Search Result
Results for "
thiol group
" in MedChemExpress (MCE) Product Catalog:
60
Biochemical Assay Reagents
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-D1390A
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Fluorescent Dye
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Others
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Sulfo-Cy5-Mal is a fluorescent dye with the form of active ester that reacts with thiol groups in proteins to form stable conjugates. Sulfo-Cy5-Mal that can be used to label protein .
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- HY-130080
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Maytansinoid DM3
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ADC Payload
Microtubule/Tubulin
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Cancer
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DM3 (Maytansinoid DM3), a Maytansine (HY-13674) analog bearing disulfide or thiol groups, and is a tubulin inhibitor. DM3 a cytotoxic moiety of antibody-drug conjugates (ADCs) .
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- HY-W013754
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Glutathione S-transferase
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Others
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S-Hexylglutathione is an S-substituted glutathione in which the hydrogen of the thiol has been replaced by a hexyl group. S-Hexylglutathione is also an competitive inhibitor against glutathione-S-transferase. S-Hexylglutathione can be used as an affinity chromatographic ligand for glutathione-S-transferase and glutathione peroxidase .
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- HY-156377
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Drug-Linker Conjugates for ADC
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Cancer
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Biotin-PEG7-Maleimide is a biotinylation reagent that reacts with thiol groups (SH). Biotin-PEG7-Maleimide can be used as Drug-Linker Conjugates for ADCs .
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- HY-137541
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NTCB
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Biochemical Assay Reagents
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Others
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2-Nitro-5-thiocyanatobenzoic acid (NTCB) is a highly reactive reagent that transfers its cyano group rapidly to a nucleophilic thiolate. 2-Nitro-5-thiocyanatobenzoic acid has been proposed as a reagent for converting thiol groups in proteins into their S-cyano derivatives .
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- HY-W998680
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5-FITC-Maleimide
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Fluorescent Dye
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Others
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Fluorescein-maleimide is a fluorescein dye linker containing a maleimide group. The maleimides in Fluorescein-maleimide react with thiol-containing compounds or biomolecules to form thioester bonds between pH 6.5 and 7.5. Fluorescein-maleimide is specifically designed for fluorescent labeling of proteins, nucleic acids, or other molecules containing one or more thiol groups .
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- HY-D1526
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Fluorescent Dye
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Others
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N-(4-Anilino-1-naphthyl)maleimide is a fluorescent probe that can be used to detect thiol groups in proteins. N-(4-Anilino-1-naphthyl)maleimide reacts with thiol groups and immediately produces a stable fluorescent compound with the λex=355 nm, λem=448 nm .
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- HY-D1654
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Fluorescent Dye
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Others
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BDP 581/591 maleimide is a linker of the BDP 581/591 dye. It has a long fluorescence lifetime and can be used for fluorescence polarization assays. The maleimide group can react with thiol groups to form thioester bonds between pH 6.5 to 7.5, for the labeling of sulfhydryl groups of proteins and peptides.
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- HY-P10533
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Biochemical Assay Reagents
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Others
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Cysteine peptide is a heptapeptide containing a cysteine residue whose thiol group makes it susceptible to a range of oxidative modifications. Cysteine peptide is used to detect the skin sensitization potential of chemicals including cosmetic ingredients .
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- HY-W441004
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Liposome
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Others
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DSPE-Thiol is a phophalipid capped with thiol group. The thiol capped head can selectively react with maleimide. DSPE-Thiol can also be used for the preparation of phospholipid dimers .
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- HY-W1048549H
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HOOC-PEG-thiol (MW 1000)
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Biochemical Assay Reagents
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Others
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HOOC-PEG-SH (MW 1000) (HOOC-PEG-Thiol (MW 1000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
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- HY-W1048549J
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HOOC-PEG-thiol (MW 40000)
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Biochemical Assay Reagents
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Others
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HOOC-PEG-SH (MW 40000) (HOOC-PEG-Thiol (MW 40000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
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- HY-116427
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ADC Linker
PROTAC Linkers
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Cancer
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Propargyl-PEG4-thiol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-thiol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG4-thiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-W395122
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Biochemical Assay Reagents
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Others
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Mal-PEG1-PNP-carbonate is a amine-reactive compound. PNP is a good leaving group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
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- HY-W800648
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Biochemical Assay Reagents
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Others
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Mal-PEG2-Amide is a PEG linker with a maleimide group which can react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
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- HY-W591975
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Biochemical Assay Reagents
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Others
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Alkyne maleimide is a bifunctional linker reagent with a terminal malimide group and a propargyl group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The propargyl group can be linked to azide-containing biomolecules via Click Chemistry.
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- HY-W1048549A
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HOOC-PEG-thiol (MW 2000)
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Biochemical Assay Reagents
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Others
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HOOC-PEG-SH (MW 2000) (HOOC-PEG-Thiol (MW 2000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
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- HY-W1048549B
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HOOC-PEG-thiol (MW 3400)
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Biochemical Assay Reagents
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Others
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HOOC-PEG-SH (MW 3400) (HOOC-PEG-Thiol (MW 3400)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
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- HY-W1048549C
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HOOC-PEG-thiol (MW 5000)
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Biochemical Assay Reagents
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Others
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HOOC-PEG-SH (MW 5000) (HOOC-PEG-Thiol (MW 5000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
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- HY-W1048549E
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HOOC-PEG-thiol (MW 20000)
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Biochemical Assay Reagents
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Others
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HOOC-PEG-SH (MW 20000) (HOOC-PEG-Thiol (MW 20000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
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- HY-W1048549D
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HOOC-PEG-thiol (MW 10000)
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Biochemical Assay Reagents
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Others
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HOOC-PEG-SH (MW 10000) (HOOC-PEG-Thiol (MW 10000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
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- HY-138525
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PROTAC Linkers
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Cancer
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Azido-PEG4-Thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG4-Thiol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-174949C
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FMOC-NH-PEG-thiol (MW 5000)
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Biochemical Assay Reagents
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Others
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FMOC-NH-PEG-SH (MW 5000) (FMOC-NH-PEG-Thiol (MW 5000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
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- HY-174949D
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FMOC-NH-PEG-thiol (MW 10000)
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Biochemical Assay Reagents
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Others
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FMOC-NH-PEG-SH (MW 10000) (FMOC-NH-PEG-Thiol (MW 10000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
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- HY-174949
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FMOC-NH-PEG-thiol (MW 1000)
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Biochemical Assay Reagents
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Others
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FMOC-NH-PEG-SH (MW 1000) (FMOC-NH-PEG-Thiol (MW 1000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
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- HY-174949B
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FMOC-NH-PEG-thiol (MW 3400)
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Biochemical Assay Reagents
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Others
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FMOC-NH-PEG-SH (MW 3400) (FMOC-NH-PEG-Thiol (MW 3400)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
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- HY-174949A
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FMOC-NH-PEG-thiol (MW 2000)
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Biochemical Assay Reagents
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Others
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FMOC-NH-PEG-SH (MW 2000) (FMOC-NH-PEG-Thiol (MW 2000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
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- HY-W190877
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SH-PEG1-COOH
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Biochemical Assay Reagents
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Others
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Thiol-PEG1-acid (SH-PEG1-COOH) is a PEG derivative consisting of a thiol (-SH), 1 PEG unit, and a carboxyl (-COOH). The thiol is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. The carboxyl group can easily form stable amide bonds with amino groups, and can also form ester bonds with hydroxyl groups.
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- HY-W1048849A
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4-Arm PEG-thiol (MW 5000)
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Biochemical Assay Reagents
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Others
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4-Arm PEG-SH (MW 5000) (4-Arm PEG-thiol (MW 5000)) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .
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- HY-W1048849D
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4-Arm PEG-thiol (MW 40000)
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Biochemical Assay Reagents
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Others
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4-Arm PEG-SH (MW 40000) (4-Arm PEG-thiol (MW 40000)) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .
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- HY-W1048849C
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4-Arm PEG-thiol (MW 20000)
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Biochemical Assay Reagents
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Others
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4-Arm PEG-SH (MW 20000) (4-Arm PEG-thiol (MW 20000)) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .
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- HY-W1048849B
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4-Arm PEG-thiol (MW 10000)
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Biochemical Assay Reagents
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Others
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4-Arm PEG-SH (MW 10000) (4-Arm PEG-thiol (MW 10000)) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .
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- HY-162159
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Others
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Others
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Ac-Cys-NHMe is a Cys dipeptide with thiol group .
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- HY-W020780D
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Biochemical Assay Reagents
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Others
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mPEG-Mal (MW 40000) is a thiol-reactive PEG derivative that can be used to selectively modify proteins, peptides, or any other surface with available thiol groups .
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- HY-W591469
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Biochemical Assay Reagents
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Others
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mPEG-Mal (MW 1000) is a thiol-reactive PEG derivative that can be used to selectively modify proteins, peptides, or any other surface with available thiol groups .
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- HY-D1364
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Biochemical Assay Reagents
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Others
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Pyrene maleimide is a polyaromatic fluorescent hydrocarbon with a termininal maleimide group. The maleimide group will react with a thiol group to form a covalent bond.
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- HY-172505
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Biochemical Assay Reagents
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Others
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Mal-PEG12-t-butyl ester is a PEG linker containing a maleimide group and a t-butyl ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
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- HY-W800654
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Biochemical Assay Reagents
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Others
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Mal-PEG5-amine is a PEG linker containing a maleimide group and an amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
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- HY-W190922
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Biochemical Assay Reagents
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Others
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Mal-PEG4-amine is a PEG linker containing a maleimide group and an amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
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- HY-136130
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ADC Linker
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Cancer
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N,N-Bis(PEG2-alkyne)-N-amido-PEG2-thiol is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . N,N-Bis(PEG2-alkyne)-N-amido-PEG2-thiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-135133
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- HY-134428
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Endogenous Metabolite
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Metabolic Disease
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Arachidonoyl coenzyme A lithium is an unsaturated fatty acyl coenzyme A, formed by the condensation of the thiol group of coenzyme A with the carboxyl group of arachidonic acid .
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- HY-W590555
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Liposome
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Cancer
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Thiol-PEG-DMG, MW 2000 is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. The terminal thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc.
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- HY-174944
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SH-PEG4-NH2
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Biochemical Assay Reagents
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Others
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Thiol-PEG4-NH2 (SH-PEG4-NH2) is a PEG derivative consisting of a thiol (-SH), 1 PEG unit, and NH2. Thiol is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds.
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- HY-136129
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ADC Linker
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Cancer
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N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-15915
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DTNB
Maximum Cited Publications
8 Publications Verification
Ellman’s Reagent
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Biochemical Assay Reagents
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Others
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DTNB (Ellman’s Reagent) is a chemical used to quantify the number or concentration of thiol groups .
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- HY-W800722
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Biochemical Assay Reagents
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Others
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N-(PEG1-acid)-L-Lysine-amido-Mal is a PEG based linker with terminal malimide and carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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- HY-W591479
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ADC Linker
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Cancer
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MC-Val-Ala-NHS ester is a cleavable ADC linker with a malimide group and an NHS ester group. The Val-Ala linkers can be cleaved by Cathepsin B. Maleimide group is reactive toward thiol groups. MC is reactive with thiol moieties. The NHS ester is able to react specifically and efficiently with amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond.
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- HY-W800670
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Biochemical Assay Reagents
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Others
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Mal-amido-PEG5-alkyne is a PEG linker containing a maleimide group and an alkyne. The hydrophilic PEG spacer increases solubility in aqueous media. The alkyne group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
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- HY-W736950A
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Amino Acid Derivatives
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Others
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H-L-Cys(MDNPE)-OH hydrochloride is a cysteine derivative with a short peptide sequence attached to the thiol group of cysteine.
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- HY-D0042
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NBD-Cl
1 Publications Verification
NBD chloride
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Fluorescent Dye
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Others
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NBD-Cl is a nonfluorescent reagent which becomes highly fluorescent after reaction with thiol or amino groups .
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- HY-W800787
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Liposome
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Cancer
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18:1 PE MCC is a maleimide-functionalized thiol-reactive lipid with a phosphoethanolamine linked to two oleic acid tails and a maleimide group.
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- HY-W800786
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N-MCC-PE
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Liposome
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Cancer
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16:0 PE MCC is a maleimide-functionalized thiol-reactive lipid with a phosphoethanolamine linked to two palmitic acid tails and a maleimide group.
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- HY-D2498
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Fluorescent Dye
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Others
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Cy7 maleimide is a fluorescent dye containing a Maleimide (HY-W007324) functional group. Maleimide can be used to label thiol groups on antibodies, proteins and peptides .
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- HY-W800789
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Liposome
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Cancer
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16:0 MPB PE is a maleimide-functionalized thiol-reactive lipid with a phosphoethanolamine linked to two palmitic acid tails and a phenyl maleimide group.
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- HY-W800788
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Liposome
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Cancer
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18:1 MPB PE is a maleimide-functionalized thiol-reactive lipid with a phosphoethanolamine linked to two oleic acid tails and a phenyl maleimide group.
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- HY-W1048527A
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8-Arm PEG-thiol (MW 20000)
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Biochemical Assay Reagents
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Others
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8-Arm PEG-SH (MW 20000) (8-Arm PEG-Thiol (MW 20000)) is a multi-arm PEG derivative with thiol groups at each end of the eight arms. 8-Arm PEG-SH (MW 20000) can be used for drug delivery .
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- HY-W1048527
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8-Arm PEG-thiol (MW 5000)
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Biochemical Assay Reagents
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Others
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8-Arm PEG-SH (MW 5000) (8-Arm PEG-Thiol (MW 5000)) is a multi-arm PEG derivative with thiol groups at each end of the eight arms. 8-Arm PEG-SH (MW 5000) can be used for drug delivery .
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- HY-W1048527B
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8-Arm PEG-thiol (MW 40000)
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Biochemical Assay Reagents
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Others
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8-Arm PEG-SH (MW 40000) (8-Arm PEG-Thiol (MW 40000)) is a multi-arm PEG derivative with thiol groups at each end of the eight arms. 8-Arm PEG-SH (MW040000) can be used for drug delivery .
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- HY-W1048527C
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8-Arm PEG-thiol (MW 10000)
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Biochemical Assay Reagents
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Others
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8-Arm PEG-SH (MW 10000) (8-Arm PEG-Thiol (MW 10000)) is a multi-arm PEG derivative with thiol groups at each end of the eight arms. 8-Arm PEG-SH (MW 10000) can be used for drug delivery .
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- HY-D1363
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Fluorescent Dye
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Others
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BDP R6G maleimide is a borodipyrromethane fluorophore with absorption and emission wavelengths similar to those of R6G rhodamine. Sulfhydryl labelling is a common protein modification where the cysteine residues in the protein allow more site-specific labelling than the NHS ester of the amine group. BDP R6G maleimide is a thiol reactive dye that reacts with thiol groups to form thioester bonds .
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- HY-D2091
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Fluorescent Dye
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Others
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PE-VF647 Maleimide is a double-dye dye that can undergo thiol reaction. It contains maleimide groups that can react with thiol groups to form covalent bonds. PE-VF647 Maleimide contains two dyes, PE and VF, with excitation wavelengths (Ex) of 495 nm and 566 nm, respectively. PE-VF594 Maleimide has an emission wavelength (Em) of 665 nm.
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- HY-D2488
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Fluorescent Dye
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Others
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Sulfo Cy5.5-maleimide is a fluorescent dye containing a Maleimide (HY-W007324) functional group. Maleimide can be used to label thiol groups on antibodies, proteins and peptides.
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- HY-D2093
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Fluorescent Dye
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Others
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PE-VF750 Maleimide is a thiol-reactive double-dye dye that contains maleimide groups that can react with thiol groups to form covalent bonds. Ex/Em=495-566/777 nm. PE-VF750 Maleimide contains two dyes, PE and VF, with excitation wavelengths (Ex) of 495 nm and 566 nm, respectively. PE-VF594 Maleimide has an emission wavelength (Em) of 777 nm.
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- HY-W800828
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Biochemical Assay Reagents
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Others
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Iodoacetamido-PEG3-NHS ester is a PEG reagent containing an Iodoacetamide group and a Boc-protected amino group. The iodoacetamide group is an alkylating agent that can be used to bind covalently with the thiol group. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-E70264
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Endogenous Metabolite
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Metabolic Disease
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16:0 Coenzyme A triammonium is palmitoyl-CoA, which can serve as a reaction substrate to transfer the palmitoyl group to the free thiol group of the target protein through palmitoylation catalyzed by protein acyl transferases (PATs) .
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- HY-W800682
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Biochemical Assay Reagents
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Others
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Bis-Sulfone-PEG4-acid is a reagent with a sulfone and an acid. The sulfone group can be conjugated with thiol groups of proteins. The terminal acid reacts with primary amines with the help of activators (EDC or HATU) to from stable amide bonds.
|
-
- HY-136386
-
|
|
Reactive Oxygen Species (ROS)
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Others
|
|
N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group, but cannot enter the glutathione metabolic pathway .
|
-
- HY-D2092
-
|
|
Fluorescent Dye
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Others
|
|
PE-VF680 Maleimide is a double-dye dye that can undergo thiol reaction. It contains maleimide groups that can react with thiol groups to form covalent bonds. Ex/Em=495-566/701 nm. PE-VF680 Maleimide contains two dyes, PE and VF, with excitation wavelengths (Ex) of 495 nm and 566 nm, respectively. PE-VF594 Maleimide has an emission wavelength (Em) of 701 nm.
|
-
- HY-W591476
-
|
mPEG-SH (MW 1000)
|
Biochemical Assay Reagents
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Others
|
|
m-PEG-thiol (MW 1000) is a surface modifier that can modify DNA thiolation and is used in the synthesis of gold nanorods (AuNR). m-PEG-thiol (MW 1000) can load thiolated DNA onto AuNR, form a covalent bond with the surface of gold nanoparticles through the thiol group, and stabilize the nanoparticles by the steric hindrance effect of the polyethylene glycol chain, preventing aggregation and enhancing its biocompatibility. m-PEG-thiol (MW 1000) can also provide a platform for the subsequent coupling of biomolecules (such as DNA, antibodies) by replacing surfactants (such as CTAB) on the surface of nanoparticles, thereby exerting its activity in promoting the functionalization of nanomaterials .
|
-
- HY-W615173
-
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|
Biochemical Assay Reagents
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Others
|
|
NHS ester-C2-NHCO-C2-NHS is a heterobifunctional PEG linker, featuring a terminal NHS ester that can be used to label amine compounds and maleimide group for reactions with thiol groups.
|
-
- HY-W441003
-
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|
Biochemical Assay Reagents
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Others
|
|
DSPE-PEG-IA, MW 2000 is a thiol reactive phospholipid polyPEG. The iodoacetyll group is reactive with thiol to produce a thioether linkage. The polymer can self-assemble in water to form lipid bilayer and can be used to encapsulate drugs in targeted delivery application, such as liposomal doxorubicin as an anti cancer drug or mRNA vaccine. Reagent grade, for research use only.
|
-
- HY-W800817
-
|
|
Biochemical Assay Reagents
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Others
|
|
TCO-PEG4-maleimide is a click chemistry building block containing a TCO moiety and a maleimide group. The maleimide group will react with a thiol group to form a covalent bond. TCO moiety is very reactive with tetrazine (3rd generation click chemistry).
|
-
- HY-118112
-
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|
Biochemical Assay Reagents
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Others
|
|
4-N-Maleimidobenzoicacid-NHS is a PEG linker that finds utility in bioconjugation endeavors and protein labeling ventures. Specifically designed for selective reaction with thiol groups, the maleimide group establishes covalent linkages, thereby facilitating the coupling of proteins, peptides, or diverse molecules to thiol-bearing biomolecules. The NHS ester is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic conditions to form a covalent bond.
|
-
- HY-W585396
-
|
|
Fluorescent Dye
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Others
|
|
BDP TR maleimide is a linker of BDP TR dye which is commonly used for microscopy and fluorescence polarization assays. The maleimide group can react with thiol groups to form thioester bonds between pH 6.5 to 7.5.
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-
- HY-W590586
-
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|
Biochemical Assay Reagents
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Others
|
|
Mal-PEG4-NH-Boc is a PEG linker containing a maleimide group and a Boc protected amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The protected amine can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond.
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-
- HY-W800803
-
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|
Biochemical Assay Reagents
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Others
|
|
Mal-PEG5-NH-Boc is a PEG linker containing a maleimide group and a Boc protected amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The protected amine can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond.
|
-
- HY-CE00380
-
|
(S)-3-Hydroxyoctanoyl-Coenzyme A
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
(S)-3-Hydroxyoctanoyl-CoA ((S)-3-Hydroxyoctanoyl-Coenzyme A) is a hydroxy fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (S)-3-hydroxyoctanoic acid.
|
-
- HY-CE00399
-
|
(S)-3-Hydroxylauroyl-coenzyme A
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
(S)-3-Hydroxylauroyl-CoA ((S)-3-Hydroxylauroyl-coenzyme A) is a hydroxy fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (S)-3-hydroxydodecanoic acid.
|
-
- HY-W190947
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Iodoacetamido-PEG8-acid is a PEG reagent containing an Iodoacetamide group and a carboxlic acid moiety. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The iodoacetamide group is an alkylating agent that can be used to bind covalently with the thiol group.
|
-
- HY-CE00476
-
|
(3R)-Hydroxyvaleryl-coenzyme A
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
(R)-3-Hydroxyvaleryl-CoA ((3R)-Hydroxyvaleryl-coenzyme A) is a 3-hydroxy fatty acyl-CoA resulting from the formal condensation of the thiol group of coenzyme A with the carboxy group of (R)-3-hydroxypentanoic acid.
|
-
- HY-D2103
-
|
|
Fluorescent Dye
|
Others
|
|
TAMRA-PEG3-Maleimide is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Maleimide contains maleimide groups that react with thiol groups to form covalent bonds.
|
-
- HY-W020780B
-
|
mPEG-Maleimide (MW 750)
|
Biochemical Assay Reagents
|
Others
|
|
mPEG-Mal (MW 750) is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
|
-
- HY-W020780C
-
|
mPEG-Maleimide (MW 3400)
|
Biochemical Assay Reagents
|
Others
|
|
mPEG-Mal (MW 3400) is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
|
-
- HY-W020780A
-
|
mPEG-Maleimide (MW 350)
|
Biochemical Assay Reagents
|
Others
|
|
mPEG-Mal (MW 350) is a PEG derivative used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
|
-
- HY-W800805
-
|
|
Liposome
|
Cancer
|
|
DOPE-Mal is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions with a terminal maliemide group. The maleimide group will react with a thiol group to form a covalent bond. The hydrophilic PEG spacer increases solubility in aqueous media.
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-
- HY-D2104
-
|
|
Fluorescent Dye
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Others
|
|
TAMRA-PEG7-Maleimide is a dye derivative of TAMRA (HY-135640) containing 7 PEG units. TAMRA-PEG7-Maleimide contains a maleimide group that can react with a thiol group to form a covalent bond.
|
-
- HY-W190932
-
|
|
Fluorescent Dye
|
Others
|
|
TAMRA-PEG2-Maleimide is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG2-Maleimide contains a maleimide group that can react with a thiol group to form a covalent bond.
|
-
- HY-CE00475
-
|
(R)-3-Hydroxytetradecanoyl-coenzyme A
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
(R)-3-Hydroxytetradecanoyl-CoA ((R)-3-Hydroxytetradecanoyl-coenzyme A) is a 3-hydroxy fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (R)-3-hydroxytetradecanoic acid.
|
-
- HY-D2448
-
|
|
Fluorescent Dye
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Cancer
|
|
Cy3-PEG-Thiol (Cy3-PEG-SH) is a near infrared fluorescent labeling reagent that combines Cy3 fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) polyethylene glycol derivatives, and is suitable for molecular coupling. Cy3-PEG-Thiol is absorbed at 550nm and has high solubility and end-group substitution rate .
|
-
- HY-CE00299
-
|
(3S)-3-Hydroxyicosanoyl-coenzyme A
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
(3S)-3-Hydroxyicosanoyl-CoA ((3S)-3-Hydroxyicosanoyl-coenzyme A) is a 3-hydroxyicosanoyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (3S)-hydroxyicosanoic acid.
|
-
- HY-W394551
-
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|
Biochemical Assay Reagents
|
Others
|
|
Methyl 3,4-dibromo-2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate is a small pyrrolidone molecule which features two bromine atoms and a methyl ester. The unsaturated dibromo motif is a covalent ligand for thiol groups, and may be used to label cysteine residues in proteins. The presence of two leaving groups on this molecule allows this linker to bind two thiols at a time. The methyl ester can be saponified to link this molecule to amines to form larger structures.
|
-
- HY-CE00408
-
|
(S)-3-Hydroxyoctanedioyl-coenzyme A
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
(S)-3-Hydroxyoctanedioyl-CoA ((S)-3-Hydroxyoctanedioyl-coenzyme A) is an (S)-3-hydroxyacyl-CoA resulting from the formal condensation of the thiol group of coenzyme A with the 1-carboxy group of (S)-3-hydroxyoctanedioic acid.
|
-
- HY-156391A
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO4-PEG2-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG2-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
|
-
- HY-W143822
-
|
|
Biochemical Assay Reagents
|
Others
|
|
6-(Tritylthio)hexanoic acid is a linker with a Tst group and a terminal carboxylic acid. The Tst group can be deprotected under acidic conditions to obtain the free thiol which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-156391
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO4-PEG2-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG2-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
|
-
- HY-156392
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO4-PEG7-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG7-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
|
-
- HY-W872575A
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
|
-
- HY-W872575
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
|
-
- HY-171561
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DOTAM-Maleimide triTFA is a bifunctional chelator, combining the DOTAM structure with a maleimide group for efficient thiol coupling. DOTAM-Maleimide triTFA forms stable complexes with radiometals, promising for applications in molecular imaging and radiotherapy .
|
-
- HY-168938
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Poly(ethylene glycol) methyl ether maleimide (Mn 2000) is a polyethylene glycol containing Maleimide (HY-W007324). Due to the Maleimide functional group, Poly(ethylene glycol) methyl ether maleimide (Mn 2000) can be used to conjugate biomolecules containing thiol groups.
|
-
- HY-D2497
-
|
|
Fluorescent Dye
|
Others
|
|
Sulfo Cy7 bis-SH is a fluorescent dye that contains sulfonated Cyanine7 (Sulfo-CY7) fluorescent dye and thiol (-SH) functional group. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds .
|
-
- HY-174965B
-
|
DBCO-PEG-thiol (MW 1000)
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-PEG-SH (MW 1000) (DBCO-PEG-Thiol (MW 1000)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 1000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174965H
-
|
DBCO-PEG-thiol (MW 10000)
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-PEG-SH (MW 10000) (DBCO-PEG-Thiol (MW 10000)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 10000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174965E
-
|
DBCO-PEG-thiol (MW 5000)
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-PEG-SH (MW 5000) (DBCO-PEG-Thiol (MW 5000)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 5000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174965D
-
|
DBCO-PEG-thiol (MW 3400)
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-PEG-SH (MW 3400) (DBCO-PEG-Thiol (MW 3400)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 3400) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174965C
-
|
DBCO-PEG-thiol (MW 2000)
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-PEG-SH (MW 2000) (DBCO-PEG-Thiol (MW 2000)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 2000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174965
-
|
DBCO-PEG-thiol (MW 400)
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-PEG-SH (MW 400) (DBCO-PEG-Thiol (MW 400)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 400) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174965A
-
|
DBCO-PEG-thiol (MW 600)
|
Biochemical Assay Reagents
|
Others
|
|
DBCO-PEG-SH (MW 600) (DBCO-PEG-Thiol (MW 600)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 600) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-D2150
-
|
|
Fluorescent Dye
|
Others
|
|
AF 430 maleimide is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 425 nm and an emission wavelength of 542 nm. AF 430 maleimide contains maleimide groups that react with thiol groups to form covalent bonds. To achieve specific coupling of dye labels and biomolecules .
|
-
- HY-CE00465
-
|
1,4-Dihydroxy-2-naphthoyl-coenzyme A
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
1,4-Dihydroxy-2-naphthoyl-CoA (1,4-Dihydroxy-2-naphthoyl-coenzyme A) is an acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 1,4-dihydroxy-2-naphthoic acid.
|
-
- HY-W674381
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
5-(2-Chloroacetamide) thalidomide is a Thalidomide (HY-14658) analogue. Thalidomide recruits E3 Ligase for the ubiquitinylation and subsequent destruction of a given protein. This structure features a chloroacetamide, which is a thiol-specific reactive group.
|
-
- HY-W591360
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Iodoacetamido-PEG6-azide is an aqueous soluble PEG linker containing an azide and a terminal Iodoacetamido group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Iodoacetamido moiety is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds.
|
-
- HY-CE00413
-
|
(3S)-3-Hydroxyoleoyl-coenzyme A
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
(3S)-3-Hydroxyoleoyl-CoA ((3S)-3-Hydroxyoleoyl-coenzyme A) is a 3-hydroxy fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (3S)-3-hydroxyoleic acid.
|
-
- HY-E70254
-
|
|
Others
|
Others
|
|
Tricosanoyl-CoA triammonium is a very long-chain fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A (HY-128851) with the carboxy group of tricosanoic acid (HY-W009081). Tricosanoyl-CoA is functionally related to a tricosanoic acid. Tricosanoyl-CoA is a conjugate acid of a tricosanoyl-CoA(4-).
|
-
- HY-155901
-
|
Maleimide-NH-PEG-amine TFA (MW 2000)
|
Biochemical Assay Reagents
|
Others
|
|
Mal-NH-PEG-NH2 (TFA) (MW 2000) is a PEG derivative that may be used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
|
-
- HY-D2094
-
|
|
Fluorescent Dye
|
Inflammation/Immunology
Cancer
|
|
PerCP Maleimide is a fluorescent dye that reacts with free sulfhydryl groups on proteins. PerCP is a red fluorescence albuminous dye for immunostaining and Maleimide can be leveraged for the preparation of fluorogenic probe, which is mainly used for the specific detection of thiol analytes .
|
-
- HY-W393115
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Diethyl 6-bromohexylphosphonate is a short linker featuring a bromide and a diethyl phosphonate. The bromide is a good leaving group which can be easily displaced by nucleophiles like alcohols, amines or thiols, while the diethyl phosphonate may be hydrolyzed to allow for esterification.
|
-
- HY-D2763
-
|
|
Fluorescent Dye
|
Others
|
|
BP Fluor 532 maleimide is a photostable, bright yellow-fluorescent dye with pH insensitive emission from pH 4 to pH 10. The excitation of BP Fluor 532 is ideally suited for the frequency-doubled Nd:YAG laser line. BP Fluor 532 dye can be conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, and is often used for the generation of stable signals in imaging and flow cytometry.
Maleimide is the most popular sulfhydryl-reactive group for conjugating the dye to a thiol group on a protein, oligonucleotide thiophosphate, or low molecular weight ligand. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form a stable thioether bond. The resulting conjugates exhibit brighter fluorescence and greater photostability than the conjugates of many other spectrally similar fluorophores.
|
-
- HY-W440896
-
|
|
Liposome
|
Others
|
|
DSPE-PEG-SH, MW 2000 is a pegylated phospholipid with thiol group which is reactive with maleimide to form a covalent thioether linkage. The amphiphatic polymer can form lipid bilayer in aqueous solution and be used to encapsulate agents for drug delivery system, such as mRNA vaccine.
|
-
- HY-W1048553C
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-NH2 TFA (MW 5000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W1048553H
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-NH2 TFA (MW 40000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W1048553A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-NH2 TFA (MW 2000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W007671
-
|
|
Endogenous Metabolite
Tyrosinase
|
Others
|
|
H-Tyr-OMe is an endogenous metabolite. H-Tyr-OMe quenches the fluorescence of carbon dots by oxidizing the phenolic hydroxyl group to quinone under the catalysis of Tyrosinase, and its amino and thiol binding ability can respond to changes in the concentration of biothiols .
|
-
- HY-W1048553B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-NH2 TFA (MW 3400) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W1048553E
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-NH2 TFA (MW 20000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W1048553
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-NH2 TFA (MW 1000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W1048553D
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-NH2 TFA (MW 10000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-173390
-
|
|
Drug Intermediate
Biochemical Assay Reagents
|
Others
|
|
BCN-E-BCN is a strained cycloalkyne-based probe designed for detecting protein sulfenylation, the primary intermediate in protein oxidation. This structurally constrained cycloalkyne compound specifically recognizes sulfenic acid groups formed during thiol oxidation, while remaining completely unreactive toward other oxidative states (such as free thiols, sulfinic, or sulfonic acid groups). Researchers can leverage its efficient conjugation with azide-bearing tags through copper-free click chemistry to amplify detection signals. Compared to conventional detection methods, BCN-E-BCN demonstrates superior reaction kinetics and enhanced sensitivity. With these advantages, BCN-E-BCN shows great promise as an effective tool for protein oxidation research .
|
-
- HY-D2381
-
|
|
Fluorescent Dye
|
Others
|
|
AF 488 maleimide is a thiol-reactive dye for labeling of protein SH groups, and it can be used to attach AF 488 fluorophore to proteins and peptides containing cysteine residues, as well as to other thiolated molecules. AF488 exhibits the λem and λex wavelength of 520 nm and 470 nm, respectively .
|
-
- HY-D1260
-
|
PSH-red
|
Fluorescent Dye
|
Neurological Disease
|
|
FM-red (PSH-red) is a red-emitting and environment-sensitive probe for selectively detecting and labeling protein thiols. FM-red can be used to image protein sulfhydryl groups in live cells and in vivo. FM-red also could be used to measure of the redox states of thioredoxin (Trx) .
|
-
- HY-136386R
-
|
|
Reference Standards
Reactive Oxygen Species (ROS)
|
Others
|
|
N-Acetyl-D-cysteine (Standard) is the analytical standard of N-Acetyl-D-cysteine. This product is intended for research and analytical applications. N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group, but cannot enter the glutathione metabolic pathway .
|
-
- HY-W879048
-
|
|
ADC Linker
|
Others
|
|
DBCO-PEG24-Maleimide contains a maleimide and a DBCO group. DBCO-PEG24-Maleimide can be used for thiol-containing biomolecule conjugations. DBCO-PEG24-Maleimide can be used in click chemistry with azide-bearing biomolecules .
|
-
- HY-172291
-
|
|
ADC Linker
|
Cancer
|
|
Mal-amide-PEG8-Val-Cit-PAB-PNP is a cleavable ADC linker featuring a maleimide, a PEG spacer, a Val-Cit dipeptide, a PAB. and a PNP carbonate. Maleimide is a thiol-specific covalent linker which is used to label cysteine residues in proteins while the PNP group acts as a highly activated leaving group. Val-Cit linkers are cleaved by cytoplasmic peptidases.
|
-
- HY-W144703
-
|
9-Aminoheptadecane
|
Biochemical Assay Reagents
|
Others
|
|
Heptadecan-9-amine (9-Aminoheptadecane) is PEG linker containing a maleimide and TFP ester end group. Maleimide groups are reactive with thiols between pH 6.5 and 7.5. The TFP ester can react with primary amine groups and is also less susceptible to undergo hydrolysis compared to NHS ester. The hydrophilic PEG chains increase the water solubility of a compound in aqueous media. Longer PEG chains have improved water solubility relative to shorter PEG chains.
|
-
- HY-W800713
-
|
|
Biochemical Assay Reagents
|
Others
|
|
SPDP-Gly-Pro-acid is a linker with SPDP and carboxylic acid moieties. The SPDP is an amine and thiol reactive crosslinker. It is also membrane permeable, allowing it to participate in intracellular crosslinking reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
|
-
- HY-157920
-
|
N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine
|
Biochemical Assay Reagents
|
Others
|
|
Biotin-PE-maleimide (N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine) is a bulky, membrane-impermeable, sulfhydryl-containing reagent with a relatively large molecular size. Biotin-PE-maleimide can be used for biotin labeling (such as thiol groups) and detection of proteins or other biomolecules .
|
-
- HY-D1871
-
|
|
Fluorescent Dye
|
Others
|
|
Cy3 maleimide chloride is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing maleimide functional groups. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The alkyne functional group of Cy3 maleimide chloride can undergo a "thiol-acrylamide" reaction with molecules containing sulfur-oxygen functional groups to form covalent bonds. Cy3 maleimide chloride can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
|
-
- HY-157977
-
|
|
Radionuclide-Drug Conjugates (RDCs)
Biochemical Assay Reagents
MMP
|
Cancer
|
|
DOTA-GA-maleimide is a bifunctional chelator containing a DOTA macrocycle chelator, a GA linker, and a maleimide reactive group. DOTA-GA-maleimide can achieve radiolabeling of proteins by forming a stable coordination complex between the DOTA macrocycle and radioactive metal ions (such as 111In) through the specific binding of maleimide to protein thiol groups. DOTA-GA-maleimide can be used for SPECT imaging studies of MMP activity-related cancers .
|
-
- HY-D1404
-
|
|
Fluorescent Dye
|
Others
|
|
5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . 5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-12638
-
|
DDM
|
Bacterial
Fungal
Parasite
|
Infection
|
|
Dichlorophen is a chlorophenol antimicrobial agent that can destroy the integrity of microbial cell membranes and interfere with the activity of metabolic enzymes. Dichlorophen can covalently bind to the thiol groups of microbial proteins and has broad-spectrum antibacterial, antifungal and anthelmintic activity. Dichlorophen can be used as an antimicrobial agent in the study of drug-resistant bacterial infections .
|
-
- HY-W578278
-
|
|
Biochemical Assay Reagents
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Others
|
|
tert-Butyl (2-(pyridin-2-yldisulfanyl)ethyl)carbamate consists of a tert-butyl group, where the protected amine can be deprotected under mild acidic conditions, and the other part of the molecule may act as a thiol-specific labeling reagent, commonly used in reversibly binding cysteine residues on proteins.
|
-
- HY-W800719
-
|
|
Biochemical Assay Reagents
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Others
|
|
N-Boc-N'-(PEG1-t-butyl ester)-L-Lysine-amido-Mal is the amino acid, lysine, with a maleimide at its C-terminus, a Boc-protecting group on its α-amine, and an amido-PEG1-t-butyl ester on its ε-amine. Maleimide is a thiol-reactive covalent group used to conjugate cysteine residues, while the Boc and the t-butyl ester can be later deprotected to perform further reactions.
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-
- HY-D1407
-
|
|
Fluorescent Dye
|
Others
|
|
Br-5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . Br-5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W073382
-
|
Bis–sulfone Acid
|
Biochemical Assay Reagents
|
Others
|
|
4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid (Bis-sulfone Acid) is a strong covalent linker featuring a free carboxylic acid and two tosyl groups. Each tosyl group can be displaced by thiol or amine nucleophiles via a Michael addition, and the inclusion of two on this molecule allow this reaction to proceed twice. This may be used to “staple” two reduced cysteine residues on a given protein to reform disulfide bridges. The carboxylic acid is free to react to form amides or esters.
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-
- HY-172721
-
|
|
Fluorescent Dye
|
Others
|
|
Cy3B maleimide is a mono-reactive dye containing maleimide group, which can selectively and efficiently attach Cyanine3 fluorophore (an analog of Cy3) to proteins and peptides containing cysteine residues, as well as to other thiolated molecules (such as thiol-containing oligonucleotides). Cy3B is an improved version of Cy3 dyes with significantly increased fluorescence quantum yield and photostability.
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-
- HY-W1048555B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-SCM (MW 3400) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 3400) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
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-
- HY-W1048555A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-SCM (MW 2000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 2000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
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-
- HY-W440902
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DSPE-PEG-IA, MW 3400 is an iodoacetyll PEG lipid. The polymer can form lipid bilayer or micelles spontaneoulsy in water. The lipophilic tails can be used to encapsulate hydrophobic therapeutic agents while the hydrophilic head can be used to encapuslate hydrophilic drugs/nutrient, such as antibody, mRNA/DNA. The iodoacetyl group is reactive with thiol to produce a thioether linkage. Reagent grade, for research use only.
|
-
- HY-152919
-
|
|
ADC Linker
|
Cancer
|
|
Mal-amide-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker featuring a maleimide, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB functional group. Maleimide is used to covalently bind free thiols on the cysteine residues of proteins. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery with the help of the PAB structure.
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-
- HY-W1048555D
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-SCM (MW 10000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 10000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
-
- HY-W1048555H
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-SCM (MW 40000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 40000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
-
- HY-W1048555C
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-SCM (MW 5000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 5000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
-
- HY-W1048555E
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-SCM (MW 20000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 20000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
-
- HY-W1048555
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-SCM (MW 1000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 1000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
-
- HY-W060216
-
|
|
Biochemical Assay Reagents
|
Others
|
|
2-Acetamido-3-methyl-3-sulfanylbutanoic acid is an organic compound that belongs to the class of amino acids. It is a derivative of methionine, an essential amino acid commonly found in various foods. 2-Acetamido-3-methyl-3-sulfanylbutanoic acid contains a thiol group and an acetamido group at specific positions in the amino acid chain. It has various applications in the food industry, especially as a flavor enhancer and umami seasoning. Additionally, it has potential research utility in liver disease and other metabolic disorders.
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-
- HY-15941
-
|
Fluorescein 5(6)-isothiocyanate; Fluorescein isothiocyanate 5- and 6- isomers
|
Fluorescent Dye
|
Others
|
|
5(6)-FITC (Fluorescein 5(6)-isothiocyanate) is an amine-reactive derivative of a fluorescent dye, characterized by high absorbance and excellent fluorescence quantum yield. The isothiocyanate group of FITC can react with various functional groups on proteins, including amines, thiols, imidazoles, tyrosines and carbonyls, enabling the labeling of proteins such as antibodies and lectins. 5(6)-FITC has a wide range of applications, including flow cytometry, immunofluorescence, protease assays and conjugation. The maximum excitation/emission wavelengths are 492/518 nm .
|
-
- HY-D2513
-
|
|
Fluorescent Dye
|
Cancer
|
|
Cy3-PEG-SH (MW 10000) (Cy3-PEG-Thiol) is a near infrared fluorescent labeling reagent that combines Cy3 fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) polyethylene glycol derivatives, and is suitable for molecular coupling. Cy3-PEG-SH (MW 10000) is absorbed at 550nm and has high solubility and end-group substitution rate .
|
-
- HY-D2510
-
|
|
Fluorescent Dye
|
Cancer
|
|
Cy3-PEG-SH (MW 2000) (Cy3-PEG-Thiol) is a near infrared fluorescent labeling reagent that combines Cy3 fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) polyethylene glycol derivatives, and is suitable for molecular coupling. Cy3-PEG-SH (MW 2000) is absorbed at 550nm and has high solubility and end-group substitution rate .
|
-
- HY-D2511
-
|
|
Fluorescent Dye
|
Cancer
|
|
Cy3-PEG-SH (MW 3400) (Cy3-PEG-Thiol) is a near infrared fluorescent labeling reagent that combines Cy3 fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) polyethylene glycol derivatives, and is suitable for molecular coupling. Cy3-PEG-SH (MW 3400) is absorbed at 550nm and has high solubility and end-group substitution rate .
|
-
- HY-12638R
-
|
DDM (Standard)
|
Reference Standards
Bacterial
Fungal
Parasite
|
Infection
|
|
Dichlorophen (Standard) is the analytical standard of Dichlorophen (HY-12638). This product is intended for research and analytical applications. Dichlorophen is a chlorophenol antimicrobial agent that can destroy the integrity of microbial cell membranes and interfere with the activity of metabolic enzymes. Dichlorophen can covalently bind to the thiol groups of microbial proteins and has broad-spectrum antibacterial, antifungal and anthelmintic activity. Dichlorophen can be used as an antimicrobial agent in the study of drug-resistant bacterial infections .
|
-
- HY-W800833
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Benzyl N-[2-(prop-2-enamido)ethyl]carbamate is a short aliphatic linker featuring a Cbz-protected amine and an acrylamide. Acrylamide is a Michael acceptor which is a good Michael acceptor which can be used in thiol-based bioconjugation or polymerization. Meanwhile, the Cbz protecting group can be removed using Pd-C hydrogenation to reveal a free amine that can participate in a wide variety of reactions such as couplings or reductive amination.
|
-
![Benzyl N-[2-(prop-2-enamido)ethyl]carbamate](//file.medchemexpress.eu/product_pic/hy-w800833.gif)
- HY-CE00300
-
|
(9Z,12Z,15Z,18Z,21Z)-3-Oxotetracosapentaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
(9Z,12Z,15Z,18Z,21Z)-3-Oxotetracosapentaenoyl-CoA ((9Z,12Z,15Z,18Z,21Z)-3-Oxotetracosapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoic acid.
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-D1390A
-
|
|
Fluorescent Dyes/Probes
|
|
Sulfo-Cy5-Mal is a fluorescent dye with the form of active ester that reacts with thiol groups in proteins to form stable conjugates. Sulfo-Cy5-Mal that can be used to label protein .
|
-
- HY-D0042
-
NBD-Cl
1 Publications Verification
NBD chloride
|
Dyes
|
|
NBD-Cl is a nonfluorescent reagent which becomes highly fluorescent after reaction with thiol or amino groups .
|
-
- HY-W998680
-
|
5-FITC-Maleimide
|
Fluorescent Dyes/Probes
|
|
Fluorescein-maleimide is a fluorescein dye linker containing a maleimide group. The maleimides in Fluorescein-maleimide react with thiol-containing compounds or biomolecules to form thioester bonds between pH 6.5 and 7.5. Fluorescein-maleimide is specifically designed for fluorescent labeling of proteins, nucleic acids, or other molecules containing one or more thiol groups .
|
-
- HY-D1526
-
|
|
Fluorescent Dyes/Probes
|
|
N-(4-Anilino-1-naphthyl)maleimide is a fluorescent probe that can be used to detect thiol groups in proteins. N-(4-Anilino-1-naphthyl)maleimide reacts with thiol groups and immediately produces a stable fluorescent compound with the λex=355 nm, λem=448 nm .
|
-
- HY-D1654
-
|
|
Fluorescent Dyes/Probes
|
|
BDP 581/591 maleimide is a linker of the BDP 581/591 dye. It has a long fluorescence lifetime and can be used for fluorescence polarization assays. The maleimide group can react with thiol groups to form thioester bonds between pH 6.5 to 7.5, for the labeling of sulfhydryl groups of proteins and peptides.
|
-
- HY-D2498
-
|
|
Fluorescent Dyes/Probes
|
|
Cy7 maleimide is a fluorescent dye containing a Maleimide (HY-W007324) functional group. Maleimide can be used to label thiol groups on antibodies, proteins and peptides .
|
-
- HY-D1363
-
|
|
Fluorescent Dyes/Probes
|
|
BDP R6G maleimide is a borodipyrromethane fluorophore with absorption and emission wavelengths similar to those of R6G rhodamine. Sulfhydryl labelling is a common protein modification where the cysteine residues in the protein allow more site-specific labelling than the NHS ester of the amine group. BDP R6G maleimide is a thiol reactive dye that reacts with thiol groups to form thioester bonds .
|
-
- HY-D2091
-
|
|
Protein Labeling
|
|
PE-VF647 Maleimide is a double-dye dye that can undergo thiol reaction. It contains maleimide groups that can react with thiol groups to form covalent bonds. PE-VF647 Maleimide contains two dyes, PE and VF, with excitation wavelengths (Ex) of 495 nm and 566 nm, respectively. PE-VF594 Maleimide has an emission wavelength (Em) of 665 nm.
|
-
- HY-D2488
-
|
|
Fluorescent Dyes/Probes
|
|
Sulfo Cy5.5-maleimide is a fluorescent dye containing a Maleimide (HY-W007324) functional group. Maleimide can be used to label thiol groups on antibodies, proteins and peptides.
|
-
- HY-D2093
-
|
|
Protein Labeling
|
|
PE-VF750 Maleimide is a thiol-reactive double-dye dye that contains maleimide groups that can react with thiol groups to form covalent bonds. Ex/Em=495-566/777 nm. PE-VF750 Maleimide contains two dyes, PE and VF, with excitation wavelengths (Ex) of 495 nm and 566 nm, respectively. PE-VF594 Maleimide has an emission wavelength (Em) of 777 nm.
|
-
- HY-D2092
-
|
|
Protein Labeling
|
|
PE-VF680 Maleimide is a double-dye dye that can undergo thiol reaction. It contains maleimide groups that can react with thiol groups to form covalent bonds. Ex/Em=495-566/701 nm. PE-VF680 Maleimide contains two dyes, PE and VF, with excitation wavelengths (Ex) of 495 nm and 566 nm, respectively. PE-VF594 Maleimide has an emission wavelength (Em) of 701 nm.
|
-
- HY-W585396
-
|
|
Fluorescent Dyes/Probes
|
|
BDP TR maleimide is a linker of BDP TR dye which is commonly used for microscopy and fluorescence polarization assays. The maleimide group can react with thiol groups to form thioester bonds between pH 6.5 to 7.5.
|
-
- HY-D2103
-
|
|
Fluorescent Dyes/Probes
|
|
TAMRA-PEG3-Maleimide is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Maleimide contains maleimide groups that react with thiol groups to form covalent bonds.
|
-
- HY-D2104
-
|
|
Fluorescent Dyes/Probes
|
|
TAMRA-PEG7-Maleimide is a dye derivative of TAMRA (HY-135640) containing 7 PEG units. TAMRA-PEG7-Maleimide contains a maleimide group that can react with a thiol group to form a covalent bond.
|
-
- HY-W190932
-
|
|
Fluorescent Dyes/Probes
|
|
TAMRA-PEG2-Maleimide is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG2-Maleimide contains a maleimide group that can react with a thiol group to form a covalent bond.
|
-
- HY-D2448
-
|
|
Fluorescent Dyes/Probes
|
|
Cy3-PEG-Thiol (Cy3-PEG-SH) is a near infrared fluorescent labeling reagent that combines Cy3 fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) polyethylene glycol derivatives, and is suitable for molecular coupling. Cy3-PEG-Thiol is absorbed at 550nm and has high solubility and end-group substitution rate .
|
-
- HY-D2497
-
|
|
Fluorescent Dyes/Probes
|
|
Sulfo Cy7 bis-SH is a fluorescent dye that contains sulfonated Cyanine7 (Sulfo-CY7) fluorescent dye and thiol (-SH) functional group. SH is highly reactive and can react with a variety of functional groups (such as maleimide) to form stable thioether bonds .
|
-
- HY-D2150
-
|
|
Fluorescent Dyes/Probes
|
|
AF 430 maleimide is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 425 nm and an emission wavelength of 542 nm. AF 430 maleimide contains maleimide groups that react with thiol groups to form covalent bonds. To achieve specific coupling of dye labels and biomolecules .
|
-
- HY-D2094
-
|
|
Protein Labeling
|
|
PerCP Maleimide is a fluorescent dye that reacts with free sulfhydryl groups on proteins. PerCP is a red fluorescence albuminous dye for immunostaining and Maleimide can be leveraged for the preparation of fluorogenic probe, which is mainly used for the specific detection of thiol analytes .
|
-
- HY-D2763
-
|
|
Fluorescent Dyes/Probes
|
|
BP Fluor 532 maleimide is a photostable, bright yellow-fluorescent dye with pH insensitive emission from pH 4 to pH 10. The excitation of BP Fluor 532 is ideally suited for the frequency-doubled Nd:YAG laser line. BP Fluor 532 dye can be conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, and is often used for the generation of stable signals in imaging and flow cytometry.
Maleimide is the most popular sulfhydryl-reactive group for conjugating the dye to a thiol group on a protein, oligonucleotide thiophosphate, or low molecular weight ligand. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form a stable thioether bond. The resulting conjugates exhibit brighter fluorescence and greater photostability than the conjugates of many other spectrally similar fluorophores.
|
-
- HY-D2381
-
|
|
Fluorescent Dyes/Probes
|
|
AF 488 maleimide is a thiol-reactive dye for labeling of protein SH groups, and it can be used to attach AF 488 fluorophore to proteins and peptides containing cysteine residues, as well as to other thiolated molecules. AF488 exhibits the λem and λex wavelength of 520 nm and 470 nm, respectively .
|
-
- HY-D1260
-
|
PSH-red
|
Fluorescent Dyes/Probes
|
|
FM-red (PSH-red) is a red-emitting and environment-sensitive probe for selectively detecting and labeling protein thiols. FM-red can be used to image protein sulfhydryl groups in live cells and in vivo. FM-red also could be used to measure of the redox states of thioredoxin (Trx) .
|
-
- HY-D1871
-
|
|
Fluorescent Dyes/Probes
|
|
Cy3 maleimide chloride is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing maleimide functional groups. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The alkyne functional group of Cy3 maleimide chloride can undergo a "thiol-acrylamide" reaction with molecules containing sulfur-oxygen functional groups to form covalent bonds. Cy3 maleimide chloride can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
|
-
- HY-D1404
-
|
|
Protein Labeling
|
|
5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . 5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-D1407
-
|
|
Protein Labeling
|
|
Br-5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . Br-5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-172721
-
|
|
Fluorescent Dyes/Probes
|
|
Cy3B maleimide is a mono-reactive dye containing maleimide group, which can selectively and efficiently attach Cyanine3 fluorophore (an analog of Cy3) to proteins and peptides containing cysteine residues, as well as to other thiolated molecules (such as thiol-containing oligonucleotides). Cy3B is an improved version of Cy3 dyes with significantly increased fluorescence quantum yield and photostability.
|
-
- HY-15941
-
|
Fluorescein 5(6)-isothiocyanate; Fluorescein isothiocyanate 5- and 6- isomers
|
Fluorescent Dyes/Probes
|
|
5(6)-FITC (Fluorescein 5(6)-isothiocyanate) is an amine-reactive derivative of a fluorescent dye, characterized by high absorbance and excellent fluorescence quantum yield. The isothiocyanate group of FITC can react with various functional groups on proteins, including amines, thiols, imidazoles, tyrosines and carbonyls, enabling the labeling of proteins such as antibodies and lectins. 5(6)-FITC has a wide range of applications, including flow cytometry, immunofluorescence, protease assays and conjugation. The maximum excitation/emission wavelengths are 492/518 nm .
|
-
- HY-D2513
-
|
|
Fluorescent Dyes/Probes
|
|
Cy3-PEG-SH (MW 10000) (Cy3-PEG-Thiol) is a near infrared fluorescent labeling reagent that combines Cy3 fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) polyethylene glycol derivatives, and is suitable for molecular coupling. Cy3-PEG-SH (MW 10000) is absorbed at 550nm and has high solubility and end-group substitution rate .
|
-
- HY-D2510
-
|
|
Fluorescent Dyes/Probes
|
|
Cy3-PEG-SH (MW 2000) (Cy3-PEG-Thiol) is a near infrared fluorescent labeling reagent that combines Cy3 fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) polyethylene glycol derivatives, and is suitable for molecular coupling. Cy3-PEG-SH (MW 2000) is absorbed at 550nm and has high solubility and end-group substitution rate .
|
-
- HY-D2511
-
|
|
Fluorescent Dyes/Probes
|
|
Cy3-PEG-SH (MW 3400) (Cy3-PEG-Thiol) is a near infrared fluorescent labeling reagent that combines Cy3 fluorescent dye, polyethylene glycol (PEG) and sulfhydryl (SH) polyethylene glycol derivatives, and is suitable for molecular coupling. Cy3-PEG-SH (MW 3400) is absorbed at 550nm and has high solubility and end-group substitution rate .
|
| Cat. No. |
Product Name |
Type |
-
- HY-W441004
-
|
|
Drug Delivery
|
|
DSPE-Thiol is a phophalipid capped with thiol group. The thiol capped head can selectively react with maleimide. DSPE-Thiol can also be used for the preparation of phospholipid dimers .
|
-
- HY-W1048549H
-
|
HOOC-PEG-thiol (MW 1000)
|
Drug Delivery
|
|
HOOC-PEG-SH (MW 1000) (HOOC-PEG-Thiol (MW 1000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
|
-
- HY-W1048549J
-
|
HOOC-PEG-thiol (MW 40000)
|
Drug Delivery
|
|
HOOC-PEG-SH (MW 40000) (HOOC-PEG-Thiol (MW 40000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
|
-
- HY-W1048549A
-
|
HOOC-PEG-thiol (MW 2000)
|
Drug Delivery
|
|
HOOC-PEG-SH (MW 2000) (HOOC-PEG-Thiol (MW 2000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
|
-
- HY-W1048549B
-
|
HOOC-PEG-thiol (MW 3400)
|
Drug Delivery
|
|
HOOC-PEG-SH (MW 3400) (HOOC-PEG-Thiol (MW 3400)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
|
-
- HY-W1048549C
-
|
HOOC-PEG-thiol (MW 5000)
|
Drug Delivery
|
|
HOOC-PEG-SH (MW 5000) (HOOC-PEG-Thiol (MW 5000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
|
-
- HY-W1048549E
-
|
HOOC-PEG-thiol (MW 20000)
|
Drug Delivery
|
|
HOOC-PEG-SH (MW 20000) (HOOC-PEG-Thiol (MW 20000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
|
-
- HY-W1048549D
-
|
HOOC-PEG-thiol (MW 10000)
|
Drug Delivery
|
|
HOOC-PEG-SH (MW 10000) (HOOC-PEG-Thiol (MW 10000)) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .
|
-
- HY-174949C
-
|
FMOC-NH-PEG-thiol (MW 5000)
|
Drug Delivery
|
|
FMOC-NH-PEG-SH (MW 5000) (FMOC-NH-PEG-Thiol (MW 5000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
|
-
- HY-174949D
-
|
FMOC-NH-PEG-thiol (MW 10000)
|
Drug Delivery
|
|
FMOC-NH-PEG-SH (MW 10000) (FMOC-NH-PEG-Thiol (MW 10000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
|
-
- HY-174949
-
|
FMOC-NH-PEG-thiol (MW 1000)
|
Drug Delivery
|
|
FMOC-NH-PEG-SH (MW 1000) (FMOC-NH-PEG-Thiol (MW 1000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
|
-
- HY-174949B
-
|
FMOC-NH-PEG-thiol (MW 3400)
|
Drug Delivery
|
|
FMOC-NH-PEG-SH (MW 3400) (FMOC-NH-PEG-Thiol (MW 3400)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
|
-
- HY-174949A
-
|
FMOC-NH-PEG-thiol (MW 2000)
|
Drug Delivery
|
|
FMOC-NH-PEG-SH (MW 2000) (FMOC-NH-PEG-Thiol (MW 2000)) is a PEG derivative with an Fmoc protecting group and a thiol (-SH) reactive group. The thiol group is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed when a specific coupling reaction is required.
|
-
- HY-W190877
-
|
SH-PEG1-COOH
|
Drug Delivery
|
|
Thiol-PEG1-acid (SH-PEG1-COOH) is a PEG derivative consisting of a thiol (-SH), 1 PEG unit, and a carboxyl (-COOH). The thiol is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds. The carboxyl group can easily form stable amide bonds with amino groups, and can also form ester bonds with hydroxyl groups.
|
-
- HY-W1048849A
-
|
4-Arm PEG-thiol (MW 5000)
|
Drug Delivery
|
|
4-Arm PEG-SH (MW 5000) (4-Arm PEG-thiol (MW 5000)) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .
|
-
- HY-W1048849D
-
|
4-Arm PEG-thiol (MW 40000)
|
Drug Delivery
|
|
4-Arm PEG-SH (MW 40000) (4-Arm PEG-thiol (MW 40000)) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .
|
-
- HY-W1048849C
-
|
4-Arm PEG-thiol (MW 20000)
|
Drug Delivery
|
|
4-Arm PEG-SH (MW 20000) (4-Arm PEG-thiol (MW 20000)) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .
|
-
- HY-W1048849B
-
|
4-Arm PEG-thiol (MW 10000)
|
Drug Delivery
|
|
4-Arm PEG-SH (MW 10000) (4-Arm PEG-thiol (MW 10000)) is a multi-arm PEG derivative with thiol groups at each end of the four arms. The reactive free thiol, SH or sulfhydryl groups react selectively with maleimide and transition metal surfaces including gold and silver .
|
-
- HY-W020780D
-
|
|
Drug Delivery
|
|
mPEG-Mal (MW 40000) is a thiol-reactive PEG derivative that can be used to selectively modify proteins, peptides, or any other surface with available thiol groups .
|
-
- HY-W591469
-
|
|
Drug Delivery
|
|
mPEG-Mal (MW 1000) is a thiol-reactive PEG derivative that can be used to selectively modify proteins, peptides, or any other surface with available thiol groups .
|
-
- HY-D1364
-
|
|
Biochemical Assay Reagents
|
|
Pyrene maleimide is a polyaromatic fluorescent hydrocarbon with a termininal maleimide group. The maleimide group will react with a thiol group to form a covalent bond.
|
-
- HY-134428
-
|
|
Enzyme Substrates
|
|
Arachidonoyl coenzyme A lithium is an unsaturated fatty acyl coenzyme A, formed by the condensation of the thiol group of coenzyme A with the carboxyl group of arachidonic acid .
|
-
- HY-174944
-
|
SH-PEG4-NH2
|
Drug Delivery
|
|
Thiol-PEG4-NH2 (SH-PEG4-NH2) is a PEG derivative consisting of a thiol (-SH), 1 PEG unit, and NH2. Thiol is a highly reactive chemical group that can react specifically with a variety of molecules to form stable covalent bonds.
|
-
- HY-15915
-
|
Ellman’s Reagent
|
Indicators
|
|
DTNB (Ellman’s Reagent) is a chemical used to quantify the number or concentration of thiol groups .
|
-
- HY-W1048527A
-
|
8-Arm PEG-thiol (MW 20000)
|
Drug Delivery
|
|
8-Arm PEG-SH (MW 20000) (8-Arm PEG-Thiol (MW 20000)) is a multi-arm PEG derivative with thiol groups at each end of the eight arms. 8-Arm PEG-SH (MW 20000) can be used for drug delivery .
|
-
- HY-W1048527
-
|
8-Arm PEG-thiol (MW 5000)
|
Drug Delivery
|
|
8-Arm PEG-SH (MW 5000) (8-Arm PEG-Thiol (MW 5000)) is a multi-arm PEG derivative with thiol groups at each end of the eight arms. 8-Arm PEG-SH (MW 5000) can be used for drug delivery .
|
-
- HY-W1048527B
-
|
8-Arm PEG-thiol (MW 40000)
|
Drug Delivery
|
|
8-Arm PEG-SH (MW 40000) (8-Arm PEG-Thiol (MW 40000)) is a multi-arm PEG derivative with thiol groups at each end of the eight arms. 8-Arm PEG-SH (MW040000) can be used for drug delivery .
|
-
- HY-W1048527C
-
|
8-Arm PEG-thiol (MW 10000)
|
Drug Delivery
|
|
8-Arm PEG-SH (MW 10000) (8-Arm PEG-Thiol (MW 10000)) is a multi-arm PEG derivative with thiol groups at each end of the eight arms. 8-Arm PEG-SH (MW 10000) can be used for drug delivery .
|
-
- HY-W591476
-
|
mPEG-SH (MW 1000)
|
Drug Delivery
|
|
m-PEG-thiol (MW 1000) is a surface modifier that can modify DNA thiolation and is used in the synthesis of gold nanorods (AuNR). m-PEG-thiol (MW 1000) can load thiolated DNA onto AuNR, form a covalent bond with the surface of gold nanoparticles through the thiol group, and stabilize the nanoparticles by the steric hindrance effect of the polyethylene glycol chain, preventing aggregation and enhancing its biocompatibility. m-PEG-thiol (MW 1000) can also provide a platform for the subsequent coupling of biomolecules (such as DNA, antibodies) by replacing surfactants (such as CTAB) on the surface of nanoparticles, thereby exerting its activity in promoting the functionalization of nanomaterials .
|
-
- HY-W441003
-
|
|
Drug Delivery
|
|
DSPE-PEG-IA, MW 2000 is a thiol reactive phospholipid polyPEG. The iodoacetyll group is reactive with thiol to produce a thioether linkage. The polymer can self-assemble in water to form lipid bilayer and can be used to encapsulate drugs in targeted delivery application, such as liposomal doxorubicin as an anti cancer drug or mRNA vaccine. Reagent grade, for research use only.
|
-
- HY-W020780B
-
|
mPEG-Maleimide (MW 750)
|
Drug Delivery
|
|
mPEG-Mal (MW 750) is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
|
-
- HY-W020780C
-
|
mPEG-Maleimide (MW 3400)
|
Drug Delivery
|
|
mPEG-Mal (MW 3400) is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
|
-
- HY-W020780A
-
|
mPEG-Maleimide (MW 350)
|
Drug Delivery
|
|
mPEG-Mal (MW 350) is a PEG derivative used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
|
-
- HY-168938
-
|
|
Drug Delivery
|
|
Poly(ethylene glycol) methyl ether maleimide (Mn 2000) is a polyethylene glycol containing Maleimide (HY-W007324). Due to the Maleimide functional group, Poly(ethylene glycol) methyl ether maleimide (Mn 2000) can be used to conjugate biomolecules containing thiol groups.
|
-
- HY-174965B
-
|
DBCO-PEG-thiol (MW 1000)
|
Drug Delivery
|
|
DBCO-PEG-SH (MW 1000) (DBCO-PEG-Thiol (MW 1000)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 1000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174965H
-
|
DBCO-PEG-thiol (MW 10000)
|
Drug Delivery
|
|
DBCO-PEG-SH (MW 10000) (DBCO-PEG-Thiol (MW 10000)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 10000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174965E
-
|
DBCO-PEG-thiol (MW 5000)
|
Drug Delivery
|
|
DBCO-PEG-SH (MW 5000) (DBCO-PEG-Thiol (MW 5000)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 5000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174965D
-
|
DBCO-PEG-thiol (MW 3400)
|
Drug Delivery
|
|
DBCO-PEG-SH (MW 3400) (DBCO-PEG-Thiol (MW 3400)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 3400) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174965C
-
|
DBCO-PEG-thiol (MW 2000)
|
Drug Delivery
|
|
DBCO-PEG-SH (MW 2000) (DBCO-PEG-Thiol (MW 2000)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 2000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174965
-
|
DBCO-PEG-thiol (MW 400)
|
Drug Delivery
|
|
DBCO-PEG-SH (MW 400) (DBCO-PEG-Thiol (MW 400)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 400) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-174965A
-
|
DBCO-PEG-thiol (MW 600)
|
Drug Delivery
|
|
DBCO-PEG-SH (MW 600) (DBCO-PEG-Thiol (MW 600)) is a DBCO-modified PEG derivative. DBCO-PEG-SH (MW 600) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
|
-
- HY-155901
-
|
Maleimide-NH-PEG-amine TFA (MW 2000)
|
Drug Delivery
|
|
Mal-NH-PEG-NH2 (TFA) (MW 2000) is a PEG derivative that may be used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
|
-
- HY-W440896
-
|
|
Drug Delivery
|
|
DSPE-PEG-SH, MW 2000 is a pegylated phospholipid with thiol group which is reactive with maleimide to form a covalent thioether linkage. The amphiphatic polymer can form lipid bilayer in aqueous solution and be used to encapsulate agents for drug delivery system, such as mRNA vaccine.
|
-
- HY-W1048553C
-
|
|
Drug Delivery
|
|
Mal-PEG-NH2 TFA (MW 5000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W1048553H
-
|
|
Drug Delivery
|
|
Mal-PEG-NH2 TFA (MW 40000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W1048553A
-
|
|
Drug Delivery
|
|
Mal-PEG-NH2 TFA (MW 2000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W1048553B
-
|
|
Drug Delivery
|
|
Mal-PEG-NH2 TFA (MW 3400) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W1048553E
-
|
|
Drug Delivery
|
|
Mal-PEG-NH2 TFA (MW 20000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W1048553
-
|
|
Drug Delivery
|
|
Mal-PEG-NH2 TFA (MW 1000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W1048553D
-
|
|
Drug Delivery
|
|
Mal-PEG-NH2 TFA (MW 10000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
- HY-157920
-
|
N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine
|
Biochemical Assay Reagents
|
|
Biotin-PE-maleimide (N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine) is a bulky, membrane-impermeable, sulfhydryl-containing reagent with a relatively large molecular size. Biotin-PE-maleimide can be used for biotin labeling (such as thiol groups) and detection of proteins or other biomolecules .
|
- HY-W1048555B
-
|
|
Drug Delivery
|
|
Mal-PEG-SCM (MW 3400) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 3400) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
- HY-W1048555A
-
|
|
Drug Delivery
|
|
Mal-PEG-SCM (MW 2000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 2000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
- HY-W440902
-
|
|
Drug Delivery
|
|
DSPE-PEG-IA, MW 3400 is an iodoacetyll PEG lipid. The polymer can form lipid bilayer or micelles spontaneoulsy in water. The lipophilic tails can be used to encapsulate hydrophobic therapeutic agents while the hydrophilic head can be used to encapuslate hydrophilic drugs/nutrient, such as antibody, mRNA/DNA. The iodoacetyl group is reactive with thiol to produce a thioether linkage. Reagent grade, for research use only.
|
- HY-W1048555D
-
|
|
Drug Delivery
|
|
Mal-PEG-SCM (MW 10000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 10000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
- HY-W1048555H
-
|
|
Drug Delivery
|
|
Mal-PEG-SCM (MW 40000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 40000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
- HY-W1048555C
-
|
|
Drug Delivery
|
|
Mal-PEG-SCM (MW 5000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 5000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
- HY-W1048555E
-
|
|
Drug Delivery
|
|
Mal-PEG-SCM (MW 20000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 20000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
- HY-W1048555
-
|
|
Drug Delivery
|
|
Mal-PEG-SCM (MW 1000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 1000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
- HY-W060216
-
|
|
Biochemical Assay Reagents
|
|
2-Acetamido-3-methyl-3-sulfanylbutanoic acid is an organic compound that belongs to the class of amino acids. It is a derivative of methionine, an essential amino acid commonly found in various foods. 2-Acetamido-3-methyl-3-sulfanylbutanoic acid contains a thiol group and an acetamido group at specific positions in the amino acid chain. It has various applications in the food industry, especially as a flavor enhancer and umami seasoning. Additionally, it has potential research utility in liver disease and other metabolic disorders.
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P4094
-
CTP
1 Publications Verification
Cardiac targeting peptide
|
Peptides
|
Cardiovascular Disease
|
|
CTP (cardiac targeting peptide) can transduce cardiomyocytes in vitro. CTP leads to efficient and specific transduction of heart tissue in mice model. CTP can be reversibly linked (e.g. via enolases, thiol groups) to cargo (e.g. miRNAs) for delivery specifically to cardiomyocytes over all other organs .
|
-
- HY-P10533
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Cysteine peptide is a heptapeptide containing a cysteine residue whose thiol group makes it susceptible to a range of oxidative modifications. Cysteine peptide is used to detect the skin sensitization potential of chemicals including cosmetic ingredients .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
|
Classification |
-
- HY-116427
-
|
|
|
ADC Synthesis
PROTAC Synthesis
Alkynes
|
|
Propargyl-PEG4-thiol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-thiol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG4-thiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-138525
-
|
|
|
PROTAC Synthesis
Azide
|
|
Azido-PEG4-Thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG4-Thiol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-136130
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ADC Synthesis
Alkynes
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N,N-Bis(PEG2-alkyne)-N-amido-PEG2-thiol is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . N,N-Bis(PEG2-alkyne)-N-amido-PEG2-thiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-136129
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Azide
ADC Synthesis
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N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-156391A
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TCO
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TCO4-PEG2-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG2-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
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- HY-156391
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TCO
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TCO4-PEG2-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG2-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
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- HY-156392
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TCO
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TCO4-PEG7-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG7-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
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- HY-W872575A
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TCO
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TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
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- HY-W872575
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TCO
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TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
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- HY-W591360
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Azide
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Iodoacetamido-PEG6-azide is an aqueous soluble PEG linker containing an azide and a terminal Iodoacetamido group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Iodoacetamido moiety is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds.
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- HY-W879048
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DBCO
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DBCO-PEG24-Maleimide contains a maleimide and a DBCO group. DBCO-PEG24-Maleimide can be used for thiol-containing biomolecule conjugations. DBCO-PEG24-Maleimide can be used in click chemistry with azide-bearing biomolecules .
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- HY-D1404
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Alkynes
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5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . 5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-D1407
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Alkynes
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Br-5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . Br-5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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| Cat. No. |
Product Name |
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Classification |
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- HY-W591476
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mPEG-SH (MW 1000)
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Polymers
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m-PEG-thiol (MW 1000) is a surface modifier that can modify DNA thiolation and is used in the synthesis of gold nanorods (AuNR). m-PEG-thiol (MW 1000) can load thiolated DNA onto AuNR, form a covalent bond with the surface of gold nanoparticles through the thiol group, and stabilize the nanoparticles by the steric hindrance effect of the polyethylene glycol chain, preventing aggregation and enhancing its biocompatibility. m-PEG-thiol (MW 1000) can also provide a platform for the subsequent coupling of biomolecules (such as DNA, antibodies) by replacing surfactants (such as CTAB) on the surface of nanoparticles, thereby exerting its activity in promoting the functionalization of nanomaterials .
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- HY-W020780C
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mPEG-Maleimide (MW 3400)
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Polymers
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mPEG-Mal (MW 3400) is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
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- HY-W441004
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Phospholipids
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DSPE-Thiol is a phophalipid capped with thiol group. The thiol capped head can selectively react with maleimide. DSPE-Thiol can also be used for the preparation of phospholipid dimers .
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-
- HY-W590555
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Pegylated Lipids
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Thiol-PEG-DMG, MW 2000 is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. The terminal thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc.
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-
- HY-W800787
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Phospholipids
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18:1 PE MCC is a maleimide-functionalized thiol-reactive lipid with a phosphoethanolamine linked to two oleic acid tails and a maleimide group.
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-
- HY-W800786
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N-MCC-PE
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Phospholipids
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16:0 PE MCC is a maleimide-functionalized thiol-reactive lipid with a phosphoethanolamine linked to two palmitic acid tails and a maleimide group.
|
-
- HY-W800789
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Phospholipids
|
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16:0 MPB PE is a maleimide-functionalized thiol-reactive lipid with a phosphoethanolamine linked to two palmitic acid tails and a phenyl maleimide group.
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-
- HY-W800788
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Phospholipids
|
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18:1 MPB PE is a maleimide-functionalized thiol-reactive lipid with a phosphoethanolamine linked to two oleic acid tails and a phenyl maleimide group.
|
-
- HY-W020780B
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mPEG-Maleimide (MW 750)
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|
Polymers
|
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mPEG-Mal (MW 750) is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
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-
- HY-W020780A
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mPEG-Maleimide (MW 350)
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Polymers
|
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mPEG-Mal (MW 350) is a PEG derivative used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
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-
- HY-W800805
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Phospholipids
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DOPE-Mal is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions with a terminal maliemide group. The maleimide group will react with a thiol group to form a covalent bond. The hydrophilic PEG spacer increases solubility in aqueous media.
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-
- HY-155901
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Maleimide-NH-PEG-amine TFA (MW 2000)
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Polymers
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Mal-NH-PEG-NH2 (TFA) (MW 2000) is a PEG derivative that may be used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
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-
- HY-W440896
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Pegylated Lipids
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DSPE-PEG-SH, MW 2000 is a pegylated phospholipid with thiol group which is reactive with maleimide to form a covalent thioether linkage. The amphiphatic polymer can form lipid bilayer in aqueous solution and be used to encapsulate agents for drug delivery system, such as mRNA vaccine.
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