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Results for "

tetracyclic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) ADC Cytotoxin (1) Adrenergic Receptor (4) Akt (1) Antibiotic (8) Apoptosis (6) Autophagy (6) Bacterial (6) Biochemical Assay Reagents (2) COX (4) Drug Intermediate (1) Endogenous Metabolite (3) Fungal (1) HIF/HIF Prolyl-Hydroxylase (2) Histamine Receptor (5) HIV (2) Integrin (2) Isotope-Labeled Compounds (3) MAGL (1) Neurokinin Receptor (1) NF-κB (1) Opioid Receptor (1) Parasite (1) Phospholipase (2) Phytohormone (1) Reactive Oxygen Species (1) ROS Kinase (2) Ser/Thr Protease (1) Sirtuin (2) Somatostatin Receptor (1)
By Research Areas:	Cancer (14) Endocrinology (5) Infection (10) Inflammation/Immunology (9) Neurological Disease (20)

By Targets:

5-HT Receptor (4)

ADC Cytotoxin (1)

Adrenergic Receptor (4)

Akt (1)

Antibiotic (8)

Apoptosis (6)

Autophagy (6)

Bacterial (6)

Biochemical Assay Reagents (2)

COX (4)

Drug Intermediate (1)

Endogenous Metabolite (3)

Fungal (1)

HIF/HIF Prolyl-Hydroxylase (2)

Histamine Receptor (5)

HIV (2)

Integrin (2)

Isotope-Labeled Compounds (3)

MAGL (1)

Neurokinin Receptor (1)

NF-κB (1)

Opioid Receptor (1)

Parasite (1)

Phospholipase (2)

Phytohormone (1)

Reactive Oxygen Species (1)

ROS Kinase (2)

Ser/Thr Protease (1)

Sirtuin (2)

Somatostatin Receptor (1)

By Research Areas:

Cancer (14)

Endocrinology (5)

Infection (10)

Inflammation/Immunology (9)

Neurological Disease (20)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N8137

Cucurbitacin Q1	Others	Others
Cucurbitacin Q1 is a tetracyclic triterpene that can be found in Cucumis prophetarum .

HY-32329A

Setiptiline maleate MO-8282	5-HT Receptor	Neurological Disease
Setiptiline maleate (MO-8282 maleate) is a serotonin receptor antagonist. Setiptiline maleate is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline maleate acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT_2A, 5-HT_2C, and/or 5-HT₃ subtypes, as well as an H1 receptor inverse agonist/antihistamine .

HY-N2556

Tirucallol	Others	Inflammation/Immunology
Tirucallol, a tetracyclic triterpene, is isolated from Euphorbia lacteal latex. Tirucallol has topical anti-inflammatory effect. Tirucallol can suppress ear edema in the mouse model and inhibit nitrite production in lipopolysaccharide-stimulated macrophages .

HY-N0901

Corynoxine 1 Publications Verification	Autophagy	Neurological Disease Cancer
Corynoxine, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway .

HY-113818

Kadsuracoccinic acid A	HIV	Infection
Kadsuracoccinic acid A is a tetracyclic natural compound that can be isolated from the stems of Kadsura coccinea. Kadsuracoccinic acid A has vitro anti-HIV-1 activitiy with an EC₅₀ value of 68.7 μM .

HY-137309

4-Deoxy-4α-phorbol	HIV	Others
4-Deoxy-4α-phorbol is a tetracyclic diterpene found in E. desmondi. It has been used in the semisynthesis of inhibitors of the HIV-1-induced cytopathic effect on MT-4 cells and 4α-phorbol esters .

HY-N0901B

Corynoxine hydrochloride	Autophagy	Neurological Disease Cancer
Corynoxine hydrochloride, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria macrophylla. Corynoxine hydrochloride is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway .

HY-125664

Lucialdehyde B	Antibiotic	Cancer
Lucialdehyde B is a tetracyclic triterpene isolated from the substrates of Ganoderma lucidum with antiviral and cytotoxic activities. Lucialdehyde B has cytotoxic effects against Lewis lung cancer (LLC), T-47D, Sarcoma 180 and Meth-A tumor cell lines .

HY-142777

Lp-PLA2-IN-9	Phospholipase	Neurological Disease
Lp-PLA2-IN-9 (compound 17), a tetracyclic pyrimidinone compound, is a potent Lp-PLA2 inhibitor with a pIC₅₀ of 10.1 for rhLp-PLA2. Lp-PLA2-IN-9 has the potential for neurodegenerative related diseases research .

HY-142774

Lp-PLA2-IN-6	Phospholipase	Neurological Disease
Lp-PLA2-IN-6 (compound 18), a tetracyclic pyrimidinone compound, is a potent Lp-PLA2 inhibitor with a pIC₅₀ of 10.0 for rhLp-PLA2. Lp-PLA2-IN-6 has the potential for neurodegenerative related diseases research .

HY-106338

Polyketomycin	Bacterial ADC Cytotoxin Parasite	Infection Cancer
Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities .

HY-N13167

3-Keto-tirucall-8,24-dien-21-oic acid	Reactive Oxygen Species	Inflammation/Immunology Cancer
3-Keto-tirucall-8,24-dien-21-oic acid is a tetracyclic triterpene compound that can be isolated from frankincense. 3-Keto-tirucall-8,24-dien-21-oic acid has activities like anti-inflammatory, anti-tumor, anti-ulcer, memory improvement, and antioxidant properties .

HY-N1511

Ganoderic acid D 2 Publications Verification	Sirtuin Apoptosis	Cancer
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells . Ganoderic acid D induces HeLa human cervical carcinoma apoptosis .

HY-N1511R

Ganoderic acid D (Standard)	Sirtuin Apoptosis	Cancer
Ganoderic acid D (Standard) is the analytical standard of Ganoderic acid D. This product is intended for research and analytical applications. Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells . Ganoderic acid D induces HeLa human cervical carcinoma apoptosis .

HY-133194

Taxinine M	Others	Others
Taxinine M, a tetracyclic taxane, can be isolated from Taxus brevifolia .

HY-19081

KB-5246	Bacterial Antibiotic	Infection
KB-5246 is a tetracyclic quinolone and displays antibacterial activities.

HY-B0188

Mianserin Mianserine	Histamine Receptor	Neurological Disease Endocrinology
Mianserin is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.

HY-122300

R-(-)-Oxaprotiline hydrochloride Levoprotiline hydrochloride	Adrenergic Receptor	Neurological Disease
R-(-)-Oxaprotiline (Levoprotiline) hydrochloride is the R-enantiomer of Oxaprotiline. Oxaprotiline is a tetracyclic antidepressant agent .

HY-N1542

Prionitin	Others	Others
Prionitin is a tetracyclic diterpene that can be isolated from the roots of S. prionitis Hance .

HY-169511

Anthrotainin	Neurokinin Receptor	Neurological Disease
Anthrotainin, a tetracyclic compound, is a substance P binding inhibitor with an IC₅₀ of 3 μM .

HY-N1281

Sendanolactone	Others	Others
Sendanolactone is a new tetracyclic triterpenoid from the bark of M. azedarach L. var. japonica Makino .

HY-P1695

Cinnamycin Ro 09-0198	Antibiotic Bacterial	Infection
Cinnamycin (Ro 09-0198) is a tetracyclic peptide antibiotic that binds specifically to phosphatidylethanolamine (PE) .

HY-B0188A

Mianserin hydrochloride Org GB 94	Histamine Receptor	Neurological Disease Endocrinology
Mianserin hydrochloride (Org GB 94) is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.

HY-N3924

Ganoderiol F	Others	Others
Ganoderiol F, a tetracyclic triterpene, is isolated from Ganoderma amboinense and found to induce senescence of cancer cell lines .

HY-B0444S

Maprotiline-d5 hydrochloride	Isotope-Labeled Compounds Autophagy	Neurological Disease
Maprotiline-d₅ (hydrochloride) is the deuterium labeled Maprotiline hydrochloride. Maprotiline hydrochloride is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant .

HY-N9737

(−)-Acutumine	Others	Neurological Disease
(−)-Acutumine is a tetracyclic chloroalkaloid that exhibits selective cytotoxicity to cultured human T cells and memory-enhancing properties in the Wistar rat model .

HY-B0188AS

Mianserin-d3 hydrochloride Org GB 94-d₃	Histamine Receptor	Neurological Disease Endocrinology
Mianserin-d₃ (hydrochloride) is the deuterium labeled Mianserin hydrochloride. Mianserin hydrochloride (Org GB 94) is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.

HY-P2331

Actagardin Antibiotic A 3802-IV-3; Gardimycin	Antibiotic	Infection
Actagardin is a tetracyclic lantibiotic produced by several species of Actinoplanes. It is composed of macrocyclic rings formed by thioether bridges. Actagardin preferably targets Gram-positive bacteria, inhibiting the synthesis of peptidoglycan.

HY-163669

ITI-333	5-HT Receptor Opioid Receptor Adrenergic Receptor	Neurological Disease
ITI-333 is a tetracyclic compound with oral bioavailability and analgesic activity, targeting multiple receptors. ITI-333 can be used for research on various forms of pain .

HY-B0188S

Mianserin-d3 Mianserine-d₃	Histamine Receptor Isotope-Labeled Compounds	Neurological Disease
Mianserin-d3 is the deuterium labeled Mianserin (HY-B0188). Mianserin? is a Histamine 1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant .

HY-P3193A

Cyclic nona-L-arginine hydrochloride	Biochemical Assay Reagents	Others
Cyclic nona-L-arginine hydrochloride, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .

HY-N0481

Roburic acid	COX	Inflammation/Immunology
Roburic acid, a tetracyclic triterpenoid found in Gentiana macrophylla, acts as an inhibitor of COX, with IC₅₀s of 5 and 9 μM for COX-1 and COX-2, respectively .

HY-B0188AR

Mianserin (hydrochloride) (Standard)	Histamine Receptor	Neurological Disease Endocrinology
Mianserin (hydrochloride) (Standard) is the analytical standard of Mianserin (hydrochloride). This product is intended for research and analytical applications. Mianserin hydrochloride (Org GB 94) is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.

HY-N5191

Epidermin	Antibiotic Bacterial	Infection
Epidermin is a type A lantibiotic that is a tetracyclic 21-amino-acid peptide. Epidermin exhibits antibiotic activity against many Gram-positive bacteria. Epidermin has a role as a metabolite and an antibacterial agent .

HY-125132

Agelastatin A (-)-Agelastatin A; AglA	Apoptosis	Cancer
Agelastatin A ((-)-Agelastatin A; AglA), a tetracyclic alkaloid isolated from the sponge Agelas dendromorpha, induces apoptosis and arrests cells in the G2/M phase of the cell cycle, exhibiting antitumor activity .

HY-P10672

SEI144	Biochemical Assay Reagents	Others
SEI144 is a low nanomolar binder of USP15 and does not inhibit USP15 activity .

HY-N3188

Niloticin	Akt NF-κB	Infection
Niloticin, tetracyclic triterpenoid compound, is a osteoclastogenesis inhibitor. Niloticin shows anti-viral, antioxidative, and mosquitocidal activities. Niloticin inhibits osteoclastogenesis by blocking RANKL-RANK interaction and suppressing the AKT, MAPK, and NF-κB signaling pathways .

HY-N6252

Gypenoside XLVI 1 Publications Verification	Others	Cancer
Gypenoside XLVI is one of the major dammarane-type triterpenoid saponins from Gynostamma pentaphallum . Gypenoside XLVI has a tetracyclic triterpene structure and possess potent non-small cell lung carcinoma A549 cell inhibitory activity .

HY-N0829

Shionone	Others	Inflammation/Immunology
Shionone is the major triterpenoid isolated from Aster tataricus, has anti-tussive, anti-inflammatory activities . Shionone possesses a unique six-membered tetracyclic skeleton and 3-oxo-4-monomethyl structure .

HY-N0481R

Roburic acid (Standard)	COX	Inflammation/Immunology
Roburic acid (Standard) is the analytical standard of Roburic acid. This product is intended for research and analytical applications. Roburic acid, a tetracyclic triterpenoid found in Gentiana macrophylla, acts as an inhibitor of COX, with IC₅₀s of 5 and 9 μM for COX-1 and COX-2, respectively .

HY-156843

Antiproliferative agent-38	Others	Cancer
Antiproliferative agent-38 (com 18) is a tetracyclic ring，but its most reactive ring nitrogen (probably the quinoline moiety) cannot undergo N-alkylation. Antiproliferative agent-38 lacks anti-malarial activity and lacks anti-cancer cell proliferation activity .

HY-P10033

SFTI-1	Ser/Thr Protease	Others
SFTI-1 is a cyclic peptide trypsin inhibitor comprising 14 amino acid residues. SFTI-1 is a potent Bowman-Birk inhibitor.

HY-N0416

Cucurbitacin B Maximum Cited Publications 8 Publications Verification	HIF/HIF Prolyl-Hydroxylase Integrin Autophagy Apoptosis Endogenous Metabolite ROS Kinase COX	Others Neurological Disease Inflammation/Immunology Cancer
Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity .

HY-N0829R

Shionone (Standard)	Others	Inflammation/Immunology
Shionone (Standard) is the analytical standard of Shionone. This product is intended for research and analytical applications. Shionone is the major triterpenoid isolated from Aster tataricus, has anti-tussive, anti-inflammatory activities . Shionone possesses a unique six-membered tetracyclic skeleton and 3-oxo-4-monomethyl structure .

HY-N0313

Euphol	MAGL Endogenous Metabolite	Inflammation/Immunology
Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC₅₀=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain .

HY-167629

Gibberellenic acid	Phytohormone Drug Intermediate	Others
Gibberellenic acid is an intermediate gibberellin compound with a tetracyclic diterpenoid skeleton, and can be generated by thermal decomposition of Gibberellic acid (GA₃, HY-N1964) in aqueous solution. Gibberellenic acid is thermally unstable in water and can further convert into allogibberic acid (approximately 80%) and 9-epiallogibberic acid (approximately 10%). It plays an important role in the degradation pathway and structural elucidation of Gibberellins .

HY-N7241

Saudin	Others	Endocrinology
Saudin, derived from Clutia lanceolata, is a hypoglycemic compound that significantly enhances glucose-triggered insulin release from murine pancreatic islets. It belongs to a group of new diterpenoids with a distinct tetracyclic core, suggesting potential as a therapeutic agent for diabetes treatment. Proposed biosynthetic pathways outline alternative cyclization routes from a common precursor, with Lanceolide P (16) identified as a promising lead compound for further development in managing diabetes .

HY-N0416R

Cucurbitacin B (Standard)	HIF/HIF Prolyl-Hydroxylase Integrin Autophagy Apoptosis Endogenous Metabolite ROS Kinase COX	Others Neurological Disease Inflammation/Immunology Cancer
Cucurbitacin B (Standard) is the analytical standard of Cucurbitacin B. This product is intended for research and analytical applications. Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity .

HY-32329

Setiptiline Org-8282	5-HT Receptor Adrenergic Receptor	Neurological Disease
Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine.

HY-P10027A

Clovibactin TFA	Antibiotic Bacterial	Infection
Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027). Clovibactin TFA is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .

Cat. No.	Product Name	Target	Research Area

HY-P3193A

Cyclic nona-L-arginine hydrochloride	Biochemical Assay Reagents	Others
Cyclic nona-L-arginine hydrochloride, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .

HY-P4102

Cyclic PSAP peptide	Peptides	Cancer
Cyclic PSAP peptide is a cyclic pentapeptide (DWLPK). Cyclic PSAP peptide exhibits agent-like properties and could inhibit metastatic spread and restrain tumor development in general in vivo .

HY-P10033

SFTI-1	Ser/Thr Protease	Others
SFTI-1 is a cyclic peptide trypsin inhibitor comprising 14 amino acid residues. SFTI-1 is a potent Bowman-Birk inhibitor.

HY-P10027A

Clovibactin TFA	Antibiotic Bacterial	Infection
Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027). Clovibactin TFA is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .

HY-P1206

CH 275	Somatostatin Receptor	Neurological Disease
CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst₁) with a K_i of 52 nM . CH 275 acts as a potent and selective sst₁ agonist (IC₅₀=30.9 nM) and also displays IC₅₀ values of 345 nM, >1 μM, >10 μM, >10 μM for human sst₃, sst₄, sst₂ and sst₅, respectively . CH 275 can be used for the research of alzheimer’s disease .

HY-N6693

Valinomycin 5 Publications Verification NSC 122023	Apoptosis Antibiotic Autophagy Fungal	Infection Others Cancer
Valinomycin is a potassium-specific ionophore, the valinomycin-K ⁺ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K ⁺ gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research .

HY-P2331

Actagardin Antibiotic A 3802-IV-3; Gardimycin	Antibiotic	Infection
Actagardin is a tetracyclic lantibiotic produced by several species of Actinoplanes. It is composed of macrocyclic rings formed by thioether bridges. Actagardin preferably targets Gram-positive bacteria, inhibiting the synthesis of peptidoglycan.

HY-P3193

Cyclic nona-L-arginine TFA	Peptides	Others
Cyclic nona-L-arginine TFA, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .

HY-P10672

SEI144	Biochemical Assay Reagents	Others
SEI144 is a low nanomolar binder of USP15 and does not inhibit USP15 activity .

HY-P10027

Clovibactin	Antibiotic Bacterial	Infection
Clovibactin is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8137

Cucurbitacin Q1	Triterpenes other families Classification of Application Fields Terpenoids Source classification Other Diseases Plants Disease Research Fields	Others
Cucurbitacin Q1 is a tetracyclic triterpene that can be found in Cucumis prophetarum .

HY-N2556

Tirucallol	Triterpenes Classification of Application Fields Euphorbia boetica Terpenoids Source classification Euphorbiaceae Plants Disease Research Fields Inflammation/Immunology	Others
Tirucallol, a tetracyclic triterpene, is isolated from Euphorbia lacteal latex. Tirucallol has topical anti-inflammatory effect. Tirucallol can suppress ear edema in the mouse model and inhibit nitrite production in lipopolysaccharide-stimulated macrophages .

HY-N0901

Corynoxine 1 Publications Verification	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Source classification Rubiaceae Plants Indole Alkaloids	Autophagy
Corynoxine, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway .

HY-N1511

Ganoderic acid D 2 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields Cancer	Sirtuin Apoptosis
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells . Ganoderic acid D induces HeLa human cervical carcinoma apoptosis .

HY-113818

Kadsuracoccinic acid A	Structural Classification Natural Products Source classification Plants Kadsura coccinea (Lem.) A. C. Smith Schisandraceae	HIV
Kadsuracoccinic acid A is a tetracyclic natural compound that can be isolated from the stems of Kadsura coccinea. Kadsuracoccinic acid A has vitro anti-HIV-1 activitiy with an EC₅₀ value of 68.7 μM .

HY-137309

4-Deoxy-4α-phorbol	Structural Classification Terpenoids Source classification Euphorbia cooperi N. E. Br. ex A. Berger Diterpenoids Euphorbiaceae Plants	HIV
4-Deoxy-4α-phorbol is a tetracyclic diterpene found in E. desmondi. It has been used in the semisynthesis of inhibitors of the HIV-1-induced cytopathic effect on MT-4 cells and 4α-phorbol esters .

HY-N0901B

Corynoxine hydrochloride	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Source classification Rubiaceae Plants Indole Alkaloids	Autophagy
Corynoxine hydrochloride, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria macrophylla. Corynoxine hydrochloride is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway .

HY-125664

Lucialdehyde B	Triterpenes Structural Classification Microorganisms Classification of Application Fields Terpenoids Disease Research Fields Cancer	Antibiotic
Lucialdehyde B is a tetracyclic triterpene isolated from the substrates of Ganoderma lucidum with antiviral and cytotoxic activities. Lucialdehyde B has cytotoxic effects against Lewis lung cancer (LLC), T-47D, Sarcoma 180 and Meth-A tumor cell lines .

HY-106338

Polyketomycin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Naphthalene Quinones Disease Research Fields	Bacterial ADC Cytotoxin Parasite
Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities .

HY-N13167

3-Keto-tirucall-8,24-dien-21-oic acid	Structural Classification Tetracyclic Triterpenoids Terpenoids Boswellia sacra Flück. Source classification Plants Burseraceae	Reactive Oxygen Species
3-Keto-tirucall-8,24-dien-21-oic acid is a tetracyclic triterpene compound that can be isolated from frankincense. 3-Keto-tirucall-8,24-dien-21-oic acid has activities like anti-inflammatory, anti-tumor, anti-ulcer, memory improvement, and antioxidant properties .

HY-N1511R

Ganoderic acid D (Standard)	Triterpenes Structural Classification Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants	Sirtuin Apoptosis
Ganoderic acid D (Standard) is the analytical standard of Ganoderic acid D. This product is intended for research and analytical applications. Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells . Ganoderic acid D induces HeLa human cervical carcinoma apoptosis .

HY-133194

Taxinine M	Structural Classification Natural Products Taxus cuspidata Siebold & Zucc. Source classification Taxaceae Plants	Others
Taxinine M, a tetracyclic taxane, can be isolated from Taxus brevifolia .

HY-N1542

Prionitin	Structural Classification Tetracyclic Triterpenoids Terpenoids Labiatae Source classification Plants Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Others
Prionitin is a tetracyclic diterpene that can be isolated from the roots of S. prionitis Hance .

HY-N1281

Sendanolactone	Triterpenes Structural Classification Melia azedarach Linn. Terpenoids Source classification Plants Meliaceae	Others
Sendanolactone is a new tetracyclic triterpenoid from the bark of M. azedarach L. var. japonica Makino .

HY-B0188A

Mianserin hydrochloride Org GB 94	Alkaloids Structural Classification Neurological Disease Classification of Application Fields Leguminosae Other Alkaloids Source classification Crotalaria pallida Ait. Plants Disease Research Fields Endocrinology	Histamine Receptor
Mianserin hydrochloride (Org GB 94) is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.

HY-N3924

Ganoderiol F	Triterpenes Microorganisms Terpenoids Source classification	Others
Ganoderiol F, a tetracyclic triterpene, is isolated from Ganoderma amboinense and found to induce senescence of cancer cell lines .

HY-N9737

(−)-Acutumine	Structural Classification Alkaloids Pyrrole Alkaloids Source classification Plants Menispermaceae	Others
(−)-Acutumine is a tetracyclic chloroalkaloid that exhibits selective cytotoxicity to cultured human T cells and memory-enhancing properties in the Wistar rat model .

HY-N0481

Roburic acid	Triterpenes Structural Classification Gentiana macrophylla Pall. Classification of Application Fields Terpenoids Source classification Gentianaceae Plants Inflammation/Immunology Disease Research Fields	COX
Roburic acid, a tetracyclic triterpenoid found in Gentiana macrophylla, acts as an inhibitor of COX, with IC₅₀s of 5 and 9 μM for COX-1 and COX-2, respectively .

HY-B0188AR

Mianserin (hydrochloride) (Standard)	Alkaloids Structural Classification Leguminosae Other Alkaloids Source classification Crotalaria pallida Ait. Plants	Histamine Receptor
Mianserin (hydrochloride) (Standard) is the analytical standard of Mianserin (hydrochloride). This product is intended for research and analytical applications. Mianserin hydrochloride (Org GB 94) is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.

HY-N5191

Epidermin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Epidermin is a type A lantibiotic that is a tetracyclic 21-amino-acid peptide. Epidermin exhibits antibiotic activity against many Gram-positive bacteria. Epidermin has a role as a metabolite and an antibacterial agent .

HY-125132

Agelastatin A (-)-Agelastatin A; AglA	Structural Classification Alkaloids Animals Other Alkaloids Source classification	Apoptosis
Agelastatin A ((-)-Agelastatin A; AglA), a tetracyclic alkaloid isolated from the sponge Agelas dendromorpha, induces apoptosis and arrests cells in the G2/M phase of the cell cycle, exhibiting antitumor activity .

HY-N3188

Niloticin	Infection Triterpenes Structural Classification Phellodendron chinense Schneid. Classification of Application Fields Terpenoids Source classification Rutaceae Plants Disease Research Fields	Akt NF-κB
Niloticin, tetracyclic triterpenoid compound, is a osteoclastogenesis inhibitor. Niloticin shows anti-viral, antioxidative, and mosquitocidal activities. Niloticin inhibits osteoclastogenesis by blocking RANKL-RANK interaction and suppressing the AKT, MAPK, and NF-κB signaling pathways .

HY-N6252

Gypenoside XLVI 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Plants Disease Research Fields Gynostemma pentaphyllum (Thunb.) Makino Cancer	Others
Gypenoside XLVI is one of the major dammarane-type triterpenoid saponins from Gynostamma pentaphallum . Gypenoside XLVI has a tetracyclic triterpene structure and possess potent non-small cell lung carcinoma A549 cell inhibitory activity .

HY-N0829

Shionone	Structural Classification Classification of Application Fields Terpenoids Diterpenoids Plants Compositae Sesbania vesicaria (Jacq.) Elliott Inflammation/Immunology Disease Research Fields	Others
Shionone is the major triterpenoid isolated from Aster tataricus, has anti-tussive, anti-inflammatory activities . Shionone possesses a unique six-membered tetracyclic skeleton and 3-oxo-4-monomethyl structure .

HY-N0481R

Roburic acid (Standard)	Triterpenes Structural Classification Gentiana macrophylla Pall. Terpenoids Source classification Gentianaceae Plants	COX
Roburic acid (Standard) is the analytical standard of Roburic acid. This product is intended for research and analytical applications. Roburic acid, a tetracyclic triterpenoid found in Gentiana macrophylla, acts as an inhibitor of COX, with IC₅₀s of 5 and 9 μM for COX-1 and COX-2, respectively .

HY-N0416

Cucurbitacin B Maximum Cited Publications 8 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Trichosanthes cucumerina L. Plants Endogenous metabolite Disease Research Fields Cancer	HIF/HIF Prolyl-Hydroxylase Integrin Autophagy Apoptosis Endogenous Metabolite ROS Kinase COX
Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity .

HY-N0829R

Shionone (Standard)	Structural Classification Terpenoids Diterpenoids Plants Compositae Sesbania vesicaria (Jacq.) Elliott	Others
Shionone (Standard) is the analytical standard of Shionone. This product is intended for research and analytical applications. Shionone is the major triterpenoid isolated from Aster tataricus, has anti-tussive, anti-inflammatory activities . Shionone possesses a unique six-membered tetracyclic skeleton and 3-oxo-4-monomethyl structure .

HY-N0313

Euphol	Triterpenes Structural Classification Classification of Application Fields Terpenoids Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields	MAGL Endogenous Metabolite
Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC₅₀=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain .

HY-N7241

Saudin	Clutia lanceolata Forssk. Structural Classification Other Monoterpenes Terpenoids Source classification Euphorbiaceae Plants	Others
Saudin, derived from Clutia lanceolata, is a hypoglycemic compound that significantly enhances glucose-triggered insulin release from murine pancreatic islets. It belongs to a group of new diterpenoids with a distinct tetracyclic core, suggesting potential as a therapeutic agent for diabetes treatment. Proposed biosynthetic pathways outline alternative cyclization routes from a common precursor, with Lanceolide P (16) identified as a promising lead compound for further development in managing diabetes .

HY-N0416R

Cucurbitacin B (Standard)	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Trichosanthes cucumerina L. Plants Endogenous metabolite	HIF/HIF Prolyl-Hydroxylase Integrin Autophagy Apoptosis Endogenous Metabolite ROS Kinase COX
Cucurbitacin B (Standard) is the analytical standard of Cucurbitacin B. This product is intended for research and analytical applications. Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity .

HY-N6693

Valinomycin 5 Publications Verification NSC 122023	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Apoptosis Antibiotic Autophagy Fungal
Valinomycin is a potassium-specific ionophore, the valinomycin-K ⁺ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K ⁺ gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research .

Cat. No.	Product Name	Chemical Structure

HY-B0444S

Maprotiline-d5 hydrochloride
Maprotiline-d₅ (hydrochloride) is the deuterium labeled Maprotiline hydrochloride. Maprotiline hydrochloride is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant .

HY-B0188AS

Mianserin-d3 hydrochloride
Mianserin-d₃ (hydrochloride) is the deuterium labeled Mianserin hydrochloride. Mianserin hydrochloride (Org GB 94) is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.

HY-B0188S

Mianserin-d3
Mianserin-d3 is the deuterium labeled Mianserin (HY-B0188). Mianserin? is a Histamine 1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant .

HY-32329S

Setiptiline-d3

Setiptiline-d₃ is the deuterium labeled Setiptiline. Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine .

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