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Results for "

spheroid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Aldehyde Dehydrogenase (ALDH) (1) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (2) Aurora Kinase (1) c-Myc (1) Carbonic Anhydrase (1) Carboxylesterase (CES) (1) CD3 (1) CDK (1) Cytochrome P450 (1) DNA/RNA Synthesis (3) EGFR (2) Endogenous Metabolite (1) Epigenetic Reader Domain (1) FAK (1) Fluorescent Dye (1) Gli (1) Hedgehog (1) Isotope-Labeled Compounds (1) MDM-2/p53 (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) Oct3/4 (1) PERK (1) Phosphatase (1) PI3K (1) Reactive Oxygen Species (ROS) (2) STAT (1) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (21) Cardiovascular Disease (2) Metabolic Disease (1)

By Targets:

Akt (1)

Aldehyde Dehydrogenase (ALDH) (1)

Anaplastic lymphoma kinase (ALK) (1)

Apoptosis (2)

Aurora Kinase (1)

c-Myc (1)

Carbonic Anhydrase (1)

Carboxylesterase (CES) (1)

CD3 (1)

CDK (1)

Cytochrome P450 (1)

DNA/RNA Synthesis (3)

EGFR (2)

Endogenous Metabolite (1)

Epigenetic Reader Domain (1)

FAK (1)

Fluorescent Dye (1)

Gli (1)

Hedgehog (1)

Isotope-Labeled Compounds (1)

MDM-2/p53 (1)

Microtubule/Tubulin (1)

Mitochondrial Metabolism (1)

Oct3/4 (1)

PERK (1)

Phosphatase (1)

PI3K (1)

Reactive Oxygen Species (ROS) (2)

STAT (1)

Transmembrane Glycoprotein (1)

By Research Areas:

Cancer (21)

Cardiovascular Disease (2)

Metabolic Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148243

IGUANA-1 free base 1 Publications Verification STL5-T-0057	Aldehyde Dehydrogenase (ALDH)	Cancer
IGUANA-1 free base (STL5-T-0057) is an selective ALDH1 B1 inhibitor with an IC₅₀ value of 30 nM. IGUANA-1 free base inhibits cell growth of SW480 cells in adherent and spheroid conditions with IC₅₀ values of 2.46 and 0.39 μM, respectively. IGUANA-1 free base can be used for the research of cancer .

HY-P99896

Runimotamab BTRC-4017A; RG-6194	EGFR CD3	Cancer
Runimotamab (RG-6194) is a HER2 and CD3 T cell-engaging bispecific antibody. Runimotamab can decrease the size of liver tumor spheroids. Runimotamab can be studied in oncology research such as HER2-expressing cancers. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-128974

N-Dodecyl-β-D-maltoside 4 Publications Verification Lauryl Maltoside	DNA/RNA Synthesis	Others
N-Dodecyl-β-D-maltoside (Lauryl Maltoside) is a non-ionic detergent. N-Dodecyl-β-D-maltoside has strong adsorption on alumina, titanium dioxide and hematite. N-Dodecyl-β-D-maltoside can promote the reactivation of various proteins. N-Dodecyl-β-D-maltoside can effectively stabilize photoactive reaction center complexes (RCs) and inhibit the degradation of Rhodopseudomonas spheroides R-26 reaction center in solution. N-Dodecyl-β-D-maltoside can be used for purification and stabilization of RNA polymerase and for detection of protein-lipid interactions .

HY-156675A

Plecstatin-1 hydrochloride 1 Publications Verification	Microtubule/Tubulin	Cancer
Plecstatin-1 hydrochloride is an anticancer agent containing organoeuropium. Plecstatin-1 hydrochloride selectively targets plectin, a scaffolding protein and cellular connector, in tumor spheroids .

HY-P2768

Leucine dehydrogenase, Microorganism LDH, EC 1.4.1.9	Endogenous Metabolite	Metabolic Disease
Leucine dehydrogenase, Microorganism (EC 1.4.1.9) can be purified from Bacillus spheroides. Leucine dehydrogenase catalyzed the oxidative deamination of L-leucine, L-valine, L-isoleucine, L-norvaline, L-alpha-aminobutyrate, and L-norleucine, and the reductive amination of their keto analogues .

HY-156675

Plecstatin-1	Others	Cancer
Plecstatin-1 is a potent organoruthenium anti-cancer agent . Plecstatin-1 selectively targets plectin (a scaffold protein and cytolinker) in tumour spheroids .

HY-D2474

PSP	Fluorescent Dye	Cancer
PSP is a two-photon fluorescent probe for selective and sensitive detection of H₂S_n in live cells and tumor spheroids (Ex/Em = 440/640 nm). PSP can be utilized in ferroptosis research .

HY-147706

AR524	Others	Cancer
Ar524 has higher inhibitory activity than the known transgenic inhibitor kifunensine. At the same time, ar524 inhibited low concentration (10 μ M) Spheroid formation of human malignant cells.

HY-176056

Hedgehog IN-9	Hedgehog Gli Epigenetic Reader Domain	Cancer
Hedgehog IN-9 (compound 1) is a Hedgehog inhibitor. Hedgehog IN-9 prevents GLI1 expression and enhances cellular *BRD2 protein levels. Hedgehog IN-9 inhibits growth of medulloblastoma spheroid* cells and can be used for synthesis of photoaffinity labeling probe .**

HY-161661

Anticancer agent 223	Others	Cancer
Anticancer agent 223 (Compound V-d) is an anticancer agent that triggers cell death through caspase-dependent and caspase-independent mechanisms. Anticancer agent 223 inhibits tumor spheroid formation and resensitizes cisplatin (HY-17394)-resistant A2780 cells to cisplatin (HY-17394) treatment .

HY-168437

LIN28-IN-2	DNA/RNA Synthesis	Cancer
LIN28-IN-2 (Compound Ln268) blocks the binding of the zinc finger domain (ZKD) of Lin28 to RNA substrates, and inhibits Lin28a and Lin28b. LIN28-IN-2 inhibits the proliferation of Lin28-positive cancer cell and spheroid growth .

HY-147915

Benz-AP	Carboxylesterase (CES) Reactive Oxygen Species (ROS)	Cancer
Benz-AP is a potent photosensitizer. Benz-AP produces singlet oxygen, with a negative correlation with hCES2 (Human carboxylesterase 2) activity. Benz-AP displays a higher photocytotoxicity potency in cancer cells under low hCES2 environments. Upon TPE (Two-photon excitation), Benz-AP produces ROS and kills cancer cells and tumor spheroids .

HY-155074

EGFR-IN-79	EGFR	Cancer
EGFR-IN-79 (compound 21) is an EGFR inhibior with antitumor activity. EGFR-IN-79 induces ROS-independent apoptosis and EGFR/AKT/mTOR-mediated autophagy. EGFR-IN-79 induces cell death at both proliferating and quiescent zones of EJ28 spheroids. EGFR-IN-79 exhibits safety profile in the zebrafish-based model .

HY-122844B

Ifebemtinib tosylate BI-853520 tosylate; IN-10018 tosylate	FAK	Cancer
Ifebemtinib (tosylate) (BI-853520 (tosylate); IN-10018 (tosylate)) is a highly selective PTK2 kinase inhibitor. Ifebemtinib (tosylate) demonstrates anti-tumor activity. Ifebemtinib (tosylate) inhibits FAK autophosphorylation in prostate carcinoma cells. Ifebemtinib (tosylate) can inhibit spheroid formation and orthotopic tumor growth in vivo. Ifebemtinib (tosylate) can be studied in anticancer research such as solid tumors, breast cancer, and malignant pleural mesothelioma .

HY-149897

HA-CD44 interaction inhibitor 2	Transmembrane Glycoprotein	Cancer
HA-CD44 interaction inhibitor 2 (compound 5) is an Hyaluronic acid (HA)-CD44 interaction inhibitor that effectively disrupts the integrity of cancer spheroids. HA-CD44 interaction inhibitor 2 also exhibits antiproliferative activity against cancer cells. Antitumor agent-109 inhibits MDA-MB-231 cells with EC50 value of 0.59 μM .

HY-152159

CYP4Z1-IN-1	Cytochrome P450	Cancer
CYP4Z1-IN-1 (compound 7c) is a potent CYP4Z1 inhibitor, with an IC₅₀ of 41.8 nM. CYP4Z1-IN-1 decreases the expression of breast CSCs stemness markers, spheroid formation, and metastatic ability as well as tumor-initiation capability in a concentration-dependent manner in vitro and in vivo .

HY-125575

FC11409B	Carbonic Anhydrase	Cancer
FC11409B is an ureido-sulfamate carbonic anhydrase IX (CAIX) inhibitor. FC11409B inhibits proliferation and migration of breast cancer cell lines in both hypoxic (0.5% O₂) and normoxic conditions (21% O₂). FC11409B also inhibits 3D spheroid of breast cancer subtypes invasion. FC11409B is promising for research of breast and ovarian cancers .

HY-155974

MeOIstPyrd 1 Publications Verification	MDM-2/p53	Cancer
MeOIstPyrd is an anti-skin cancer agent. MeOIstPyrd inhibits cell proliferation, migration, and spheroid formation by activating the mitochondrial intrinsic apoptotic pathway. MeOIstPyrd induces DNA damage. MeOIstPyrd activates p53, and increases the half-life of p53 and stabilizes p53 by phosphorylating it at ser15. MeOIstPyrd binds to MDM2 in the p53 sub-pocket and blocks p53-MDM2 interaction .

HY-135457

JMS-053 1 Publications Verification	Phosphatase	Cancer
JMS-053 is a potent, selective and reversible PTP4A inhibitor, with IC₅₀s of 29.1 nM, 48.0 nM, 34.7 nM, 92.6 nM, and 207.6 nM for PTP4A1, PTP4A2, PTP4A3, CDC25B, and DUSP3, respectively. JMS-053 can inhibit cancer cell migration and spheroid growth in vitro, attenuate in vivo ovarian tumor growth .

HY-159580

STAT3-IN-31	STAT	Cancer
STAT3-IN-31 (compound K2071) is a STATtic-derived STAT3 and mitotic inhibitor. STAT3-IN-31 blocks mitotic progression and affects the formation of mitotic spindles. STAT3-IN-31 also affects glioblastoma cell migration and inhibits cell proliferation in tumor spheroids. STAT3-IN-31 is also able to induce glioblastoma senescence, inhibit the growth of Temozolomide (HY-17364)-resistant cells and the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein MCP-1 .

HY-165606

SB-T-1214	Oct3/4 c-Myc Apoptosis	Cancer
SB-T-1214 (SBT) is a taxane. SB-T-1214 efficiently inhibits expression of stem cell-related genes (Oct4, Sox2, and c-Myc) and induces apoptosis of colon cancer spheroids with drug resistant tumorigenic CD133 ⁺/CD44 ⁺ cells. SB-T-1214 strongly represses tumor growth in Pgp+ DLD-1 human colon tumor xenografts mice model. SB-T-1214 can be used for antitumor research, especially against tumors with drug resistance, such as colon, pancreatic and renal cancers .

HY-N3737

Derrone	Aurora Kinase PERK Reactive Oxygen Species (ROS)	Cancer
Derrone, a prenylated isoflavones, is an Aurora kinase inhibitor, with IC₅₀ values of 6 and 22.3 μM against Aurora B and Aurora A, respectively. Derrone shows anti-tumor activity .

HY-128974S

N-Dodecyl-β-D-maltoside-d25 Lauryl Maltoside-d₂₅	Isotope-Labeled Compounds DNA/RNA Synthesis	Others
N-Dodecyl-β-D-maltoside-d₂₅ (Lauryl Maltoside-d₂₅) is deuterium labeled N-Dodecyl-β-D-maltoside (HY-128974). N-Dodecyl-β-D-maltoside is a non-ionic detergent. N-Dodecyl-β-D-maltoside has strong adsorption on alumina, titanium dioxide and hematite. N-Dodecyl-β-D-maltoside can promote the reactivation of various proteins. N-Dodecyl-β-D-maltoside can effectively stabilize photoactive reaction center complexes (RCs) and inhibit the degradation of Rhodopseudomonas spheroides R-26 reaction center in solution. N-Dodecyl-β-D-maltoside can be used for purification and stabilization of RNA polymerase and for detection of protein-lipid interactions .

HY-173007

ALK/PI3K/AKT-IN-1	Akt PI3K Anaplastic lymphoma kinase (ALK) CDK Apoptosis Mitochondrial Metabolism	Cancer
ALK/PI3K/AKT-IN-1 (Compound 45) inhibits the proliferation of cancer cell A549, H1975 and PC9 with an IC₅₀ of 0.44, 0.83 and 1.51 μM. ALK/PI3K/AKT-IN-1 increases the expression of p21 and p27, inhibits the activity of CDK2 and p-Rb, arrests the cell cycle at G1 phase. ALK/PI3K/AKT-IN-1 inhibits the ALK/PI3K/AKT signaling pathway, promotes the depolarization of mitochondrial membrane potential, and inducing apoptosis in A549 cell. ALK/PI3K/AKT-IN-1 inhibits the formation and growth of A549 cell spheroids .

Cat. No.	Product Name	Type

HY-D2474

PSP	Fluorescent Dyes/Probes
PSP is a two-photon fluorescent probe for selective and sensitive detection of H₂S_n in live cells and tumor spheroids (Ex/Em = 440/640 nm). PSP can be utilized in ferroptosis research .

Cat. No.	Product Name	Target	Research Area

HY-P0306

Fibronectin Adhesion-promoting Peptide Heparin Binding Peptide	Peptides	Cardiovascular Disease
Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin. It promotes assembly of mesenchymal stem cell (MSC) spheroids into larger aggregates. Fibronectin Adhesion-promoting Peptide directly promotes the adhesion, spreading, and migration of endothelial cells by reacting with heparin binding domains of cells .

HY-P0306A

Fibronectin Adhesion-promoting Peptide TFA Heparin Binding Peptide TFA	Peptides	Cardiovascular Disease
Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin. It promotes assembly of mesenchymal stem cell (MSC) spheroids into larger aggregates. Fibronectin Adhesion-promoting Peptide directly promotes the adhesion, spreading, and migration of endothelial cells by reacting with heparin binding domains of cells .

Cat. No.	Product Name	Target	Research Area

HY-P99896

Runimotamab BTRC-4017A; RG-6194	EGFR CD3	Cancer
Runimotamab (RG-6194) is a HER2 and CD3 T cell-engaging bispecific antibody. Runimotamab can decrease the size of liver tumor spheroids. Runimotamab can be studied in oncology research such as HER2-expressing cancers. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3737

Derrone	Infection Monophenols Flavonoids Source classification Phenols Maclura pomifera (Raf.) Schneid. Plants Moraceae Disease Research Fields Isoflavones	Aurora Kinase PERK Reactive Oxygen Species (ROS)
Derrone, a prenylated isoflavones, is an Aurora kinase inhibitor, with IC₅₀ values of 6 and 22.3 μM against Aurora B and Aurora A, respectively. Derrone shows anti-tumor activity .

Cat. No.	Product Name	Chemical Structure

HY-128974S

N-Dodecyl-β-D-maltoside-d25
N-Dodecyl-β-D-maltoside-d₂₅ (Lauryl Maltoside-d₂₅) is deuterium labeled N-Dodecyl-β-D-maltoside (HY-128974). N-Dodecyl-β-D-maltoside is a non-ionic detergent. N-Dodecyl-β-D-maltoside has strong adsorption on alumina, titanium dioxide and hematite. N-Dodecyl-β-D-maltoside can promote the reactivation of various proteins. N-Dodecyl-β-D-maltoside can effectively stabilize photoactive reaction center complexes (RCs) and inhibit the degradation of Rhodopseudomonas spheroides R-26 reaction center in solution. N-Dodecyl-β-D-maltoside can be used for purification and stabilization of RNA polymerase and for detection of protein-lipid interactions .

N-Dodecyl-β-D-maltoside-d25

N-Dodecyl-β-D-maltoside-d₂₅ (Lauryl Maltoside-d₂₅) is deuterium labeled N-Dodecyl-β-D-maltoside (HY-128974). N-Dodecyl-β-D-maltoside is a non-ionic detergent. N-Dodecyl-β-D-maltoside has strong adsorption on alumina, titanium dioxide and hematite. N-Dodecyl-β-D-maltoside can promote the reactivation of various proteins. N-Dodecyl-β-D-maltoside can effectively stabilize photoactive reaction center complexes (RCs) and inhibit the degradation of Rhodopseudomonas spheroides R-26 reaction center in solution. N-Dodecyl-β-D-maltoside can be used for purification and stabilization of RNA polymerase and for detection of protein-lipid interactions .

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spheroid

Inhibitors & Agonists

Fluorescent Dye

Peptides

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Natural
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