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spermine

" in MedChemExpress (MCE) Product Catalog:

42

Inhibitors & Agonists

2

Biochemical Assay Reagents

11

Natural
Products

4

Isotope-Labeled Compounds

1

Antibodies

2

Click Chemistry

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1777
    Spermine
    4 Publications Verification

    NSC 268508; Neuridine

    		 Endogenous Metabolite Bacterial Reactive Oxygen Species (ROS) DNA/RNA Synthesis Infection Neurological Disease Inflammation/Immunology
    Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro .
    Spermine
  • HY-101394
    Spermine NONOate
    1 Publications Verification

    		 NO Synthase Others
    Spermine NONOate is a complex of nitric oxide (NO) with spermine and acts as a NO donor. Spermine NONOate can be used for NO aqueous solutions preparing .
    Spermine NONOate
  • HY-B1777A
    Spermine tetrahydrochloride
    4 Publications Verification

    		 Endogenous Metabolite Bacterial Reactive Oxygen Species (ROS) DNA/RNA Synthesis Infection Neurological Disease Inflammation/Immunology
    Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro. Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells .
    Spermine tetrahydrochloride
  • HY-B1777AS
    Spermine-d8 tetrahydrochloride

    		Isotope-Labeled Compounds Endogenous Metabolite Reactive Oxygen Species (ROS) Bacterial DNA/RNA Synthesis Metabolic Disease
    Spermine-d8 (tetrahydrochloride) is the deuterium labeled Spermine tetrahydrochloride. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro. Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells .
    Spermine-d8 tetrahydrochloride
  • HY-151717
    N1-Azido-spermine trihydrochloride

    spermine(HHHN3) trihydrochloride

    		 ADC Linker Others
    N1-Azido-spermine [Spermine(HHHN3)] trihydrochloride is a click chemistry agent containing azide. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    N1-Azido-spermine trihydrochloride
  • HY-B1777R
    Spermine (Standard)

    NSC 268508 (Standard); Neuridine (Standard)

    		 Reference Standards Endogenous Metabolite Influenza Virus Infection Metabolic Disease Cancer
    Spermine (Standard) is the analytical standard of Spermine. This product is intended for research and analytical applications. Spermine (NSC 268508) functions directly as a free radical scabenger to protect DNA from free radical attack. Spermine has antiviral effects.
    Spermine (Standard)
  • HY-W654342
    Spermine-d20

    NSC 268508-d20; Neuridine-d20

    		 Isotope-Labeled Compounds Endogenous Metabolite Influenza Virus Infection Metabolic Disease Cancer
    Spermine-d20 (NSC 268508-d20) is deuterium labeled Spermine. Spermine (NSC 268508) functions directly as a free radical scabenger to protect DNA from free radical attack. Spermine has antiviral effects .
    Spermine-d20
  • HY-151657
    Spermine(N3BBB)
    1 Publications Verification

    		 ADC Linker Others
    Spermine(N3BBB) is a click chemistry reagent containing an azide group and can be used for various biochemical studies . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Spermine(N3BBB)
  • HY-139995
    Spermine Prodrug-1

    		Drug Intermediate Others
    Spermine precursor-1 (Compound 1) is a redox-sensitive spermine precursor for the potential research of snyder robinson syndrome. Spermine precursor-1 inhibits wild-type (CMS-24949) and spermine synthase gene (SMS) mutant (CMS-26559, and CMS-6233) fibroblast cells with IC50s of 326.7, 198.5, and 244.1 μM, respectively .
    Spermine Prodrug-1
  • HY-B1777AR
    Spermine tetrahydrochloride (Standard)

    		Reference Standards Endogenous Metabolite Bacterial Reactive Oxygen Species (ROS) DNA/RNA Synthesis Infection Neurological Disease Inflammation/Immunology
    Spermine (tetrahydrochloride) (Standard) is the analytical standard of Spermine (tetrahydrochloride). This product is intended for research and analytical applications. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro. Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells .
    Spermine tetrahydrochloride (Standard)
  • HY-100835
    N-(4-Hydroxyphenylacetyl)spermine

    		Drug Derivative Others
    N-(4-Hydroxyphenylacetyl)spermine is an active compound.
    N-(4-Hydroxyphenylacetyl)spermine
  • HY-149037
    GL67

    N4-spermine cholesteryl carbamate

    		 Liposome Others
    GL67 (N4-Spermine cholesteryl carbamate) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .
    GL67
  • HY-12506A
    Naspm trihydrochloride
    Maximum Cited Publications
    7 Publications Verification

    1-Naphthylacetyl spermine trihydrochloride

    		 iGluR Neurological Disease
    Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
    Naspm trihydrochloride
  • HY-144752
    cSPM

    Cyclic spermine

    		 Amyloid-β Neurological Disease
    cSPM (Cyclic spermine) is a Aβ42 inhibitor. cSPM could suppress the aggregation of three different peptides, Aβ42, amylin and insulin, and decreases cytotoxicity .
    cSPM
  • HY-12506
    Naspm
    Maximum Cited Publications
    7 Publications Verification

    1-Naphthylacetyl spermine

    		 iGluR Neurological Disease
    Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
    Naspm
  • HY-149037A
    GL67 pentahydrochloride

    N4-spermine cholesteryl carbamate pentahydrochloride

    		 Liposome Others
    GL67 (N4-Spermine cholesteryl carbamate) (pentahydrochloride) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection .
    GL67 pentahydrochloride
  • HY-W190953
    N1,N12-Di-Boc-spermine

    		Biochemical Assay Reagents Others
    N1,N12-Di-boc-spermine is a spermine linker containing two a Boc-protected amino groups. The Boc groups can be deprotected under mild acidic conditions to form the free amine. Spermidine is a polyamine that modulates various cellular activities like cellular development and differentiation, stability of DNA, and apoptosis.
    N1,N12-Di-Boc-spermine
  • HY-W190905
    N4,N9-di-Boc-spermine

    		Biochemical Assay Reagents Others
    N4, N9-di-Boc-spermine is a spermine linker containing two a Boc-protected amino groups and two amine groups. The Boc groups can be deprotected under mild acidic conditions to form the free amine. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. Spermidine is a polyamine that modulates various cellular activities like cellular development and differentiation, stability of DNA, and apoptosis.
    N4,N9-di-Boc-spermine
  • HY-151115
    JNJ-1289

    		Smo Inflammation/Immunology Cancer
    JNJ-1289 is a potent, selective, competitive and allosteric human spermine oxidase (hSMOX) inhibitor (IC50: 50 nM). JNJ-1289 can be used in the research of polyamine catabolism, inflammation and cancers .
    JNJ-1289
  • HY-132822
    Ivospemin

    SBP-101

    		 Others Cancer
    Ivospemin (SBP-101) is an antineoplastic spermine analog. Ivospemin has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin is promising for research of cancers .
    Ivospemin
  • HY-13610B
    N1,N11-Diethylnorspermine hydrobromide

    		Caspase Cancer
    N1,N11-Diethylnorspermine hydrobromide is a potent anticancer agent. N1,N11-Diethylnorspermine hydrobromide is a spermine analog that activates polyamine catabolism. N1,N11-Diethylnorspermine hydrobromide induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine hydrobromide kills glioblastoma multiforme (GBM) cells through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production .
    N1,N11-Diethylnorspermine hydrobromide
  • HY-13610
    N1,N11-Diethylnorspermine

    Diethylnorspermine; BENSPM; DENSPM; BE-333

    		 Caspase mTOR Cancer
    N1,N11-Diethylnorspermine is a synthetic analog of the naturally occurring polyamine spermine, can induce polyamine depletion and inhibit tumor cell growth. N1,N11-Diethylnorspermine activates polyamine catabolism and downregulates mTOR protein. N1,N11-Diethylnorspermine induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine tetrahydrochloride kills glioblastoma multiforme (GBM) through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production .
    N1,N11-Diethylnorspermine
  • HY-178174
    MGB4

    		DNA/RNA Synthesis Topoisomerase Cancer
    MGB4 is a DNA minor groove binder. MGB4 binds to ARE-containing DNA and inhibition of topoisomerase I activity. MGB4 can impacts key cellular pathways, including inhibition oftranslation and alterations in sphingolipid and amino acid metabolism. MGB4 also reduces spermine and spermidine metabolism companied with Doxorubicin (HY-15142A). MGB4 can be used for the research of cancer, such as Prostate cancer .
    MGB4
  • HY-13610A
    N1,N11-Diethylnorspermine tetrahydrochloride
    4 Publications Verification

    Diethylnorspermine tetrahydrochloride; DENSPM tetrahydrochloride; BENSPM tetrahydrochloride

    		 Caspase mTOR Cancer
    N1, N11-Diethylnorspermine tetrahydrochloride (DENSPM tetrahydrochloride) is a potent anticancer agent. N1,N11-Diethylnorspermine tetrahydrochloride activates polyamine catabolism and downregulates mTOR protein. N1,N11-Diethylnorspermine tetrahydrochloride induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine tetrahydrochloride kills glioblastoma multiforme (GBM) through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production .
    N1,N11-Diethylnorspermine tetrahydrochloride
  • HY-N2392
    Kukoamine A
    1 Publications Verification

    		 Parasite Infection Cardiovascular Disease
    Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity .
    Kukoamine A
  • HY-149712
    Spermatinamine

    		ICMT Cancer
    Spermatinamine is a novel alkaloid with a bromotyrosyl-spermine-bromotyrosyl sequence, and a natural ICMT inhibitor. Spermatinamine can be isolated from the Australian sponge Pseudoceratina .
    Spermatinamine
  • HY-13610AR
    N1,N11-Diethylnorspermine tetrahydrochloride (Standard)

    		Caspase mTOR Cancer
    N1,N11-Diethylnorspermine (tetrahydrochloride) (Standard) is the analytical standard of N1,N11-Diethylnorspermine (tetrahydrochloride). This product is intended for research and analytical applications. N1, N11-Diethylnorspermine tetrahydrochloride (DENSPM tetrahydrochloride) is a potent anticancer agent. N1,N11-Diethylnorspermine tetrahydrochloride activates polyamine catabolism and downregulates mTOR protein. N1,N11-Diethylnorspermine tetrahydrochloride induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine tetrahydrochloride kills glioblastoma multiforme (GBM) through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production .
    N1,N11-Diethylnorspermine tetrahydrochloride (Standard)
  • HY-W007856R
    5-Methoxysalicylic acid (Standard)

    		Endogenous Metabolite Others
    5-Methoxysalicylic acid (5-MeOSA) is a natural compound, used as a useful matrix in the MALDI MS analysis of oligonucleotides when combined with spermine .
    5-Methoxysalicylic acid (Standard)
  • HY-W007856
    5-Methoxysalicylic acid

    5-MeOSA

    		 Endogenous Metabolite Others
    5-Methoxysalicylic acid (5-MeOSA) is a natural compound, used as a useful matrix in the MALDI MS analysis of oligonucleotides when combined with spermine .
    5-Methoxysalicylic acid
  • HY-151224
    Thermospermine

    		DNA/RNA Synthesis Others
    Thermospermine, a structural isomer of Spermine, is synthesized by a thermospermine synthase designated ACAULIS5 (ACL5). Thermospermine suppresses auxin-inducible xylem differentiation in Arabidopsis thaliana .
    Thermospermine
  • HY-N2392S
    Kukoamine A-d8 dihydrochloride

    		Isotope-Labeled Compounds Parasite Infection Cardiovascular Disease
    Kukoamine A-d8 (dihydrochloride) is deuterium labeled Kukoamine A. Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity .
    Kukoamine A-d8 dihydrochloride
  • HY-16394
    PG-11047 tetrahydrochloride

    CGC-11047 tetrahydrochloride

    		 Drug Derivative Cancer
    PG-11047 (CGC-11047), a polyamine analogue, is a nonfunctional competitor of the natural polyamine spermine. PG-11047 has broad spectrum anticancer activities .
    PG-11047 tetrahydrochloride
  • HY-W015514
    N-(3-Aminopropyl)cyclohexylamine

    		JAK Neurological Disease
    N-(3-Aminopropyl)cyclohexylamine, a cyclohexylamine derivative, acts as a selective and competitive inhibitor of spermine synthase. N-(3-Aminopropyl)cyclohexylamine can be used for the research of neurological diseases .
    N-(3-Aminopropyl)cyclohexylamine
  • HY-113374A
    N1,N12-Diacetylspermine dihydrochloride

    DiAcSpm dihydrochloride

    		 Endogenous Metabolite Cancer
    N1,N12-Diacetylspermine dihydrochloride is a diacetylated derivative of Spermine. Upregulation of N1,N12-Diacetylspermine dihydrochloride has been linked to the incidence of cancer, making it to be a potential biomarker for cancer detection.
    N1,N12-Diacetylspermine dihydrochloride
  • HY-Q36392
    JNJ-9350
    1 Publications Verification

    		 Histone Demethylase Cancer
    JNJ-9350, a chemical probe, is an inhibitor of spermine oxidase (SMOX) with an IC50 value of 0.01 μM. JNJ-9350 also inhibits polyamine oxidase (PAO) with an IC50 value of 0.79 μM. JNJ-9350 can be used for the research of cancer .
    JNJ-9350
  • HY-W099540
    OES2-0017

    		Bacterial Infection
    OES2-0017 shows potent synergy with polyamines and growth-inhibitory effects at the low micromolar range. OES2-0017 inhibits spermine/spermidine acetyltransferase (SpeG) (IC50: 34.82 μM ) and other polyamine detoxification enzymes in low concentrations, perturbed the bacterial membrane in higher concentrations .
    OES2-0017
  • HY-N2393A
    Kukoamine B mesylate

    		Apoptosis MMP MARK PI3K Akt ROS Kinase DNA/RNA Synthesis Neurological Disease Metabolic Disease Inflammation/Immunology
    Kukoamine B, a spermine alkaloid, is a potent dual LPS and CpG DNA inhibitor with Kd values of 1.23 µM and 0.66 µM, respectively. Kukoamine B exerts anti-inflammatory, anti-diabetic, anti-oxidant, anti-osteoporotic and neuroprotective effects. Kukoamine B has the potential for the study of sepsis. .
    Kukoamine B mesylate
  • HY-N2393
    Kukoamine B

    		Apoptosis MMP MAPKAPK2 (MK2) p38 MAPK PI3K Akt Reactive Oxygen Species (ROS) DNA/RNA Synthesis Neurological Disease Metabolic Disease Inflammation/Immunology
    Kukoamine B, a spermine alkaloid, is a potent dual LPS and CpG DNA inhibitor with Kd values of 1.23 µM and 0.66 µM, respectively. Kukoamine B exerts anti-inflammatory, anti-diabetic, anti-oxidant, anti-osteoporotic and neuroprotective effects. Kukoamine B has the potential for the study of sepsis .
    Kukoamine B
  • HY-W190917
    N1, N4-Bisazidospermine bistosylate

    		Biochemical Assay Reagents Others
    N1, N4-Bisazidospermine bistosylate is a spermine linker containing two azide groups. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Spermidine is a polyamine that modulates various cellular activities like cellular development and differentiation, stability of DNA, and apoptosis.
    N1, N4-Bisazidospermine bistosylate
  • HY-N2393S
    Kukoamine B-d5 dihydrochloride

    		MMP Apoptosis MAPKAPK2 (MK2) p38 MAPK PI3K Akt ROS Kinase DNA/RNA Synthesis Neurological Disease Metabolic Disease Inflammation/Immunology
    Kukoamine B, a spermine alkaloid, is a potent dual LPS and CpG DNA inhibitor with Kd values of 1.23 µM and 0.66 µM, respectively. Kukoamine B exerts anti-inflammatory, anti-diabetic, anti-oxidant, anti-osteoporotic and neuroprotective effects. Kukoamine B has the potential for the study of sepsis. .
    Kukoamine B-d5 dihydrochloride
  • HY-N2393R
    Kukoamine B (Standard)

    		Reference Standards Apoptosis MMP MAPKAPK2 (MK2) p38 MAPK PI3K Akt ROS Kinase DNA/RNA Synthesis Neurological Disease Metabolic Disease Inflammation/Immunology
    Kukoamine B (Standard) is the analytical standard of Kukoamine B. This product is intended for research and analytical applications. Kukoamine B, a spermine alkaloid, is a potent dual LPS and CpG DNA inhibitor with Kd values of 1.23 µM and 0.66 µM, respectively. Kukoamine B exerts anti-inflammatory, anti-diabetic, anti-oxidant, anti-osteoporotic and neuroprotective effects. Kukoamine B has the potential for the study of sepsis .
    Kukoamine B (Standard)
  • HY-106031
    F-14512

    		Topoisomerase Cancer
    F-14512 is a targeted cytotoxic compound that utilizes the polyamine transport system (PTS) to selectively deliver polyamine-containing drugs to cancer cells. F-14512 combines an epipodophyllotoxin core that targets topoisomerase II with a spermine group that acts as a cell delivery vehicle, with improved selectivity for tumor cells. F-14512 exhibits significant cytotoxicity against cells with high PTS activity and demonstrates high potency in multiple human cell lines (median IC50=0.18 μM). In the MX1 breast tumor xenograft model, F-14512 exhibits potent antitumor activity .
    F-14512

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