Search Result
        
        
            
                Results for "
peptide drug conjugate
" in MedChemExpress (MCE) Product Catalog:
            
         
        
        
            
                
            
            
            
                
            
            
                
                    10
Biochemical Assay Reagents
 
            
            
                
            
            
            
                
            
            
                
            
            
            
                
                    4
Isotope-Labeled Compounds
 
            
            
            
                
            
            
                
            
         
        
            
            
                
                    
                    
                        
                            | Cat. No. | Product Name | Target | Research Areas | Chemical Structure | 
                    
                    
                        
                            
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                                    - HY-P10741
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                                    - HY-19813A
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                                                |  | Drug-Linker Conjugates for ADC | Cancer |  
                                                | mDPR-Val-Cit-PAB-MMAE TFA is a drug-linker conjugate for ADC (Drug-Linker Conjugates for ADC), consisting of a tubulin polymerization inhibitor MMAE (HY-15162) and an ADC linker (peptide Val-Cit- PAB) composition [1] . |  
 
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                                    - HY-106244A
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                                                |  | Radionuclide-Drug Conjugates (RDCs) | Cancer |  
                                                | DOTATATE acetate is a DOTA-conjugated peptide. DOTATATE acetate can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT)    . DOTATATE (acetate) can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). |  
 
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                                    - HY-106244
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                                                |  | Radionuclide-Drug Conjugates (RDCs) | Cancer |  
                                                | DOTATATE is a DOTA-conjugated peptide. DOTATATE can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT)    . DOTATATE can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). |  
 
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                                    - HY-P10895
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                                                |  | Biochemical Assay Reagents | Others |  
                                                | HR97 TFA is a cell-penetrating peptide that can be combined with engineered melanin to prepare eye drops HR97-SunitiGel. The peptide-drug conjugate in HR97-SunitiGel can provide sustained ocular drug delivery . |  
 
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                                    - HY-147021
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                                                |  | ADC Linker | Cancer |  
                                                | MC-Val-D-Cit-PAB-PNP is a cleavable peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). MC-Val-D-Cit-PAB-PNP contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-nitrophenol (PNP) group that allows the peptide to be linked to antitumor compounds. |  
 
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                                    - HY-129360
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                                                |  | ADC Linker | Cancer |  
                                                | Ala-Ala-Asn-PAB is a peptide cleavable ADC linker for antibody-drug conjugates (ADCs) . |  
 
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                                    - HY-129360A
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                                                |  | ADC Linker | Cancer |  
                                                | Ala-Ala-Asn-PAB TFA is a peptide cleavable ADC linker for antibody-drug conjugates (ADCs) . |  
 
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                                    - HY-P11315
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                                                |  | Biochemical Assay Reagents | Neurological Disease |  
                                                | MG1 peptide is a M1 Microglia-targeting peptide. MG1 peptide can conjugate to anoparticles, crossing the BBB to precisely M1 microglia recognition and achieving controlled release and specific accumulation of drugs through intelligent molecular switching. MG1 peptide can be used for drug delivery for ischemic stroke research . |  
 
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                                    - HY-128937
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                                                |  | Liposome
                                                    
                                                        Folate Receptor (FR) | Cancer |  
                                                | EC1454 is a peptide compound with anticancer activity that targets folate receptor-expressing cancers. EC1454 is a folate-tubulysin conjugate that can be used to prepare drug delivery conjugates for targeted therapy . |  
 
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                                    - HY-164166
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                                                |  | Biochemical Assay Reagents | Others |  
                                                | Fmoc-Sar-Sar-Sar-OH is a small molecule polypeptide composed of four sarcosine residues, in which the N-terminus of the peptide chain is protected by Fmoc. Fmoc-Sar-Sar-Sar-OH can be used for peptide synthesis or synthesis of drug-peptide ligand conjugates . |  
 
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                                    - HY-150241
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                                                |  | Liposome | Others |  
                                                | DOPE-NHS is a linker. DOPE-NHS can be used for peptides to be conjugated to exosomes and possibly other membrane-based nanoparticles. DOPE-NHS can be used for drug delivery . |  
 
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                                    - HY-P2218
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                                                |  | Radionuclide-Drug Conjugates (RDCs)
                                                    
                                                        CXCR | Cancer |  
                                                | Anditixafortide (Pentixather) is an endoradiotherapeutic vector. Anditixafortide is a CXCR4-targeting peptide derivative . Anditixafortide can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). |  
 
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                                    - HY-153395
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                                                |  | Drug-Linker Conjugates for ADC | Cancer |  
                                                | PH-HG-005-5 (compound 16c) is a derivative of SN-38 (HY-13704) and can be used as Drug-Linker Conjugates for ADC.  PH-HG-005-5 can conjugate to targeting peptides for ADCs synthesis . |  
 
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                                    - HY-13631E
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                                                            Deruxtecan
                                                            
                                                        
                                                        
                                                            
                                                                
                                                                    Maximum Cited Publications 21 Publications Verification MC-GGFG-DXD | Drug-Linker Conjugates for ADC | Cancer |  
                                                | Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing Trastuzumab deruxtecan (HY-138298A) and Patritumab deruxtecan (HY-P99813)  . |  
 
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                                    - HY-P99881
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                                                | ABBV 176 | Drug-Linker Conjugates for ADC | Cancer |  
                                                | Rolinsatamab talirine (ABBV 176) is an antibody-drug conjugate (ADC) targeting prolactin receptor (PRLR). Rolinsatamab talirine consists of rolinsatamab (HY-P99238), an enzymatically cleavable peptide linker, and SGD-1882 (HY-101127) . |  
 
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                                    - HY-P10757
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                                    - HY-153549
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                                                |  | Radionuclide-Drug Conjugates (RDCs)
                                                    
                                                        CXCR | Others |  
                                                | Pentixafor is a peptide that targets CXCR4. Pentixafor is capable of being labelled with  68Gallium ( 68Ga) for positron emission tomography (PET) imaging    . Pentixafor can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). |  
 
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                                    - HY-158199
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                                                |  | ADC Linker | Cancer |  
                                                | BCN-HS-PEG2-bis(PNP) (Compound 62) is a p-nitrophenyl-containing ADC linker that can be used to further couple ADC cytotoxins with peptide linkers. BCN-HS-PEG2-bis(PNP) can conjugate with vc-PABC-MMAE (HY-15162) to form Drug-Linker Conjugates for ADC . |  
 
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                                    - HY-172270D
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                                                |  | Liposome | Cancer |  
                                                | DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors . |  
 
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                                    - HY-172270C
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                                                |  | Liposome | Cancer |  
                                                | DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors . |  
 
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                                    - HY-172270
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                                                |  | Liposome | Cancer |  
                                                | DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors . |  
 
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                                    - HY-172270A
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                                                |  | Liposome | Cancer |  
                                                | DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors . |  
 
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                                    - HY-138298
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                                                | DS-8201 (solution); DS-8201a (solution) | Antibody-Drug Conjugates (ADCs)
                                                    
                                                        EGFR | Cancer |  
                                                | Trastuzumab deruxtecan (T-DXd; DS-8201a) (solution) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer  . |  
 
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                                    - HY-138298A
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                                                | DS-8201;  DS-8201a | Antibody-Drug Conjugates (ADCs)
                                                    
                                                        EGFR | Cancer |  
                                                | Trastuzumab deruxtecan (DS-8201a) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer  . |  
 
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                                    - HY-P10444
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                                                |  | Radionuclide-Drug Conjugates (RDCs)
                                                    
                                                        CXCR | Cancer |  
                                                | DOTA Conjugated JM#21 derivative 7 (compound Ligand-7) is a derivative of CXCR4 targeting peptide conjugated with DOTA and can be used to produce radioligands. Radiolabeled DOTA Conjugated JM#21 derivative 7, i.e., 177Lu-DOTA, has excellent CXCR4 tumor targeting. In vitro biodistribution results of 177Lu-DOTA showed very low uptake in all non-targeted organs except kidney . DOTA Conjugated JM#21 derivative 7 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). |  
 
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                                    - HY-W071967
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                                                |  | ADC Linker | Cancer |  
                                                | Alloc-Val-Ala-PAB is a peptide cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer. |  
 
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                                    - HY-172273B
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                                                |  | Liposome | Cancer |  
                                                | DSPE-PEG5000-M2pep is a PEG compound which composed of DSPE and a M2-polarized macrophages targeting peptide (M2pep). M2pep is conjugated to a proapoptotic peptide as monovalent or multivalent ligands to concentrate the toxic effect of the peptide to M2 macrophages. DSPE-PEG5000-M2pep can be used for drug delivery . |  
 
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                                    - HY-172273A
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                                                |  | Liposome | Cancer |  
                                                | DSPE-PEG2000-M2pep is a PEG compound which composed of DSPE and a M2-polarized macrophages targeting peptide (M2pep). M2pep is conjugated to a proapoptotic peptide as monovalent or multivalent ligands to concentrate the toxic effect of the peptide to M2 macrophages. DSPE-PEG2000-M2pep can be used for drug delivery . |  
 
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                                    - HY-172273
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                                                |  | Liposome | Cancer |  
                                                | DSPE-PEG1000-M2pep is a PEG compound which composed of DSPE and a M2-polarized macrophages targeting peptide (M2pep). M2pep is conjugated to a proapoptotic peptide as monovalent or multivalent ligands to concentrate the toxic effect of the peptide to M2 macrophages. DSPE-PEG1000-M2pep can be used for drug delivery . |  
 
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                                    - HY-172273C
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                                                |  | Liposome | Cancer |  
                                                | DSPE-PEG3400-M2pep is a PEG compound which composed of DSPE and a M2-polarized macrophages targeting peptide (M2pep). M2pep is conjugated to a proapoptotic peptide as monovalent or multivalent ligands to concentrate the toxic effect of the peptide to M2 macrophages. DSPE-PEG3400-M2pep can be used for drug delivery . |  
 
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                                    - HY-13631ES4
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                                    - HY-13631ES
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                                    - HY-13631ES3
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                                                | MC-GGFG-DXD-d2 | Drug-Linker Conjugates for ADC
                                                    
                                                        Isotope-Labeled Compounds | Others |  
                                                | Deruxtecan-d2 is the deuterium labeled Deruxtecan (HY-13631E) . Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402. |  
 
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                                    - HY-13631ES2
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                                                | MC-GGFG-DXD-d4-1 | Drug-Linker Conjugates for ADC
                                                    
                                                        Isotope-Labeled Compounds | Others |  
                                                | Deruxtecan-d4-1 is the deuterium labeled Adenosine Deruxtecan (HY-13631E) . Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402. |  
 
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                                    - HY-125586
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                                                |  | DNA/RNA Synthesis
                                                    
                                                        ADC Payload | Cancer |  
                                                | β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs)  . |  
 
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                                    - HY-W729138
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                                                |  | ADC Linker | Others |  
                                                | Fmoc-D-homoArg(Et)2-OH (hydrochloride) is a Fmoc-protected derivative of D-Homoarginine (HArg) that renders peptides and proteins resistant to proteolysis by trypsin. Fmoc-D-homoArg(Et)2-OH (hydrochloride) can be used as a cleavable ADC linker to synthesize antibody-drug conjugates (ADCs) . |  
 
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                                    - HY-P10307
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                                                |  | Radionuclide-Drug Conjugates (RDCs)
                                                    
                                                        Bacterial | Infection |  
                                                | DOTA-ubiquicidin (29-41), an antimicrobial peptide fragment derivative, can be used for synthesis of [ 68Ga]Ga-DOTA-Ubiquicidin29-41 and then used for imaging of infectious processes using PET/CT . DOTA-ubiquicidin (29–41) can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). |  
 
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                                    - HY-P5297
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                                                |  | Radionuclide-Drug Conjugates (RDCs)
                                                    
                                                        CXCR | Cancer |  
                                                | DOTA-CXCR4-L is a CXCR4 targeting peptide. DOTA-CXCR4-L can be used in the study of cancers, including glioblastoma and triple-negative breast cancer. NODAGA-LM3 can be labeled with [68Ga]/[177Lu] for the synthesis/research of Radionuclide-Drug Conjugates (RDCs) . |  
 
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                                    - HY-P10740
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                                                |  | Peptide-Drug Conjugates (PDCs)
                                                    
                                                        Antifolate | Cancer |  
                                                | CBP-1018 is a PDC (peptide drug conjugate) consisting of a dual targeting FRα/prostate-specific membrane antigen (PSMA) ligand (blue part) coupled to Monomethyl auristatin E (HY-15162) (red part) via a linker (HY-78738) (black part). CBP-1018 is expected to be used in breast cancer research . |  
 
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                                    - HY-P10770
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                                                |  | Peptide-Drug Conjugates (PDCs)
                                                    
                                                        E-Selectin | Cardiovascular Disease
                                                    
                                                        Cancer |  
                                                | P-ESBP-DOX is a HPMA copolymer-drug conjugate, which is consistituted of the E-selectin binding peptide and the Doxorubicin (HY-15142). P-ESBP-DOX exhibits cytotoxicity against TNFα-activated human vascular endothelial cells IVECs with an IC50 of 0.28 μM. P-ESBP-DOX can be used in research about tumor vasculature . |  
 
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                                    - HY-P10762
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                                                | CBP-1008;  LDC 10B | Peptide-Drug Conjugates (PDCs)
                                                    
                                                        Folate Receptor (FR)
                                                    
                                                        TRP Channel | Cancer |  
                                                | Ricorfotide vedotin (CBP-1008) is a dual-ligand peptide-drug conjugate (PDC) conjugated to MMAE (HY-15162), targeting Folate receptor α (FRα) and TRPV6. Ricorfotide vedotin binds to FRα with high affinity and TRPV6 with low affinity. Ricorfotide vedotin has antitumor activity, and can be used in advanced solid tumor research (eg: colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma and follicular dendritic cell sarcoma)   . |  
 
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                                    - HY-P10760
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                                                |  | Peptide-Drug Conjugates (PDCs) | Cancer |  
                                                | PhAc-ALGP-Dox, a peptide-drug conjugate, is a novel anticancer prodrug, with IC50 values ranged from 311 nM to 34.25 μM for TNBC (E0771), normal murine epithelium (HC-11), human TNBC (MDA-MB-231 and MDA-MB-468), human CrC (LS 174T), normal human epithelium (HME-1) cells . 
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                                    - HY-15582
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                                                |  | Microtubule/Tubulin
                                                    
                                                        ADC Payload | Cancer |  
                                                | Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 (HY-15580), is linear peptides comprised of four amino acids   . |  
 
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                                    - HY-P4073
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                                                | GRN1005;  Paclitaxel trevatide | Peptide-Drug Conjugates (PDCs)
                                                    
                                                        LDLR | Cancer |  
                                                | ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system   . |  
 
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                                    - HY-13631EG
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                                                | MC-GGFG-DXD | Drug-Linker Conjugates for ADC | Cancer |  
                                                | Deruxtecan (GMP) (MC-GGFG-DXD (GMP)) is Deruxtecan (HY-13631E) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing Trastuzumab deruxtecan (HY-138298A) and Patritumab deruxtecan (HY-P99813)  . |  
 
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                                    - HY-164992
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                                                | MRG002;  Trastuzumab MMAE | Antibody-Drug Conjugates (ADCs)
                                                    
                                                        EGFR
                                                    
                                                        Microtubule/Tubulin | Cancer |  
                                                | Trastuzumab vedotin (MRG002) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab vedotin is composed of a humanized anti-HER2 antibody Trastuzumab (HY-P9907), an enzymatically cleavable peptide-linker Valine-citrulline, a tubulin inhibitor Monomethyl auristatin E (MMAE; HY-15162). Trastuzumab vedotin can be used for the research of HER2-positive breast cancer . |  
 
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                                    - HY-P10947
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                                                |  | Epigenetic Reader Domain
                                                    
                                                        YAP | Cancer |  
                                                | MACTIDE-V is an orally active and selective peptide-drug conjugate targeting CD206. MACTIDE-V delivers Verteporfin (HY-B0146) to CD206 + tumor-associated macrophages (TAM) to inhibit the YAP/TAZ signaling pathway, prompting YAP exclusion from the nucleus, inducing TAM polarization toward an anti-tumoral phenotype with enhanced phagocytosis and antigen presentation, and boosting T cell infiltration and NK cell activity. MACTIDE-V suppresses primary tumor growth and lung metastasis in triple-negative breast cancer (TNBC) mouse models . |  
 
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                                    - HY-P10761
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                                                |  | Radionuclide-Drug Conjugates (RDCs)
                                                    
                                                        Carbonic Anhydrase | Cancer |  
                                                | DPI-4452 is a CAIX-targeting cyclic peptide with a DOTA cage, and can be chelated with radionuclide for CAIX-expressing tumor PET-CT imaging and study. DPI-4452 specifically and selectively binds CAIX without interaction with an in vitro off-target receptor panel of 55 targets (IC50 for recombinant hCAIX: 130 nM). Radiolabeled DPI-4452 inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models . DPI-4452 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). |  
 
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                                    - HY-115693
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                                                |  | Bacterial | Infection |  
                                                | CAP 3 is a cholic acid-peptide conjugate (CAP) antimicrobial agent. CAP 3 effectively inhibits Gram-negative bacteria, with MIC99 (minimum inhibitory concentration for 99% bacterial killing) values of 8 μM, 16 μM, and 16 μM against E. coli, Klebsiella pneumoniae and Acinetobacter baumannii, respectively. CAP 3 exerts its antibacterial effects by disrupting the structural integrity of the bacterial lipopolysaccharide (LPS) outer membrane. CAP 3 rapidly kills bacteria, inhibits biofilm formation, and effectively combats drug-resistant strains and persistent bacterial infections . |  
 
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                                    - HY-P11018
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                                                |  | Peptide-Drug Conjugates (PDCs)
                                                    
                                                        Ephrin Receptor | Cancer |  
                                                | (123B9)2-L2-PTX is an EphA2-agonistic peptide-drug conjugate (PDC). (123B9)2-L2-PTX consists of a dimeric 123B9 (HY-P10579) and Paclitaxel (HY-B0015). (123B9)2-L2-PTX significantly reduces circulating tumor cells and inhibits lung tumor metastasis in breast-cancer-Metastasis mice model. (123B9)2-L2-PTX can be used for cancers research, such as melanomas and ovarian and breast cancers . |  
 
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                            | Cat. No. | Product Name | Type | 
                    
                    
                        
                            
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                                    - HY-138298A
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                                                | DS-8201;  DS-8201a | Chromogenic Assays |  
                                                | Trastuzumab deruxtecan (DS-8201a) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer  . |  
 
 
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                                    - HY-13631EG
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                                                | MC-GGFG-DXD (GMP) | Fluorescent Dye |  
                                                | Deruxtecan (GMP) (MC-GGFG-DXD (GMP)) is Deruxtecan (HY-13631E) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing Trastuzumab deruxtecan (HY-138298A) and Patritumab deruxtecan (HY-P99813)  . |  
 
 
 
            
            
            
                
                    
                        
                            | Cat. No. | Product Name | Type | 
                    
                    
                        
                            
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                                    - HY-150241
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                                                |  | Drug Delivery |  
                                                | DOPE-NHS is a linker. DOPE-NHS can be used for peptides to be conjugated to exosomes and possibly other membrane-based nanoparticles. DOPE-NHS can be used for drug delivery . |  
 
 
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                                    - HY-13631EG
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                                                | MC-GGFG-DXD (GMP) | Biochemical Assay Reagents |  
                                                | Deruxtecan (GMP) (MC-GGFG-DXD (GMP)) is Deruxtecan (HY-13631E) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing Trastuzumab deruxtecan (HY-138298A) and Patritumab deruxtecan (HY-P99813)  . |  
 
 
- 
                                
                                    - HY-172270D
- 
                                        
                                            
                                                |  | Drug Delivery |  
                                                | DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors . |  
 
 
- 
                                
                                    - HY-172270C
- 
                                        
                                            
                                                |  | Drug Delivery |  
                                                | DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors . |  
 
 
- 
                                
                                    - HY-172270
- 
                                        
                                            
                                                |  | Drug Delivery |  
                                                | DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors . |  
 
 
- 
                                
                                    - HY-172270A
- 
                                        
                                            
                                                |  | Drug Delivery |  
                                                | DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors . |  
 
 
- 
                                
                                    - HY-172273B
- 
                                        
                                            
                                                |  | Drug Delivery |  
                                                | DSPE-PEG5000-M2pep is a PEG compound which composed of DSPE and a M2-polarized macrophages targeting peptide (M2pep). M2pep is conjugated to a proapoptotic peptide as monovalent or multivalent ligands to concentrate the toxic effect of the peptide to M2 macrophages. DSPE-PEG5000-M2pep can be used for drug delivery . |  
 
 
- 
                                
                                    - HY-172273A
- 
                                        
                                            
                                                |  | Drug Delivery |  
                                                | DSPE-PEG2000-M2pep is a PEG compound which composed of DSPE and a M2-polarized macrophages targeting peptide (M2pep). M2pep is conjugated to a proapoptotic peptide as monovalent or multivalent ligands to concentrate the toxic effect of the peptide to M2 macrophages. DSPE-PEG2000-M2pep can be used for drug delivery . |  
 
 
- 
                                
                                    - HY-172273
- 
                                        
                                            
                                                |  | Drug Delivery |  
                                                | DSPE-PEG1000-M2pep is a PEG compound which composed of DSPE and a M2-polarized macrophages targeting peptide (M2pep). M2pep is conjugated to a proapoptotic peptide as monovalent or multivalent ligands to concentrate the toxic effect of the peptide to M2 macrophages. DSPE-PEG1000-M2pep can be used for drug delivery . |  
 
 
- 
                                
                                    - HY-172273C
- 
                                        
                                            
                                                |  | Drug Delivery |  
                                                | DSPE-PEG3400-M2pep is a PEG compound which composed of DSPE and a M2-polarized macrophages targeting peptide (M2pep). M2pep is conjugated to a proapoptotic peptide as monovalent or multivalent ligands to concentrate the toxic effect of the peptide to M2 macrophages. DSPE-PEG3400-M2pep can be used for drug delivery . |  
 
 
 
            
            
            
                
                    
                        
                            | Cat. No. | Product Name | Target | Research Area | 
                    
                    
                        
                            
                            - 
                                
                                    - HY-P10741
- 
                                        
                                    
 
- 
                                
                                    - HY-106244A
- 
                                        
                                            
                                                |  | Radionuclide-Drug Conjugates (RDCs) | Cancer |  
                                                | DOTATATE acetate is a DOTA-conjugated peptide. DOTATATE acetate can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT)    . DOTATATE (acetate) can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). |  
 
 
- 
                                
                                    - HY-106244
- 
                                        
                                            
                                                |  | Radionuclide-Drug Conjugates (RDCs) | Cancer |  
                                                | DOTATATE is a DOTA-conjugated peptide. DOTATATE can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT)    . DOTATATE can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). |  
 
 
- 
                                
                                    - HY-P10895
- 
                                        
                                            
                                                |  | Biochemical Assay Reagents | Others |  
                                                | HR97 TFA is a cell-penetrating peptide that can be combined with engineered melanin to prepare eye drops HR97-SunitiGel. The peptide-drug conjugate in HR97-SunitiGel can provide sustained ocular drug delivery . |  
 
 
- 
                                
                                    - HY-164166
- 
                                        
                                            
                                                |  | Biochemical Assay Reagents | Others |  
                                                | Fmoc-Sar-Sar-Sar-OH is a small molecule polypeptide composed of four sarcosine residues, in which the N-terminus of the peptide chain is protected by Fmoc. Fmoc-Sar-Sar-Sar-OH can be used for peptide synthesis or synthesis of drug-peptide ligand conjugates . |  
 
 
- 
                                
                                    - HY-P2218
- 
                                        
                                            
                                                |  | Radionuclide-Drug Conjugates (RDCs)
                                                        
                                                    
                                                        
                                                        
                                                            CXCR | Cancer |  
                                                | Anditixafortide (Pentixather) is an endoradiotherapeutic vector. Anditixafortide is a CXCR4-targeting peptide derivative . Anditixafortide can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). |  
 
 
- 
                                
                                    - HY-113003
- 
                                        
                                            
                                                | γ-Glutamylglutamine;  γ-Glu-Gln | Peptides | Others
                                                    
                                                        Cancer |  
                                                | H-γ-Glu-Gln-OH is a hydrophilic peptide and can be conjugated to drugs. The carrier composed of H-γ-Glu-Gln-OH has the characteristics of high water solubility and drug-loading capacity, good biocompatibility, low toxicity, improved tumor targeting ability, and anti-tumor efficacy . |  
 
 
- 
                                
                                    - HY-P11030
- 
                                        
                                            
                                                |  | Peptides | Cancer |  
                                                | Ahx-CES is a CES peptide-linker conjugate targeting Synaptosomal associated protein 25 (SNAP25). Ahx-CES can be used for synthesis of peptide-drug conjugates with Verteporfin (HY-B0146) for cancers research . |  
 
 
- 
                                
                                    - HY-P11315
- 
                                        
                                            
                                                |  | Biochemical Assay Reagents | Neurological Disease |  
                                                | MG1 peptide is a M1 Microglia-targeting peptide. MG1 peptide can conjugate to anoparticles, crossing the BBB to precisely M1 microglia recognition and achieving controlled release and specific accumulation of drugs through intelligent molecular switching. MG1 peptide can be used for drug delivery for ischemic stroke research . |  
 
 
- 
                                
                                    - HY-P10794
- 
                                        
                                            
                                                |  | Peptides | Cancer |  
                                                | LH2 peptide is a pH-responsive cell-penetrating peptide dimer with the amino acid sequence LHHLCHLLHHLCHLAG. It can increase its uptake in tumor cells under weakly acidic conditions (such as the tumor microenvironment) through the protonation of histidine residues (pKa approximately 6). When conjugated with the anticancer drug Paclitaxel (HY-B0015), the PTX-LH2 conjugate showed superior tumor suppression effects compared to paclitaxel alone in a subcutaneous breast tumor model. The LH2 peptide holds potential as a drug delivery vehicle in cancer research . |  
 
 
- 
                                
                                    - HY-P10757
- 
                                        
                                    
 
- 
                                
                                    - HY-153549
- 
                                        
                                            
                                                |  | Radionuclide-Drug Conjugates (RDCs)
                                                        
                                                    
                                                        
                                                        
                                                            CXCR | Others |  
                                                | Pentixafor is a peptide that targets CXCR4. Pentixafor is capable of being labelled with  68Gallium ( 68Ga) for positron emission tomography (PET) imaging    . Pentixafor can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). |  
 
 
- 
                                
                                    - HY-P10444
- 
                                        
                                            
                                                |  | Radionuclide-Drug Conjugates (RDCs)
                                                        
                                                    
                                                        
                                                        
                                                            CXCR | Cancer |  
                                                | DOTA Conjugated JM#21 derivative 7 (compound Ligand-7) is a derivative of CXCR4 targeting peptide conjugated with DOTA and can be used to produce radioligands. Radiolabeled DOTA Conjugated JM#21 derivative 7, i.e., 177Lu-DOTA, has excellent CXCR4 tumor targeting. In vitro biodistribution results of 177Lu-DOTA showed very low uptake in all non-targeted organs except kidney . DOTA Conjugated JM#21 derivative 7 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). |  
 
 
- 
                                
                                    - HY-125586
- 
                                        
                                            
                                                |  | DNA/RNA Synthesis
                                                        
                                                    
                                                        
                                                        
                                                            ADC Payload | Cancer |  
                                                | β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs)  . |  
 
 
- 
                                
                                    - HY-W729138
- 
                                        
                                            
                                                |  | ADC Linker | Others |  
                                                | Fmoc-D-homoArg(Et)2-OH (hydrochloride) is a Fmoc-protected derivative of D-Homoarginine (HArg) that renders peptides and proteins resistant to proteolysis by trypsin. Fmoc-D-homoArg(Et)2-OH (hydrochloride) can be used as a cleavable ADC linker to synthesize antibody-drug conjugates (ADCs) . |  
 
 
- 
                                
                                    - HY-P10307
- 
                                        
                                            
                                                |  | Radionuclide-Drug Conjugates (RDCs)
                                                        
                                                    
                                                        
                                                        
                                                            Bacterial | Infection |  
                                                | DOTA-ubiquicidin (29-41), an antimicrobial peptide fragment derivative, can be used for synthesis of [ 68Ga]Ga-DOTA-Ubiquicidin29-41 and then used for imaging of infectious processes using PET/CT . DOTA-ubiquicidin (29–41) can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). |  
 
 
- 
                                
                                    - HY-P5297
- 
                                        
                                            
                                                |  | Radionuclide-Drug Conjugates (RDCs)
                                                        
                                                    
                                                        
                                                        
                                                            CXCR | Cancer |  
                                                | DOTA-CXCR4-L is a CXCR4 targeting peptide. DOTA-CXCR4-L can be used in the study of cancers, including glioblastoma and triple-negative breast cancer. NODAGA-LM3 can be labeled with [68Ga]/[177Lu] for the synthesis/research of Radionuclide-Drug Conjugates (RDCs) . |  
 
 
- 
                                
                                    - HY-P10740
- 
                                        
                                            
                                                |  | Peptide-Drug Conjugates (PDCs)
                                                        
                                                    
                                                        
                                                        
                                                            Antifolate | Cancer |  
                                                | CBP-1018 is a PDC (peptide drug conjugate) consisting of a dual targeting FRα/prostate-specific membrane antigen (PSMA) ligand (blue part) coupled to Monomethyl auristatin E (HY-15162) (red part) via a linker (HY-78738) (black part). CBP-1018 is expected to be used in breast cancer research . |  
 
 
- 
                                
                                    - HY-P10770
- 
                                        
                                            
                                                |  | Peptide-Drug Conjugates (PDCs)
                                                        
                                                    
                                                        
                                                        
                                                            E-Selectin | Cardiovascular Disease
                                                    
                                                        Cancer |  
                                                | P-ESBP-DOX is a HPMA copolymer-drug conjugate, which is consistituted of the E-selectin binding peptide and the Doxorubicin (HY-15142). P-ESBP-DOX exhibits cytotoxicity against TNFα-activated human vascular endothelial cells IVECs with an IC50 of 0.28 μM. P-ESBP-DOX can be used in research about tumor vasculature . |  
 
 
- 
                                
                                    - HY-P10762
- 
                                        
                                            
                                                | CBP-1008;  LDC 10B | Peptide-Drug Conjugates (PDCs)
                                                        
                                                    
                                                        
                                                        
                                                            Folate Receptor (FR)
                                                        
                                                    
                                                        
                                                        
                                                            TRP Channel | Cancer |  
                                                | Ricorfotide vedotin (CBP-1008) is a dual-ligand peptide-drug conjugate (PDC) conjugated to MMAE (HY-15162), targeting Folate receptor α (FRα) and TRPV6. Ricorfotide vedotin binds to FRα with high affinity and TRPV6 with low affinity. Ricorfotide vedotin has antitumor activity, and can be used in advanced solid tumor research (eg: colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma and follicular dendritic cell sarcoma)   . |  
 
 
- 
                                
                                    - HY-P10760
- 
                                        
                                            
                                                |  | Peptide-Drug Conjugates (PDCs) | Cancer |  
                                                | PhAc-ALGP-Dox, a peptide-drug conjugate, is a novel anticancer prodrug, with IC50 values ranged from 311 nM to 34.25 μM for TNBC (E0771), normal murine epithelium (HC-11), human TNBC (MDA-MB-231 and MDA-MB-468), human CrC (LS 174T), normal human epithelium (HME-1) cells . 
 |  
 
 
- 
                                
                                    - HY-P4073
- 
                                        
                                            
                                                | GRN1005;  Paclitaxel trevatide | Peptide-Drug Conjugates (PDCs)
                                                        
                                                    
                                                        
                                                        
                                                            LDLR | Cancer |  
                                                | ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system   . |  
 
 
- 
                                
                                    - HY-P10947
- 
                                        
                                            
                                                |  | Epigenetic Reader Domain
                                                        
                                                    
                                                        
                                                        
                                                            YAP | Cancer |  
                                                | MACTIDE-V is an orally active and selective peptide-drug conjugate targeting CD206. MACTIDE-V delivers Verteporfin (HY-B0146) to CD206 + tumor-associated macrophages (TAM) to inhibit the YAP/TAZ signaling pathway, prompting YAP exclusion from the nucleus, inducing TAM polarization toward an anti-tumoral phenotype with enhanced phagocytosis and antigen presentation, and boosting T cell infiltration and NK cell activity. MACTIDE-V suppresses primary tumor growth and lung metastasis in triple-negative breast cancer (TNBC) mouse models . |  
 
 
- 
                                
                                    - HY-P10761
- 
                                        
                                            
                                                |  | Radionuclide-Drug Conjugates (RDCs)
                                                        
                                                    
                                                        
                                                        
                                                            Carbonic Anhydrase | Cancer |  
                                                | DPI-4452 is a CAIX-targeting cyclic peptide with a DOTA cage, and can be chelated with radionuclide for CAIX-expressing tumor PET-CT imaging and study. DPI-4452 specifically and selectively binds CAIX without interaction with an in vitro off-target receptor panel of 55 targets (IC50 for recombinant hCAIX: 130 nM). Radiolabeled DPI-4452 inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models . DPI-4452 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). |  
 
 
- 
                                
                                    - HY-P11018
- 
                                        
                                            
                                                |  | Peptide-Drug Conjugates (PDCs)
                                                        
                                                    
                                                        
                                                        
                                                            Ephrin Receptor | Cancer |  
                                                | (123B9)2-L2-PTX is an EphA2-agonistic peptide-drug conjugate (PDC). (123B9)2-L2-PTX consists of a dimeric 123B9 (HY-P10579) and Paclitaxel (HY-B0015). (123B9)2-L2-PTX significantly reduces circulating tumor cells and inhibits lung tumor metastasis in breast-cancer-Metastasis mice model. (123B9)2-L2-PTX can be used for cancers research, such as melanomas and ovarian and breast cancers . |  
 
 
 
            
            
            
            
            
                
                    
                        
                            | Cat. No. | Product Name | Target | Research Area | 
                    
                    
                        
                            
                            - 
                                
                                    - HY-P99881
- 
                                        
                                            
                                                | ABBV 176 | Drug-Linker Conjugates for ADC | Cancer |  
                                                | Rolinsatamab talirine (ABBV 176) is an antibody-drug conjugate (ADC) targeting prolactin receptor (PRLR). Rolinsatamab talirine consists of rolinsatamab (HY-P99238), an enzymatically cleavable peptide linker, and SGD-1882 (HY-101127) . |  
 
 
 
            
            
            
                
                    
                        
                            | Cat. No. | Product Name | Category | Target | Chemical Structure | 
                    
                    
                 
            
            
            
            
            
                
                    
                        
                            | Cat. No. | Product Name | Chemical Structure | 
                    
                    
                        
                            
                            - 
                                
                                    - HY-13631ES4
- 
                                        
                                            
                                                |  |  
                                                | Deruxtecan-d5 is deuterium labeled Deruxtecan (HY-13631E). Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402. |  
 
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-13631ES
- 
                                        
                                            
                                                |  |  
                                                | Deruxtecan-d4 is deuterium labeled Deruxtecan (HY-13631E). Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402. |  
 
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-13631ES3
- 
                                        
                                            
                                                |  |  
                                                | Deruxtecan-d2 is the deuterium labeled Deruxtecan (HY-13631E) . Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402. |  
 
- 
                                        
                                        
                                              
 
- 
                                
                                    - HY-13631ES2
- 
                                        
                                            
                                                |  |  
                                                | Deruxtecan-d4-1 is the deuterium labeled Adenosine Deruxtecan (HY-13631E) . Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402. |  
 
- 
                                        
                                        
                                              
 
 
            
            
            
            
            
                
                    
                        
                            | Cat. No. | Product Name |  | Classification | 
                    
                    
                        
                            
                            - 
                                
                                    - HY-158199
- 
                                        
                                            
                                                |  |  | BCN |  
                                                | BCN-HS-PEG2-bis(PNP) (Compound 62) is a p-nitrophenyl-containing ADC linker that can be used to further couple ADC cytotoxins with peptide linkers. BCN-HS-PEG2-bis(PNP) can conjugate with vc-PABC-MMAE (HY-15162) to form Drug-Linker Conjugates for ADC . |  
 
 
 
            
                
                
                    
                        
                            
                                | Cat. No. | Product Name |  | Classification | 
                        
                        
                            
                            
                        - 
                            
                                - HY-150241
- 
                                    
                                        
                                            |  |  | Phospholipids |  
                                            | DOPE-NHS is a linker. DOPE-NHS can be used for peptides to be conjugated to exosomes and possibly other membrane-based nanoparticles. DOPE-NHS can be used for drug delivery . |  
 
 
- 
                            
                                - HY-172270
- 
                                    
                                        
                                            |  |  | Pegylated Lipids |  
                                            | DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors . |  
 
 
- 
                            
                                - HY-172270A
- 
                                    
                                        
                                            |  |  | Pegylated Lipids |  
                                            | DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors . |  
 
 
- 
                            
                                - HY-172273B
- 
                                    
                                        
                                            |  |  | Pegylated Lipids |  
                                            | DSPE-PEG5000-M2pep is a PEG compound which composed of DSPE and a M2-polarized macrophages targeting peptide (M2pep). M2pep is conjugated to a proapoptotic peptide as monovalent or multivalent ligands to concentrate the toxic effect of the peptide to M2 macrophages. DSPE-PEG5000-M2pep can be used for drug delivery . |  
 
 
- 
                            
                                - HY-172273A
- 
                                    
                                        
                                            |  |  | Pegylated Lipids |  
                                            | DSPE-PEG2000-M2pep is a PEG compound which composed of DSPE and a M2-polarized macrophages targeting peptide (M2pep). M2pep is conjugated to a proapoptotic peptide as monovalent or multivalent ligands to concentrate the toxic effect of the peptide to M2 macrophages. DSPE-PEG2000-M2pep can be used for drug delivery . |  
 
 
- 
                            
                                - HY-172273
- 
                                    
                                        
                                            |  |  | Pegylated Lipids |  
                                            | DSPE-PEG1000-M2pep is a PEG compound which composed of DSPE and a M2-polarized macrophages targeting peptide (M2pep). M2pep is conjugated to a proapoptotic peptide as monovalent or multivalent ligands to concentrate the toxic effect of the peptide to M2 macrophages. DSPE-PEG1000-M2pep can be used for drug delivery . |  
 
 
 
                
         
        
        
        
        
        
        
            
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