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Results for "

prototypic

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50

Inhibitors & Agonists

5

Fluorescent Dye

8

Peptides

5

Natural
Products

6

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-135416
    Streptolysin O
    1 Publications Verification

    		 Endogenous Metabolite Infection
    Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state .
    Streptolysin O
  • HY-135416A
    Streptolysin O (≥1000000 units/mg)

    		Endogenous Metabolite Infection
    Streptolysin O (≥1000000 units/mg) is a ≥1000000 units/mg Streptolysin O (HY-135416). Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state .
    Streptolysin O (≥1000000 units/mg)
  • HY-B1540
    Beclometasone
    3 Publications Verification

    Beclomethasone

    		 Glucocorticoid Receptor Inflammation/Immunology Endocrinology Cancer
    Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist.
    Beclometasone
  • HY-121404A
    Muscarine chloride

    (+)-Muscarine chloride

    		 mAChR Neurological Disease
    Muscarine ((+)-Muscarine) chloride is an agonist of prototype mAChR. Muscarine chloride is a toxin that can stimulate the parasympathetic nervous system .
    Muscarine chloride
  • HY-B0681
    Acamprosate

    		iGluR Neurological Disease Metabolic Disease
    Acamprosate is an orally active prototypic neuromodulator. Acamprosate can be used for the research of alcohol dependence and alcoholism .
    Acamprosate
  • HY-P2191
    KISS1-305

    		Kisspeptin Receptor Endocrinology
    KISS1-305, the Metastin/Kisspeptin analog, is a prototype peptide and a chemical probe. KISS1-305 has suboptimal KISS1R agonistic activity, and resists plasma protease degradation .
    KISS1-305
  • HY-139126
    (±)-Muscarine chloride

    DL-Muscarin chloride

    		 mAChR Neurological Disease
    (±)-Muscarine chloride is the racemate of Muscarine chloride. Muscarine is a prototype muscarinic acetylcholine receptor agonist .
    (±)-Muscarine chloride
  • HY-B1540S
    Beclomethasone-d5

    		Glucocorticoid Receptor Inflammation/Immunology Endocrinology
    Beclomethasone-d5 is the deuterium labeled Beclometasone. Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist.
    Beclomethasone-d5
  • HY-121404
    Muscarine

    (+)-Muscarine

    		 mAChR Neurological Disease
    Muscarine ((+)-Muscarine) is an agonist of prototype mAChR. Muscarine is a toxin that can stimulate the parasympathetic nervous system .
    Muscarine
  • HY-121404B
    Muscarine tosylate

    (+)-Muscarine tosylate

    		 mAChR Neurological Disease
    Muscarine ((+)-Muscarine) tosylate is an agonist of prototype mAChR. Muscarine tosylate is a toxin that can stimulate the parasympathetic nervous system .
    Muscarine tosylate
  • HY-B1540R
    Beclometasone (Standard)

    Beclomethasone (Standard)

    		 Reference Standards Glucocorticoid Receptor Inflammation/Immunology Endocrinology Cancer
    Beclometasone (Standard) is the analytical standard of Beclometasone. This product is intended for research and analytical applications. Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist.
    Beclometasone (Standard)
  • HY-126076
    VPC-80051 racemate

    		Drug Isomer DNA/RNA Synthesis Others
    VPC-80051 racemate is a racemate of VPC-80051. VPC-80051 is a prototype inhibitor of the hnRNP A1 splicing factor .
    VPC-80051 racemate
  • HY-107654
    Muscarine iodide

    (+)-Muscarine iodide

    		 mAChR Neurological Disease
    Muscarine ((+)-Muscarine) iodide is a toxin that can stimulate the parasympathetic nervous system. Muscarine iodide is a prototype muscarinic acetylcholine receptor agonist .
    Muscarine iodide
  • HY-D1472
    Azure A eosinate

    		Fluorescent Dye Others
    Azure A eosinate is a dye for hematological and histological applications. Azure A eosinate can be used as new photosensitizer prototypes to determine growth inhibition of Candida albicans .
    Azure A eosinate
  • HY-W416250
    p-Cresol glucuronide

    		Drug Metabolite Cardiovascular Disease
    p-Cresol glucuronide, a metabolite of p-cresol, is a prototype protein-bound uremic toxin. p-Cresol glucuronide is associated with chronic kidney disease (CKD) .
    p-Cresol glucuronide
  • HY-12505
    CX546
    4 Publications Verification

    		 iGluR Autophagy Neurological Disease
    CX546 is a first-generation and selective benzamide-type positive AMPAR modulator. CX546 is a prototypical ampakine agent and has antipsychotic effects .
    CX546
  • HY-W615104
    BTTP

    		Biochemical Assay Reagents Others
    BTTP is a tris(triazolylmethyl)amine-based ligand. BTTP can accelerate the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), the prototypical reaction in click chemistry .
    BTTP
  • HY-D1301
    BODIPY 581/591 C11
    Maximum Cited Publications
    82 Publications Verification

    		 Fluorescent Dye Ferroptosis Metabolic Disease Inflammation/Immunology Cancer
    BODIPY 581/591 C11 is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type) .
    BODIPY 581/591 C11
  • HY-111431AS
    p-Cresol sulfate-d7 potassium

    p-Tolyl sulfate-d7 (potassium)

    		 Endogenous Metabolite Metabolic Disease
    p-Cresol sulfate-d7 (potassium) is the deuterium labeled p-Cresyl sulfate potassium. p-Methylphenyl potassium sulfate is a prototype protein-bound uremic toxin[1][2].
    p-Cresol sulfate-d7 potassium
  • HY-146232
    F 13714

    F 14679

    		 5-HT Receptor Others
    F 13714 (F 14679) is a prototypical 5-HT1A agonist with a pKi of 10.23. F 13714 induces large Ca 2+ responses .
    F 13714
  • HY-150095
    YE6144
    1 Publications Verification

    		 IFNAR Inflammation/Immunology
    YE6144 is a prototypical interferon regulatory factor 5 (IRF5) inhibitor. YE6144 selectively suppresses IRF5 activity through inhibition of IRF5 phosphorylation .
    YE6144
  • HY-P3991
    Bradykinin potentiator C

    		Angiotensin-converting Enzyme (ACE) Metabolic Disease
    Bradykinin potentiator C is a potent angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 7.1 μM for rabbit lung ACE. Bradykinin potentiator C is a postulated prototype of functional peptide .
    Bradykinin potentiator C
  • HY-103684
    RT-NH2

    Real Thiol-NH2

    		 Fluorescent Dye Neurological Disease
    RT-NH2 is a RealThiol prototype without the carboxylic acid groups. RT-NH2 is fairly hydrophobic and cannot distribute in the nucleus, which is a hallmark of protein binding for fluorescent probe.
    RT-NH2
  • HY-137281
    HMB-Val-Ser-Leu-VE

    		Ser/Thr Protease Others
    HMB-Val-Ser-Leu-VE is a prototype vinyl ester inhibitor. HMB-Val-Ser-Leu-VE is against trypsin-like (T-L) proteasome activity with an IC50 of 0.033 μM .
    HMB-Val-Ser-Leu-VE
  • HY-107654S
    Muscarine-d9 iodide

    (+)-Muscarine-d9 iodide

    		 Isotope-Labeled Compounds mAChR Neurological Disease
    Muscarine-d9 (iodide) is the deuterium labeled Muscarine iodide. Muscarine ((+)-Muscarine) iodide is a toxin that can stimulate the parasympathetic nervous system. Muscarine iodide is a prototype muscarinic acetylcholine receptor agonist .
    Muscarine-d9 iodide
  • HY-111431A
    p-Cresyl sulfate potassium
    5 Publications Verification

    p-Tolyl sulfate potassium

    		 Endogenous Metabolite JNK p38 MAPK Metabolic Disease Inflammation/Immunology
    p-Cresyl sulfate potassium is a uremic toxin that binds to a prototype protein. p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways. p-Cresyl sulfate potassium has pro-inflammatory activity .
    p-Cresyl sulfate potassium
  • HY-P3432
    DfTat

    		Biochemical Assay Reagents Others
    DfTat is a dimer of the prototypical cell-penetrating peptide TAT. DfTat can deliver small molecules, peptides and proteins into live cells with a particularly high efficiency. DfTat labeled with the rhodamine can be used as a tracer for easy detection .
    DfTat
  • HY-D1443
    BSB

    (trans,trans)-1-Bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene

    		 Amyloid-β Others
    BSB is a Congo red-derived fluorescent probe. BSB binds not only to extracellular amyloid β protein, but also many intracellular lesions composed of abnormal tau and synuclein proteins. BSB acts as a prototype imaging agent for Alzheimer's disease .
    BSB
  • HY-D1063
    IR-780

    		Fluorescent Dye Cancer
    IR780 is a prototypic NIR heptamethine cyanine agent, with a high molar extinction coefficient. The maximum excitation wavelength of IR780 was 777-780 nm, and the maximum emission wavelength was 798-823 nm. IR780 can be used in cancer PTT/PDT and imaging .
    IR-780
  • HY-P2980
    Carboxypeptidase A, Bovine pancreas

    EC 3.4.2.1

    		 Endogenous Metabolite Others
    Carboxypeptidase A, Bovine pancreas (EC 3.4.2.1) is a zinc-containing metalloprotease, is often used in biochemical studies. Carboxypeptidase A catalyzes the hydrolysis of the peptide bonds that are adjacent to the C-terminal end of a polypeptide chain. Carboxypeptidase A is a prototypical enzyme for metalloproteases that plays important roles in biological systems .
    Carboxypeptidase A, Bovine pancreas
  • HY-141494
    Pparδ agonist 5

    		PPAR Metabolic Disease
    Pparδ agonist 5, an orally active PPARδ-selective agonist (EC50=0.335 μM), is much greater than that of the prototypical standard GW0742. Pparδ agonist 5 promotes improvements in bone density and microarchitecture in vivo .
    Pparδ agonist 5
  • HY-13562
    Banoxantrone

    AQ4N

    		 NO Synthase Cancer
    Banoxantrone (AQ4N), as a prototype hypoxia selective cytotoxin, can be reduced to AQ4, a potent topoisomerase II inhibitor. Banoxantrone selectively kills hypoxic cells via an iNOS-dependent mechanism. Banoxantrone shows a potent cytotoxicity and hypoxia-selective effect enhanced by radiation .
    Banoxantrone
  • HY-14266
    Dapivirine
    2 Publications Verification

    TMC120; R147681

    		 HIV Reverse Transcriptase Apoptosis Autophagy Infection
    Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations .
    Dapivirine
  • HY-N10429
    Geissoschizoline

    (+)-Geissoschizoline

    		 Cholinesterase (ChE) Neurological Disease Inflammation/Immunology
    Geissoschizoline ((+)-Geissoschizoline) is a potent inhibitor of human AChE/BChE, with IC50s of 20.40 µM and 10.21 µM, respectively. Geissoschizoline emerges as a possible multi-target prototype that can be very useful in studies of preventing neurodegeneration and restoring neurotransmission. Geissoschizoline aiso is a potent anti-inflammatory agent .
    Geissoschizoline
  • HY-143239
    PPARα/γ agonist 1

    		PPAR Metabolic Disease
    PPARα/γ agonist 1 (compound 5b) is a potent and dual PPARα/γ partial agonist with EC50 values of 28 nM and 69 nM for PPARα and PPARγ, respectively. PPARα/γ agonist 1 is a promising prototype for dyslipidemia and diabetes research .
    PPARα/γ agonist 1
  • HY-131723
    Pregnenolone 16α-carbonitrile
    3 Publications Verification

    		 Cytochrome P450 Metabolic Disease
    Pregnenolone 16α-carbonitrile is an orally active prototypical and effective rodent-PXR activator. Pregnenolone 16α-carbonitrile, a synthetic steroid, induces cytochrome P450 3A expression. Pregnenolone 16α-carbonitrile exhibits increased resistance to subsequent stressful insults .
    Pregnenolone 16α-carbonitrile
  • HY-W654121
    p-Cresol sulfate-d4 potassium

    p-Tolyl sulfate-d4 potassium

    		 Isotope-Labeled Compounds Endogenous Metabolite p38 MAPK JNK Inflammation/Immunology
    p-Cresol sulfate-d4 (potassium) is deuterium labeled p-Cresyl sulfate (potassium). p-Cresyl sulfate potassium is a uremic toxin that binds to a prototype protein. p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways. p-Cresyl sulfate potassium has pro-inflammatory activity .
    p-Cresol sulfate-d4 potassium
  • HY-107743
    Naloxone benzoylhydrazone

    NalBzoH

    		 Opioid Receptor Neurological Disease
    Naloxone benzoylhydrazone (NalBzoH) is a mixed agonist/antagonist. Naloxone benzoylhydrazone is a prototypic κ3-opioid receptor agonist, and a partial agonist at the cloned μ and δ opioid receptors, and an antagonist at opioid-like NOP receptors. Naloxone benzoylhydrazone has potently analgesia effect .
    Naloxone benzoylhydrazone
  • HY-152038
    SPEN-IN-1

    		Others Others
    SPEN-IN-1 (compound X1) is an inhibitor of SPEN which is a protein factor with a Kd value of 47 nM. SPEN-IN-1 has high selectivity for RepA, a 431-nucleotide domain in Xist (a non-coding RNA prototype) that comprises 8.5 units of a GC-rich motif responsible for gene silencing .
    SPEN-IN-1
  • HY-120465
    ZINC36617540

    		HIV Infection
    ZINC36617540 is a novel Nef protein inhibitor with anti-HIV activity. ZINC36617540 exhibits superior binding affinity by binding to Nef protein. ZINC36617540 shows a similar binding mode to the prototype molecule B9 in molecular docking. The mechanism of action of ZINC36617540 mainly depends on its hydrophobic and electrostatic interactions with Nef protein .
    ZINC36617540
  • HY-14266S
    Dapivirine-d11

    TMC120-d11; R147681-d11

    		 Isotope-Labeled Compounds HIV Reverse Transcriptase Apoptosis Autophagy Infection
    Dapivirine-d11 is the deuterium labeled Dapivirine. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations .
    Dapivirine-d11
  • HY-117583A
    BG47

    		HDAC Histone Methyltransferase Neurological Disease
    BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. BG47 can be used for neurological disease research .
    BG47
  • HY-14266R
    Dapivirine (Standard)

    		HIV Reverse Transcriptase Apoptosis Autophagy Infection
    Dapivirine (Standard) is the analytical standard of Dapivirine. This product is intended for research and analytical applications. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations .
    Dapivirine (Standard)
  • HY-14266S1
    Dapivirine-d4

    TMC120-d4; R147681-d4

    		 Isotope-Labeled Compounds Apoptosis Reverse Transcriptase Autophagy HIV Infection
    Dapivirine-d4 (TMC120-d4) is deuterium labeled Dapivirine. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations .
    Dapivirine-d4
  • HY-117583
    cis-BG47

    		HDAC Histone Methyltransferase Neurological Disease
    cis-BG47 is an cis-isomer of BG47, BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. cis-BG47 can be used for neurological disease research .
    cis-BG47
  • HY-P2729
    Subtilisin

    EC 3.4.21.14

    		 Ser/Thr Protease Apoptosis Interleukin Related Bacterial Inflammation/Immunology Cancer
    Subtilisin (EC 3.4.21.14) is a bacterial serine protease. Subtilisin induces Apoptosis. Subtilisin stimulates the expression of pro-allergic cytokines (IL-1α, IL-33). Subtilisin induces prototypic allergic lung inflammation. Subtilisin exhibits anticancer activity against breast and colon cancer. Subtilisin shows antifouling activity. Subtilisin can be used as a detergent additive .
    Subtilisin
  • HY-150680
    SARS-CoV-2 nsp14-IN-1

    		SARS-CoV Histone Methyltransferase DNA Methyltransferase Infection
    SARS-CoV-2 nsp14-IN-1 (Compound 3) is a prototypic bisubstrate inhibitor of SARS-CoV-2 Nsp14 MTase with an IC50 value of 0.061 μM. SARS-CoV-2 nsp14-IN-1 (Compound 3) has an excellent selectivity profile over a panel of human methyltransferases, can against apanel of 10 human MTases including histone lysine, proteinarginine, and DNA and RNA MTases .
    SARS-CoV-2 nsp14-IN-1
  • HY-119706
    Barbadin
    10+ Cited Publications

    		 Apoptosis Arrestin Others
    Barbadin is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC50 values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors. Barbadin can induce apoptosis .
    Barbadin
  • HY-107748A
    5'-Guanidinonaltrindole TFA

    5'-GNTI TFA

    		 Endogenous Metabolite Neurological Disease
    5'-Guanidinonaltrindole TFA is a selective kappa-opioid receptor antagonist with significant opioid antagonist activity. 5'-Guanidinonaltrindole TFA exhibits 5 times the antagonistic potency of the prototypical kappa-opioid receptor antagonist norbinatorphimine in smooth muscle preparations, with a selectivity ratio exceeding 500 times. Binding and functional studies of 5'-Guanidinonaltrindole TFA showed pA(2) values comparable to smooth muscle data. 5'-Guanidinonaltrindole TFA is regarded as a potentially valuable pharmacological tool for studying opioids due to its high selectivity and potency .
    5'-Guanidinonaltrindole TFA
  • HY-171936
    Ganglioside GM1 ammonium

    GM1 (d18:1/C18:0) ammonium; C18 Ganglioside GM1 (d18:1/18:0) ammonium

    		 Endogenous Metabolite Neurological Disease
    Ganglioside GM1 (ammonium) is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue. Ganglioside GM1 (ammonium) is one of the most abundant gangliosides in the brain which provides neuroprotection. Ganglioside GM1 (ammonium) exhibits anti-inflammatory property. Ganglioside GM1 (ammonium) has a well-balanced amphiphilic behavior. Ganglioside GM1 (ammonium) can reduce the fluidity of the plasma membrane that implies a retention and enrichment of the ganglioside in specific membrane domains that are called lipid rafts. Ganglioside GM1 (ammonium) can modify the process of differentiation, amplifies responses to neurotrophic factors, protects against excitatory amino acid-related neurotoxicity. Ganglioside GM1 (ammonium) can alleviate acute nerve cell damage through blocking cytotoxicity and potentiating neurotophic factors. Ganglioside GM1 (ammonium) can be studied in neurodegenerative diseases such as Alzheimer’s disease [1] [2] [3] .
    Ganglioside GM1 ammonium

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