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Results for "

periodontitis

" in MedChemExpress (MCE) Product Catalog:

37

Inhibitors & Agonists

2

Biochemical Assay Reagents

8

Peptides

6

Natural
Products

4

Isotope-Labeled Compounds

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P1717B
    AMY-101 acetate
    4 Publications Verification

    Cp40 acetate

    		 Complement System SARS-CoV Inflammation/Immunology
    AMY-101 acetate (Cp40 acetate), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 acetate (Cp40 acetate) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation .
    AMY-101 acetate
  • HY-P1717A
    AMY-101 TFA
    4 Publications Verification

    Cp40 TFA

    		 Complement System SARS-CoV Inflammation/Immunology
    AMY-101 TFA (Cp40 TFA), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation .
    AMY-101 TFA
  • HY-P1717
    AMY-101
    4 Publications Verification

    Cp40

    		 Complement System SARS-CoV Inflammation/Immunology
    AMY-101 (Cp40), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation .
    AMY-101
  • HY-B0330A
    Levofloxacin hydrate
    Maximum Cited Publications
    21 Publications Verification

    Levofloxacin hemihydrate

    		 Bacterial Antibiotic Topoisomerase DNA/RNA Synthesis Orthopoxvirus Infection Cancer
    Levofloxacin hydrate (Levofloxacin hemihydrate) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrate inhibits the DNA gyrase and topoisomerase IV. Levofloxacin hydrate can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin hydrate shows anti-orthopoxvirus activity .
    Levofloxacin hydrate
  • HY-B0330
    Levofloxacin
    Maximum Cited Publications
    21 Publications Verification

    (-)-Ofloxacin

    		 Topoisomerase DNA/RNA Synthesis Antibiotic Bacterial Orthopoxvirus Infection Cancer
    Levofloxacin ((-)-Ofloxacin) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin inhibits the DNA gyrase and topoisomerase IV. Levofloxacin can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin shows anti-orthopoxvirus activity .
    Levofloxacin
  • HY-113721
    BML-244

    		Cathepsin Inflammation/Immunology
    BML-244 is a potent cathepsin K inhibitor. BML-244 can be used in the study of rheumatoid arthritis (RA) and periodontitis .
    BML-244
  • HY-N12740
    Napyradiomycin B4

    		MEK ERK Others
    Napyradiomycin B4 is a Napyradiomycin derivative, which inhibits the RANKL-induced MEK-ERK signaling pathway. Napyradiomycin B4 attenuates osteoclastogenesis and prevents alveolar bone destruction in experimental periodontitis .
    Napyradiomycin B4
  • HY-162280
    PROTAC BTK Degrader-9

    		PROTACs RANKL/RANK Nuclear Factor of activated T Cells (NFAT) Btk Cancer
    PROTAC BTK Degrader-9 (compound 23) is a PROTAC degrader that effectively targets BTK. PROTAC BTK Degrader-9 downregulates the BTK-PLCγ2-Ca 2+-NFATc1 signaling pathway activated by RANKL. Thus, PROTAC BTK Degrader-9 was able to inhibit osteoclastogenesis and attenuate alveolar bone resorption in a mouse periodontitis model .
    PROTAC BTK Degrader-9
  • HY-W338859
    Levofloxacin mesylate

    		Bacterial Topoisomerase Antibiotic Infection Cancer
    Levofloxacin mesylate is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin mesylate inhibits the DNA gyrase and topoisomerase IV. Levofloxacin mesylate can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin mesylate shows anti-orthopoxvirus activity .
    Levofloxacin mesylate
  • HY-B0330C
    Levofloxacin sodium

    (-)-Ofloxacin sodium

    		 Antibiotic Orthopoxvirus Bacterial DNA/RNA Synthesis Topoisomerase Infection Inflammation/Immunology Cancer
    Levofloxacin ((-)-Ofloxacin) sodium is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin sodium inhibits the DNA gyrase and topoisomerase IV. Levofloxacin sodium can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin sodium shows anti-orthopoxvirus activity .
    Levofloxacin sodium
  • HY-B0330AR
    Levofloxacin hydrate (Standard)

    Levofloxacin hemihydrate (Standard)

    		 Reference Standards Bacterial Antibiotic Topoisomerase DNA/RNA Synthesis Orthopoxvirus Infection Cancer
    Levofloxacin (hydrate) (Standard) is the analytical standard of Levofloxacin (hydrate). This product is intended for research and analytical applications. Levofloxacin hydrate (Levofloxacin hemihydrate) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrate inhibits the DNA gyrase and topoisomerase IV. Levofloxacin hydrate can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin hydrate shows anti-orthopoxvirus activity .
    Levofloxacin hydrate (Standard)
  • HY-B0330R
    Levofloxacin (Standard)
    15+ Cited Publications

    (-)-Ofloxacin (Standard)

    		 Antibiotic DNA/RNA Synthesis Orthopoxvirus Topoisomerase Bacterial Reference Standards Infection Cancer
    Levofloxacin (Standard) is the analytical standard of Levofloxacin. This product is intended for research and analytical applications. Levofloxacin ((-)-Ofloxacin) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin inhibits the DNA gyrase and topoisomerase IV. Levofloxacin can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin shows anti-orthopoxvirus activity .
    Levofloxacin (Standard)
  • HY-B0330B
    Levofloxacin hydrochloride
    Maximum Cited Publications
    21 Publications Verification

    (-)-Ofloxacin hydrochloride

    		 Antibiotic Bacterial DNA/RNA Synthesis Topoisomerase Orthopoxvirus Apoptosis Infection Neurological Disease Cancer
    Levofloxacin hydrochloride is an orally active antibiotic. Levofloxacin inhibits DNA gyrase and topoisomerase IV activity, inducing Apoptosis. Levofloxacin hydrochloride has antibacterial activity against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrochloride exhibits anticancer activity against lung cancer. Levofloxacin hydrochloride has anti-acnegenic, anxiogenic, and analgesic effects. Levofloxacin hydrochloride shortens sleep duration in mice. Levofloxacin hydrochloride can be used in the research of infectious diseases (such as tuberculosis, chronic periodontitis, bacterial infections associated with stable COPD, and BK viremia) and lung cancer .
    Levofloxacin hydrochloride
  • HY-N10059
    Quebecol

    		Others Inflammation/Immunology
    Quebecol is a nutraceutical agent against periodontitis.
    Quebecol
  • HY-B0330BR
    Levofloxacin hydrochloride (Standard)

    (-)-Ofloxacin hydrochloride (Standard)

    		 Reference Standards Antibiotic Bacterial DNA/RNA Synthesis Topoisomerase Orthopoxvirus Apoptosis Infection Neurological Disease Cancer
    Levofloxacin (hydrochloride) (Standard) is the analytical standard of Levofloxacin hydrochloride (HY-B0330B). This product is intended for research and analytical applications. Levofloxacin hydrochloride is an orally active antibiotic. Levofloxacin inhibits DNA gyrase and topoisomerase IV activity, inducing Apoptosis. Levofloxacin hydrochloride has antibacterial activity against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrochloride exhibits anticancer activity against lung cancer. Levofloxacin hydrochloride has anti-acnegenic, anxiogenic, and analgesic effects. Levofloxacin hydrochloride shortens sleep duration in mice. Levofloxacin hydrochloride can be used in the research of infectious diseases (such as tuberculosis, chronic periodontitis, bacterial infections associated with stable COPD, and BK viremia) and lung cancer .
    Levofloxacin hydrochloride (Standard)
  • HY-N0753
    Eupalinolide B

    		Others Apoptosis Autophagy Reactive Oxygen Species (ROS) GSK-3 β-catenin MAP3K JNK NF-κB p38 MAPK Neurological Disease Inflammation/Immunology Cancer
    Eupalinolide B is a germ sesquiterpene. Eupalinolide B can be isolated from Eupatorium lindleyanum. Eupalinolide B induces Apoptosis, elevates ROS, promotes Autophagy. regulates GSK-3β/β-catenin, targets UBE2D3 and TAK1, activates ROS-ER-JNK, inhibits NF-κB and MAPKs. Eupalinolide B has anticancer activity against pancreatic cancer and liver cancer. Eupalinolide B relieves rheumatoid arthritis, acute lung injury, periodontitis, depression .
    Eupalinolide B
  • HY-138454
    MEG hemisulfate

    Mercaptoethylguanidine hemisulfate

    		 NO Synthase Inflammation/Immunology
    MEG (Mercaptoethylguanidine) hemisulfate is a potent and selective inhibitor of the inducible NO synthase (iNOS), with EC50s of 11.5, 110, and 60 μM for iNOS, ecNOS, and bNOS respectively in tissue homogenates. MEG hemisulfate is also a potent scavenger of peroxynitrite and inhibits peroxynitrite-induced oxidative processes. MEG hemisulfate has a protective effect in many experimental models of inflammation, including ischemia/reperfusion injury, periodontitis, hemorrhagic shock, inflammatory bowel disease, and endotoxic and septic shock .
    MEG hemisulfate
  • HY-P3567
    (p-Iodo-Phe7)-ACTH (4-10)

    		Melanocortin Receptor Neurological Disease
    (p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats .
    (p-Iodo-Phe7)-ACTH (4-10)
  • HY-P2434
    AP102

    		Somatostatin Receptor Neurological Disease Metabolic Disease Cancer
    AP102 is a dual SSTR2/SSTR5-specific somatostatin analog (SSA). AP102 is a disulfide-bridged octapeptide SSA containing synthetic iodinated amino acids. AP102 binds with subnanomolar affinity to SSTR2 and SSTR5 (IC50: 0.63 and 0.65 nM, respectively). AP102 does not bind to SSTR1 or SSTR3. AP102 can be used for acromegaly and neuroendocrine tumors research .
    AP102
  • HY-W004294
    1-Tetradecanol

    		Bacterial Interleukin Related Infection Inflammation/Immunology Endocrinology
    1-Tetradecanol is a straight-chain saturated fatty alcohol and antibacterial agent. 1-Tetradecanol can be isolated from Myristica fragrans. 1-Tetradecanol possesses antibacterial and anti-inflammatory (periodontitis) activity .
    1-Tetradecanol
  • HY-W004294S1
    1-Tetradecanol-d2

    		Bacterial Infection
    1-Tetradecanol-d2 is the deuterium labeled 1-Tetradecanol . 1-Tetradecanol, isolated from Myristica fragrans, is a straight-chain saturated fatty alcohol. 1-Tetradecanol possesses antibacterial and anti-inflammatory (periodontitis) activity .
    1-Tetradecanol-d2
  • HY-W004294S
    1-Tetradecanol-d29

    		Bacterial Infection
    1-Tetradecanol-d29 is the deuterium labeled 1-Tetradecanol . 1-Tetradecanol, isolated from Myristica fragrans, is a straight-chain saturated fatty alcohol. 1-Tetradecanol possesses antibacterial and anti-inflammatory (periodontitis) activity .
    1-Tetradecanol-d29
  • HY-W004294R
    1-Tetradecanol (Standard)

    		Reference Standards Bacterial Infection Inflammation/Immunology
    1-Tetradecanol (Standard) is the analytical standard of 1-Tetradecanol. This product is intended for research and analytical applications. 1-Tetradecanol, isolated from Myristica fragrans, is a straight-chain saturated fatty alcohol. 1-Tetradecanol possesses antibacterial and anti-inflammatory (periodontitis) activity .
    1-Tetradecanol (Standard)
  • HY-N3831
    Epimedokoreanin B

    		Bacterial Apoptosis Infection Inflammation/Immunology Cancer
    Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation .
    Epimedokoreanin B
  • HY-100210A
    FN-439 TFA

    		MMP Inflammation/Immunology Cancer
    FN-439 TFA is a selective collagenase-1 inhibitor. FN-439 TFA inhibits collagenase-1 with an IC50 value of 1 μM. FN-439 TFA can be used for the research of cancer and inflammation .
    FN-439 TFA
  • HY-100210
    FN-439

    		MMP Inflammation/Immunology Cancer
    FN-439 is a selective collagenase-1 inhibitor. FN-439 inhibits collagenase-1 with an IC50 value of 1 μM. FN-439 can be used for the research of cancer and inflammation .
    FN-439
  • HY-B0330BS1
    Levofloxacin-d3 hydrochloride

    (-)-Ofloxacin-d3 hydrochloride

    		 Isotope-Labeled Compounds Antibiotic Bacterial Topoisomerase DNA/RNA Synthesis Orthopoxvirus Infection Cancer
    Levofloxacin-d3 ((-)-Ofloxacin-d3) hydrochlorideis deuterium labeled Levofloxacin (hydrochloride). Levofloxacin ((-)-Ofloxacin) hydrochloride is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrochloride inhibits the DNA gyrase and topoisomerase IV. Levofloxacin hydrochloride can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin hydrochloride shows anti-orthopoxvirus activity .
    Levofloxacin-d3 hydrochloride
  • HY-W110551
    2-Methacryloyloxyethyl phosphorylcholine

    		Biochemical Assay Reagents Interleukin Related Infection Inflammation/Immunology
    2-Methacryloyloxyethyl phosphorylcholine is a polymer monomer containing a phospholipid polar group. 2-Methacryloyloxyethyl phosphorylcholine polymers modify the surface properties of materials and reduce protein-surface interactions, reduce IL-8 production, inhibit cell, Staphylococcus aureus, and Porphyromonas gingivalis adhesion. 2-Methacryloyloxyethyl phosphorylcholine is used in the study of medical device-associated infections, periodontitis, and dental caries .
    2-Methacryloyloxyethyl phosphorylcholine
  • HY-W744235
    Levofloxacin-d3 sodium

    		Isotope-Labeled Compounds Topoisomerase Bacterial DNA/RNA Synthesis Antibiotic Orthopoxvirus Infection Inflammation/Immunology Cancer
    Levofloxacin-d3 sodium is the deuterium labeled Levofloxacin sodium (HY-B0330C). Levofloxacin ((-)-Ofloxacin) sodium is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin sodium inhibits the DNA gyrase and topoisomerase IV. Levofloxacin sodium can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin sodium shows anti-orthopoxvirus activity .
    Levofloxacin-d3 sodium
  • HY-15028
    Otenaproxesul

    ATB-346

    		 COX Apoptosis Inflammation/Immunology
    Otenaproxesul (ATB-346), an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2). Otenaproxesul possesses antiinflammatory and antinociceptive activities .
    Otenaproxesul
  • HY-15028R
    Otenaproxesul (Standard)

    		COX Apoptosis Inflammation/Immunology
    Otenaproxesul (Standard) is the analytical standard of Otenaproxesul. This product is intended for research and analytical applications. Otenaproxesul (ATB-346), an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2). Otenaproxesul possesses antiinflammatory and antinociceptive activities .
    Otenaproxesul (Standard)
  • HY-P1789A
    CTTHWGFTLC, CYCLIC TFA

    		MMP Inflammation/Immunology Cancer
    CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC50 value for MMP-9 is ~8 μM .
    CTTHWGFTLC, CYCLIC TFA
  • HY-P1789
    CTTHWGFTLC, CYCLIC

    		MMP Inflammation/Immunology Cancer
    CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC50 value for MMP-9 is ~8 μM .
    CTTHWGFTLC, CYCLIC
  • HY-D1056D
    Lipopolysaccharides, from P. gingivalis
    1 Publications Verification

    LPS, from Porphyromonas gingivalis

    		 Toll-like Receptor (TLR) Inflammation/Immunology
    Lipopolysaccharides, from P. gingivalis (LPS, from Porphyromonas gingivalis) are endotoxins and TLR4 activators extracted from Porphyromonas gingivalis (P. gingivalis) and are classified as S (smooth) type LPS. Lipopolysaccharides, from P. gingivalis possess the typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from P. gingivalis activate TLR-4 in immune cells and are important virulence factors in the mechanism of periodontal disease. Lipopolysaccharides, from P. gingivalis can be used in research related to periodontitis .
    It is recommended to prepare a stock solution of ≥2 mg/mL and ensure that it is fully mixed and dissolved. Due to the adsorption characteristics of LPS, low adsorption centrifuge tubes should be used for aliquoting and storage.
    Lipopolysaccharides, from P. gingivalis
  • HY-12725
    ML324
    5+ Cited Publications

    		 Histone Demethylase HSV CMV Cancer
    ML324 is a potent JMJD2 demethylase inhibitor with antiviral activity. ML324 also exhibits inhibition for the histone demethylase KDM4B, with an IC50 of 4.9 μM. ML324 has potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression .
    ML324
  • HY-A0020
    Eldecalcitol
    3 Publications Verification

    ED-71; 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3

    		 VD/VDR Apoptosis Metabolic Disease Inflammation/Immunology Cancer
    Eldecalcitol (ED-71) is an orally active vitamin D3 analogue, inhibits bone resorption and increases bone mineral density. Eldecalcitol (ED-71) displays anti-tumor effect and inhibits cell proliferation, migration and induces apoptosis by suppressing GPx-1 .
    Eldecalcitol
  • HY-A0020R
    Eldecalcitol (Standard)

    ED-71 (Standard); 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 (Standard)

    		 Reference Standards VD/VDR Apoptosis Metabolic Disease Inflammation/Immunology Cancer
    Eldecalcitol (Standard) is the analytical standard of Eldecalcitol. This product is intended for research and analytical applications. Eldecalcitol (ED-71) is an orally active vitamin D3 analogue, inhibits bone resorption and increases bone mineral density. Eldecalcitol (ED-71) displays anti-tumor effect and inhibits cell proliferation, migration and induces apoptosis by suppressing GPx-1 .
    Eldecalcitol (Standard)

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