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Results for "

scavenges hydroxyl radical

" in MedChemExpress (MCE) Product Catalog:

21

Inhibitors & Agonists

2

Biochemical Assay Reagents

1

Peptides

10

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B2196
    Gastric mucin
    2 Publications Verification

    		 Antibiotic Bacterial Infection Metabolic Disease
    Gastric mucin is a glycoprotein with natural antibiotic function. Gastric mucin against Helicobacter pylori infection. Gastric mucin effectively scavenges hydroxyl radical. Gastric mucin play a major role in the protection of the gastrointestinal tract from acid, proteases, pathogenic microorganisms, and mechanical trauma .
    Gastric mucin
  • HY-P4280
    Arg-Tyr

    		Reactive Oxygen Species (ROS) Others
    Arg-Tyr is a dipeptide which has strong hydroxyl-radical and hydrogen-peroxide scavenging activity .
    Arg-Tyr
  • HY-N9497
    Galactinol

    		Biochemical Assay Reagents Others
    Galactinol is a biochemical reagent. Galactinol scavenges hydroxyl radicals and protects plant cells from oxidative damage .
    Galactinol
  • HY-135258
    Galactinol dihydrate

    		Reactive Oxygen Species (ROS) Others
    Galactinol dihydrate is a marker for seed longevity. Galactinol dihydrate can scavenge hydroxyl radicals and protect plant cells from oxidative damage caused by MV treatment, salinity, or chilling .
    Galactinol dihydrate
  • HY-W014423
    L-Histidine hydrochloride hydrate
    3 Publications Verification

    H-His-OH.HCl.H2O

    		 Endogenous Metabolite Apoptosis Reactive Oxygen Species (ROS) Inflammation/Immunology Cancer
    L-Histidine hydrochloride hydrate is an endogenous metabolite. L-Histidine hydrochloride hydrate scavenges hydroxyl radicals and singlet oxygen, regulate the absorption of zinc, copper and iron, exhibits anti-inflammatory and antioxidant activities. L-Histidine hydrochloride hydrate is blood brain barrier penetrable .
    L-Histidine hydrochloride hydrate
  • HY-111314
    NZ 419

    5-Hydroxy-1-methylhydantoin

    		 Reactive Oxygen Species (ROS) Inflammation/Immunology
    NZ 419 (5-Hydroxy-1-methylhydantoin) is a metabolite of creatinine and an antioxidant with oral activity, which has the ability to scavenge hydroxyl radicals (•OH). NZ 419 can inhibit the progression of chronic kidney disease (CKD) in rats .
    NZ 419
  • HY-126241
    RV01

    		Aldehyde Dehydrogenase (ALDH) Inflammation/Immunology
    RV01 is an analogue of resveratrol, inhibits DNA damage, reduces acetaldehyde dehydrogenase 2 (ALDH2) mRNA expression induced by ethanol, and exhibits hydroxyl radical scavenging activity . RV01 decreases iNOS expression, with anti-neuroinflammatory activity .
    RV01
  • HY-N2625A
    Harmalol hydrochloride

    		Cytochrome P450 Cancer
    Harmalol hydrochloride, a beta carboline alkaloid, presents in several medicinal plants such as Peganum harmala. Harmalol hydrochloride, main metabolite of Harmaline, significantly inhibits the dioxin-mediated induction of CYP1A1 at the transcriptional and posttranslational levels. Harmalol hydrochloride possesses antioxidant and hydroxyl radical-scavenging properties .
    Harmalol hydrochloride
  • HY-N3289
    Methyl 3,4,5-trimethoxycinnamate

    		Others Others
    Methyl 3,4,5-trimethoxycinnamate (Compound III) is a natural compound with hydroxyl radical-scavenging effects .
    Methyl 3,4,5-trimethoxycinnamate
  • HY-N2625AR
    Harmalol hydrochloride (Standard)

    		Reference Standards Cytochrome P450 Others
    Harmalol (hydrochloride) (Standard) is the analytical standard of Harmalol (hydrochloride). This product is intended for research and analytical applications. Harmalol hydrochloride, a beta carboline alkaloid, presents in several medicinal plants such as Peganum harmala. Harmalol hydrochloride, main metabolite of Harmaline, significantly inhibits the dioxin-mediated induction of CYP1A1 at the transcriptional and posttranslational levels. Harmalol hydrochloride possesses antioxidant and hydroxyl radical-scavenging properties .
    Harmalol hydrochloride (Standard)
  • HY-W271506
    TMPO

    3,3,5,5-Tetramethyl-1-pyrroline 1-oxide

    		 Reactive Oxygen Species (ROS) Apoptosis Inflammation/Immunology
    TMPO (3,3,5,5-Tetramethyl-1-pyrroline 1-oxide) is a spin trap targeting free radicals. TMPO is capable of scavenging superoxide, hydroxyl radicals and inhibits thymocyte apoptosis with EC50 values of 19.1 mM (MPS-induced) to 30.7 mM (Etoposide-induced) for inhibiting DNA fragmentation. TMPO reacts with intracellular free radicals to form stable nitroxide radical products, reducing oxidative stress (e.g., decreasing peroxide levels, maintaining glutathione content) and blocking oxidative events in the apoptotic pathway. TMPO is promising for research of apoptosis in immune cells like thymocytes .
    TMPO
  • HY-N13022
    Humic acid

    		SOD Bacterial Inflammation/Immunology Cancer
    Humic acid is an important component of organic matter in soil and water, and serves as a plant regulator. Humic acid has multiple reactive activities such as surface adsorption, ion exchange, and complexation. Humic acid can enhance pyrene degradation by Mycobacterium NJS-1. Humic acid can inhibit the activity of superoxide dismutase and scavenge hydroxyl radicals. Humic acid is also toxic to CEM cells .
    Humic acid
  • HY-W027951
    N,N'-Dimethylthiourea
    1 Publications Verification

    DMTU

    		 Reactive Oxygen Species (ROS) Inflammation/Immunology
    N,N'-Dimethylthiourea (DMTU), isolated from Allium sativum, is an orally active scavenger of hydroxyl radical (•OH) and blocks •OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including •OH scavenging and anti-inflammatory action .
    N,N'-Dimethylthiourea
  • HY-N15727
    2,5-Dimethylchromone-7-O-β-D-glucopyranoside

    		Others Inflammation/Immunology
    2,5-Dimethylchromone-7-O-β-D-glucopyranoside is an orally active chromone glycoside found in the underground parts of Rheum australe. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside shows a DPPH radical scavenging activity with an IC50 value of 66.9 μM. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside scavenges free radicals by providing hydrogen atoms through phenolic hydroxyl groups, inhibiting lipid peroxidation. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside is promising for research of oxidative stress-related diseases such as inflammation and skin diseases .
    2,5-Dimethylchromone-7-O-β-D-glucopyranoside
  • HY-G0004
    Acetaminophen metabolite 3-hydroxy-acetaminophen

    3-Hydroxyacetaminophen

    		 Drug Metabolite Inflammation/Immunology
    Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen) is a non-toxic metabolite and antioxidant of acetaminophen (HY-66005) with free radical scavenging activity. Acetaminophen metabolite 3-hydroxy-acetaminophen can reduce oxidative damage by exerting electron donation ability and antioxidant activity through phenolic hydroxyl groups. 3-hydroxy-acetaminophen can be used to study the toxicity mechanism and drug metabolism of acetaminophen .
    Acetaminophen metabolite 3-hydroxy-acetaminophen
  • HY-76779
    4-(Chloromethyl)-7-hydroxycoumarin

    		Drug Derivative Cancer
    4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII .
    4-(Chloromethyl)-7-hydroxycoumarin
  • HY-N7075
    Inulin
    2 Publications Verification

    		 Endogenous Metabolite Metabolic Disease Cancer
    Inulin is an orally active prebiotic targeting the intestinal microbiota, selectively promoting the proliferation and activity of beneficial bacteria such as bifidobacteria and lactic acid bacteria, and playing a role in regulating the intestinal microecology. The functions of Inulin include: ① Fermentation by probiotics in the colon to produce short-chain fatty acids (such as butyrate and propionate), lowering the intestinal pH and inhibiting the overgrowth of harmful bacteria; ② Enhancing the intestinal barrier function and reducing endotoxin translocation; ③ Directly scavenging free radicals (such as superoxide free radicals, hydroxyl free radicals) and activating antioxidant enzymes (SOD, CAT) to reduce oxidative stress. Inulin can also be used in the study of intestinal diseases (constipation, IBD), metabolic syndrome (diabetes, obesity) and liver damage by regulating glucose and lipid metabolism (such as reducing triglycerides, improving insulin sensitivity) and immune response (enhancing NK cell activity, inhibiting inflammatory factors)[1][2][3][4].
    Inulin
  • HY-N0448
    10-Gingerol
    2 Publications Verification

    		 AMPK Reactive Oxygen Species (ROS) Akt PI3K Interleukin Related TNF Receptor Apoptosis Inflammation/Immunology Cancer
    10-Gingerol is an AMPK agonist, which is found in the ginger oleoresin from fresh rhizome with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol suppresses neointimal hyperplasia and inhibits vascular smooth muscle cell proliferation. 10-Gingerol exhibits substantial scavenging activities with an IC50 value of 10.47 μM against DPPH radical, an IC50 value of 1.68 μM against superoxide radical and an IC50 value of 1.35 μM against hydroxyl radical. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC50 of 12.1 μM. 10-Gingerol suppresses the proliferation, migration, invasion, and induced apoptosis through targeting the PI3K/Akt signaling pathway in MDA-MB-231/IR cells. 10-Gingerol is promising for research of ulcerative colitis .
    10-Gingerol
  • HY-W015229R
    3-Indolepropionic acid (Standard)

    Indole-3-propionic acid (Standard); 3-IPA (Standard)

    		 Reference Standards Endogenous Metabolite Reactive Oxygen Species (ROS) Neurological Disease Metabolic Disease
    3-Indolepropionic acid (Standard) is the analytical standard of 3-Indolepropionic acid. This product is intended for research and analytical applications. 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease. In Vitro: 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease . 3-Indolepropionic acid is a more potent scavenger of hydroxyl radicals than melatonin. Similar to melatonin but unlike other antioxidants, 3-Indolepropionic acid scavenges radicals without subsequently generating reactive and pro-oxidant intermediate compounds . It is also suggested that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of type 2 diabetes (T2D) that may mediate its protective effect by preservation of β-cell function .
    3-Indolepropionic acid (Standard)
  • HY-G0004R
    Acetaminophen metabolite 3-hydroxy-acetaminophen (Standard)

    3-Hydroxyacetaminophen (Standard)

    		 Reference Standards Drug Metabolite Inflammation/Immunology
    Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen) (Standard) is the analytical standard of Acetaminophen metabolite 3-hydroxy-acetaminophen (HY-G0004). This product is intended for research and analytical applications. Acetaminophen metabolite 3-hydroxy-acetaminophen is a non-toxic metabolite and antioxidant of acetaminophen (HY-66005) with free radical scavenging activity. Acetaminophen metabolite 3-hydroxy-acetaminophen can reduce oxidative damage by exerting electron donation ability and antioxidant activity through phenolic hydroxyl groups. 3-hydroxy-acetaminophen can be used to study the toxicity mechanism and drug metabolism of acetaminophen .
    Acetaminophen metabolite 3-hydroxy-acetaminophen (Standard)
  • HY-130743
    Dieugenol

    Bis-eugenol; Dehydrodieugenol

    		 Parasite Infection
    Dieugenol is a neolignan that has been found in N. leucantha and has antioxidative and antiprotozoal activities. It inhibits the formation of thiobarbituric acid reactive substances (TBARS) and scavenges superoxide anions, but not hydroxyl radicals, in cell-free assays. It has anti-trypanosomal activity against T. cruzi amastigotes and trypomastigotes (IC50s=15.1 and 11.5 μM, respectively) but is cytotoxic to NCTC L-929 fibroblasts with a 50% cytotoxic concentration (CC50) value of 58.2 μM.2 Dieugenol (15 μM) disrupts the integrity of the T. cruzi trypomastigote plasma membrane but does not induce the production of reactive oxygen species (ROS) in trypomastigotes or LPS-stimulated and unstimulated isolated mouse peritoneal macrophages.
    Dieugenol

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