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Pathways Recommended:	TGF-beta/Smad

Results for "

platelet-derived growth factor receptor beta

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PDGFR (7) VEGFR (3) Apoptosis (3) c-Fms (1) c-Kit (3) CDK (1) Drug Isomer (1) ERK (1) FLT3 (1) RET (1) Survivin (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Inflammation/Immunology (2)
Oligonucleotides:	Aptamers (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: PDGFR Platelet-activating Factor Receptor (PAFR) TGF-β Receptor TGF-beta/Smad GDNF Receptor FGFR GHR VEGFR Amyloid-β GHSR EGFR IGF-1R Beta-secretase β-glucuronidase 17β-HSD β-catenin 11β-HSD Beta-lactamase Dopamine β-hydroxylase Nuclear Hormone Receptor 4A/NR4A

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108627

DMPQ dihydrochloride	PDGFR	Others
DMPQ dihydrochloride is a potent and selective inhibitor of human platelet-derived growth factor receptor β (PDGFRβ) with an IC₅₀ of 80 nM .

HY-10408

Ki20227 5 Publications Verification	c-Fms VEGFR c-Kit PDGFR	Inflammation/Immunology
Ki20227 is an orally active and highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC₅₀s of 2 nM, 12 nM, 451 and 217 nM for CSF1R, VEGFR2 (vascular endothelial growth factor receptor-2), c-Kit (stem cell factor receptor) and PDGFRβ (platelet-derived growth factor receptor β). Ki20227 suppresses osteoclast differentiation and osteolytic bone destruction .

HY-13894

Tyrphostin AG1296 2 Publications Verification AG1296	PDGFR c-Kit FLT3 Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC₅₀ of 0.8 μM. Tyrphostin AG1296 inhibits signaling of human PDGF α- and *β-receptors* as well as of the related *stem cell factor* receptor (c-Kit). Tyrphostin AG1296 is also a potent inhibitor of FLT3, with an IC₅₀** in the micromolar range .

HY-144653

PDGFR-IN-1	PDGFR Apoptosis	Cancer
PDGFR-IN-1 (compound 7m) is a potent and orally active PDGFR (platelet-derived growth factor receptor) inhibitor, with IC₅₀ values of 2.4 and 0.9 nM for PDGFRα and PDGFRβ, respectively. PDGFR-IN-1 displays robust antitumor effects and low toxicity, and can be used to study osteosarcoma .

HY-116116

Tafetinib SIM010603	c-Kit RET VEGFR	Cancer
Tafetinib (SIM010603) is an oral multi-targets receptor tyrosine kinases inhibitor. Tafetinib inhibitsstem cell factor receptor (Kit),vascular endothelial growth factor receptor-2 (VEGFR-2),platelet-derived **growth factor receptor-β (PDGFR-β),glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET)**, andFms-like tyrosine kinase-3 (FLT3)withIC₅₀values between 5.0 and 68.1 nmol/l. Tafetinib inhibits the phosphorylation ofPDGFR-βandVEGFR-2. Tafetinib inhibits endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis .

HY-W011266

JNJ-10198409 1 Publications Verification	PDGFR	Cancer
JNJ-10198409 is a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor (IC₅₀=2 nM). It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent. JNJ-10198409 has good activity against *PDGFR-β* kinase (IC₅₀=4.2 nM) and PDGFR-α kinase (IC₅₀=45 nM) .

HY-160053

Gint4.T aptamer sodium	PDGFR	Cancer
Gint4.T aptamer sodium is a nuclease-resistant RNA aptamer-based antagonist targeting platelet-derived growth factor receptor beta (PDGFRβ) (Kd: 9.6 nM). Gint4.T aptamer sodium inhibits PDGFRβ heterodimerization and EGFR transactivation. It can significantly inhibit cell migration and proliferation, induce differentiation and prevent tumor growth in vivo. Gint4.T aptamer sodium specifically inhibits PDGFRβ-mediated tropism of mesenchymal stem cells (MSCs) toward the tumor microenvironment .

HY-19471

(rac)-ZK-304709	Drug Isomer CDK VEGFR Survivin Apoptosis	Cancer
(rac)-ZK-304709 is an isoform of ZK-304709 and is an orally active multi-targeted tumor growth inhibitor that inhibits multiple cell cycle-dependent kinases (CDKs), vascular endothelial growth factor receptor kinases (VEGF-RTKs), and platelet-derived growth factor receptor kinase β (PDGF-RTKβ). (rac)-ZK-304709 can dose-dependently inhibit the proliferation and colony formation of neuroendocrine tumor (NET) cells. (rac)-ZK-304709 directly acts on NET cells by inducing G2 cell cycle arrest and apoptosis, while reducing the expression of MCL1, survivin, and HIF1α. (rac)-ZK-304709 effectively controls tumor growth by inducing apoptosis and inhibiting tumor-induced angiogenesis, and may become a potential agent for inhibiting NET .

HY-162888

WQ-C-401	PDGFR ERK	Cardiovascular Disease
WQ-C-401 is an orally active platelet-derived growth factor receptor (PDGFR) inhibitor. WQ-C-401 inhibits cell proliferation by blocking PDGFR autophosphorylation in a concentration-dependent manner, with EC₅₀ values of 3.5 nM for PDGFRα Y849 and 5.8 nM for PDGFRβ Y1021. Additionally, WQ-C-401 can inhibit PASMCs proliferation and migration by blocking PDGF-BB-induced ERK1/2 phosphorylation, reducing collagen I synthesis, and increasing α-SMA expression, thereby preventing pulmonary vascular remodeling. WQ-C-401 holds promise for research in the field of pulmonary arterial hypertension .

Species:	Human (5) Rhesus Macaque (2) Rat (2) Cynomolgus (1)
Tag:	His (7) Avi (2) Fc (3)
Source:	HEK293 (9) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P73360

	PDGF R beta Protein, Rat (HEK293, His) platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB	Rat	HEK293
	PDGF R beta Protein, a receptor tyrosine kinase, binds ligands PDGFA, PDGFB, and PDGFD, forming homodimers or heterodimers.Ligand binding activates diverse signaling cascades in PDGF R beta, with responses contingent on the specific ligand.The modulation of responses involves heterodimer formation with another receptor, PDGFRB.PDGF R beta Protein, Rat (HEK293, His) is the recombinant rat-derived PDGF R beta protein, expressed by HEK293 , with C-His labeled tag.

HY-P74644

	PDGF R beta Protein, Rat (HEK293, Fc) platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB	Rat	HEK293
	PDGF R beta Protein, a receptor tyrosine kinase, binds ligands PDGFA, PDGFB, and PDGFD, forming homodimers or heterodimers.Ligand binding activates diverse signaling cascades in PDGF R beta, with responses contingent on the specific ligand.The modulation of responses involves heterodimer formation with another receptor, PDGFRB.PDGF R beta Protein, Rat (HEK293, Fc) is the recombinant rat-derived PDGF R beta protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72494

	PDGF R beta Protein, Human (HEK293, His) platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB	Human	HEK293
	TRF1 protein is a telomere-binding protein that plays a crucial role in telomere maintenance and chromosome stability. It is involved in regulating telomere length and preventing DNA damage. PDGF R beta Protein, Human (HEK293, His) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P77124

	PDGF R beta Protein, Human (HEK293, Fc) platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB	Human	HEK293
	TRF1 protein is a telomere-binding protein that plays a crucial role in telomere maintenance and chromosome stability. It is involved in regulating telomere length and preventing DNA damage. PDGF R beta Protein, Human (HEK293, Fc) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P77129

	PDGF R beta Protein, Rhesus Macaque (HEK293, His) platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB	Rhesus Macaque	HEK293
	PDGF R beta, a tyrosine-protein kinase receptor, crucially regulates embryonic development, overseeing cell processes like proliferation, survival, differentiation, chemotaxis, and migration. Especially vital in blood vessel development, it facilitates pericyte and smooth muscle cell proliferation, migration, and recruitment to endothelial cells, playing a significant role in blood vessel formation and maintenance. PDGF R beta Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived PDGF R beta protein, expressed by HEK293 , with C-His labeled tag.

HY-P77123

	PDGF R beta Protein, Human (HEK293, C-His-Avi) platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB	Human	HEK293
	PDGF Rβ protein is integral in embryonic development and regulates cell proliferation, survival, differentiation, chemotaxis, migration, and vascular development. It crucially recruits pericytes and smooth muscle cells to the endothelium, promoting vascular smooth muscle cell migration and neointimal formation at the site of injury. PDGF R beta Protein, Human (HEK293, C-His-Avi) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-His, C-Avi labeled tag.

HY-P702756

	PDGF R beta Protein, Human (Biotinylated, sf9, His, Avi) PDGFRB; platelet-derived growth factor receptor, beta polypeptide; PDGFR; platelet-derived growth factor receptor beta; CD140b; JTK12; PDGFR1; PDGFR-beta; PDGF-R-beta; CD140 antigen-like family member B; platelet-derived growth factor receptor 1; beta-type platelet-derived growth factor receptor; CD140B; PDGFR-1	Human	Sf9 insect cells
	PDGF Rβ protein is integral in embryonic development and regulates cell proliferation, survival, differentiation, chemotaxis, migration, and vascular development. It crucially recruits pericytes and smooth muscle cells to the endothelium, promoting vascular smooth muscle cell migration and neointimal formation at the site of injury. PDGF R beta Protein, Human (Biotinylated, sf9, His, Avi) is the recombinant human-derived PDGF R beta, expressed by Sf9 insect cells , with Avi, His labeled tag. ,

HY-P703816

	PDGF R beta Protein, Cynomolgus (HEK293, His) platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB	Cynomolgus	HEK293

HY-P77127

	PDGF R beta Protein, Human (Biotinylated, HEK293, His) platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB	Human	HEK293
	TRF1 protein is a telomere-binding protein that plays a crucial role in telomere maintenance and chromosome stability. It is involved in regulating telomere length and preventing DNA damage. PDGF R beta Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-His labeled tag.

HY-P77128

	PDGF R beta Protein, Rhesus Macaque (HEK293, Fc) platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-1; CD140b; PDGFRB	Rhesus Macaque	HEK293
	PDGF R beta, a tyrosine-protein kinase receptor, crucially regulates embryonic development, overseeing cell processes like proliferation, survival, differentiation, chemotaxis, and migration. Especially vital in blood vessel development, it facilitates pericyte and smooth muscle cell proliferation, migration, and recruitment to endothelial cells, playing a significant role in blood vessel formation and maintenance. PDGF R beta Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived PDGF R beta protein, expressed by HEK293 , with C-hFc labeled tag.

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Species
Source
Tag
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HY-P82180

	PDGFR beta Antibody (YA1925) PDGFRB; PDGFR; PDGFR1; PDGFRβ; platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; platelet-deri	WB, IP	Human, Mouse, Rat
	PDGFR beta Antibody (YA1925) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1925), targeting PDGFR beta, with a predicted molecular weight of 124 kDa (observed band size: 190 kDa). PDGFR beta Antibody (YA1925) can be used for WB, IP experiment in human, mouse, rat background.

HY-P83317

	Phospho-PDGFR beta (Tyr740) Antibody (YA3062) PDGFRB; PDGFR; PDGFR1; platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; platelet-deri	WB, ICC/IF	Mouse, Rat
	Phospho-PDGFR beta (Tyr740) Antibody (YA3062) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3062), targeting Phospho-PDGFR beta (Tyr740), with a predicted molecular weight of 124 kDa (observed band size: 190 kDa). Phospho-PDGFR beta (Tyr740) Antibody (YA3062) can be used for WB, ICC/IF experiment in mouse, rat background.

HY-P83737

	PDGF Receptor beta Antibody (YA3467) PDGFRB; PDGFR; PDGFR1; PDGFRβ; platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; platelet-deri	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	PDGF Receptor beta Antibody (YA3467) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3467), targeting PDGFR beta, with a predicted molecular weight of 124 kDa (observed band size: 190 kDa). PDGFR beta Antibody (YA3467) can be used for WB, IHC-P, IP, FC, IF-Tissue, IF-Cell, mIHC experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-160053

Gint4.T aptamer sodium		Aptamers
Gint4.T aptamer sodium is a nuclease-resistant RNA aptamer-based antagonist targeting platelet-derived growth factor receptor beta (PDGFRβ) (Kd: 9.6 nM). Gint4.T aptamer sodium inhibits PDGFRβ heterodimerization and EGFR transactivation. It can significantly inhibit cell migration and proliferation, induce differentiation and prevent tumor growth in vivo. Gint4.T aptamer sodium specifically inhibits PDGFRβ-mediated tropism of mesenchymal stem cells (MSCs) toward the tumor microenvironment .

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