steroid-receptor

By Targets:	ADC Payload (2) Apoptosis (1) Cytochrome P450 (1) Drug Isomer (1) Endogenous Metabolite (5) Enterovirus (4) Estrogen Receptor/ERR (2) Glucocorticoid Receptor (4) Isotope-Labeled Compounds (2) Mineralocorticoid Receptor (3) Paraptosis (2) PPAR (1) Prostaglandin Receptor (1) Reactive Oxygen Species (ROS) (2) Reference Standards (2) SARS-CoV (1) Src (4) Thyroid Hormone Receptor (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Endocrinology (7) Infection (5) Inflammation/Immunology (4) Metabolic Disease (1)

Targets Recommended: Steroid Sulfatase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W739985

7α-(Thiomethyl)spironolactone 7α-Thiomethylspironolactone	SARS-CoV Estrogen Receptor/ERR	Infection
7α-(Thiomethyl)spironolactone is a nuclear steroid receptor antagonist that can be used for the research of coronaviruses .

HY-107917

Desoxycorticosterone pivalate	Mineralocorticoid Receptor	Endocrinology
Desoxycorticosterone pivalate (DOCP) is a mineralocorticoid hormone and an analog of Desoxycorticosterone. Desoxycorticosterone pivalate is used for the management of canine hypoadrenocorticism .

HY-B0154

Fluticasone (propionate) 1 Publications Verification	Glucocorticoid Receptor Enterovirus Endogenous Metabolite ADC Payload	Infection Inflammation/Immunology Endocrinology
Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (K_D) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity .

HY-163469

SRC-3-IN-2	Src	Cancer
SRC-3-IN-2 (SI-12 6c)is an orally active steroid receptor coactivator 3 (SRC-3) inhibitor. SRC-3-IN-2 has antitumor activity .

HY-B0154S1

Fluticasone propionate-d5	Isotope-Labeled Compounds Glucocorticoid Receptor Enterovirus Endogenous Metabolite	Infection Inflammation/Immunology Endocrinology
Fluticasone propionate-d₅ is deuterium labeled Fluticasone (propionate). Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity .

HY-P5464

SRC-1 NR box peptide	Estrogen Receptor/ERR	Others
SRC-1 NR box peptide is a biological active peptide (This peptide is a 14-amino acid fragment from the steroid receptor cofactor SRC-1 NR II). SRC-1 NR box peptide can be used to study the regulatory mechanisms of estrogen receptor ligands .

HY-107917R

Desoxycorticosterone pivalate (Standard)	Reference Standards Mineralocorticoid Receptor	Endocrinology
Desoxycorticosterone pivalate (Standard) is the analytical standard of Desoxycorticosterone pivalate. This product is intended for research and analytical applications. Desoxycorticosterone pivalate (DOCP) is a mineralocorticoid hormone and an analog of Desoxycorticosterone. Desoxycorticosterone pivalate is used for the management of canine hypoadrenocorticism .

HY-125787

MLS000389544	Thyroid Hormone Receptor	Metabolic Disease
MLS000389544 is a selective and potent methylsulfonylnitrobenzoate thyroid hormone receptor β (TRβ) antagonist that blocks the association of TRβ with steroid receptor coactivator 2 (SRC2) .

HY-121582

(E)-SI-2 (E)-EPH 116	Drug Isomer	Cancer
(E)-SI-2 is an isomer of SI-2, an inhibitor of the steroid receptor coactivator SRC-3. SI-2 has anticancer activity and increases the number of cytotoxic immune cells in mice with breast cancer .

HY-B0154S

Fluticasone propionate-d3	Isotope-Labeled Compounds Glucocorticoid Receptor Enterovirus Endogenous Metabolite	Infection Inflammation/Immunology Endocrinology
Fluticasone propionate-d₃ is the deuterium labeled Fluticasone propionate. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity .

HY-156530

CYP11A1-IN-1	Cytochrome P450	Endocrinology
CYP11A1-IN-1 (compound 30) is an inhibitor of CYP11A1, with IC₅₀ value of 201-2000 nM. CYP11A1-IN-1 can be used for research in steroid receptor, particularly androgen receptor, dependent diseases and conditions, such as prostate cancer .

HY-P5458

SRC-1 (686-700)	Mineralocorticoid Receptor	Others
SRC-1 (686-700) is a biological active peptide. (This peptide is amino acids 686 to 700 fragment containing the second LXXLL motif, derived from NR box II of steroid receptor coactivator (SRC1). Coactivator proteins interact with nuclear receptors in a ligand-dependent manner and augment transcription.)

HY-B0154R

Fluticasone (propionate) (Standard)	Reference Standards Glucocorticoid Receptor Enterovirus Endogenous Metabolite ADC Payload	Infection Inflammation/Immunology Endocrinology
Fluticasone (propionate) (Standard) is the analytical standard of Fluticasone (propionate). This product is intended for research and analytical applications. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity .

HY-19625A

(E/Z)-MCB-613	Reactive Oxygen Species (ROS) Paraptosis	Cancer
(E/Z)-MCB-613 is a pan-Steroid Receptor Coactivator (SRC) stimulator. (E/Z)-MCB-613 overstimulates SRC activity in cancer cells resulting in excessive generation of reactive oxygen species (ROS), leading to cell stress and death by a process called paraptosis. (E/Z)-MCB-613 is a cytotoxic molecule that plays an important role in cancer .

HY-163468

SRC-3-IN-1	Src	Cancer
SRC-3-IN-1 (compound SI-10) is a steroid receptor coactivator 3 (SRC-3) inhibitor (IC₅₀=3.3 μM). SRC-3-IN-1 has good water solubility, oral bioavailability, and improved selectivity profile. SRC-3-IN-1 can be used in prostate cancer research .

HY-19625

MCB-613	Reactive Oxygen Species (ROS) Paraptosis	Cancer
MCB-613 is a potent Steroid receptor coactivator SRC small molecule ‘stimulator’ (SMS), super-stimulates SRCs’ transcriptional activity. MCB-613 increases SRCs’ interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). MCB-613 is a SMS that target oncogenes can be exploited as anti-cancer agents by over-stimulating the SRC oncogenic program .

HY-101447

SI-2 EPH 116	Src Apoptosis	Cancer
SI-2 (EPH 116) is an inhibitor for steroid receptor coactivator-3 (SRC-3), which reduces the transcriptional activity and protein concentration of SRC-3 in cells, exhibits cytotoxicity in cancer cell, inhibits migration of MDA-MB-468, induces apoptosis of MDA-MB-468. SI-2 inhibits the tumor growth in mouse models, without significant toxicity for heart and other major organs (20 mg/kg) .

HY-116028

15-deoxy-Δ12,14-Prostaglandin D2 15-Deoxy-Δ12,14-PGD2	Endogenous Metabolite Prostaglandin Receptor PPAR Src	Cardiovascular Disease
15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2), a metabolite of PGD2 (HY-101988), is an agonist of *prostaglandin receptor* 2 (DP2). 15-deoxy-Δ12,14-Prostaglandin D2 binds to DP2 (Ki=50 nM) and induces eosinophil activation (EC₅₀*=8 nM). 15-deoxy-Δ12,14-Prostaglandin D2 also stimulates the recruitment of steroid receptor* coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ), inducing PPARγ-mediated transcription. 15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2) is cytotoxic to L1210 murine leukemia cells (IC₅₀=0.3 μg/ml) and inhibits ADP-induced platelet aggregation (IC₅₀=320 ng/mL).

Cat. No.	Product Name	Target	Research Area

HY-P5464

SRC-1 NR box peptide	Estrogen Receptor/ERR	Others
SRC-1 NR box peptide is a biological active peptide (This peptide is a 14-amino acid fragment from the steroid receptor cofactor SRC-1 NR II). SRC-1 NR box peptide can be used to study the regulatory mechanisms of estrogen receptor ligands .

HY-P5458

SRC-1 (686-700)	Mineralocorticoid Receptor	Others
SRC-1 (686-700) is a biological active peptide. (This peptide is amino acids 686 to 700 fragment containing the second LXXLL motif, derived from NR box II of steroid receptor coactivator (SRC1). Coactivator proteins interact with nuclear receptors in a ligand-dependent manner and augment transcription.)

Cat. No.	Product Name

HY-K0253

Heparin Agarose 6FF
MCE Heparin Agarose 6FF is suitable for the separation and purification of heparin-binding biomolecules, including antithrombin III, coagulation factors, other plasma proteins, DNA-binding proteins, lipoproteins, protein synthesis factors, nucleic acid-related enzymes, and steroid receptors.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0154R

Fluticasone (propionate) (Standard)	Structural Classification Source classification Steroids	Reference Standards Glucocorticoid Receptor Enterovirus Endogenous Metabolite ADC Payload
Fluticasone (propionate) (Standard) is the analytical standard of Fluticasone (propionate). This product is intended for research and analytical applications. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity .

Cat. No.	Product Name	Chemical Structure

HY-B0154S1

Fluticasone propionate-d5
Fluticasone propionate-d₅ is deuterium labeled Fluticasone (propionate). Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity .

HY-B0154S

Fluticasone propionate-d3
Fluticasone propionate-d₃ is the deuterium labeled Fluticasone propionate. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P85376

	SRA1 Antibody (YA5068) SRA1; PP7684; steroid receptor RNA activator 1; steroid receptor RNA activator protein; SRAP	WB, IHC-P, ICC/IF, ELISA	Human
	SRA1 Antibody (YA5068) is a mouse-derived and non-conjugated monoclonal antibody, targeting to SRA1. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human.

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