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ProstaglandinF2α ethanolamide (Prostamide F2α) is an ethanolamide-like G protein-coupled receptor. ProstaglandinF2α is also a luteinizing hormone in sheep and may be a nociceptive mediator in the spinal cord .
ProstaglandinF2α dimethyl amine is a ProstaglandinF2α (HY-12956) derivative. ProstaglandinF2α dimethyl amine is an antagonist for ProstaglandinF receptor (FP) . ProstaglandinF2α dimethyl amine blocks the cardiovascular responses induced by orexin and Arachidonic acid (HY-109590) .
ProstaglandinF2α-biotin (PGF2α-biotin) is a biotinylated form of ProstaglandinF2α (HY-12956). ProstaglandinF2α-biotin can be used in the study of the mechanism of action of prostaglandins. In addition, ProstaglandinF2α-biotin can be detected in the ethanolic extract of Hawm Gra Dang Ngah rice .
ProstaglandinF2α ethyl amide is an analog of ProstaglandinF2α (HY-12956). ProstaglandinF2α ethyl amide is supposed to be potent lowering intraocular pressure (IOP) for its N-ethyl amide group, like Bimatoprost (HY-B0191) .
ProstaglandinF3α (PGF3α) is an eicosapentaenoic acid (EPA)-derived bioactive lipid mediator that has anti-cancer and anti-inflammatory effects. ProstaglandinF3α is a substrate of ABCC4 with a Km of 12.1 μM. ProstaglandinF3α can be used for the research of diabetes .
ProstaglandinF2α alcohol (PGF2α alcohol) is an analog of PGF2α. Dinoprost (ProstaglandinF2α) is an orally active, potent prostaglandinF (PGF) receptor (FP receptor) agonist .
ProstaglandinF2α dimethyl amide is an antagonist for ProstaglandinF2α (HY-12956), which blocks 50% contraction on gerbilMeriones unguiculatus colon induced by PGF2α at 3.2 μg/mL .
ProstaglandinF2a/BSA is an antigen-adjuvant conjugate formed by the conjugation of ProstaglandinF2a with Bovine Serum Albumin (BSA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes and can enhance cross-presentation as well as the generation of antigen-specific T cells.
ProstaglandinF2α alcohol methyl ether is an alcohol methyl ether G protein-coupled receptor. ProstaglandinF2α is also a luteinizing hormone in sheep and may be a nociceptive mediator in the spinal cord .
ProstaglandinF2α serinol amide is a serinolamide G protein-coupled receptor that increases calcium levels in human non-small cell lung cancer cells. ProstaglandinF2α is also a luteinizing hormone in sheep and may be a nociceptive mediator in the spinal cord .
Dinoprost tromethamine salt (ProstaglandinF2α tromethamine salt) is an orally active, potent prostaglandinF (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour .
ProstaglandinF2α 1,11-lactone is a prostaglandin.
ProstaglandinF2α 1,11-lactone is absorbed by the eye. ProstaglandinF2α 1,
11-Lactone has metabolic stability on the corneal surface and conjunctiva.
ProstaglandinF2α 1,11-lactone can be used in the treatment of glaucoma
.
Dinoprost (ProstaglandinF2α) is an orally active, potent prostaglandinF (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .
ProstaglandinF2α methyl ester (PGF2α methyl ester; Dinoprost methyl) is a PGF2α analog with more lipid solubility. ProstaglandinF2α methyl ester exhibits efficacy in maintaining the ocular hypotensive .
Dinoprost (tromethamine salt) (Standard) is the analytical standard of Dinoprost (tromethamine salt). This product is intended for research and analytical applications. Dinoprost tromethamine salt (ProstaglandinF2α tromethamine salt) is an orally active, potent prostaglandinF (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour .
Dinoprost (Standard) is the analytical standard of Dinoprost. This product is intended for research and analytical applications. Dinoprost (ProstaglandinF2α) is an orally active, potent prostaglandinF (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .
(5R)-Dinoprost is a metabolite produced by cyclooxygenase metabolism of arachidonic acid. (5R)-Dinoprost (ProstaglandinF2β) induces dose-dependent release of hexose containing mucin .
Dinoprost-d4 is the deuterium labeled Dinoprost. Dinoprost (ProstaglandinF2α) is an orally active, potent prostaglandinF (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .
Dinoprost-d9 is the deuterium labeled Dinoprost. Dinoprost (ProstaglandinF2α) is an orally active, potent prostaglandinF (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .
Dinoprost methoxyamine is an orally active, potent prostaglandinF (PGF) receptor (FP receptor) agonist. Dinoprost methoxyamine is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost methoxyamine plays a key role in the onset and progression of labour .
(5R)-Dinoprost tromethamine (ProstaglandinF2β tromethamine) is a metabolite produced by the metabolism of arachidonic acid cyclooxygenase. (5R)-Dinoprost tromethamine induces dose-dependent release of hexosaccharide containing mucin .
Dinoprost- 13C5 is 13C labeled Dinoprost (HY-12956). Dinoprost (ProstaglandinF2α) is an orally active, potent prostaglandinF (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .
PGF2α 1,15-lactone (ProstaglandinF2α 1,15-lactone) is a lipid-soluble internal ester of PGF2α. PGF2α 1,15-lactone decreases menstrual cycle lengths in non-pregnant rhesus monkeys. PGF2α 1,15-lactone terminates early pregnancy in the monkey .
15-keto-ProstaglandinF2α (15-keto-PGF2α) is a metabolite of ProstaglandinF2α. ProstaglandinF2α. ProstaglandinF2α is an orally active, potent prostaglandinF (PGF) receptor (FP receptor) agonist and plays a key role in the onset and progression of labour .
11-Deoxy prostaglandinF1β is a synthetic analog of PGF1β. 11-Deoxy prostaglandinF1β exhibits vasodepressor and bronchodilator activities in guinea pigs .
16-Phenoxy tetranor ProstaglandinF2α methyl ester is a metabolically stable form of ProstaglandinF2α that can binds to FP receptor. 16-Phenoxy tetranor ProstaglandinF2α methyl ester serves as prodrug that can be hydrolyzed to generate bioactive free acid .
15-keto ProstaglandinF1α (15-keto PGF1α) is a prostaglandinF1α metabolite. 15-keto ProstaglandinF1α (15-keto PGF1α) is an effective substrate for PGR-2. 15-keto ProstaglandinF1α (15-keto PGF1α) can be used to study physiological processes such as prostaglandin metabolism and lipogenesis .
8-iso ProstaglandinF1β is an isoprostane, that exhibits vasoconstrictive effect in neonatal porcine pulmonary arteries, pulmonary veins, and mesenteric arteries. 8-iso ProstaglandinF1β targets TXA2 receptor and exhibits the blood vessel contractile efficacy under the influence of tyrosine kinase and Rho kinase .
11-deoxy ProstaglandinF1α (11-deoxy PGF1α) is an analog of prostaglandinF1α, exhibits side effects on intestines and causes the uterine contraction. 11-deoxy ProstaglandinF1α exhibits activity as vasopressor and bronchoconstrictor .
15(R)-ProstaglandinF2α is the isomer of 9α,11β-ProstaglandinF2α (HY-129953). 9α,11β-ProstaglandinF2α is an endogenous metabolite present in Urine that can be used for the research of Asthma .
(17E)-ProstaglandinF3α (17-trans-PGF3α) is a double bond isomer of ProstaglandinF3α (HY-129764) and a potential metabolite of trans dietary fatty acids. (17E)-ProstaglandinF3α has anti-inflammatory activity .
5-trans ProstaglandinF2α tromethamine is a derivative of 5-trans ProstaglandinF2α (HY-129953A). 5-trans ProstaglandinF2α is an endogenous metabolite present in blood that can be used for the research of myocardial infarction .
8-iso-13,14-dihydro-15-keto ProstaglandinF2α is an oxidative metabolite of 8-iso-prostaglandinF2α (HY-113209). 8-iso-13,14-dihydro-15-keto ProstaglandinF2α can be used in the study of oxidative stress-related diseases .
TGI-15 is a highly selective prostaglandinF receptor antagonist. TGI-15 inhibits downstream signaling pathways by blocking the binding of PGF2 α to FP receptors. TGI-15 can be used for research on fibrotic and inflammatory conditions .
17-Trifluoromethylphenyl-13,14-dihydro trinor prostaglandinF1α (Compound 8) is a saturated prostaglandin analogue. 17-Trifluoromethylphenyl-13,14-dihydro trinor prostaglandinF1α has good affinity and receptor selectivity for human prostaglandinF receptor (hFP receptor) witn an EC50 of 85 nM .
ent-8-iso ProstaglandinF2α (ent-15-F2t-IsoP) is a potent vasoconstrictor of porcine retina and cerebral microvessels with EC50 values of 30.6 and 53.5 nM, respectively .
6-keto ProstaglandinF1α is an endogenous metabolite present in Cerebrospinal_Fluid, Urine and Blood that can be used for the research of Meningitis, Rheumatoid Arthritis and Cardiopulmonary Resuscitation .
3-Methoxy prostaglandinF1α is an analog of PGF1α that can be metabolized by naturally occurring extracellular antibiotic resistance genes (eARGs) that enter the intestine via the food chain .
17-Phenyl trinor prostaglandinF2α glycinamide methyl ester is a derivative of Bimatoprost (HY-B0191) and a prostaglandin analog. 17-Phenyl trinor prostaglandinF2α glycinamide methyl ester is a human prostaglandinFP receptor agonist. 17-Phenyl trinor prostaglandinF2α glycinamide methyl ester has an ocular hypotensive effect and can be used in the study of ocular hypertension and glaucoma .
8-iso ProstaglandinF2α-d9 is the deuterium labeled 8-Isoprostaglandin F2α. 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.
Ent-8-Iso-15(S)-prostaglandinF2α is an isomer of 8-Isoprostaglandin F2α, with a better inhibiting activity in the whole blood platelet aggregation inhibition assay .
2,3-Dinor-8-iso prostaglandinF₂α (2,3-Dinor-8-isoPGF2α) is the major β-oxidation metabolite of 8-iso-prostaglandinF₂α. 2,3-Dinor-8-iso prostaglandinF₂α serves as a biomarker to evaluate the in vivo production of 8-iso-prostaglandinF₂α and the level of lipid peroxidation. 2,3-Dinor-8-iso prostaglandinF₂α is promising for research of oxidative stress-related diseases such as arteriosclerosis and diabetes .
17-Phenoxy trinor prostaglandinF2α ethyl amide (17-Phenoxy trinor PGF2α ethyl amide) is an analog of Bimatoprost (HY-12956). 17-Phenoxy trinor prostaglandinF2α ethyl amide is an agonist for ProstaglandinF2α Receptor (FP receptor). 17-Phenoxy trinor prostaglandinF2α ethyl amide is potent to reduce the intraocular pressure and attenuate the glaucoma .
17-Phenyl trinor ProstaglandinF2α dimethyl amide (Bimatoprost dimethyl amide), a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) derivative, is a smooth muscle relaxant. 17-Phenyl trinor ProstaglandinF2α dimethyl amide has the potential for glaucoma research .
1α-Monohomo-17-phenyl trinor ProstaglandinF2α (1α-Monohomo-17-phenyl trinor PGF2α) is a derivative of 17-phenyl trinor prostaglandinF2α ethyl amide. 1α-Monohomo-17-phenyl trinor ProstaglandinF2α is also an isomer of 17-phenyl trinor prostaglandinF2α methyl ester.
Carboprost (15(S)-15-Methyl ProstaglandinF2α) is a metabolically stable synthetic analog of prostaglandinF2α. Carboprost stimulates uterine contractions and induces abortion. Carboprost is used for postpartum hemorrhage due to uterine atony and for the termination of pregnancy in the second trimester .
17-Phenyl trinor prostaglandinF2α 1,15-lactone (17-Phenyl trinor PGF2α 1,15-lactone) is a 1,15 lactone of 17-Phenyl trinor prostaglandinF2α. 17-Phenyl trinor prostaglandinF2α is a metabolite of Dinoprost (HY-12956) .
15(R),19(R)-Hydroxy prostaglandinF2α (15(R),19(R)-Hydroxy PGF2α) is an analog of 19(R)-Hydroxy-prostaglandinF2α. 19(R)-Hydroxy-prostaglandinF2α (HY-N7857) is an ω-1 hydroxylase metabolite of PGF2α found in human semen .
19(R)-Hydroxy-prostaglandinF2α (19(R)-hydroxy PGF2α) is an ω-1 hydroxylase metabolite of PGF2α found in human semen. The concentration of 19(R)-Hydroxy-PGFs compounds (F2α and F1α together) in fresh human semen is about 20 μg/mL. 19(R)-Hydroxy-prostaglandinF2α exhibits no activity at the FP receptor of the cat iris sphincter muscle at concentrations up to 1 μM.
N-Cyclopropyl methyl bimatoprost (17-Phenyl trinor prostaglandinF2α cyclopropyl methyl amide) is an analog of Bimatoprost (HY-12956). N-Cyclopropyl methyl bimatoprost is an agonist for ProstaglandinF2α Receptor (FP receptor). N-Cyclopropyl methyl bimatoprost is potent to reduce the intraocular pressure and attenuate the glaucoma .
9α,11β-ProstaglandinF2α-d4 is a deuterated labeled 9α,11β-ProstaglandinF2α . 9α,11β-ProstaglandinF2α is an endogenous metabolite present in Urine that can be used for the research of Asthma .
15-keto-17-phenyl trinor ProstaglandinF2α (15-keto-17-phenyl trinor PGF2α) is an F-series prostaglandin (PG) analog. The potential metabolite of 15-keto-17-phenyl trinor ProstaglandinF2α in animals is 15-keto PG. 15-keto PG can slightly reduce the intraocular pressure (1 mm Hg) in normal cynomolgus monkeys when administered at a dose of 1 μg/eye. 15-keto-17-phenyl trinor ProstaglandinF2α is a miotic agent in cats, reducing the pupil diameter by 8 mm at a dose of 5 μg/eye.
Bimatoprost cyclohexyl amide (N-Cyclohexyl-desamethyl bimatoprost; 17-Phenyl trinor prostaglandinF2α cyclohexyl amide) is an analog of bimatoprost (HY-B0191). Bimatoprost cyclohexyl amide is an agonist of the prostaglandinF2α receptor. Bimatoprost cyclohexyl amide is used in research on reducing intraocular pressure and glaucoma .
8-iso ProstaglandinF2β (8-iso PGF2β) is a biomarker for assessing oxidative stress, and its content in serum can indirectly reflect the level of oxidative stress .
8-Iso-17-phenyl trinor prostaglandinF2β is an isomer of Bimatoprost (HY-B0191). Bimatoprost is a prostaglandin analog. Bimatoprost lowers intraocular pressure by regulating scleral and trabecular outflow.
8-ISo-15-keto prostaglandinF2β is a potential metabolite of 8-Iso PGF2β via the 15-hydroxy-PG dehydrogenase pathway. 8-iso PGF2β constricts pulmonary veins in dogs and pigs .
15(R)-17-Phenyl trinor ProstaglandinF2α (15-epi Bimatoprost free acid) is a prostaglandinF (FP) analog that acts as an ocular hypotensive agent. The free acid 17-Phenyl trinor ProstaglandinF2α is a potent FP receptor agonist. 15(R)-17-Phenyl trinor ProstaglandinF2α is the 15-epi or "unnatural" isomer of this active free acid metabolite and has reduced FP receptor agonist activity.
8-iso-15-keto ProstaglandinF2α (8-iso-15-keto PGF2α) is a partial agonist for Thromboxane receptor (TP), which exhibits a vasoconstrictor efficacy with a pD2 of 5.8. 8-iso-15-keto ProstaglandinF2α mediates a weak relaxation of rats aorta rings at high concentration .
Carboprost (Standard) is the analytical standard of Carboprost. This product is intended for research and analytical applications. Carboprost (15(S)-15-Methyl ProstaglandinF2α) is a metabolically stable synthetic analog of prostaglandinF2α. Carboprost stimulates uterine contractions and induces abortion. Carboprost is used for postpartum hemorrhage due to uterine atony and for the termination of pregnancy in the second trimester .
(±)5-iPF2α-VI (5-iso ProstaglandinF2α-VI) is the racemate of 5-iPF2α-VI. 5-iPF2α-VI is a regioisomeric isoprostane formed from arachidonic acid (AA) and is a biomarker of oxidative stress .
13,14-Dihydro-15-keto ProstaglandinF2α-d4 (13,14-Dihydro-15-keto-PGF2α-d4) is a deuterated labeled 13,14-Dihydro-15-keto ProstaglandinF2α (HY-113208). 13,14-Dihydro-15-keto ProstaglandinF2α-d4 is an endogenous metabolite present in Blood that can be used for the research of Pregnancy .
15(R)-15-Methyl ProstaglandinF2α (15(R)-Carboprost; 15(R)-15-methyl PGF2α) is a metabolically stable analog of PGF2α. 15(R)-15-Methyl ProstaglandinF2α is an inactive, prodrug PGF agonist designed for activation by gastric acid after oral administration. Acid-catalyzed epimerization of 15(R)-15-Methyl ProstaglandinF2α converts it into the active 15(S)-isomer. The 15(S)-isomer induces luteolysis when injected in rhesus monkeys at a dose of about 12 mg/animal, while the 15(R)-isomer does not.
6,15-Diketo-13,14-dihydro prostaglandinF1α (6,15-Diketo-13,14-dihydro-PGF1α) is a metabolite of prostacyclin (PGI2). 6,15-Diketo-13,14-dihydro prostaglandinF1α enhances intracellular cAMP and cholesterol metabolism in bovine arterial smooth muscle cells .
16-phenoxy tetranor ProstaglandinF2α (16-phenoxy tetranor PGF2α) is a metabolically stable analog of PGF2α. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α.
15(R)-15-Methyl prostaglandinF2α methyl ester (15(R)-Methyl carboprost) (compound 15R) is a 15-methyl substituted prostaglandin analog, a member of the prostaglandin family, with potential biological activities in a variety of biological systems, but its specific activity mechanism and application details are not described in detail from the existing information.
17-Phenoxy trinor prostaglandinF2α isopropyl ester is a PGF2α (HY-12956) analog. PGF2α is an orally active agonist of the PGF receptor (FP receptor). PGF2α plays a key role in labor and delivery.
16-phenyl tetranor ProstaglandinF2α (16-phenyl tetranor PGF2α) is a metabolically stable analog of PGF2α. The affinity of 16-phenyl tetranor PGF2α at the FP receptor of ovine luteal cells is poor (8.7%) compared to PGF2α.
17-Trifluoromethylphenyl trinor prostaglandinF2α ethyl amide (compound 17-CF3PTPG2α EA) is a lipophilic analog of 17-trifluoromethylphenyl trinor PGF2α .
2,3-Dinor-11beta-prostaglandinF2alpha (2,3-Dinor-11β-PGF2α) is a metabolite of PGD2. Urinary excretion of 2,3-Dinor-11beta-prostaglandinF2alpha is increased in patients with mast cell activation disease (MCAD) and has been used as a marker of increased PGD2 levels. 2,3-Dinor-11beta-prostaglandinF2alpha levels are also increased in the urine of patients with asthma and are positively correlated with impaired lung function.
13,14-Dihydro-15-keto ProstaglandinF2α (13,14-Dihydro-15-keto-PGF2α) is an endogenous metabolite present in Blood that can be used for the research of Pregnancy .
A number of 17-phenyl trinor prostaglandinF2α (17-phenyl trinor PGF2α) derivatives have been approved for glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists.4 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost. 17-phenyl trinor PGF2α is a potent luteolytic, with a potency equal to or greater than fluprostenol and cloprostenol.
11β-ProstaglandinF2α ethanolamide (11β-PGF2α-EA) is the theoretical hepatic metabolite of PGD2-EA, produced during COX-2 metabolism of the endogenous cannabinoid AEA which is found in brain, liver, and other mammalian tissues.1 AEA can be used directly by COX-2 and specific PG synthase to produce ethanolamide congeners of the classical PGs. PGD2-EA is formed in activated RAW 264.7 cells treated with AEA.
Δ17-6-keto ProstaglandinF1α (Δ17-6-keto PGF1α) is a cyclooxygenase (COX) product of eicosapentaenoic acid (EPA) in various tissues such as seminal vesicles, lung, Polymorphonuclear leukocytes, and ocular tissues. Δ17-6-keto PGF1α and other 3-series COX products from EPA, such as PGF3α, PGE3, and thromboxane B3, may be involved in the reduced incidence of glaucoma in patients on a marine-rich (EPA-rich) diet.
11β-13,14-Dihydro-15-keto ProstaglandinF2α is the deviative of 13,14-Dihydro-15-keto PGF2a (HY-113208), which is an endogenous metabolite present in Blood that can be used for the research of Pregnancy .
AL 8810 methyl ester is a prostaglandinF(2α) analog and a prostaglandinF(2α) receptor agonist. Can competitively antagonize the effects of the FP receptor agonist Fluprostenol (HY-108560). AL 8810 methyl ester has no significant potency against TP, DP, EP(2), EP(4) receptor subtypes in cell lines .
F092 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS) with a KD value of 0.14 nM. F092 can be used in the study of allergic and inflammatory responses .
(+)-Cloprostenol (Standard) is the analytical standard of (+)-Cloprostenol. This product is intended for research and analytical applications. (+)-Cloprostenol is a prostaglandinF2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor.
Latanoprost (PHXA41) is a prostaglandinF2α analogue and can be used for glaucoma research. Latanoprost can effectively pass through cornea and be hydrolyzed by esterase to latanoprost acid. latanoprost acid is an F-prostaglandin (FP) receptor agonist, and can effectively reduce intraocular pressure (IOP) by increasing the outflow of aqueous humor through uvea .
Tafluprost ethyl ester (AFP-175) is a derivative of ProstaglandinF2α (PGF2α) (HY-12956). Tafluprost ethyl ester is an agonist for prostaglandin FP receptor, and exhibits miotic effect .
AL-3138 (11-Deoxy-16-fluoro PGF2α) is a prostaglandinF2 alpha (PGF2alpha) analogue that antagonises FP prostaglandin receptor-mediated inositol phosphate production .
Cloprostenol isopropyl ester, a prostaglandinF2α analogs, is the intermediate of (+)-Cloprostenol (HY-107381). Cloprostenol isopropyl ester is a FP receptor agonist with a Ki value of 28 nM .
Latanoprost lactone diol is an intermediate in the synthesis of Latanoprost. Latanoprost is a prostaglandinF2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP) .
Ebopiprant (OBE022) is an oral and selective prostaglandinF2α (PGF2α) receptor antagonist, with Kis of 1 nM, 26 nM for human and rat FP receptors, respectively.
Ebopiprant (OBE022) hydrochloride is an oral and selective prostaglandinF2α (PGF2α) receptor antagonist, with Kis of 1 nM, 26 nM for human and rat FP receptors, respectively.
Latanoprost tris(triethylsilyl) ether is a precursor in the synthesis of the prostaglandinF2α (PGF2α) receptor (FP receptor) agonist Latanoprost (HY-B0577).
Latanoprost-d4 is the deuterium labeled Latanoprost. Latanoprost (PHXA41) is a prostaglandinF2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP).
(+)-5-trans Cloprostenol isopropyl ester is a more lipid-soluble form of (+)-5-trans cloprostenol (HY-120955), which is a synthetic derivative of prostaglandinF2α .
Cloprostenol is a prostaglandinF2α (PGF2α (HY-12956)) analogue. Cloprostenol can induce luteolysis. Cloprostenol can be used for open-cervix pyometra research .
Latanoprostene bunod (LBN), a nitric oxide (NO)-donating prostaglandinF2a analog, is a topical ophthalmic therapeutic for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension (OHT) .
AS604872 is an orally active, potent and selective prostaglandinF2α receptor (FP) antagonist with a Ki of 35 nM in humans, 158 nM in rats and 323 nM in mice. AS604872 inhibits contractions and delays labour .
Latanoprost (Standard) is the analytical standard of Latanoprost. This product is intended for research and analytical applications. Latanoprost (PHXA41) is a prostaglandinF2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP).
AL 8810 (Item No. 16735) is an 11β-fluoro analog of prostaglandinF2α which acts as a potent and selective antagonist at the FP receptor. AL 8810 isopropyl ester is a lipid soluble, esterified prodrug form of AL 8810 analogous to the commonly used therapeutic intraocular prostaglandin compounds such as Latanoprost (HY-B0577) and Travoprost (HY-B0584).
Cloprostol, a synthetic derivative of prostaglandinF2α, is used as an ossified in veterinary medicine and the research of reproductive disorders in cattle, pigs and horses. (+)-5-trans Cloprostenol is a secondary impurity produced during the synthesis of (+) -cloprostenol .
Carboprost tromethamine is the synthetic 15-methyl analogue of prostaglandinF2α. Carboprost tromethamine can effectively promote law contraction of the uterus and significantly reduce the amount of bleeding during and after delivery .
5,7-Dihydroxy-11-ketotetranorprostanoic acid is a urinary metabolite of prostaglandinF2α and precursor to tetranor-PGF metabolites, exhibits hardly activity in blood pressure assay and smooth muscle stiumulation assay .
15-Keto-PGA1 is a metabolite of PGA1 and has significant vasoconstrictive effects. PGA1 is also a vasoconstrictor and is more potent than equivalent doses of prostaglandinF2α (PGF2α) and angiotensin II .
15-Keto Bimatoprost-d5 is the deuterium labeled 15-Keto Bimatoprost. 15-Keto Bimatoprost is a prostaglandinF2α (PGF2α) analog that can be used for the research of ocular hypotensive .
Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal .
Abz-AGLA-Nba TFA is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba TFA is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal .
Fluprostenol (ICI 81008) is a synthetic prostaglandinF2α (PGF2α) derivative. Fluprostenol, as a luteolytic agent, can cause luteal degeneration and regulate reproductive cycle. Fluprostenol can be used in the study of infertility in animals and the control of the reproductive cycle of domestic animals .
13,14-epoxy Travoprost (13,14-epoxy Fluprostenol isopropyl ester) is a mixture of diastereomeric epoxides generated during production of Travoprost (HY-B0584). Travoprost is a selective agonist for prostaglandinF receptor, which exhibits an ocular hypotensive efficacy .
Latanoprostene bunod (Standard) is the analytical standard of Latanoprostene bunod. This product is intended for research and analytical applications. Latanoprostene bunod (LBN), a nitric oxide (NO)-donating prostaglandinF2a analog, is a topical ophthalmic therapeutic for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension (OHT) .
Carboprost (tromethamine) (Standard) is the analytical standard of Carboprost (tromethamine). This product is intended for research and analytical applications. Carboprost tromethamine is the synthetic 15-methyl analogue of prostaglandinF2α. Carboprost tromethamine can effectively promote law contraction of the uterus and significantly reduce the amount of bleeding during and after delivery .
PGF2α-isopropyl ester is a ProstaglandinF2α (HY-12956) derivative, which is active in lowering the intraocular pressure (IOP) through increased uveoscleral outflow of aqueous humor. PGF2α-isopropyl ester causes side effects of conjunctival hyperemia and ocular irritation .
8-iso PGF3α is an isoprostane produced from the free-radical peroxidation of EPA. Little is known about the biological activity of 8-iso PGF3α. There is one report that it is inactive in a TP receptor mediated assay of human platelet shape change, where 8-iso PGF2α has an ED50 value of 1 μM.
15-keto Latanoprost is a potential metabolite of latanoprost (HY-B0577) when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 μg/eye.1 15-keto Latanoprost is also a miotic in the normal cat eye, causing an 8 mm Hg reduction in pupillary diameter at 5 μg/eye. Again, this is not as potent as many other F-type prostaglandins; for example, prostaglandinF2α will produce this degree of miosis at a dose of less than 1 μg/eye.
Flocoumafen (WL 108366) is an orally active vitamin K epoxide reductase inhibitor and a multi-target ligand, which includes prostaglandinF synthase, serum albumin, glucocorticoid receptor 2, and MMP-9. Flocoumafen is a second-generation anticoagulant rodenticide (ARs) with a half-life of 177.4 hours and has deadly anticoagulant effects .
Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor . Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes .
Unoprostone, a prostaglandinF2α analog, is a large conductance Ca 2+-activated K + (BK) channels and ClC-2 type chloride channels activator. Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction. Unoprostone reduces intraocular pressure and can be used for the study of glaucoma, ocular hypertension and retinitis pigmentosa .
Cloprostenol is a synthetic prostaglandinF2α (PGF2α) analog and a potent FP receptor agonist. (+)-15-epi Cloprostenol is the 15(S), or 15β-hydroxy enantiomer of (+)-cloprostenol. This epimer is less active by several orders of magnitude as an FP receptor ligand when compared to 15(R)-cloprostenol. However, the specific activity of this isomer has not been well studied.
Flocoumafen (Standard) is the analytical standard of Flocoumafen. This product is intended for research and analytical applications. Flocoumafen (WL 108366) is an orally active vitamin K epoxide reductase inhibitor and a multi-target ligand, which includes prostaglandinF synthase, serum albumin, glucocorticoid receptor 2, and MMP-9. Flocoumafen is a second-generation anticoagulant rodenticide (ARs) with a half-life of 177.4 hours and has deadly anticoagulant effects .
Pronqodine A is an Indoleamine 2,3-Dioxygenase (IDO) inhibitor, with an IC50 of 131.5 nM. Pronqodine A inhibits bradykinin-induced release of PGE2, 6-keto-prostaglandinF1α, PGD2 and induces the production of reactive oxygen species (ROS) in human synovial sarcoma SW982 cells. Pronqodine A is a good substrate for human quinone reductase NQO1. Pronqodine A can be used for the study of inflammation .
17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost.1 The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost.2 This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist.3 In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. The 17-phenyl trinor PGF2α isopropyl ester derivative is examined for IOP-lowering activity during the development of latanoprost.4 At the dose of 3 μg/eye in the monkey, 17-phenyl trinor PGF2α isopropyl ester is the most potent analog tested in reducing IOP, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost. However, this derivative is also significantly more irritating to the eye than latanoprost.
13,14-dihydro ProstaglandinF2α (13,14-dihydro PGF2α) is the analog of PGF2α which has no unsaturation in the lower side chain. It causes luteolysis in hamsters with a potency five times higher than PGF2α. The ED50 value for 13,14-dihydro PGF2α as a luteolytic agent in hamsters is 1.5 μg/100 g.
8-isoprostaglandin F2α ethanolamide (iPF2α-III ethanolamide; 8-Isoprostane ethanolamide; 8-iso PGF2α ethanolamide) is an isoprostanol ethanolamide derivative derived from anandamide (AEA) via non-enzymatic free radical oxidation. 8-isoprostaglandin F2α ethanolamide is commonly used as a marker of oxidative stress, distinguishing non-enzymatic degradation products from "prostamides" generated by enzymatic pathways such as COX-2 .
Latanoprost acid (Standard) is the analytical standard of Latanoprost acid. This product is intended for research and analytical applications. Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor . Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes .
15(S)-15-methyl ProstaglandinF2α methyl ester (15(S)-15-methyl PGF2α methyl ester) is a derivative of 15(S)-15-methyl PGF2α with increased membrane permeability. Hydrolysis of the methyl ester in vivo releases the biologically active 15(S)-15-methyl PGF2α, which is a potent uterine stimulant and abortifacient.
20-hydroxy ProstaglandinF2α (20-hydroxy PGF2α) is the ω-oxidation product of PGF2α. Cultured type II alveolar cells from pregnant rabbits metabolize exogenous PGF2α via microsomal cytochrome P450 ω-oxidation, producing 20-hydroxy PGF2α and its 15-hydroxy PGDH metabolites. Cells from male rabbits exhibit only the 15-hydroxy PGDH pathway.
15(R)-17-phenyl trinor ProstaglandinF2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2α isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC50 values for the free acid forms of 15(S)-17-phenyl trinor PGF2α and 15(R)-17-phenyl trinor PGF2α were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle.1 A 3 μg dose of 15(R)-17-phenyl trinor PGF2α caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.
ProstaglandinF2α-biotin (PGF2α-biotin) is a biotinylated form of ProstaglandinF2α (HY-12956). ProstaglandinF2α-biotin can be used in the study of the mechanism of action of prostaglandins. In addition, ProstaglandinF2α-biotin can be detected in the ethanolic extract of Hawm Gra Dang Ngah rice .
ProstaglandinF2a/BSA is an antigen-adjuvant conjugate formed by the conjugation of ProstaglandinF2a with Bovine Serum Albumin (BSA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes and can enhance cross-presentation as well as the generation of antigen-specific T cells.
Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal .
Abz-AGLA-Nba TFA is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba TFA is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal .
Dinoprost tromethamine salt (ProstaglandinF2α tromethamine salt) is an orally active, potent prostaglandinF (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour .
Dinoprost (ProstaglandinF2α) is an orally active, potent prostaglandinF (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .
15-keto-ProstaglandinF2α (15-keto-PGF2α) is a metabolite of ProstaglandinF2α. ProstaglandinF2α. ProstaglandinF2α is an orally active, potent prostaglandinF (PGF) receptor (FP receptor) agonist and plays a key role in the onset and progression of labour .
6-keto ProstaglandinF1α is an endogenous metabolite present in Cerebrospinal_Fluid, Urine and Blood that can be used for the research of Meningitis, Rheumatoid Arthritis and Cardiopulmonary Resuscitation .
13,14-Dihydro-15-keto ProstaglandinF2α (13,14-Dihydro-15-keto-PGF2α) is an endogenous metabolite present in Blood that can be used for the research of Pregnancy .
Dinoprost (tromethamine salt) (Standard) is the analytical standard of Dinoprost (tromethamine salt). This product is intended for research and analytical applications. Dinoprost tromethamine salt (ProstaglandinF2α tromethamine salt) is an orally active, potent prostaglandinF (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour .
Dinoprost (Standard) is the analytical standard of Dinoprost. This product is intended for research and analytical applications. Dinoprost (ProstaglandinF2α) is an orally active, potent prostaglandinF (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .
(5R)-Dinoprost is a metabolite produced by cyclooxygenase metabolism of arachidonic acid. (5R)-Dinoprost (ProstaglandinF2β) induces dose-dependent release of hexose containing mucin .
AL-3138 (11-Deoxy-16-fluoro PGF2α) is a prostaglandinF2 alpha (PGF2alpha) analogue that antagonises FP prostaglandin receptor-mediated inositol phosphate production .
Pronqodine A is an Indoleamine 2,3-Dioxygenase (IDO) inhibitor, with an IC50 of 131.5 nM. Pronqodine A inhibits bradykinin-induced release of PGE2, 6-keto-prostaglandinF1α, PGD2 and induces the production of reactive oxygen species (ROS) in human synovial sarcoma SW982 cells. Pronqodine A is a good substrate for human quinone reductase NQO1. Pronqodine A can be used for the study of inflammation .
FPRP/PTGFRN protein plays a key role in regulating prostaglandin F2-α (PGF2-α) signaling by inhibiting the binding of PGF2-α to its FP receptor. This inhibition reduces receptor number without changing the affinity constant, revealing subtle mechanisms. FPRP/PTGFRN Protein, Human (HEK293, His) is the recombinant human-derived FPRP/PTGFRN protein, expressed by HEK293 , with C-His labeled tag.
Prostaglandin F2 receptor inhibitor (PTGFRN) is a type I transmembrane Ig superfamily cell adhesion molecule. PTGFRN is overexpressed in glioblastoma and promotes cell growth and radiation resistance through the PI3K-AKT signaling pathway. PTGFRN is involved in adipocyte maturation, muscle regeneration, tumor angiogenesis, metastasis, inhibition of follicle-stimulating hormone and luteinizing hormone secretion, and plasmodium infection. FPRP/PTGFRN Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived FPRP/PTGFRN protein, expressed by HEK293 , with C-His labeled tag.
AKR1C3 Protein, Human (HEK293, His) expresses in HEK293 cells with a His tag. Aldo-keto reductase family 1 member C3 (AKR1C3) is a steroidogenic enzyme that plays a crucial role in the conversion of adrenal androgen dehydroepiandrosterone (DHEA) into high-affinity ligands for the androgen receptor (testosterone [T] and dihydrotestosterone [DHT]).
The FPRP/PTGFRN Protein inhibits PGF2-alpha binding to its FP receptor, mainly by reducing receptor numbers.It interacts with CD9 and CD81, preventing myotube fusion in myoblasts during muscle regeneration.It also forms a complex with CD9, CD81, and IGSF8, potentially interacting with other tetraspanins like CD63, CD82, and CD151.These interactions highlight its regulatory role in prostaglandin signaling and muscle regeneration.FPRP/PTGFRN Protein, Mouse (HEK293, His) is the recombinant mouse-derived FPRP/PTGFRN protein, expressed by HEK293 , with C-His labeled tag.
Dinoprost-d4 is the deuterium labeled Dinoprost. Dinoprost (ProstaglandinF2α) is an orally active, potent prostaglandinF (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .
Dinoprost-d9 is the deuterium labeled Dinoprost. Dinoprost (ProstaglandinF2α) is an orally active, potent prostaglandinF (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .
Dinoprost- 13C5 is 13C labeled Dinoprost (HY-12956). Dinoprost (ProstaglandinF2α) is an orally active, potent prostaglandinF (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour .
8-iso ProstaglandinF2α-d9 is the deuterium labeled 8-Isoprostaglandin F2α. 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.
9α,11β-ProstaglandinF2α-d4 is a deuterated labeled 9α,11β-ProstaglandinF2α . 9α,11β-ProstaglandinF2α is an endogenous metabolite present in Urine that can be used for the research of Asthma .
13,14-Dihydro-15-keto ProstaglandinF2α-d4 (13,14-Dihydro-15-keto-PGF2α-d4) is a deuterated labeled 13,14-Dihydro-15-keto ProstaglandinF2α (HY-113208). 13,14-Dihydro-15-keto ProstaglandinF2α-d4 is an endogenous metabolite present in Blood that can be used for the research of Pregnancy .
Latanoprost-d4 is the deuterium labeled Latanoprost. Latanoprost (PHXA41) is a prostaglandinF2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP).
15-Keto Bimatoprost-d5 is the deuterium labeled 15-Keto Bimatoprost. 15-Keto Bimatoprost is a prostaglandinF2α (PGF2α) analog that can be used for the research of ocular hypotensive .
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