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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

stem-like cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PERK (1) Acyltransferase (1) Aldehyde Dehydrogenase (ALDH) (1) Apoptosis (4) Caspase (2) Dopamine Receptor (1) Endogenous Metabolite (2) ERK (2) Eukaryotic Initiation Factor (eIF) (1) Fluorescent Dye (1) HSP (2) IKK (1) Isocitrate Dehydrogenase (IDH) (2) Isotope-Labeled Compounds (1) JAK (2) JNK (2) Mitochondrial Metabolism (1) Necroptosis (1) NF-κB (1) Notch (1) p38 MAPK (2) Peptide-Drug Conjugates (PDCs) (1) PPAR (2) Reactive Oxygen Species (ROS) (1) Reference Standards (1) STAT (2)
By Research Areas:	Cancer (11) Inflammation/Immunology (1) Metabolic Disease (3) Neurological Disease (2)

By Targets:

PERK (1)

Acyltransferase (1)

Aldehyde Dehydrogenase (ALDH) (1)

Apoptosis (4)

Caspase (2)

Dopamine Receptor (1)

Endogenous Metabolite (2)

ERK (2)

Eukaryotic Initiation Factor (eIF) (1)

Fluorescent Dye (1)

HSP (2)

IKK (1)

Isocitrate Dehydrogenase (IDH) (2)

Isotope-Labeled Compounds (1)

JAK (2)

JNK (2)

Mitochondrial Metabolism (1)

Necroptosis (1)

NF-κB (1)

Notch (1)

p38 MAPK (2)

Peptide-Drug Conjugates (PDCs) (1)

PPAR (2)

Reactive Oxygen Species (ROS) (1)

Reference Standards (1)

STAT (2)

By Research Areas:

Cancer (11)

Inflammation/Immunology (1)

Metabolic Disease (3)

Neurological Disease (2)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Polo-like Kinase (PLK) NOD-like Receptor (NLR) Toll-like Receptor (TLR) C-type Lectin-like Receptors (CTLRs) Nuclear Factor of activated T Cells (NFAT) TREM receptor KLF ANGPTL PERK ULK METTL3 HRASLS MASTL CDKL Programmed Cell Death 4 (PDCD4) ADAMTS IGF-1R LOX-1 FLT3 Nuclear Hormone Receptor 4A/NR4A Scavenger Receptor Class B type I (SR-BI）

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145102

NCT-58	HSP Apoptosis	Cancer
NCT-58 is a potent inhibitor of C-terminal HSP90. NCT-58 does not induce the heat shock response (HSR) due to its targeting of the C-terminal region and elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills Trastuzumab-resistant breast cancer stem-like cells. NCT-58 induces apoptosis in HER2-positive breast cancer cells .

HY-117651

2-Fluoropalmitic acid	Acyltransferase	Cancer
2-Fluoropalmitic acid, an acyl-CoA synthetase inhibitor, acts as a candidate anti-glioma agent. 2-Fluoropalmitic acid suppresses the viability and stem-like phenotype of glioma stem cells (GSCs). 2-Fluoropalmitic acid also inhibits proliferation and invasion of glioma cell lines .

HY-128888B

(S,R)-GSK321	Isocitrate Dehydrogenase (IDH)	Cancer
(S,R)-GSK321 is the (S,R)-enantiomer of GSK321 (HY-18948). GSK321 is a potent, selective mutant IDH1 inhibitor with IC₅₀ values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively, and >100-fold selectivity over IDH2. GSK321 induces decrease in intracellular 2-HG, abrogation of the myeloid differentiation block and induction of granulocytic differentiation at the level of leukemic blasts and more immature stem-like cells. GSK321can be used for research of acute myeloid leukemia (AML) and other cancers .

HY-121608

Lumiflavin Lumiflavine	Fluorescent Dye Notch	Cancer
Lumiflavin (Lumiflavine), a riboflavine analog, causes significant inhibition of riboflavine uptake. Lumiflavin can effectively reduce the riboflavin enrichment in cancer stem-like cells (CSCs) and sensitize the effect of cisplatin Diamminedichloroplatinum (DDP) on CSCs. Lumiflavin is promising for research of ovarian cancer .

HY-122912

ALDH1A inhibitor 673A ALDH1Ai 673A	Aldehyde Dehydrogenase (ALDH) Mitochondrial Metabolism Necroptosis	Cancer
ALDH1A inhibitor 673A is an ALDH1A inhibitor with IC₅₀s of 246 nM (ALDH1A1), 230 nM (ALDH1A2), 348 nM (ALDH1A3), respectively. ALDH1A inhibitor 673A has little or no inhibitory effect on other ALDH family members. ALDH1A inhibitor 673A induces necroptotic ovarian cancer stem-like cells (CSCs) death. ALDH1A inhibitor 673A induces DNA double stand breaks in cancer cells. ALDH1A inhibitor 673A can be used for the study of ovarian cancer .

HY-18948

GSK321 1 Publications Verification	Isocitrate Dehydrogenase (IDH)	Cancer
GSK321 is a potent, selective mutant IDH1 inhibitor with IC₅₀ values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively, and >100-fold selectivity over IDH2. GSK321 induces decrease in intracellular α-Hydroxyglutaric acid (2-HG) (HY-113038B), abrogation of the myeloid differentiation block and induction of granulocytic differentiation at the level of leukemic blasts and more immature stem-like cells. GSK321can be used for research of acute myeloid leukemia (AML) and other cancers .

HY-N12432

Glomeratide A	Others	Metabolic Disease
Glomeratide A is a benzophenone C-glucoside with hepatoprotective effects. Glomeratide A has a protective effect against d-galactosamine-induced hepatotoxicity in rat liver epithelial stem-like cells.

HY-164480

GTCpFE	IKK NF-κB	Inflammation/Immunology Cancer
GTCpFE inhibits IKKα/β in the NF-κB pathway with anti-inflammatory activities and blocks p65 nuclear entry, which consists of Dimethyl fumarate (DMF) (HY-17363) linked to Aspirin (ASA) (HY-14654). GTCpFE exhibits selective anti-cancer stem-like cell (CSC) activity by reducing mammosphere growth and the CD44 ⁺ CD24 ^- immunophenotype. GTCpFE inhibits breast cancer stem cells, an important NFκB- and PGE2-dependent phenotype in aggressive cancers .

HY-176305S

Neurofilament, U-15N	Isotope-Labeled Compounds	Neurological Disease
Neurofilament, U- ¹⁵N is the ¹⁵N-labeled Neurofilament.

HY-139211

Difluorinated Curcumin 3,4-Difluorobenzylidene curcumin	Reactive Oxygen Species (ROS)	Cancer
Difluorinated Curcumin (3,4-Difluorobenzylidene curcumin) is a fluorinated curcumin analog with high bioavailability and anticancer activity. Difluorinated Curcumin inhibits the self-renewal ability of tumor stem/stem-like cells, clonogenicity, invasiveness and angiogenesis of tumor cells. Difluorinated Curcumin also increases cell sensitivity to chemotherapy .

HY-W004283R

Pentadecanoic acid (Standard)	Reference Standards Endogenous Metabolite JAK STAT PPAR p38 MAPK JNK ERK Caspase Apoptosis	Metabolic Disease Cancer
α-Linolenic acid (Standard) is the analytical standard of α-Linolenic acid. This product is intended for research and analytical applications. α-Linolenic acid, isolated from Perilla frutescens, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .

HY-W004283

Pentadecanoic acid	Endogenous Metabolite JAK STAT PPAR p38 MAPK JNK ERK Caspase Apoptosis	Metabolic Disease Cancer
Pentadecylic acid is a saturated fatty acid with a 15-carbon backbone.

HY-P10757

DTX-P7	Peptide-Drug Conjugates (PDCs) Apoptosis HSP Eukaryotic Initiation Factor (eIF) PERK	Cancer
DTX-P7 is a peptide-drug conjugate. DTX-P7, composed of Docetaxel (DTX, HY-B0011) and a heptapeptide (P7), induces unfolded protein response and subsequent apoptosis by degrading Hsp90 .

HY-B1019

Sulpiride 5+ Cited Publications	Dopamine Receptor	Neurological Disease
Sulpiride is an orally active dopamine D2/D3 receptor antagonist. Sulpiride is an atypical antipsychotic agent of the benzamide family. Sulpiride can be used in research into anxiety, depression and breast cancer .

Cat. No.	Product Name	Type