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Results for "

primary amine group

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (20) Biochemical Assay Reagents (66) Drug Intermediate (1) Fluorescent Dye (25) Ligands for E3 Ligase (1) Liposome (2) PROTAC Linkers (18) Reactive Oxygen Species (1)
By Research Areas:	Cancer (34) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)
Click Chemistry:	Labeling and Fluorescence Imaging (1) TCO (1) DBCO (5) Azide (1) Tetrazine (1)
Oligonucleotides:	Pegylated Lipids (1) Cationic Lipids (1)

135

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

MCE Kits

Click Chemistry

Oligonucleotides

Targets Recommended: Amine N-methyltransferase Trace Amine-associated Receptor (TAAR) HMG Family VAP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1372A

Cyanine3 amine TFA	Fluorescent Dye	Others
Cyanine3 amine (TFA), an analog of Cyanine3 amine, is a potent green fluorescent dye. Cyanine3 amine (TFA) has the primary amine group and is covalently coupled with reactive groups such as NHS esters, carboxy groups (after carbodiimide activation), and epoxides. (λ_ex=555 nm, λ_em=570 nm) .

HY-118431

DMABA NHS ester	Biochemical Assay Reagents	Others
DMABA NHS ester can chemically react with the primary amine groups of the major phospholipid component of the cell membrane, Phosphatidylethanolamine (PE). Through precursor ion scanning, all PE subclasses labeled with DMABA can be detected. DMABA NHS ester can be used in combination with isotope-labeled compounds such as DMABA-d6 NHS ester, DMABA-d10 NHS ester, and DMABA-d4 NHS ester to observe changes in the distribution of PE lipids and the formation of novel PE lipid products .

HY-111377

Amine-PEG3-Biotin 2 Publications Verification	Fluorescent Dye	Others
Amine-PEG3-Biotin is a signal amplification label containing a biotin group and a terminal primary amine group .

HY-W614180

3-Amino-2-sulfopropanoic acid	Biochemical Assay Reagents	Others
3-Amino-2-sulfopropanoic acid is a short molecule featuring a carboxylic acid, a sulfonate group, and a primary amine. The carboxylic acid and the primary amine are free to link this molecule to larger structures while the sulfonate group provides high water solubility to this aliphatic compound.

HY-D0975

Sulfo-SMCC sodium 4 Publications Verification	ADC Linker	Cancer
Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.

HY-D1372

Cyanine3 amine hydrochloride	Fluorescent Dye	Others
Cyanine3 amine hydrochloride, an analog of Cyanine3 amine, is a potent green fluorescent dye. Cyanine3 amine hydrochloride has the primary amine group and is covalently coupled with reactive groups such as NHS esters, carboxy groups (after carbodiimide activation), and epoxides. (λ_ex=555 nm, λ_em=570 nm) .

HY-D1650

BDP 630/650 carboxylic acid	Fluorescent Dye	Others
BDP 630/650 carboxylic acid is a bright far-red fluorophore based on a borondipyrromethene scaffold. BDP 630/650 carboxylic acid is a BDP linker containing carboxylic acid. BDP 630/650 carboxylic acid can react with primary amine groups to form a stable amide bond. (λ_ex=630 nm, λ_em=650 nm) .

HY-172719

Fmoc-PEG9-alcohol	Biochemical Assay Reagents	Others
Fmoc-PEG9-alcohol is a heterobifunctional PEG linker featuring a Fmoc-protected primary amine and an alcohol group. The hydroxy group is a versatile functionality while the Fmoc protecting group can be removed with base to reveal a primary amine.

HY-W800846

Fmoc-Amido-Tri-(carboxyethoxymethyl)-methane	Biochemical Assay Reagents	Others
Fmoc-Amido-Tri-(carboxyethoxymethyl)-methane is a multifunctional reagent containing three carboxylic acids and a primary amine that is Fmoc-protected. The carboxylic acids can react with primary amine groups to form stable amide bonds. The Fmoc protecting group can be removed using piperidine, freeing up the amine for a variety of uses such as coupling with carboxylic acids to form amide bonds.

HY-W591977

Boc-5-aminopentanoic NHS ester	Biochemical Assay Reagents	Others
Boc-5-aminopentanoic NHS ester is a linker containing an NHS ester and a t-Boc protected amine group. The t-Boc group can be deprotected under mild acidic conditions to form a free amine. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

HY-W040289

Mal-amido-PEG2-NHS ester	ADC Linker	Cancer
Mal-amido-PEG2-NHS ester is a nonclaevable ADC linker containing a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules .

HY-W800650

Aminooxy-PEG1-amine	Biochemical Assay Reagents	Others
Aminooxy-PEG1-amine is a chemical reagent containing an aminooxy group and a primary amine. The aminooxy group is reactive with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The amino group is reactive withactivated NHS esters, or carboxylic acid in the presence of coupling reagent EDC. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term.

HY-173303

PEG3-Bis-nitrophenyl carbonate	Biochemical Assay Reagents	Others
PEG3-Bis-nitrophenyl carbonate is a PEG linker with two nitrophenyl carbonate groups that can react rapidly with primary amines.

HY-W190934

Fmoc-Ala-Pro-OH	Biochemical Assay Reagents	Others
Fmoc-Ala-Pro-OH is a linker with an Fmoc-protected amine and a terminal carboxylic acid. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W591965

t-Boc-aminooxy-pentane-amine	Biochemical Assay Reagents	Others
t-Boc-Aminooxy-pentane-amine is a linker containing an aminooxy group and a primary amine. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

HY-W800684

Benzyloxy carbonyl-PEG4-NHS ester	Biochemical Assay Reagents	Others
Benzyloxy carbonyl-PEG4-NHS ester is a reagent with a benzyl protecting group and an NHS ester. The NHS ester reacts with primary amines (-NH2). The benzyl protecting group can be removed by hydrogenolysis.

HY-126509

Mal-amido-PEG10-C2-NHS ester	ADC Linker	Cancer
Mal-amido-PEG10-C2-NHS ester is a nonclaevable ADC linker containing a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules .

HY-126508

Mal-amido-PEG5-C2-NHS ester	ADC Linker	Cancer
Mal-amido-PEG10-C2-NHS ester is a nonclaevable ADC linker containing a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules

HY-126507

Mal-amido-PEG1-C2-NHS ester	ADC Linker	Cancer
Mal-amido-PEG1-C2-NHS ester is a nonclaevable ADC linker containing a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules

HY-W190926

2, 5-Dioxo-1-pyrrolidinyl 11-azidoundecanoate	Biochemical Assay Reagents	Others
2,5 -Dioxo-1-pyrrolidinyl 11-azidoundecanoate is a linker containing an azide group and an NHS ester. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

HY-W671472

10-Oxononadecanedioic acid	Biochemical Assay Reagents	Others
10-Oxononadecanedioic acid is a long alkane linker with two terminal carboxylic acid groups. The terminal carboxylic acid groups can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.

HY-W574509

Tos-PEG2-acid	Biochemical Assay Reagents	Cancer
Tos-PEG2-acid (compound 30) is a PEG linker containing a tosyl group and a terminal carboxylic acid. Tos-PEG2-acid can react with primary amine groups .

HY-D1376A

Sulfo-Cyanine5.5 amine	Fluorescent Dye	Others
Sulfo-Cyanine5.5 amine consists of four sulfonate groups and has highly hydrophilic. Sulfo-Cyanine5.5 amine is an amine-containing fluorescent dye, the aliphatic primary amine group can be coupled with various electrophiles (activated esters, epoxides, etc). Sulfo-Cyanine5.5 amine can be used for the research of far red/NIR applications (such as in vivo imaging) and also can be used for enzymatic transamination labeling .

HY-W160298

N-Cbz-7-Aminoheptanoic acid	Biochemical Assay Reagents	Others
N-Cbz-7-Aminoheptanoic acid is a six carbon linker containing an carboxylic acid (CO2H) group and a benzyl (Cbz) protecting group. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The benzyl protecting group can be removed via hydrogenolysis to form a free amine.

HY-W190958

Boc-NH-Tri-(carbonylethoxymethyl)-methane	Biochemical Assay Reagents	Others
Boc-NH-Tri-(carbonylethoxymethyl)-methane is a branched PEG linker with a Boc-protected amino and three terminal carboxilic acid groups. The Boc group can be deprotected under mild acidic conditions to form the free amine. The terminal carboxylic acid groups can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-153631

Sulfo-TAG NHS ester disodium	Drug Intermediate	Inflammation/Immunology
Sulfo-TAG NHS ester (disodium) is an N-hydroxysuccinimide ester that can be coupled to proteins via primary amine groups. Sulfo-TAG NHS ester (disodium) can be used for antibody labeling .

HY-44249

Thalidomide-CH2NH2 hydrochloride	Ligands for E3 Ligase	Cancer
Thalidomide-CH2NH2 hydrochloride is a Thalidomide analogue featuring a primary amine, which is a versatile group which may participate in many reactions.

HY-W286613

N-Boc-Biocytin	Biochemical Assay Reagents	Others
N-Boc-Biocytin is a biotin PEG linker containing a carboxylic group and Boc-protected amine. Reaction of carboxylic with primary amino (-NH2) forms stable, irreversible amide bonds. The Boc group can be deprotected under acidic condition to obtain the free amine which can be used for further conjugations.

HY-W190950

AZD-PEG5-PFP	Biochemical Assay Reagents	Others
AZD-PEG5-PFP is a PEG linker containing an AZD group and a PFP ester group, an activated ester that reacts with primary amines to form amide bonds. PFP ester has been found to be more stable than other amine reactive groups because it is less likely to undergo hydrolysis. The hydrophilic PEG spacer increases solubility in aqueous media.

HY-W800610

AZD-PEG13-PFP	Biochemical Assay Reagents	Others
AZD-PEG13-PFP is a PEG linker containing an AZD group and a PFP ester group, an activated ester that reacts with primary amines to form amide bonds. PFP ester has been found to be more stable than other amine reactive groups because it is less likely to undergo hydrolysis. The hydrophilic PEG spacer increases solubility in aqueous media.

HY-D2741

MB 488 NHS ester	Fluorescent Dye	Others
MB 488 NHS ester is a fluroescent agent with a terminal NHS ester group. MB 488 NHS ester is a green fluorescent, very hydrophilic dye molecule that has a maximal absorption of 501 nm and emission at 524 nm. The NHS ester can be applied to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

HY-W097128

Fmoc-12-aminododecanoic acid	PROTAC Linkers	Cancer
Fmoc-12-aminododecanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W800686

Acid-PEG4-NHS ester	Biochemical Assay Reagents	Others
Acid-PEG4-NHS ester is a PEG linker with a carboxylic acid and an NHS ester. Both functional group can react with primary amine, but the carboxylic acid will need activators such as EDC or HATU.

HY-W800682

Bis-sulfone-PEG4-acid	Biochemical Assay Reagents	Others
Bis-Sulfone-PEG4-acid is a reagent with a sulfone and an acid. The sulfone group can be conjugated with thiol groups of proteins. The terminal acid reacts with primary amines with the help of activators (EDC or HATU) to from stable amide bonds.

HY-W190912

AZD-PEG2-PFP	Biochemical Assay Reagents	Others
AZD-PEG2-PFP is a PEG linker containing an AZD group and a PFP ester group, an activated ester that reacts with primary amines to form amide bonds. The hydrophilic PEG spacer increases solubility in aqueous media.

HY-W800753

2,5-Dioxopyrrolidin-1-yl 6-bromohexanoate	Biochemical Assay Reagents	Others
2,5-Dioxopyrrolidin-1-yl 6-bromohexanoate is an alkane linker with a terminal bromide and an NHS ester. The bromide is a very good leaving group for nucleophilic substitution reactions. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

HY-D1370

BDP TMR amine	Fluorescent Dye
BDP TMR amine is a dye for the TAMRA channel. However, unlike original TAMRA, it has very good quantum yield and therefore high brightness. This derivative contains primary amine groups that can be conjugated to a variety of electrophiles. It can also participate in enzymatic transamination reactions.

HY-W105737

18-Methoxy-18-oxooctadecanoic acid	Biochemical Assay Reagents	Others
18-Methoxy-18-oxooctadecanoic acid is a long alkane linker with a terminal carboxylic acid group. The terminal carboxylic acid group can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.

HY-23629

16-Aminohexadecanoic acid	PROTAC Linkers	Cancer
16-Aminohexadecanoic acid is an alkane chain with terminal carboxlic acid and amine groups. 16-Aminohexadecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.

HY-W401143

15-Aminopentadecanoic acid	PROTAC Linkers	Cancer
15-Aminopentadecanoic Acid can be used as a PROTAC linker in the synthesis of PROTACs. 15-Aminopentadecanoic Acid is an alkane chain with terminal carboxlic acid and amine groups. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.

HY-W111228

Fmoc-9-Aminononanoic acid	PROTAC Linkers	Cancer
Fmoc-9-aminononanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and and other conjugation applications. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W190753

BocNH-PEG8-CH2CH2COONHS	Biochemical Assay Reagents	Others
BocNH-PEG8-CH2CH2COONHS is a PEG linker containing an NHS ester and a Boc-protected amino group. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. The Boc group can be deprotected under mild acidic conditions to form a free amine. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

HY-W700975

12-Ketostearic acid sodium	Biochemical Assay Reagents	Others
12-Ketostearic acid sodium is a synthetic membrane probe that binds to the hydrophobic regions in lipid bilayer membranes. The terminal carboxylic acid can react with primary amine groups to form a stable amide bond.

HY-W800681

Benzyloxy carbonyl-PEG4-acid	Biochemical Assay Reagents	Others
Benzyloxy carbonyl-PEG4-acid is a linker with a benzyl protecting group and a carboxylic acid. The carboxylic acid can undergo reactions with primary amines with the help of activators (EDC or HATU). The benzyl protecting group can be removed via hydrogenolysis.

HY-W800653

N-(Azido-PEG3)-NH-PEG3-t-butyl ester	Biochemical Assay Reagents	Others
N-(Azido-PEG3)-NH-PEG3-t-butyl ester is a click chemistry reagent with a terminal azide group and secondary amine NH group. NH group is reactive with NHS ester, The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The azide group can participate in Click Chemistry.

HY-W800754

8-Bromo-octanoic acid 2,5-dioxo-pyrrolidin-1-yl ester	Biochemical Assay Reagents	Others
8-Bromo-octanoic acid 2,5-dioxo-pyrrolidin-1-yl ester is an alkane linker with a terminal bromide and an NHS ester. The bromide is a very good leaving group for nucleophilic substitution reactions. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

HY-W097110

Fmoc-11-aminoundecanoic acid	PROTAC Linkers	Cancer
Fmoc-11-aminoundecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Fmoc-11-aminoundecanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W591968

14-(Fmoc-amino)-tetradecanoic acid	PROTAC Linkers	Cancer
14-(Fmoc-amino)-tetradecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. 14-(Fmoc-amino)-tetradecanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W009030

N-Fmoc-8-aminooctanoic acid	PROTAC Linkers	Cancer
N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W144703

Heptadecan-9-amine 9-Aminoheptadecane	Biochemical Assay Reagents	Others
Heptadecan-9-amine (9-Aminoheptadecane) is PEG linker containing a maleimide and TFP ester end group. Maleimide groups are reactive with thiols between pH 6.5 and 7.5. The TFP ester can react with primary amine groups and is also less susceptible to undergo hydrolysis compared to NHS ester. The hydrophilic PEG chains increase the water solubility of a compound in aqueous media. Longer PEG chains have improved water solubility relative to shorter PEG chains.

Cat. No.	Product Name	Type

HY-D1372A

Cyanine3 amine TFA	Fluorescent Dyes/Probes
Cyanine3 amine (TFA), an analog of Cyanine3 amine, is a potent green fluorescent dye. Cyanine3 amine (TFA) has the primary amine group and is covalently coupled with reactive groups such as NHS esters, carboxy groups (after carbodiimide activation), and epoxides. (λ_ex=555 nm, λ_em=570 nm) .

HY-111377

Amine-PEG3-Biotin 2 Publications Verification	Chromogenic Assays
Amine-PEG3-Biotin is a signal amplification label containing a biotin group and a terminal primary amine group .

HY-D0715

Fluorescamine Ro 20-7234	Protein Labeling
Fluorescamine is a spirocyclic compound that is non-fluorescent. Fluorescamine reacts rapidly with primary amine groups in proteins under alkaline conditions to generate products with strong fluorescence (Ex/Em : 390/475 nm). Fluorescamine can be used to detect amine-containing compounds, including amino acids, peptides, and proteins .

HY-D0017

Dansyl chloride DNSCl	Protein Labeling
Dansyl chloride is a reagent that produces stable blue or blue-green fluorescent sulfonamide adducts in the reaction of aliphatic and aromatic amines with primary amino groups, and is widely used for modified amino acids, protein sequencing and amino acid analysis .

HY-D1372

Cyanine3 amine hydrochloride	Fluorescent Dyes/Probes
Cyanine3 amine hydrochloride, an analog of Cyanine3 amine, is a potent green fluorescent dye. Cyanine3 amine hydrochloride has the primary amine group and is covalently coupled with reactive groups such as NHS esters, carboxy groups (after carbodiimide activation), and epoxides. (λ_ex=555 nm, λ_em=570 nm) .

HY-D1650

BDP 630/650 carboxylic acid	Fluorescent Dyes/Probes
BDP 630/650 carboxylic acid is a bright far-red fluorophore based on a borondipyrromethene scaffold. BDP 630/650 carboxylic acid is a BDP linker containing carboxylic acid. BDP 630/650 carboxylic acid can react with primary amine groups to form a stable amide bond. (λ_ex=630 nm, λ_em=650 nm) .

HY-D1376A

Sulfo-Cyanine5.5 amine

Fluorescent Dyes/Probes

Sulfo-Cyanine5.5 amine consists of four sulfonate groups and has highly hydrophilic. Sulfo-Cyanine5.5 amine is an amine-containing fluorescent dye, the aliphatic primary amine group can be coupled with various electrophiles (activated esters, epoxides, etc). Sulfo-Cyanine5.5 amine can be used for the research of far red/NIR applications (such as in vivo imaging) and also can be used for enzymatic transamination labeling .

HY-D2741

MB 488 NHS ester	Fluorescent Dyes/Probes
MB 488 NHS ester is a fluroescent agent with a terminal NHS ester group. MB 488 NHS ester is a green fluorescent, very hydrophilic dye molecule that has a maximal absorption of 501 nm and emission at 524 nm. The NHS ester can be applied to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

HY-D1370

BDP TMR amine	Fluorescent Dyes/Probes
BDP TMR amine is a dye for the TAMRA channel. However, unlike original TAMRA, it has very good quantum yield and therefore high brightness. This derivative contains primary amine groups that can be conjugated to a variety of electrophiles. It can also participate in enzymatic transamination reactions.

HY-W585383

BDP TR hydrazide hydrochloride	Fluorescent Dyes/Probes
BDP TR hydrazide is a BDP TR linker with a hydrazide group. The BDP dye is popular for the microscopy and fluorescence polarization assays. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-D1085

AMCA-X SE	Fluorescent Dyes/Probes
AMCA-X-SE is a coumarin derivative that generates fixed blue fluorescence and an NHS-activated ester that forms stable amide bonds with primary amine groups. It is used as a reactive dye for labeling amino groups of peptides, proteins, and oligonucleotides. Maximum excitation/emission wavelength: 354/442 nm .

HY-D1376

Sulfo-Cyanine5.5 amine potassium

Fluorescent Dyes/Probes

Sulfo-Cyanine5.5 amine potassium is a water-soluble cyanine dye suitable for far-red/near-infrared applications such as in vivo imaging. The dye has four sulfonate groups, making it highly hydrophilic and water-soluble. Like other cyanines, sulfo-Cyanine5.5 has an excellent extinction coefficient, making it a bright fluorescent marker in the far-red region. This is an amine-containing fluorescent dye. The amine group is separated from the fluorophore by a relatively long linker that facilitates conjugation. Aliphatic primary amine groups can be coupled with various electrophiles (activated esters, epoxides, etc.) and can also be used for enzymatic transamination labeling.

HY-D1366A

Sulfo-Cyanine5.5 carboxylic acid potassium	Fluorescent Dyes/Probes
Sulfo-Cyanine5.5 carboxylic acid potassium is a fluorescent dye with excitation/emission wavelengths at 673/707 nm. The introduction of the sulfite group enhances the hydrophilic properties of the compound. The terminal carboxylic acid can react with primary amine groups in the presence of activators such as EDC and HATU, to form stable amide bonds.

HY-W585390

BDP 581/591 hydrazide hydrochloride	Fluorescent Dyes/Probes
BDP 581/591 hydrazide hydrochloride is a BDP linker containing a hydrazide. The BDP 581/591 is very photostable. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-D2735

QSY-9-succinimidyl ester

Dyes

QSY-9-succinimidyl ester is a nonfluorescent acceptor molecule with a terminal NHS ester group. QSY-9-succinimidyl ester has a wide and intense quenching range from 500-600 nm that makes it useful as an acceptor in fluorescence resonance energy transfer (FRET) applications in conjunction with fluorescent dyes at 500 nm to 600 nm. The NHS ester can be applied to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

HY-W585384

BDP 558/568 carboxylic acid	Fluorescent Dyes/Probes
BDP 558/568 carboxylic acid is a BDP linker containing a carboxylic acid. The BDP 558/568 has similar excitation and emission wavelengths to Cy3. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-D0715R

Fluorescamine (Standard)

Ro 20-7234 (Standard)

Protein Labeling

Fluorescamine (Standard) is the analytical standard of Fluorescamine (HY-D0715). This product is intended for research and analytical applications. Fluorescamine is a spirocyclic compound that is non-fluorescent. Fluorescamine reacts rapidly with primary amine groups in proteins under alkaline conditions to generate products with strong fluorescence (Ex/Em : 390/475 nm). Fluorescamine can be used to detect amine-containing compounds, including amino acids, peptides, and proteins .

HY-D1169

BDP R6G carboxylic acid	Fluorescent Dyes/Probes
BDP R6G carboxylic acid is a borondipyrromethene dye (Excitation: 530 nM; Emission: 548 nM). BDP R6G carboxylic acid terminal carboxylic acid can react with primary amine groups in the presence of activators to form a stable amide bond, for subsequent labeling reactions like Steglich esterification .

HY-D1656

BDP 581/591 carboxylic acid	Fluorescent Dyes/Probes
BDP 581/591 carboxylic acid is a fluorescent dye (Ex=585 nm, Em=594 nm). BDP 581/591 carboxylic acid has a free carboxylic acid group, which can be catalyzed by a catalyst (such as EDC or HATU) to react with primary amines to form stable amide bonds. BDP 581/591 carboxylic acid is highly photostable and can be used for ROS detection.

HY-D2768

BP Fluor 430 NHS ester

Fluorescent Dyes/Probes

BP Fluor 430 NHS Ester is a water-soluble, green-fluorescent dye that is often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode. BP Fluor 405 conjugates are pH-insensitive from pH 4 to pH 10. The NHS ester (or succinimidyl ester) is the most popular amine reactive group for labeling the primary amines of proteins (Lys), amine-modified oligonucleotides, and other amine-containing molecules. Proteins can be labeled with BP Fluor 430 NHS Ester at high molar ratios without significant self-quenching, leading to brighter conjugates and more sensitive detection.

HY-D2771

BP Fluor 405 NHS ester

Fluorescent Dyes/Probes

BP Fluor 405 NHS Ester is a water-soluble, blue-fluorescent dye that is often used in multi-color applications, including flow cytometry and super-resolution microscopy using STORM. Its excitation is ideally suited for the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode. BP Fluor 405 conjugates are pH-insensitive from pH 4 to pH 10. The NHS ester (or succinimidyl ester) is the most popular amine reactive group for labeling with the primary amines of proteins (Lys), amine-modified oligonucleotides, and other amine-containing molecules. Proteins can be labeled with BP Fluor 405 NHS Ester at high molar ratios without significant self-quenching, leading to brighter conjugates and more sensitive detection. BP Fluor 405 conjugates can also be used for the detection of abundance targets.

HY-131026

Janelia Fluor® 635, SE JF635, SE; JF635, NHS	Dyes
Janelia Fluor® 635, SE (JF635, SE) is a red fluorogenic fluorescent dye containing an NHS ester that can be conjugated with primary amine groups. JF635, SE can be used for live cell imaging . Janelia Fluor® products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-D1653

BDP 581/591 NHS ester

Fluorescent Dyes/Probes

BDP 581/591 NHS ester is a a borondipyrromethene dye (Ex=585 nm, Em=594 nm) that has relatively long fluorescence lifetime and two photon excitation cross section. BDP 581/591 NHS ester can be used for fluorescence polarization analysis and also reacts with reactive oxygen species (ROS) and alter fluorescence. BDP 581/591 NHS ester is also an NHS ester derivative that can be used to bind primary and secondary amine groups of proteins, peptides and other molecules.

HY-131025

Janelia Fluor® 585, SE

JF585, SE; JF585, NHS

Fluorescent Dyes/Probes

Janelia Fluor 585, SE (JF585, SE) is an orange fluorescent dye containing an NHS ester that can be conjugated with primary amine groups. Janelia Fluor 585, SE can be used immediately for structured illumination (SIM) and stimulated emission depletion (STED) imaging and could be converted to photoactivatable derivative for single-molecule localization microscopy (SMLM) experiments . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-133535

PA Janelia Fluor® 646, SE

PA-JF646-NHS

Dyes

PA Janelia Fluor® 646, SE (PA-JF646-NHS), a photoactivatable fluorescent dye, is an NHS ester for coupling to primary amine groups. PA-JF646-NHS is non-fluorescent until activated at 365 nm. NHS ester can be converted to relevant substrate for use in self-labeling tag systems, e.g.HaloTag ^® and SNAP-tag ^®. PA-JF646-NHS is used for single molecule tracking and super resolution microscopy in live cells, specifically live cell sptPALM and fixed cell PALM. (λ_{Excitation/emission}~650/664 nm). Janelia Fluor® products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

Cat. No.	Product Name	Type

HY-D0975

Sulfo-SMCC sodium 4 Publications Verification	Biochemical Assay Reagents
Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.

HY-79647

Fmoc-OSu

N-(Fmoc-oxy)succinimide

Biochemical Assay Reagents

Fmoc-OSu (N-(Fmoc-oxy)succinimide) is an acylating agent that targets amino groups (-NH2). It can selectively protect the amino groups of amino acids by covalently binding with primary or secondary amines through nucleophilic substitution reactions. Fmoc-OSu forms a stable amide bond with the amino group to avoid side reactions of the amino group in peptide synthesis. It can also be used as a fluorescent labeling reagent to react with glycosylamines for efficient labeling of N-sugar chains. Fmoc-OSu can be used as an Fmoc protection strategy in peptide synthesis, and as a fluorescent labeling and analysis method for N-sugar chains .

HY-NP001

Cationic Bovine Serum Albumin

CBSA

Native Proteins

Cationic Bovine Serum Albumin is a bovine serum albumin (BSA) modified with excess ethylenediamine, which has enhanced immunogenicity compared to native BSA. Positively charged primary amines block all negatively charged carboxyl groups, making Cationic Bovine Serum Albumin a cationic protein. Cationic Bovine Serum Albumin has remarkable neuroprotective effects on ischemic stroke when in combination with Tanshinone IIA (HY-N0135) .

HY-Y0623

N-Hydroxysuccinimide

HOSu; 1-Hydroxy-2,5-pyrrolidinedione

Biochemical Assay Reagents

N-Hydroxysuccinimide (HOSu; 1-Hydroxy-2,5-pyrrolidinedione) is a covalent crosslinker commonly used in bioconjugation technology with a primary amine group. N-Hydroxysuccinimide reacts with amino groups (-NH2) to form a stable amide bond, which can modify amino-containing biomolecules. N-Hydroxysuccinimide can be used, for example, for protein labeling with fluorescent dyes and enzymes, surface activation of chromatography supports, microbeads, nanoparticles and microarray slides, and chemical synthesis of peptides. N-Hydroxysuccinimide has a wide range of applications in biomaterial synthesis (such as collagen, chitosan crosslinking), drug delivery systems (such as hydrogel preparation) and tissue engineering .

Cat. No.	Product Name

HY-K0226

CHO Magnetic Beads (200 nm, 10 mg/mL)
MCE CHO Magnetic Beads (200 nm, 10 mg/mL) contain CHO functional groups, which react with primary amines on proteins or other molecules to form stable amide linkages，can covalently immobilize proteins for the affinity purification of antibodies, antigens and other biomolecules.

HY-K0227

NHS Magnetic Beads (200nm, 10 mg/mL)
MCE NHS Magnetic Beads (200 nm, 10 mg/mL) contain N-hydroxysuccinimide (NHS) functional groups, which react with primary amines on proteins or other molecules to form stable amide linkages，can covalently immobilize proteins for the affinity purification of antibodies, antigens and other biomolecules.

Cat. No.	Product Name		Classification

HY-151820

DBCO-PEG24-acid		DBCO
DBCO-PEG24-acid is a click chemistry reagent. DBCO-PEG24-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain allows for increased water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .

HY-151827

DBCO-PEG2-NHS ester		DBCO
DBCO-PEG2-NHS ester is a click chemistry reagent containing an azide group. DBCO-PEG2-NHS ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only .

HY-W591390

6-Azidohexanoic acid STP ester		Azide
6-Azidohexanoic Acid STP Ester is an amine-reactive, water-soluble labeling reagent with an azide group and a terminal 4-Sulfo-2,3,5,6-tetrafluorophenyl (STP) group. 6-Azidohexanoic Acid STP Ester is used to modify proteins, antibodies, and other amine-containing biopolymers in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. STP esters can react with primary amines, forming covalent amide bonds, and typically display much better stability toward hydrolysis in aqueous media, resulting in more efficiency and better reproducible labeling of biopolymers.

HY-151821

Sulfo DBCO-PEG3-acid		DBCO
Sulfo DBCO-PEG3-acid is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .

HY-160773

DBCO-PEG6-NHS ester		DBCO
DBCO-PEG6-NHS ester is a click chemistry PEG reagent containing an NHS ester that reacts specifically with primary amines, such as side chains of lysine residues or aminosilane-coated surfaces, under neutral or slightly alkaline conditions. , efficient reaction to form covalent bonds. DBCO-PEG6-NHS ester also contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups .

HY-148840

Sulfo DBCO-PEG3-NHS ester		DBCO
Sulfo DBCO-PEG3-NHS ester is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-NHS ester is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO group is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .

HY-151769

TCO-PEG2-Sulfo-NHS ester-EDC Urea		Labeling and Fluorescence Imaging TCO
TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent containing an azide group. TCO-PEG2-Sulfo-NHS ester is a PEG linker containing a TCO moiety and a sulfo-NHS ester moiety. The sulfo group makes this molecule soluble in waqueous buffer. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety. Reagent grade, for research use only . TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-151833

Methyltetrazine-amido-N-bis(PEG4-acid)		Tetrazine
Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent containing an azide group. Methyltetrazine-amido-N-bis(PEG4-acid) is a PEG derivative that contains a methyltetrazine group and two acid groups. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. PEG linker increases the water solubility of the compound. Reagent grade, for research use only . Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

Cat. No.	Product Name		Classification

HY-W591461

DSPE-PEG-COOH, MW 2000		Pegylated Lipids
DSPE-PEG-COOH, MW 2000 is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. The terminal carboxylic acid can react with primary amine groups to form a stable amide bond.

HY-W800825

Octadecanedioic acid mono-L-carnitine ester		Cationic Lipids
Octadecanedioic Acid Mono-L-carnitine ester is a cationic lipid which may be used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Its terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.

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