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prenyl

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) AMPK (1) Antibiotic (1) Autophagy (1) Bacterial (3) Cytochrome P450 (1) Farnesyl Transferase (2) GGTase (1) Interleukin Related (1) NF-κB (1) p38 MAPK (1) Phosphodiesterase (PDE) (1) PI3K (1) Ras (1) Reactive Oxygen Species (ROS) (2) Sirtuin (1) SOD (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Endocrinology (1) Infection (3) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (3)

16

Inhibitors & Agonists

2

Peptides

10

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

1-Methoxynaphthalene	Reactive Oxygen Species (ROS)	Others
1-Methoxynaphthalene is used as the substrate to investigate the activity of cytochrome c peroxidase (CcP). 1-Methoxynaphthalene also can be used to synthesize prenyl naphthalen-ols .

Licoflavone C 1 Publications Verification	Others	Cancer
Licoflavone C is a prenyl-flavone extracted from Genista ephedroides, reduces the genotoxicity of cancer agents in human peripheral lymphocytes .

Isobavachin 4 Publications Verification	Autophagy Cytochrome P450 p38 MAPK NF-κB	Neurological Disease
Isobavachin, an antioxidant isaolated from Psoralea corylifolia with a prenyl group at position 8 of ring A, promotes neuronal differentiation and the potential role of its protein prenylation .

Prenyl-IN-1	Farnesyl Transferase GGTase	Neurological Disease
Prenyl-IN-1 is a protein prenylation inhibitor, especially a geranylgeranyltransferase (GGT) or a farnesyltransferase (FT) inhibitor, exhibiting potent activity against oxidative stress, and particularly in the treatment of Parkinson's Disease.

*2-Prenyl-1-naphthol*	Others	Others
2-Prenyl-1-naphthol is a Sesquiterpenoids product that can be isolated from the herbs of Catalpa ovata .

*3-Prenyl-2,4,6-trihydroxybenzophenone*	Others	Others
3-Prenyl-2,4,6-trihydroxybenzophenone is a Xanthones product that can be isolated from the herbs of Garcinia cowa .

*Methyl 1,4-bisglucosyloxy-3-prenyl-2-naphthoate*	Others	Others
Methyl 1,4-bisglucosyloxy-3-prenyl-2-naphthoate is a natural product .

*1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole*	Bacterial Interleukin Related	Infection Inflammation/Immunology
1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole (Compound 19) is a carbazole alkaloid that can be isolated from Murraya koenigii. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole exhibits anti-inflammatory and antimicrobial activities. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole can inhibit the production of pro-inflammatory cytokines TNF-α and IL-6 . 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole has IC₅₀ values of 10.9 μM and 95 μM for Bacillus cereus and Staphylococcus aureus, respectively. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole can be used in the research of inflammatory and infectious diseases .

*3'-Geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone*	Others	Cancer
3'-Geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone displays cytotoxicity of 1.32, 3.92 and 5.22 μm against the human cervical carcinoma HeLa, human breast carcinoma MCF-7, and human hepatocarcinoma Hep3B cells .

Dodoviscin J	Others	Others
Dodoviscin J is a prenyl flavonol derivative can be isolated from the aerial parts of Dodonaea viscosa .

Paenilagicin	Antibiotic Bacterial	Infection
Paenilagicin is a Gram-positive active antibiotic with a unique diphosphorylated prenyl binding mechanism that does not induce drug resistance. Paenilagicin exhibits a MIC value of 2 μg/mL against multidrug-resistant Gram-positive bacteria .

6-Prenylapigenin 6-prenyl-4',5,7-trihydroxyflavone; 6-C-prenylapigenin	Others	Cancer
6-Prenylapigenin is a biologically active flavonoid with anti-tumor activity and antiangiogenic properties. 6-Prenylapigenin exerts cytotoxicity against cancer cells, such as leukemia and solid cancer cells .

NHTD	Ras Phosphodiesterase (PDE)	Cancer
NHTD is a KRAS-PDEδ inhibitor. NHTD targets the prenyl-binding pocket of PDEδ, altering the cellular localization of KRAS, thereby inhibiting the proliferation of KRAS-mutant cancer cells and inducing apoptosis. NHTD can be used for research on KRAS-driven non-small cell lung cancer (NSCLC) .

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

8-Prenylnaringenin 1 Publications Verification	PI3K Akt AMPK Sirtuin Reactive Oxygen Species (ROS) SOD	Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology Cancer
8-Prenylnaringenin is an orally active prenyl flavonoid. 8-Prenylnaringenin can be isolated from the hop spike Humulus lupulus. 8-Prenylnaringenin activates the PI3K/Akt pathway and the AMPK pathway, upregulates OXPHOS complexes (II, III, and V) and Sirt1, and reduces ROS production and SOD activity. 8-Prenylnaringenin improves muscle atrophy and obesity and inhibits angiogenesis. 8-Prenylnaringenin exhibits anticancer activity against glioblastoma and colon cancer. 8-Prenylnaringenin also has LH/FSH regulatory activity. 8-prenylnaringenin may be used in bone health research .

AZD3409 EBP-921	Akt Farnesyl Transferase	Cancer
AZD3409 is a prenyl inhibitor that exhibits inhibitory activity against both farnesyl transferase and geranylgeranyl transferase I. AZD3409 inhibits the growth of breast cancer cells, with IC₅₀s of 220 nM (MDA-MB-468), 180 nM (MDA-MB-361), and 290 nM (SK-Br-3). AZD3409 significantly reduces the activation level of AKT in breast cancer cell lines. AZD3409 induces G0/G1 phase arrest in MDA-MB-468 cells, causes G2/M phase arrest in MDA-MB-361 cells. AZD3409 can be used for the study of breast cancer .

Cat. No.	Product Name	Target	Research Area

Paenilagicin	Antibiotic Bacterial	Infection
Paenilagicin is a Gram-positive active antibiotic with a unique diphosphorylated prenyl binding mechanism that does not induce drug resistance. Paenilagicin exhibits a MIC value of 2 μg/mL against multidrug-resistant Gram-positive bacteria .

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

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