Protein Labeling
|
|
PE-VF680 Maleimide is a double-dye dye that can undergo thiol reaction. It contains maleimide groups that can react with thiol groups to form covalent bonds. Ex/Em=495-566/701 nm. PE-VF680 Maleimide contains two dyes, PE and VF, with excitation wavelengths (Ex) of 495 nm and 566 nm, respectively. PE-VF594 Maleimide has an emission wavelength (Em) of 701 nm.
|
| Cat. No. |
Product Name |
Type |
-
- HY-W1048549J
-
|
HOOC-PEG-thiol (MW 40000)
|
Drug Delivery
|
|
HOOC-PEG-SH (MW 40000) (HOOC-PEG-Thiol (MW 40000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
|
-
- HY-W1048549H
-
|
HOOC-PEG-thiol (MW 1000)
|
Drug Delivery
|
|
HOOC-PEG-SH (MW 1000) (HOOC-PEG-Thiol (MW 1000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
|
-
- HY-174949B
-
|
FMOC-NH-PEG-thiol (MW 3400)
|
Drug Delivery
|
|
FMOC-NH-PEG-SH (MW 3400) (FMOC-NH-PEG-Thiol (MW 3400)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
|
-
- HY-174949C
-
|
FMOC-NH-PEG-thiol (MW 5000)
|
Drug Delivery
|
|
FMOC-NH-PEG-SH (MW 5000) (FMOC-NH-PEG-Thiol (MW 5000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
|
-
- HY-174949D
-
|
FMOC-NH-PEG-thiol (MW 10000)
|
Drug Delivery
|
|
FMOC-NH-PEG-SH (MW 10000) (FMOC-NH-PEG-Thiol (MW 10000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
|
-
- HY-174949
-
|
FMOC-NH-PEG-thiol (MW 1000)
|
Drug Delivery
|
|
FMOC-NH-PEG-SH (MW 1000) (FMOC-NH-PEG-Thiol (MW 1000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
|
-
- HY-174949A
-
|
FMOC-NH-PEG-thiol (MW 2000)
|
Drug Delivery
|
|
FMOC-NH-PEG-SH (MW 2000) (FMOC-NH-PEG-Thiol (MW 2000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
|
-
- HY-W440905
-
|
|
Drug Delivery
|
|
DSPE-PEG-Vinylsulfone, MW 2000 is a phospholipid PEG which can self-assemble to form lipid bilayer in water. The polymer can be used to encapsulate therapeutics, such as nucleic acid (mRNA/DNA) or protein, in drug delivery system. The vinyl sulfone is reactive with thiol molecule via thiol-ene reaction for bioconjugation. Reagent grade, for research use only.
|
-
- HY-W440907
-
|
|
Drug Delivery
|
|
DSPE-PEG-Vinylsulfone, MW 5000 is a viniyl sulfone PEG lipid which can be used for bioconjugation with cysteine or other thiol molecule through thiol-ene reaction. The polymer is a self-assembling reagetn which forms lipid bilayer in water and can be used as drug carrier to delivery therapeutic agents, such as mRNA or DNA vaccine. Reagent grade, for research use only.
|
-
- HY-167324
-
|
|
Drug Delivery
|
|
PLLA4000-PEG2000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA4000-PEG2000-SPDP can be used in drug delivery research .
|
-
- HY-167333
-
|
|
Drug Delivery
|
|
PLLA2000-PEG1000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA2000-PEG1000-SPDP can be used in drug delivery research .
|
-
- HY-167335
-
|
|
Drug Delivery
|
|
PLLA1000-PEG3000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA1000-PEG3000-SPDP can be used in drug delivery research .
|
-
- HY-167338
-
|
|
Drug Delivery
|
|
PLLA10000-PEG5000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA10000-PEG5000-SPDP can be used in drug delivery research .
|
-
- HY-167341
-
|
|
Drug Delivery
|
|
PLLA10000-PEG1000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA10000-PEG1000-SPDP can be used in drug delivery research .
|
-
- HY-167336
-
|
|
Drug Delivery
|
|
PLLA1000-PEG2000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA1000-PEG2000-SPDP can be used in drug delivery research .
|
-
- HY-167331
-
|
|
Drug Delivery
|
|
PLLA2000-PEG3000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA2000-PEG3000-SPDP can be used in drug delivery research .
|
-
- HY-167332
-
|
|
Drug Delivery
|
|
PLLA2000-PEG2000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA2000-PEG2000-SPDP can be used in drug delivery research .
|
-
- HY-167321
-
|
|
Drug Delivery
|
|
PLLA5000-PEG1000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA5000-PEG1000-SPDP can be used in drug delivery research .
|
-
- HY-167328
-
|
|
Drug Delivery
|
|
PLLA3000-PEG2000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA3000-PEG2000-SPDP can be used in drug delivery research .
|
-
- HY-167320
-
|
|
Drug Delivery
|
|
PLLA5000-PEG2000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA5000-PEG2000-SPDP can be used in drug delivery research .
|
-
- HY-167327
-
|
|
Drug Delivery
|
|
PLLA3000-PEG3000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA3000-PEG3000-SPDP can be used in drug delivery research .
|
-
- HY-167326
-
|
|
Drug Delivery
|
|
PLLA3000-PEG5000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA3000-PEG5000-SPDP can be used in drug delivery research .
|
-
- HY-167334
-
|
|
Drug Delivery
|
|
PLLA1000-PEG5000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA1000-PEG5000-SPDP can be used in drug delivery research .
|
-
- HY-167318
-
|
|
Drug Delivery
|
|
PLLA5000-PEG5000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA5000-PEG5000-SPDP can be used in drug delivery research .
|
-
- HY-167323
-
|
|
Drug Delivery
|
|
PLLA4000-PEG3000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA4000-PEG3000-SPDP can be used in drug delivery research .
|
-
- HY-167322
-
|
|
Drug Delivery
|
|
PLLA4000-PEG5000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA4000-PEG5000-SPDP can be used in drug delivery research .
|
-
- HY-167339
-
|
|
Drug Delivery
|
|
PLLA10000-PEG3000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA10000-PEG3000-SPDP can be used in drug delivery research .
|
-
- HY-167330
-
|
|
Drug Delivery
|
|
PLLA2000-PEG5000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA2000-PEG5000-SPDP can be used in drug delivery research .
|
-
- HY-167325
-
|
|
Drug Delivery
|
|
PLLA4000-PEG1000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA4000-PEG1000-SPDP can be used in drug delivery research .
|
-
- HY-167340
-
|
|
Drug Delivery
|
|
PLLA10000-PEG2000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA10000-PEG2000-SPDP can be used in drug delivery research .
|
-
- HY-167337
-
|
|
Drug Delivery
|
|
PLLA1000-PEG1000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA1000-PEG1000-SPDP can be used in drug delivery research .
|
-
- HY-167319
-
|
|
Drug Delivery
|
|
PLLA5000-PEG3000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA5000-PEG3000-SPDP can be used in drug delivery research .
|
-
- HY-167329
-
|
|
Drug Delivery
|
|
PLLA3000-PEG1000-SPDP is a polylactic acid derivative that can form micelles in water and the SPDP moiety can react with thiols. PLLA3000-PEG1000-SPDP can be used in drug delivery research .
|
-
- HY-174965H
-
|
DBCO-PEG-thiol (MW 10000)
|
Drug Delivery
|
|
DBCO-PEG-SH (MW 10000) (DBCO-PEG-Thiol (MW 10000)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 10000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174965E
-
|
DBCO-PEG-thiol (MW 5000)
|
Drug Delivery
|
|
DBCO-PEG-SH (MW 5000) (DBCO-PEG-Thiol (MW 5000)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 5000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174965D
-
|
DBCO-PEG-thiol (MW 3400)
|
Drug Delivery
|
|
DBCO-PEG-SH (MW 3400) (DBCO-PEG-Thiol (MW 3400)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 3400) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174965C
-
|
DBCO-PEG-thiol (MW 2000)
|
Drug Delivery
|
|
DBCO-PEG-SH (MW 2000) (DBCO-PEG-Thiol (MW 2000)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 2000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174965
-
|
DBCO-PEG-thiol (MW 400)
|
Drug Delivery
|
|
DBCO-PEG-SH (MW 400) (DBCO-PEG-Thiol (MW 400)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 400) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174965B
-
|
DBCO-PEG-thiol (MW 1000)
|
Drug Delivery
|
|
DBCO-PEG-SH (MW 1000) (DBCO-PEG-Thiol (MW 1000)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 1000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174965A
-
|
DBCO-PEG-thiol (MW 600)
|
Drug Delivery
|
|
DBCO-PEG-SH (MW 600) (DBCO-PEG-Thiol (MW 600)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 600) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-W440955
-
|
|
Drug Delivery
|
|
Stearic acid-PEG-CH2CO2H, MW 3400 is a lipophilic thiol-reactive PEG polymer. The stearic acid can be used to encapsulate hydrophobic therapeutic agents while the PEG chain increases overall water solubility and biocompatibilty. Reaction between carboxylic acid (-COOH) and amine (-NH2) vai condensation in the presence of activator, such as HATU or EDC, generates a stable amide linkage. Reagent grade, for research use only.
|
-
- HY-W011696
-
|
cis-1-Amino-9-octadecene, 80-90%
|
Surfactants
|
|
Oleylamine, 80-90% (cis-1-Amino-9-octadecene, 80-90%) is a multifunctional reagent for metal ion coordination and nanoparticle surface modification. Oleylamine, 80-90% is a solvent, surfactant and reducing agent in the synthesis of metal oxide nanoparticles. Oleylamine, 80-90% can regulate nanoparticle morphology, magnetization and water proton relaxation rate through thiol-ene "click" reaction, and increase the colloidal stability of nanoparticles in organic reagents. Oleylamine, 80-90% is mainly used in the research and application of nanomaterial synthesis, biomedical imaging (MRI contrast agents, fluorescent probes), cancer cell targeting and drug delivery .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W011500S
-
1 Publications Verification
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TCEP-d16 (hydrochloride) is the deuterium labeled TCEP hydrochloride . TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry .
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- HY-W700621
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TCEP-d12 (hydrochloride) (Tris(2-?carboxyethyl)?phosphine hydrochloride-d12) is deuterium labeled TCEP (hydrochloride). TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry .
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| Cat. No. |
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Classification |
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- HY-138525
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PROTAC Synthesis
Azide
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Azido-PEG4-Thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG4-Thiol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-136129
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Azide
ADC Synthesis
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N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-156392
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TCO
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TCO4-PEG7-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG7-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
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- HY-156391A
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TCO
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TCO4-PEG2-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG2-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
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- HY-156391
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TCO
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TCO4-PEG2-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG2-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
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- HY-W872575A
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TCO
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TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
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- HY-W872575
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TCO
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TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
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| Cat. No. |
Product Name |
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Classification |
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- HY-W440727
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Pegylated Lipids
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Cholesterol-PEG-Vinylsulfone (MW 2000) is a thiol reactive polyPEG via thiol-ene reaction to form a thioether bond. It can self-assemble in water and is used to prepare liposome as drug vehicle for targeted delivery into tissues.
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![Benzyl N-[2-(prop-2-enamido)ethyl]carbamate](http://file.medchemexpress.eu/product_pic/hy-w800833.gif)
