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Ki20227 is an orally active and highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC50s of 2 nM, 12 nM, 451 and 217 nM for CSF1R, VEGFR2 (vascular endothelial growthfactorreceptor-2), c-Kit (stem cell factorreceptor) and PDGFRβ (platelet-derivedgrowthfactorreceptorβ). Ki20227 suppresses osteoclast differentiation and osteolytic bone destruction .
Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derivedgrowthfactorreceptor (PDGFR), with an IC50 of 0.8 μM. Tyrphostin AG1296 inhibits signaling of human PDGF α- and β-receptors as well as of the related stem cell factorreceptor (c-Kit). Tyrphostin AG1296 is also a potent inhibitor of FLT3, with an IC50 in the micromolar range .
PDGFR-IN-1 (compound 7m) is a potent and orally active PDGFR (platelet-derivedgrowthfactorreceptor) inhibitor, with IC50 values of 2.4 and 0.9 nM for PDGFRα and PDGFRβ, respectively. PDGFR-IN-1 displays robust antitumor effects and low toxicity, and can be used to study osteosarcoma .
JNJ-10198409 is a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derivedgrowthfactorreceptor tyrosine kinase) inhibitor (IC50=2 nM). It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent. JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) and PDGFR-α kinase (IC50=45 nM) .
Anti-CD44 Antibody (Hermes-1) is a kind of rat IgG2a, κ chimeric antibody, targeting to human CD44. Anti-CD44 Antibody (Hermes-1) blocks the binding of hyaluronan to CD44. Anti-CD44 Antibody (Hermes-1) restores (Platelet-derivedGrowthFactor-BB)-induced β-receptor activation and motility in fibroblasts. Anti-CD44 Antibody (Hermes-1) causes partial loss of the anti-aging effect of hyaluronic .
Tyrphostin AG1296 (Standard) is the analytical standard of Tyrphostin AG1296. This product is intended for research and analytical applications. Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derivedgrowthfactorreceptor (PDGFR), with an IC50 of 0.8 μM. Tyrphostin AG1296 inhibits signaling of human PDGF α- and β-receptors as well as of the related stem cell factorreceptor (c-Kit). Tyrphostin AG1296 is also a potent inhibitor of FLT3, with an IC50 in the micromolar range .
(rac)-ZK-304709 is an isoform of ZK-304709 and is an orally active multi-targeted tumor growth inhibitor that inhibits multiple cell cycle-dependent kinases (CDKs), vascular endothelial growthfactorreceptor kinases (VEGF-RTKs), and platelet-derivedgrowthfactorreceptor kinase β (PDGF-RTKβ). (rac)-ZK-304709 can dose-dependently inhibit the proliferation and colony formation of neuroendocrine tumor (NET) cells. (rac)-ZK-304709 directly acts on NET cells by inducing G2 cell cycle arrest and apoptosis, while reducing the expression of MCL1, survivin, and HIF1α. (rac)-ZK-304709 effectively controls tumor growth by inducing apoptosis and inhibiting tumor-induced angiogenesis, and may become a potential agent for inhibiting NET .
WQ-C-401 is an orally active platelet-derivedgrowthfactorreceptor (PDGFR) inhibitor. WQ-C-401 inhibits cell proliferation by blocking PDGFR autophosphorylation in a concentration-dependent manner, with EC50 values of 3.5 nM for PDGFRα Y849 and 5.8 nM for PDGFRβ Y1021. Additionally, WQ-C-401 can inhibit PASMCs proliferation and migration by blocking PDGF-BB-induced ERK1/2 phosphorylation, reducing collagen I synthesis, and increasing α-SMA expression, thereby preventing pulmonary vascular remodeling. WQ-C-401 holds promise for research in the field of pulmonary arterial hypertension .
Anti-CD44 Antibody (Hermes-1) is a kind of rat IgG2a, κ chimeric antibody, targeting to human CD44. Anti-CD44 Antibody (Hermes-1) blocks the binding of hyaluronan to CD44. Anti-CD44 Antibody (Hermes-1) restores (Platelet-derivedGrowthFactor-BB)-induced β-receptor activation and motility in fibroblasts. Anti-CD44 Antibody (Hermes-1) causes partial loss of the anti-aging effect of hyaluronic .
PDGF R beta Protein, a receptor tyrosine kinase, binds ligands PDGFA, PDGFB, and PDGFD, forming homodimers or heterodimers.Ligand binding activates diverse signaling cascades in PDGF R beta, with responses contingent on the specific ligand.The modulation of responses involves heterodimer formation with another receptor, PDGFRB.PDGF R beta Protein, Rat (HEK293, His) is the recombinant rat-derived PDGF R beta protein, expressed by HEK293 , with C-His labeled tag.
PDGF R beta Protein, a receptor tyrosine kinase, binds ligands PDGFA, PDGFB, and PDGFD, forming homodimers or heterodimers.Ligand binding activates diverse signaling cascades in PDGF R beta, with responses contingent on the specific ligand.The modulation of responses involves heterodimer formation with another receptor, PDGFRB.PDGF R beta Protein, Rat (HEK293, Fc) is the recombinant rat-derived PDGF R beta protein, expressed by HEK293 , with C-hFc labeled tag.
TRF1 protein is a telomere-binding protein that plays a crucial role in telomere maintenance and chromosome stability. It is involved in regulating telomere length and preventing DNA damage. PDGF R beta Protein, Human (HEK293, His) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-6*His labeled tag.
TRF1 protein is a telomere-binding protein that plays a crucial role in telomere maintenance and chromosome stability. It is involved in regulating telomere length and preventing DNA damage. PDGF R beta Protein, Human (HEK293, Fc) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-hFc labeled tag.
PDGF R beta, a tyrosine-protein kinase receptor, crucially regulates embryonic development, overseeing cell processes like proliferation, survival, differentiation, chemotaxis, and migration. Especially vital in blood vessel development, it facilitates pericyte and smooth muscle cell proliferation, migration, and recruitment to endothelial cells, playing a significant role in blood vessel formation and maintenance. PDGF R beta Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived PDGF R beta protein, expressed by HEK293 , with C-His labeled tag.
PDGF Rβ protein is integral in embryonic development and regulates cell proliferation, survival, differentiation, chemotaxis, migration, and vascular development. It crucially recruits pericytes and smooth muscle cells to the endothelium, promoting vascular smooth muscle cell migration and neointimal formation at the site of injury. PDGF R beta Protein, Human (HEK293, C-His-Avi) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-His, C-Avi labeled tag.
PDGF Rβ protein is integral in embryonic development and regulates cell proliferation, survival, differentiation, chemotaxis, migration, and vascular development. It crucially recruits pericytes and smooth muscle cells to the endothelium, promoting vascular smooth muscle cell migration and neointimal formation at the site of injury. PDGF R beta Protein, Human (Biotinylated, sf9, His, Avi) is the recombinant human-derived PDGF R beta, expressed by Sf9 insect cells , with Avi, His labeled tag. ,
TRF1 protein is a telomere-binding protein that plays a crucial role in telomere maintenance and chromosome stability. It is involved in regulating telomere length and preventing DNA damage. PDGF R beta Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-His labeled tag.
PDGF R beta, a tyrosine-protein kinase receptor, crucially regulates embryonic development, overseeing cell processes like proliferation, survival, differentiation, chemotaxis, and migration. Especially vital in blood vessel development, it facilitates pericyte and smooth muscle cell proliferation, migration, and recruitment to endothelial cells, playing a significant role in blood vessel formation and maintenance. PDGF R beta Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived PDGF R beta protein, expressed by HEK293 , with C-hFc labeled tag.
PDGFRB; PDGFR; PDGFR1; PDGFRβ; platelet-derivedgrowthfactorreceptorbeta; PDGF-R-beta; PDGFR-beta; betaplatelet-derivedgrowthfactorreceptor; beta-type platelet-derivedgrowthfactorreceptor; CD140 antigen-like family member B; platelet-deri
WB, IHC-P, IHC-F, ICC/IF, IP, FC, IF-Tissue, mIHC
Human, Mouse, Rat
PDGF Receptor beta Antibody (YA3467) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3467), targeting PDGFR beta, with a predicted molecular weight of 124 kDa (observed band size: 190 kDa). PDGFR beta Antibody (YA3467) can be used for WB, IHC-P, IHC-Fr, IP, FC, IF-Tissue, IF-Cell, mIHC experiment in human, mouse, rat background.
PDGFRB; PDGFR; PDGFR1; PDGFRβ; platelet-derivedgrowthfactorreceptorbeta; PDGF-R-beta; PDGFR-beta; betaplatelet-derivedgrowthfactorreceptor; beta-type platelet-derivedgrowthfactorreceptor; CD140 antigen-like family member B; platelet-deri
WB, IP
Human, Mouse, Rat
PDGFR beta Antibody (YA1925) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1925), targeting PDGFR beta, with a predicted molecular weight of 124 kDa (observed band size: 190 kDa). PDGFR beta Antibody (YA1925) can be used for WB, IP experiment in human, mouse, rat background.
PDGFRB; PDGFR; PDGFR1; platelet-derivedgrowthfactorreceptorbeta; PDGF-R-beta; PDGFR-beta; betaplatelet-derivedgrowthfactorreceptor; beta-type platelet-derivedgrowthfactorreceptor; CD140 antigen-like family member B; platelet-deri
WB, ICC/IF
Mouse, Rat
Phospho-PDGFR beta (Tyr740) Antibody (YA3062) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3062), targeting Phospho-PDGFR beta (Tyr740), with a predicted molecular weight of 124 kDa (observed band size: 190 kDa). Phospho-PDGFR beta (Tyr740) Antibody (YA3062) can be used for WB, ICC/IF experiment in mouse, rat background.
PDGFRB; PDGFR; PDGFR1; platelet-derivedgrowthfactorreceptorbeta; PDGF-R-beta; PDGFR-beta; betaplatelet-derivedgrowthfactorreceptor; beta-type platelet-derivedgrowthfactorreceptor; CD140 antigen-like family member B; platelet-deri
WB, ELISA
Human, Mouse
PDGFR-β Antibody (YA5012) is a mouse-derived and non-conjugated monoclonal antibody, targeting to PDGFR-β. It can be applicated for WB, ELISA assays, in the background of human, mouse.
PDGFRB; PDGFR; PDGFR1; platelet-derivedgrowthfactorreceptorbeta; PDGF-R-beta; PDGFR-beta; betaplatelet-derivedgrowthfactorreceptor; beta-type platelet-derivedgrowthfactorreceptor; CD140 antigen-like family member B; platelet-deri
WB, IHC-P, ICC/IF, IP, ELISA
Human, Mouse, Rat
PDGFR-β Antibody (YA6019) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PDGFR-β. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.
