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status

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Androgen Receptor (1) Apoptosis (8) Autophagy (5) Biochemical Assay Reagents (1) Cannabinoid Receptor (2) CD73 (1) CDK (2) Cytochrome P450 (3) DNA/RNA Synthesis (1) Drug Metabolite (2) E1/E2/E3 Enzyme (1) EGFR (1) Endogenous Metabolite (28) Estrogen Receptor/ERR (1) Fatty Acid Synthase (FASN) (1) Fluorescent Dye (3) GABA Receptor (5) HDAC (2) HOXA (1) Isotope-Labeled Compounds (16) Keap1-Nrf2 (2) MDM-2/p53 (2) mGluR (1) Microtubule/Tubulin (1) NEKs (1) NF-κB (2) Phosphatase (2) Prostaglandin Receptor (1) RAR/RXR (5) Reactive Oxygen Species (ROS) (3) Reference Standards (7) SARS-CoV (1) SOD (2) TRP Channel (2) VD/VDR (3)
By Research Areas:	Cancer (18) Cardiovascular Disease (5) Endocrinology (5) Inflammation/Immunology (6) Metabolic Disease (28) Neurological Disease (15)

By Targets:

Akt (1)

Androgen Receptor (1)

Apoptosis (8)

Autophagy (5)

Biochemical Assay Reagents (1)

Cannabinoid Receptor (2)

CD73 (1)

CDK (2)

Cytochrome P450 (3)

DNA/RNA Synthesis (1)

Drug Metabolite (2)

E1/E2/E3 Enzyme (1)

EGFR (1)

Endogenous Metabolite (28)

Estrogen Receptor/ERR (1)

Fatty Acid Synthase (FASN) (1)

Fluorescent Dye (3)

GABA Receptor (5)

HDAC (2)

HOXA (1)

Isotope-Labeled Compounds (16)

Keap1-Nrf2 (2)

MDM-2/p53 (2)

mGluR (1)

Microtubule/Tubulin (1)

NEKs (1)

NF-κB (2)

Phosphatase (2)

Prostaglandin Receptor (1)

RAR/RXR (5)

Reactive Oxygen Species (ROS) (3)

Reference Standards (7)

SARS-CoV (1)

SOD (2)

TRP Channel (2)

VD/VDR (3)

By Research Areas:

Cancer (18)

Cardiovascular Disease (5)

Endocrinology (5)

Inflammation/Immunology (6)

Metabolic Disease (28)

Neurological Disease (15)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-32349

Ercalcidiol 2 Publications Verification 25-Hydroxy Vitamin D2	VD/VDR Endogenous Metabolite	Metabolic Disease
Ercalcidiol is a metabolite of vitamin D₂, is regarded as an indicator of vitamin D nutritional status.

HY-121877

Valnoctamide 1 Publications Verification Valmethamide	GABA Receptor	Neurological Disease
Valnoctamide (Valmethamide), a derivative of valproate, suppresses benzodiazepine-refractory status epilepticus. Valnoctamide (Valmethamide) acts directly on GABA_A receptors .

HY-32349S

Ercalcidiol-d3 25-Hydroxy Vitamin D2-d₃	Isotope-Labeled Compounds Endogenous Metabolite VD/VDR	Metabolic Disease
Ercalcidiol-d₃ is the deuterium labeled Ercalcidiol. Ercalcidiol is a metabolite of Vitamins D2. Ercalcidiol can be used as an indicator of vitamins D status .

HY-113415A

Testosterone sulfate (pyridinium) 1 Publications Verification	Endogenous Metabolite Drug Metabolite	Endocrinology
Testosterone sulfate pyridinium is a Testosterone sulfate with a pyridinium. Testosterone sulfate is the metabolite of Testosterone. Testosterone is the main male sex hormone which determination is useful for assessment of androgen status .

HY-173520

EGFR/HDAC-IN-1	EGFR HDAC	Cancer
EGFR/HDAC-IN-1 (Compound 22c2) is a potent dual inhibitor of epidermal growth factor receptor (EGFR) and histone deacetylase (HDAC) with IC₅₀ values of 4.81 nM, 119.4 nM and 354.8 nM for EGFR, HDAC1 and HDAC3, respectively. EGFR/HDAC-IN-1 blocks the EGFR signaling pathway and affects the histone acetylation status, thereby inhibiting tumor cell proliferation. EGFR/HDAC-IN-1 is promising for research of non-small cell lung cancer (NSCLC) .

HY-D1441

Zinquin AM ester	Fluorescent Dye	Others
Zinquin AM ester is an AM ester form of Zinquin. Zinquin, a fluorescent dye, is a commonly used sensor for cellular Zn ²⁺ status .

HY-113415

Testosterone sulfate	Endogenous Metabolite Drug Metabolite	Others
Testosterone sulfate is the metabolite of Testosterone. Testosterone is the main male sex hormone which determination is useful for assessment of androgen status .

HY-32349R

Ercalcidiol (Standard) 25-Hydroxy Vitamin D2 (Standard)	Reference Standards VD/VDR Endogenous Metabolite	Metabolic Disease
Ercalcidiol (Standard) is the analytical standard of Ercalcidiol. This product is intended for research and analytical applications. Ercalcidiol is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status.

HY-103232

IEM-1925 bromide	mGluR	Neurological Disease
IEM-1925 bromide is an orally active glutamate receptor antagonist, increases the latent period and decreases the duration of status epilepticus in rats in a lithium-pilocarpine model of epilepsy .

HY-121877S

Valnoctamide-d5	Isotope-Labeled Compounds GABA Receptor	Neurological Disease
Valnoctamide-d₅ is the deuterium labeled Valnoctamide. Valnoctamide (Valmethamide), a derivative of valproate, suppresses benzodiazepine-refractory status epilepticus. Valnoctamide (Valmethamide) acts directly on GABAA receptors .

HY-168101

ERα degrader 11	Estrogen Receptor/ERR	Cancer
ERα degrader 11 (compound B16) is a selective ERα degrader that can be used as an estrogen receptor probe to investigate ER status in ER-positive breast cancer cells .

HY-N13079

3-Epicinobufagin	Others	Others
3-Epicinobufagin (compound IX) can be used as an internal standard for the metabolism of Bufalin (HY-N0877), by detecting its content in serum and urine to provide feedback on the corresponding metabolic status .

HY-121877R

Valnoctamide (Standard)	GABA Receptor	Neurological Disease
Valnoctamide (Standard) is the analytical standard of Valnoctamide. This product is intended for research and analytical applications. Valnoctamide (Valmethamide), a derivative of valproate, suppresses benzodiazepine-refractory status epilepticus. Valnoctamide (Valmethamide) acts directly on GABAA receptors .

HY-B0389

D-Glucose Maximum Cited Publications 34 Publications Verification Glucose; D-(+)-Glucose; Dextrose	Endogenous Metabolite	Cardiovascular Disease Others Metabolic Disease Endocrinology Cancer
D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response .

HY-129105

Clomethiazole 3 Publications Verification	GABA Receptor Cytochrome P450	Neurological Disease
Chlormethiazole is an potent and orally active GABA_A agonist . Chlormethiazole inhibits cytochrome P450 isoforms: CYP2A6 and CYP2E1 in human liver microsomes. Chlormethiazole is an anticonvulsant agent and has the potential for treating convulsive status epilepticus .

HY-A0296

Chlormethiazole hydrochloride 3 Publications Verification Clomethiazole hydrochloride	Cytochrome P450	Neurological Disease
Clomethiazole hydrochloride is a potent and orally active GABA_A agonist . Clomethiazole hydrochloride inhibits cytochrome P450 isoforms: CYP2A6 and CYP2E1 in human liver microsomes. Clomethiazole hydrochloride is an anticonvulsant agent and has the potential for treating convulsive status epilepticus .

HY-D1359

Mito Red	Fluorescent Dye	Others
Mito Red is a vital dye and mitochondrial stain that can be used to detect and evaluate mitochondrial function and status. Mito Red accumulates in mitochondria, and its fluorescence intensity is positively correlated with mitochondrial membrane potential. When the mitochondrial membrane potential increases, the fluorescence signal of Mito Red increases .

HY-171001

ZM522	CD73	Inflammation/Immunology Cancer
ZM522 is a CD73 inhibitor with an IC₅₀ value of 0.56 μM. ZM522 effectively increases the levels of interferon-γ (INF-γ) and enhances immune activity by regulating the activation status of T cells. ZM522 holds promise for research in the fields of immunology and cancer therapy .

HY-B0389S6

D-Glucose-d7 Glucose-d₇; D-(+)-Glucose-d₇; Dextrose-d₇	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
D-Glucose-d₇7 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S7

D-Glucose-d1-3 Glucose-d₁-3; D-(+)-Glucose-d₁-3; Dextrose-d₁-3	Endogenous Metabolite	Metabolic Disease
D-Glucose-d-33 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S5

D-Glucose-d2 Glucose-d₂; D-(+)-Glucose-d₂; Dextrose-d₂	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
D-Glucose-d₂2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S10

D-Glucose-13C 1 Publications Verification Glucose-¹³C; D-(+)-Glucose-¹³C; Dextrose-¹³C	Endogenous Metabolite	Metabolic Disease
D-Glucose- ¹³C is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S8

D-Glucose-d1-4 Glucose-d₁-4; D-(+)-Glucose-d₁-4; Dextrose-d₁-4	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
D-Glucose-d-44 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S3

D-Glucose-d1-1 Glucose-d₁-1; D-(+)-Glucose-d₁-1; Dextrose-d₁-1	Endogenous Metabolite	Metabolic Disease
D-Glucose-d-11 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S4

D-Glucose-d1-2 Glucose-d₁-2; D-(+)-Glucose-d₁-2; Dextrose-d₁-2	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
D-Glucose-d₁-2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S2

D-Glucose-d12-1 Glucose-d₁₂-1; D-(+)-Glucose-d₁₂-1; Dextrose-d₁₂-1	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
D-Glucose-d₁₂-12 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S11

D-Glucose-13C-1 Glucose-¹³C-1; D-(+)-Glucose-¹³C-1; Dextrose-¹³C-1	Endogenous Metabolite	Metabolic Disease
D-Glucose- ¹³C-1 is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S17

D-Glucose-13C-5 Glucose-¹³C-5; D-(+)-Glucose-¹³C-5; Dextrose-¹³C-5	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
D-Glucose- ¹³C-5 is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S16

D-Glucose-13C-4 Glucose-¹³C-4; D-(+)-Glucose-¹³C-4; Dextrose-¹³C-4	Endogenous Metabolite	Metabolic Disease
D-Glucose- ¹³C-4 is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S13

D-Glucose-13C-3 Glucose-¹³C-3; D-(+)-Glucose-¹³C-3; Dextrose-¹³C-3	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
D-Glucose- ¹³C-3 is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S14

D-Glucose-13C2 Glucose-¹³C₂; D-(+)-Glucose-¹³C₂; Dextrose-¹³C₂	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
D-Glucose- ¹³C₂ is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].

HY-B0389S15

D-Glucose-13C2-4 Glucose-¹³C₂-4; D-(+)-Glucose-¹³C₂-4; Dextrose-¹³C₂-4	Endogenous Metabolite	Metabolic Disease
D-Glucose- ¹³C₂-4 is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S12

D-Glucose-13C-2 Glucose-¹³C-2; D-(+)-Glucose-¹³C-2; Dextrose-¹³C-2	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
D-Glucose- ¹³C-2 is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].

HY-106586A

Ioxaglate sodium P-286 sodium	Biochemical Assay Reagents	Cardiovascular Disease Cancer
Ioxaglate sodium (P-286 sodium) is an ionic, dimeric diagnostic contrast agent whose activity is mainly reflected in its ability to provide sufficient X-ray absorption to enhance visualization of blood vessels and other structures during imaging. Ioxaglate sodium is used to study the anatomical structure and functional status of cardiac vessels, especially in the diagnosis of coronary artery disease .

HY-B0389S18

D-Glucose-13C3-1 Glucose-¹³C₃-1; D-(+)-Glucose-¹³C₃-1; Dextrose-¹³C₃-1	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
D-Glucose- ¹³C₃-1 is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-D2041

3-HTC	Fluorescent Dye	Cancer
3-HTC is a chemical fluorescent probe. 3-HTC reacts reversibly with thiols and disulfides, and can be used to measure dynamic GSH/GSSH ratios in vitro as well as to monitor the reversible redox status of whole cell lysates (λ_max: 448 nm in its reduced thiolate form, and a λ_max 370-410 nm for the oxidized mixed disulfide) .

HY-B0389R

D-Glucose (Standard) Glucose (Standard); D-(+)-Glucose (Standard); Dextrose (Standard)	Reference Standards Endogenous Metabolite	Cardiovascular Disease Others Metabolic Disease Endocrinology Cancer
D-Glucose (Standard) is the analytical standard of D-Glucose. This product is intended for research and analytical applications. D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response .

HY-129105R

Clomethiazole (Standard)	GABA Receptor Cytochrome P450	Neurological Disease
Clomethiazole (Standard) is the analytical standard of Clomethiazole. This product is intended for research and analytical applications. Chlormethiazole is an potent and orally active GABAA agonist . Chlormethiazole inhibits cytochrome P450 isoforms: CYP2A6 and CYP2E1 in human liver microsomes. Chlormethiazole is an anticonvulsant agent and has the potential for treating convulsive status epilepticus .

HY-A0067

Oxybenzone 3 Publications Verification Benzophenone 3	RAR/RXR Autophagy Apoptosis	Neurological Disease
Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-B0389S9

D-Glucose-13C3-2 Glucose-¹³C₃-2; D-(+)-Glucose-¹³C₃-2; Dextrose-¹³C₃-2	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
D-Glucose- ¹³C₃-2 is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-170515

RNF5 agonist 1	E1/E2/E3 Enzyme	Inflammation/Immunology
RNF5 agonist 1 (analog-1), a structural analog of RNF5 inhibitor inh-02 (HY-123967), is a potent RNF5 agonist. RNF5 agonist 1 increases the ubiquitylation status of ATG4B in F508del-CFTR-expressing CFBE41o- cells .

HY-112816

MA242	MDM-2/p53 Apoptosis	Cancer
MA242 is a specific dual inhibitor of MDM2 and NFAT1. MA242 directly binds both MDM2 and NFAT1 with high affinity, induces their protein degradation, and inhibits NFAT1-mediated transcription of MDM2. MA242 induces apoptosis in pancreatic cancer cell lines regardless of p53 status .

HY-128736B

D-2-Phosphoglyceric acid	Endogenous Metabolite
D-2-Phosphoglyceric acid is an important metabolic intermediate that has the activity of promoting cellular energy metabolism and regulating biosynthesis. D-2-Phosphoglyceric acid plays a key role in glycolysis and photosynthesis and is essential for the energy supply of cells. D-2-Phosphoglyceric acid can also be used as a biomarker to monitor the metabolic status in different organisms.

HY-114302

CCB02 1 Publications Verification	Microtubule/Tubulin	Cancer
CCB02 is a selective CPAP-tubulin interaction inhibitor, binding to tubulin and competing for the CPAP binding site of β-tubulin, with an IC₅₀ of 689 nM, and shows potent anti-tumor activity. CCB02 shows no inhibition on the cell cycle- and centrosome-related kinases, or the phosphorylation status of Aurora A, Plk1, Plk2, CDK2, and CHK1 .

HY-138668

JW-65	TRP Channel	Cancer
JW-65 (compound 20) is a TRPC3 inhibitor. JW-65 can be used in neurological and cardiovascular disease related research .

HY-W017960

Diludine Et-HE	SOD	Others
Diludine (Et-HE) has antioxidant properties, targeting oxidative stress-related pathways. By improving antioxidative status and reducing β-hydroxybutyrate levels, Diludine alleviates oxidative stress during the parturition period in dairy cows. It is primarily used during the transition period in dairy cows to increase milk yield and milk fat content, as well as to improve health during parturition .

HY-128417S2

D-Glucose-1,6-13C2	Isotope-Labeled Compounds Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Endocrinology Cancer
D-Glucose-1,6- ¹³C₂ is the ¹³C-labeled D-Glucose (HY-B0389). D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response .

HY-110028

Leelamine hydrochloride	Cannabinoid Receptor Fatty Acid Synthase (FASN) Androgen Receptor	Endocrinology Cancer
Leelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees . Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor, which is known to regulate fatty acid synthesis ^[2,3].

HY-112816A

MA242 free base	MDM-2/p53 Apoptosis	Cancer
MA242 free base is a specific dual inhibitor of MDM2 and NFAT1. MA242 free base directly binds both MDM2 and NFAT1 with high affinity, induces their protein degradation, and inhibits NFAT1-mediated transcription of MDM2. MA242 free base induces apoptosis in pancreatic cancer cell lines regardless of p53 status .

HY-A0067S

Oxybenzone-d5	RAR/RXR Apoptosis Autophagy	Neurological Disease
Oxybenzone-d₅ is the deuterium labeled Oxybenzone . Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

Cat. No.	Product Name

HY-L026

Clinical Compound Library

2,705 compounds

New drug development is a time-consuming and high-cost process. Drug repurposing (also called drug repositioning, reprofiling or re‑tasking) offers various advantages over developing an entirely new drug for a given indication, such as lower risk and less investment. Clinical drugs have confirmed bioactivities, clear mechanisms and high safety that are suitable for drug repurposing.

MCE owns a unique collection of 2,705 clinical compounds that refer to various research areas including anti-cancer, anti-infection, anti-inflammation, nervous disease. Those compounds are of detailed information on clinical development status, research area, targets, etc.

HY-L094

Food-Sourced Compound Library

1,965 compounds

The health benefits deriving from the consumption of certain foods have been common knowledge. All foods are made up of chemical substances. Chemicals in foods are largely harmless and often desirable. At present, numerous researchers have been focused on the beneficial role played by certain food components in the close relationship between food intake and health status. For example, polyphenols, a common class of compounds among foods, are well-known antioxidants, which may play a role in the prevention of several diseases including type 2 diabetes, cardiovascular diseases, and some types of cancer.

MCE supplies a unique collection of 1,965 compounds from variety of foods. All compounds are with specific food source(s). MCE Food-Sourced Compound Library is the useful tool to discover molecules with pharmaceutical activity from foods.

HY-L026P

Clinical Compound Library Plus

3,440 compounds

MCE owns a unique collection of 3,440 clinical compounds that refer to various research areas including anti-cancer, anti-infection, anti-inflammation, nervous disease. Those compounds are of detailed information on clinical development status, research area, targets, etc. Clinical Compound Library Plus, with powerful screening capability, further complements Clinical Compound Library (HY-L026) by adding some compounds with low solubility or solution stability (Part B) to this library. All those supplementary are supplied in powder form.

Cat. No.	Product Name	Type

HY-D1359

Mito Red	Fluorescent Dyes/Probes
Mito Red is a vital dye and mitochondrial stain that can be used to detect and evaluate mitochondrial function and status. Mito Red accumulates in mitochondria, and its fluorescence intensity is positively correlated with mitochondrial membrane potential. When the mitochondrial membrane potential increases, the fluorescence signal of Mito Red increases .

HY-D2041

3-HTC	Fluorescent Dyes/Probes
3-HTC is a chemical fluorescent probe. 3-HTC reacts reversibly with thiols and disulfides, and can be used to measure dynamic GSH/GSSH ratios in vitro as well as to monitor the reversible redox status of whole cell lysates (λ_max: 448 nm in its reduced thiolate form, and a λ_max 370-410 nm for the oxidized mixed disulfide) .

Cat. No.	Product Name	Target	Research Area

HY-P2472

Orphan GPCR SP9155 agonist P550 (mouse, rat) 26RFa (mouse, rat)	Peptides	Metabolic Disease
Orphan GPCR SP9155 agonist P550 (mouse, rat) (26RFa (mouse, rat)), a member of the RFamide peptide family with orexigenic effect, is the cognate ligand of the mouse orphan receptor GPR103, also designated SP9155 or AQ27 .

Cat. No.	Product Name

HY-K0021

Phosphatase Inhibitor Cocktail I (100× in DMSO) 500+ Cited Publications
Phosphatase Inhibitor Cocktail I (100× in DMSO) is a blend of 2 phosphatase inhibitors that can effectively inhibit alkaline phosphatases and serine/threonine phosphatases. It is used to maintain the phosphorylation status of proteins.

HY-K0023

Phosphatase Inhibitor Cocktail Ⅲ (100× in DMSO) 225+ Cited Publications
Phosphatase Inhibitor Cocktail Ⅲ (100× in DMSO) is a blend of 3 phosphatase inhibitors that can effectively inhibit serine/threonine phosphatases and alkaline phosphatases. It is used to maintain the phosphorylation status of proteins.

Cat. No.	Product Name	Target	Research Area

HY-P99278

Adecatumumab MT 201; Anti-Human EPCAM Recombinant Antibody	Inhibitory Antibodies	Cancer
Adecatumumab (Anti-Human EPCAM Recombinant Antibody; MT201) is a full human monoclonal antibody of the IgG1 isotype, targeting human EpCAM. Adecatumumab is expressed in almost all adenocarcinomas, and its activity is not dependent of K-Ras status .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-32349

Ercalcidiol 2 Publications Verification 25-Hydroxy Vitamin D2	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	VD/VDR Endogenous Metabolite
Ercalcidiol is a metabolite of vitamin D₂, is regarded as an indicator of vitamin D nutritional status.

HY-113415A

Testosterone sulfate (pyridinium) 1 Publications Verification	Structural Classification Stilbenes Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite Drug Metabolite
Testosterone sulfate pyridinium is a Testosterone sulfate with a pyridinium. Testosterone sulfate is the metabolite of Testosterone. Testosterone is the main male sex hormone which determination is useful for assessment of androgen status .

HY-B0389

D-Glucose Maximum Cited Publications 34 Publications Verification Glucose; D-(+)-Glucose; Dextrose	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Sweeteners Saccharides Monosaccharides Food Research	Endogenous Metabolite
D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response .

HY-110028

Leelamine hydrochloride	Structural Classification other families Classification of Application Fields Pinaceae Terpenoids Source classification Diterpenoids Plants Disease Research Fields Pinus massoniana Lamb. Endocrinology	Cannabinoid Receptor Fatty Acid Synthase (FASN) Androgen Receptor
Leelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees . Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor, which is known to regulate fatty acid synthesis ^[2,3].

HY-N0513

Loganic acid	Cardiovascular Disease Structural Classification Iridoids Cornaceae Classification of Application Fields Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants Disease Research Fields	Reactive Oxygen Species (ROS) Phosphatase NF-κB Keap1-Nrf2
Loganic acid is an iridoid isolated from cornelian cherry fruits. Loganic acid inhibits NF-κB signaling pathway, activates Nrf2 signaling pathway, exhibits anti-inflammatory activity. Loganic acid can modulate diet-induced atherosclerosis and redox status. Loganic acid has strong free radical scavenging activity and remarkable cyto-protective effect against heavy metal mediated toxicity. Loganic acid is orally active .

HY-113415

Testosterone sulfate	Structural Classification Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite Drug Metabolite
Testosterone sulfate is the metabolite of Testosterone. Testosterone is the main male sex hormone which determination is useful for assessment of androgen status .

HY-32349R

Ercalcidiol (Standard) 25-Hydroxy Vitamin D2 (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Reference Standards VD/VDR Endogenous Metabolite
Ercalcidiol (Standard) is the analytical standard of Ercalcidiol. This product is intended for research and analytical applications. Ercalcidiol is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status.

HY-N13079

3-Epicinobufagin	Structural Classification Animals Source classification Steroids	Others
3-Epicinobufagin (compound IX) can be used as an internal standard for the metabolism of Bufalin (HY-N0877), by detecting its content in serum and urine to provide feedback on the corresponding metabolic status .

HY-B0389R

D-Glucose (Standard) Glucose (Standard); D-(+)-Glucose (Standard); Dextrose (Standard)	Structural Classification Source classification Endogenous metabolite Saccharides Monosaccharides	Reference Standards Endogenous Metabolite
D-Glucose (Standard) is the analytical standard of D-Glucose. This product is intended for research and analytical applications. D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response .

HY-113204R

N-Oleoyl glycine (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite Cannabinoid Receptor Akt
Diludine (Standard) is the analytical standard of Diludine. This product is intended for research and analytical applications. Diludine has antioxidant properties, targeting oxidative stress-related pathways. By improving antioxidative status and reducing β-hydroxybutyrate levels, Diludine alleviates oxidative stress during the parturition period in dairy cows. It is primarily used during the transition period in dairy cows to increase milk yield and milk fat content, as well as to improve health during parturition .

HY-N0513R

Loganic acid (Standard)	Structural Classification Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants	Reference Standards Reactive Oxygen Species (ROS) Phosphatase NF-κB Keap1-Nrf2
Loganic acid (Standard) is the analytical standard of Loganic acid. This product is intended for research and analytical applications. Loganic acid is an iridoid isolated from cornelian cherry fruits. Loganic acid inhibits NF-κB signaling pathway, activates Nrf2 signaling pathway, exhibits anti-inflammatory activity. Loganic acid can modulate diet-induced atherosclerosis and redox status. Loganic acid has strong free radical scavenging activity and remarkable cyto-protective effect against heavy metal mediated toxicity. Loganic acid is orally active .

HY-101193R

Zinc Protoporphyrin (Standard) Zn(II)-protoporphyrin IX (Standard); ZnPP (Standard); Zinc Protoporphyrin-9 (Standard)	Structural Classification Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis
Zinc Protoporphyrin (Standard) is the analytical standard of Zinc Protoporphyrin. This product is intended for research and analytical applications. Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2 . Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration . Zinc Protoporphyrin has anti-cancer activity .

Cat. No.	Product Name	Chemical Structure

HY-32349S

Ercalcidiol-d3
Ercalcidiol-d₃ is the deuterium labeled Ercalcidiol. Ercalcidiol is a metabolite of Vitamins D2. Ercalcidiol can be used as an indicator of vitamins D status .

HY-B0389S6

D-Glucose-d7
D-Glucose-d₇7 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S7

D-Glucose-d1-3
D-Glucose-d-33 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S5

D-Glucose-d2
D-Glucose-d₂2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S10

D-Glucose-13C 1 Publications Verification
D-Glucose- ¹³C is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S8

D-Glucose-d1-4
D-Glucose-d-44 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S2

D-Glucose-d12-1
D-Glucose-d₁₂-12 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-121877S

Valnoctamide-d5
Valnoctamide-d₅ is the deuterium labeled Valnoctamide. Valnoctamide (Valmethamide), a derivative of valproate, suppresses benzodiazepine-refractory status epilepticus. Valnoctamide (Valmethamide) acts directly on GABAA receptors .

HY-B0389S3

D-Glucose-d1-1
D-Glucose-d-11 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S4

D-Glucose-d1-2
D-Glucose-d₁-2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S11

D-Glucose-13C-1
D-Glucose- ¹³C-1 is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S17

D-Glucose-13C-5
D-Glucose- ¹³C-5 is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S16

D-Glucose-13C-4
D-Glucose- ¹³C-4 is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S13

D-Glucose-13C-3
D-Glucose- ¹³C-3 is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S14

D-Glucose-13C2
D-Glucose- ¹³C₂ is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].

HY-B0389S15

D-Glucose-13C2-4
D-Glucose- ¹³C₂-4 is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S12

D-Glucose-13C-2
D-Glucose- ¹³C-2 is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].

HY-B0389S18

D-Glucose-13C3-1
D-Glucose- ¹³C₃-1 is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-B0389S9

D-Glucose-13C3-2
D-Glucose- ¹³C₃-2 is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-128417S2

D-Glucose-1,6-13C2
D-Glucose-1,6- ¹³C₂ is the ¹³C-labeled D-Glucose (HY-B0389). D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response .

HY-A0067S

Oxybenzone-d5
Oxybenzone-d₅ is the deuterium labeled Oxybenzone . Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-A0067S1

Oxybenzone-13C6

Oxybenzone- ¹³C₆ (Benzophenone 3- ¹³C₆) is the ¹³C-labeled Oxybenzone (HY-A0067). Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-W653958

Oxybenzone-d3

Oxybenzone-d₃ (Benzophenone 3-d₃) is a deuterium labeled Oxybenzone (HY-A0067). Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

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