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Results for "

peptide bond

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (3) Amino Acid Derivatives (2) Aminopeptidase (1) Antibiotic (5) Bacterial (9) Biochemical Assay Reagents (33) CaSR (1) Drug Intermediate (2) Endogenous Metabolite (4) Factor Xa (3) Fluorescent Dye (9) Fungal (2) HIV (1) HIV Protease (1) Isotope-Labeled Compounds (4) Liposome (1) MARCKS (1) MMP (1) PKC (1) Reference Standards (1) Ser/Thr Protease (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (3) Infection (13) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (2)
Click Chemistry:	Azide (1)

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Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

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Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Formyl Peptide Receptor (FPR) Connective Peptide Peptide-Drug Conjugates (PDCs) Natriuretic Peptide Receptor (NPR) RXFP Receptor CGRP Receptor Amyloid-β

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2980

Carboxypeptidase A, Bovine pancreas EC 3.4.2.1	Endogenous Metabolite	Others
Carboxypeptidase A, Bovine pancreas (EC 3.4.2.1) is a zinc-containing metalloprotease, is often used in biochemical studies. Carboxypeptidase A catalyzes the hydrolysis of the peptide bonds that are adjacent to the C-terminal end of a polypeptide chain. Carboxypeptidase A is a prototypical enzyme for metalloproteases that plays important roles in biological systems .

HY-Z0275

HOAT	Biochemical Assay Reagents	Others
HOAT is a commonly used peptide bond forming agent that may become an impurity in drug synthesis, but is not mutagenic. HOAT can be used for peptide fragment polycondensation and can also inhibit the racemization of peptide polycondensation .

HY-E70563

Endoproteinase Lys-N (MS grade)	Biochemical Assay Reagents	Others
Endoproteinase Lys-N (MS grade) is a protease that specifically hydrolyzes the N-terminal peptide bond of lysine fragments .

HY-131092A

H-Asn-Arg-OH diTFA	Drug Intermediate	Others
H-Asn-Arg-OH diTFA is a dipeptide formed by the connection of asparagine and arginine via a peptide bond, which can be used in polypeptide synthesis.

HY-A0162

Quinupristin 1 Publications Verification	Bacterial	Infection
Quinupristin is a streptogramin antibiotic. Quinupristin blocks peptide bond synthesis to prevent the extension of polypeptide chains and promote the detachment of incomplete protein chains in the bacterial ribosomal subunits .

HY-41121

Boc-L-Ala-OH 1 Publications Verification Boc-Ala-OH	Amino Acid Derivatives	Others
Boc-L-Ala-OH (Boc-Ala-OH) shows excellent affinity with ATP. Boc-L-Ala-OH contains an amino acid moiety, and an acylamide bond like that of the peptide and protein .

HY-118593

A2315A Madumycin II; Antibiotic A 2315A	Antibiotic	Infection
A2315A (Madumycin II) is an alanine-containing streptogramin A antibiotic. A2315A is a potent peptidyl transferase center (PTC) inhibitor. A2315A inhibits the ribosome prior to the first cycle of peptide bond formation .

HY-176305S

Neurofilament, U-15N	Isotope-Labeled Compounds	Neurological Disease
Neurofilament, U- ¹⁵N is the ¹⁵N-labeled Neurofilament.

HY-148217

DB02307	Others	Others
DB02307 is a dipeptide that contains a sequence of two alpha-amino acids joined by a peptide bond .

HY-131092

H-Asn-Arg-OH	Drug Intermediate	Others
H-Asn-Arg-OH is a dipeptide formed by the connection of asparagine and arginine via a peptide bond, which can be used in polypeptide synthesis.

HY-A0162A

Quinupristin mesylate	Bacterial	Infection
Quinupristin mesylate is a streptogramin antibiotic. Quinupristin mesylate blocks peptide bond synthesis to prevent the extension of polypeptide chains and promote the detachment of incomplete protein chains in the bacterial ribosomal subunits .

HY-W1123939

Silane-PEG-COOH (MW 1000)	Biochemical Assay Reagents	Others
Silane-PEG-COOH (MW 1000) can be used to modify proteins, peptides and other materials with active groups. The carboxyl group (-COOH) can easily form a stable amide bond with the amino group, and can also form an ester bond with the hydroxyl group. Silane-functionalized PEG (Silane-PEG-X) can be used to modify glass, silicon, etc .

HY-W1123939A

Silane-PEG-COOH (MW 2000)	Biochemical Assay Reagents	Others
Silane-PEG-COOH (MW 2000) can be used to modify proteins, peptides and other materials with active groups. The carboxyl group (-COOH) can easily form a stable amide bond with the amino group, and can also form an ester bond with the hydroxyl group. Silane-functionalized PEG (Silane-PEG-X) can be used to modify glass, silicon, etc .

HY-W1123939C

Silane-PEG-COOH (MW 5000)	Biochemical Assay Reagents	Others
Silane-PEG-COOH (MW 5000) can be used to modify proteins, peptides and other materials with active groups. The carboxyl group (-COOH) can easily form a stable amide bond with the amino group, and can also form an ester bond with the hydroxyl group. Silane-functionalized PEG (Silane-PEG-X) can be used to modify glass, silicon, etc .

HY-W1123939B

Silane-PEG-COOH (MW 3400)	Biochemical Assay Reagents	Others
Silane-PEG-COOH (MW 3400) can be used to modify proteins, peptides and other materials with active groups. The carboxyl group (-COOH) can easily form a stable amide bond with the amino group, and can also form an ester bond with the hydroxyl group. Silane-functionalized PEG (Silane-PEG-X) can be used to modify glass, silicon, etc .

HY-139036

Dicyanocobinamide	Biochemical Assay Reagents	Others
Dicyanocobinamide is a precursor to vitamin B12. Dicyanocobinamide is a catalyst for the oxidation of peptides, which is utilized for a rapid, environmentally friendly method of disulfide bond formation in water. Dicyanocobinamide exhibits good biocompatibility .

HY-153859

Ser-SNAC TFA	Biochemical Assay Reagents	Others
Ser-SNAC TFA is a small-molecule substrate for NRPS C domains. As for NRPSs, refers to nonribosomal peptide synthetases, are large multidomain proteins to catalyze the formation of biologically active natural products. Ser-SNAC TFA can be used for characterizing the substrate specificity of C domain-catalyzed peptide bond formation .

HY-E70012

Penicillinase	Endogenous Metabolite	Infection Metabolic Disease
Penicillinase is a beta-lactamase. beta-lactamase enzymes inactivate beta-lactam antibiotics by hydrolyzing the peptide bond of the characteristic four-membered beta-lactam ring rendering the antibiotic ineffective .

HY-E70453

Human prostate transglutaminase Prostate Transglutaminase; TG4; TGase 4	Biochemical Assay Reagents	Metabolic Disease
Human prostate transglutaminase (TG4; TGase 4) is an enzyme that mediates the transfer of acyl groups from glutamine residues in proteins or peptides to primary amines and belongs to the prostate transglutaminase protein family. Human prostate transglutaminase forms an ε-(γ-glutamyl)lysine bond between proteins by transferring the acyl group of a peptide-bound glutamine residue to the primary amino group of a peptide-bound lysine residue .

HY-P2054

Mvt-101	HIV Protease	Infection
Mvt-101 is a hexapeptide-based inhibitor of HIV-1 protease. Mvt-101 is also reduced-peptide-bond inhibitor. Mvt-101 inhibits reproduction of the HIV virus by blocking protease action .

HY-W843885

H-Glu-Thr-OH L-α-Glutamyl-L-threonine	CaSR	Others
H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide made up of two amino acids—glutamic acid (Glu) and threonine (Thr)—connected by a peptide bond, and it acts as an agonist for the extracellular calcium-sensing receptor (CaSR) .

HY-174809A

6-Arm-PEG-Mal (MW 600)	Biochemical Assay Reagents	Others
6-Arm-PEG-Mal (MW 600) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-174809E

6-Arm-PEG-Mal (MW 5000)	Biochemical Assay Reagents	Others
6-Arm-PEG-Mal (MW 5000) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-174809H

6-Arm-PEG-Mal (MW 10000)	Biochemical Assay Reagents	Others
6-Arm-PEG-Mal (MW 10000) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-174809

6-Arm-PEG-Mal (MW 400)	Biochemical Assay Reagents	Others
6-Arm-PEG-Mal (MW 400) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-174809C

6-Arm-PEG-Mal (MW 2000)	Biochemical Assay Reagents	Others
6-Arm-PEG-Mal (MW 2000) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-174809D

6-Arm-PEG-Mal (MW 3400)	Biochemical Assay Reagents	Others
6-Arm-PEG-Mal (MW 3400) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-W012898

Dimethylglyoxime Biacetyl dioxime	Biochemical Assay Reagents	Others
Dimethylglyoxime (Biacetyl dioxime) belongs to the class of oximes and consists of two acetyl groups attached to a nitrogen atom, which in turn is attached to another nitrogen atom through a diimine bond. Dimethylglyoxime is a specific chelator of Ni that inhibits or slows the aggregation of Aβ peptides in vitro .

HY-174809B

6-Arm-PEG-Mal (MW 1000)	Biochemical Assay Reagents	Others
6-Arm-PEG-Mal (MW 1000) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-Y1703

HATU	Biochemical Assay Reagents	Others
HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate) is a reagent used in peptide coupling chemistry to generate an active ester from a carboxylic acid. HATU can be used along with Hünig's base (N,N-diisopropylethylamine, DIPEA) to form amide bonds .

HY-128945

CL2A	ADC Linker	Inflammation/Immunology Cancer
CL2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker .

HY-P6023

D-Leu-Pro-Arg-Rh110-D-Pro	Factor Xa	Cardiovascular Disease
D-Leu-Pro-Arg-Rh110-D-Pro is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro can be used to detect FXIa activity .

HY-P6023B

D-Leu-Pro-Arg-Rh110-D-Pro acetate	Factor Xa	Cardiovascular Disease
D-Leu-Pro-Arg-Rh110-D-Pro acetate is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro acetate consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro acetate can be used to detect FXIa activity .

HY-P5439

Epsilon-V1-2, Cys-conjugated	PKC MARCKS	Others
Epsilon-V1-2, Cys-conjugated is a biological active peptide. (This peptide is the εPKC specific inhibitor. Its inhibitory activity is based on εPKC translocation and MARCKS phosphorylation. This peptide interferes with εPKC interaction with the anchoring protein εRACK. This peptide contains a cysteine residue added to the C-terminus for potential S-S bond formation with a carrier protein.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

HY-128945A

CL2A TFA	ADC Linker	Inflammation/Immunology Cancer
CL2A TFA is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A TFA is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker .

HY-P6023A

D-Leu-Pro-Arg-Rh110-D-Pro TFA	Factor Xa	Cardiovascular Disease
D-Leu-Pro-Arg-Rh110-D-Pro TFA is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro TFA consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro TFA can be used to detect FXIa activity .

HY-131498

MOCAc-PLGL(Dpa)AR Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2	Fluorescent Dye	Others
MOCAc-PLGL(Dpa)AR is a positively charged fluorescent substrate for matrix metalloproteinase-2 (MMP-2), MMP-7 and MMP-9. MOCAc-PLGL(Dpa)AR is a substrate of matrilysin, can be cleaved at the peptide bond between the glycine and leucine residues .

HY-B0239S3

Chloramphenicol-d4	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Chloramphenicol-d₄ is deuterium labeled Chloramphenicol. Chloramphenicol, a broad-spectrum antibiotic, acts as a potent inhibitor of bacterial protein biosynthesis . Chloramphenicol acts primarily on the 50S subunit of bacterial 70S rihosomes and inhibits peptide bond formation by suppressing peptidyl transferase activity .

HY-41121S1

Boc-L-Ala-OH-3-13C	Isotope-Labeled Compounds Endogenous Metabolite	Others
Boc-L-Ala-OH-3- ¹³C is a ¹³C-labeled Boc-L-Ala-OH (HY-41121). Boc-L-Ala-OH (Boc-Ala-OH) shows excellent affinity with ATP. Boc-L-Ala-OH contains an amino acid moiety, and an acylamide bond like that of the peptide and protein .

HY-41121S2

Boc-L-Ala-OH-2-13C	Isotope-Labeled Compounds	Others
Boc-L-Ala-OH-2- ¹³C is a ¹³C-labeled Boc-L-Ala-OH (HY-41121). Boc-L-Ala-OH (Boc-Ala-OH) shows excellent affinity with ATP. Boc-L-Ala-OH contains an amino acid moiety, and an acylamide bond like that of the peptide and protein .

HY-W591618D

4-Arm-PEG-Maleimide (MW 3400) 4-Arm-PEG-Mal (MW 3400)	Biochemical Assay Reagents	Others
4-Arm-PEG-Maleimide (MW 3400) (4-Arm-PEG-Mal (MW 3400)) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-W591618B

4-Arm-PEG-Maleimide (MW 600) 4-Arm-PEG-Mal (MW 600)	Biochemical Assay Reagents	Others
4-Arm-PEG-Maleimide (MW 600) (4-Arm-PEG-Mal (MW 600)) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-W591465

4-Arm-PEG-Maleimide (MW 2000) 4-Arm-PEG-Mal (MW 2000)	Biochemical Assay Reagents	Others
4-Arm-PEG-Maleimide (MW 2000) (4-Arm-PEG-Mal (MW 2000)) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-W591618A

4-Arm-PEG-Maleimide (MW 400) 4-Arm-PEG-Mal (MW 400)	Biochemical Assay Reagents	Others
4-Arm-PEG-Maleimide (MW 400) (4-Arm-PEG-Mal (MW 400)) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-W591618C

4-Arm-PEG-Maleimide (MW 1000) 4-Arm-PEG-Mal (MW 1000)	Biochemical Assay Reagents	Others
4-Arm-PEG-Maleimide (MW 1000) (4-Arm-PEG-Mal (MW 1000)) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-138232

Lys-psi(CH2NH)-Trp(Nps)-OMe LTNAM	Aminopeptidase	Neurological Disease
Lys-psi(CH2NH)-Trp(Nps)-OMe is a lysine-tryptophan (Nps) pseudodipeptide analog. It is obtained by replacing the peptide bond in the Lys-Trp(Nps) molecule with an aminomethylene bond and has analgesic activity. Lys-psi(CH2NH)-Trp(Nps)-OMe induces a dose-dependent and naloxone-reversible analgesia after intracerebroventricular administration in mice, and its analgesic effect lasts longer than that of the original compound. It protects methionine enkephalin from degradation in rat striatal slices and binds to low-dose opioid peptides to produce analgesia. Lys-psi(CH2NH)-Trp(Nps)-OMe effectively inhibits brain aminopeptidase activity both in vitro and in vivo. The enhanced resistance of this pseudodipeptide to proteolysis may explain its prolonged analgesic activity.

HY-W102456

H-Phe(4-Ac)-OH L-4-Acetylphenylalanine	Biochemical Assay Reagents Amino Acid Derivatives	Others
H-Phe(4-Ac)-OH (L-4-Acetylphenylalanine) is a keto-amino acid that can be converted from α-keto acids containing an acetyl group. H-Phe(4-Ac)-OH can be added to the amber position to form mutant Z-domain proteins. H-Phe(4-Ac)-OH is used as a functional amino acid in peptide modification to achieve chemical bonding between peptides and solid surfaces .

HY-D2753

BDP 650/665 X NHS ester	Fluorescent Dye	Others
BDP 650/665 X NHS ester is a hydrophobic fluorophore with a NHS ester. The NHS ester can react specifically and efficiently with primary amines such as the side chain of lysine residue or aminosilane-coated surfaces at neutral or slight basic conditions to form a covalent bond. BDP 650/665 X NHS ester is useful for the labeling of lipids, oligonucleotides, peptides, and many other large and small molecules.

HY-P5461

CHRG01	Bacterial	Others
CHRG01 is a biological active peptide. (CHRG01 is derived from human b-defensin 3 (hBD3) C-terminal amino acids 54 to 67, with all Cys residues substituted with Ser. This substitution removes all disulfide bond linkages within the sequence. CHRG01, like hBD3, displays electrostatic-dependent antimicrobial properties.)

HY-P2810

Rennin EC 3.4.23.4	Endogenous Metabolite Ser/Thr Protease	Metabolic Disease
Rennin, also known as Chymosin, is a pepsin-related proteolytic enzyme synthesized by cells in the stomach of certain animals that efficiently converts liquid milk into a semi-solid, allowing it to remain in the stomach for longer. The natural substrate of Rennin is K-casein, which is specifically cleaved at the peptide bond between amino acid residues 105 and 106, phenylalanine and methionine, and is widely used in cheese production .

Cat. No.	Product Name	Type

HY-131498

MOCAc-PLGL(Dpa)AR Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2	Fluorescent Dyes/Probes
MOCAc-PLGL(Dpa)AR is a positively charged fluorescent substrate for matrix metalloproteinase-2 (MMP-2), MMP-7 and MMP-9. MOCAc-PLGL(Dpa)AR is a substrate of matrilysin, can be cleaved at the peptide bond between the glycine and leucine residues .

HY-D2753

BDP 650/665 X NHS ester

Fluorescent Dyes/Probes

BDP 650/665 X NHS ester is a hydrophobic fluorophore with a NHS ester. The NHS ester can react specifically and efficiently with primary amines such as the side chain of lysine residue or aminosilane-coated surfaces at neutral or slight basic conditions to form a covalent bond. BDP 650/665 X NHS ester is useful for the labeling of lipids, oligonucleotides, peptides, and many other large and small molecules.

HY-D2772

5-TAMRA Cadaverine

Fluorescent Dyes/Probes

5-TAMRA cadaverine can used to modify carboxylic acid group in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. It also can be reversibly coupled to aldehydes and ketones to form a Schiff base – which can be reduced to a generate stable amine derivative by sodium borohydride (NaBH4) or sodium cyanoborohydride (NaCNH3). Although the mixed isomers of 5(6)-TAMRA cadaverine is a preferred, routinely used orange-fluorescent dye for staining proteins, it is rearly used for labeling peptides and nucleotides. Purification of 5(6)-TAMRA labeled peptide and nucleotides might be troublesome due to significant signal broadening in HPLC purification. Peptides and nucleotides labeled with a single isomer TAMRA usually give better resolution in HPLC purification that is often required in the conjugation processes.

HY-D2738

BP Fluor 532 NHS ester

Fluorescent Dyes/Probes

BP Fluor 532 NHS ester is an amine reactive, yellow-emitting dye routinely used to label proteins or antibodies through primary amines (Lys), amine-modified oligonucleotides, and other amine-containing biomolecules. The labeling occurs most efficiently at pH 7-9 and forms a stable, covalent amide bond. BP Fluor 532 is a bright yellow-fluorescent dye with pH insensitive emission from pH 4 to pH 10. The excitation of BP Fluor 532 is ideally suited for the frequency-doubled Nd:YAG laser line. BP Fluor 532 can be conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, and is often used for the generation of stable signals in imaging and flow cytometry.

HY-D2763

BP Fluor 532 maleimide

Fluorescent Dyes/Probes

BP Fluor 532 maleimide is a photostable, bright yellow-fluorescent dye with pH insensitive emission from pH 4 to pH 10. The excitation of BP Fluor 532 is ideally suited for the frequency-doubled Nd:YAG laser line. BP Fluor 532 dye can be conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, and is often used for the generation of stable signals in imaging and flow cytometry. Maleimide is the most popular sulfhydryl-reactive group for conjugating the dye to a thiol group on a protein, oligonucleotide thiophosphate, or low molecular weight ligand. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form a stable thioether bond. The resulting conjugates exhibit brighter fluorescence and greater photostability than the conjugates of many other spectrally similar fluorophores.

HY-D2745

BP Fluor 594 NHS ester

Fluorescent Dyes/Probes

BP Fluor 594 NHS ester is the most popular tool for modifying proteins or antibodies through the primary amines (Lys), amine-modified oligonucleotides, and other amine-containing biomolecules with BP Fluor 594 label. The labeling occurs most efficiently at pH 7-9 and forms a stable, covalent amide bond. BP Fluor 594 dye can be used for proteins labeling at high molar ratios without significant self-quenching, enabling brighter conjugates and more sensitive detection. BP Fluor 594 is bright, water-soluble, and pH-insensitive from pH 4 to pH 10 red-fluorescent dye with absorption and emission maxima at 590 and 617 nm, respectively. It can be used with the 561 nm and 594 nm laser lines. BP Fluor 594 dye conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates often used for generation of stable signal in imaging and flow cytometry.

Cat. No.	Product Name	Type

HY-W1123939

Silane-PEG-COOH (MW 1000)	Drug Delivery
Silane-PEG-COOH (MW 1000) can be used to modify proteins, peptides and other materials with active groups. The carboxyl group (-COOH) can easily form a stable amide bond with the amino group, and can also form an ester bond with the hydroxyl group. Silane-functionalized PEG (Silane-PEG-X) can be used to modify glass, silicon, etc .

HY-W1123939A

Silane-PEG-COOH (MW 2000)	Drug Delivery
Silane-PEG-COOH (MW 2000) can be used to modify proteins, peptides and other materials with active groups. The carboxyl group (-COOH) can easily form a stable amide bond with the amino group, and can also form an ester bond with the hydroxyl group. Silane-functionalized PEG (Silane-PEG-X) can be used to modify glass, silicon, etc .

HY-W1123939C

Silane-PEG-COOH (MW 5000)	Drug Delivery
Silane-PEG-COOH (MW 5000) can be used to modify proteins, peptides and other materials with active groups. The carboxyl group (-COOH) can easily form a stable amide bond with the amino group, and can also form an ester bond with the hydroxyl group. Silane-functionalized PEG (Silane-PEG-X) can be used to modify glass, silicon, etc .

HY-W1123939B

Silane-PEG-COOH (MW 3400)	Drug Delivery
Silane-PEG-COOH (MW 3400) can be used to modify proteins, peptides and other materials with active groups. The carboxyl group (-COOH) can easily form a stable amide bond with the amino group, and can also form an ester bond with the hydroxyl group. Silane-functionalized PEG (Silane-PEG-X) can be used to modify glass, silicon, etc .

HY-174809A

6-Arm-PEG-Mal (MW 600)	Drug Delivery
6-Arm-PEG-Mal (MW 600) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-174809E

6-Arm-PEG-Mal (MW 5000)	Drug Delivery
6-Arm-PEG-Mal (MW 5000) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-174809H

6-Arm-PEG-Mal (MW 10000)	Drug Delivery
6-Arm-PEG-Mal (MW 10000) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-174809

6-Arm-PEG-Mal (MW 400)	Drug Delivery
6-Arm-PEG-Mal (MW 400) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-174809C

6-Arm-PEG-Mal (MW 2000)	Drug Delivery
6-Arm-PEG-Mal (MW 2000) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-174809D

6-Arm-PEG-Mal (MW 3400)	Drug Delivery
6-Arm-PEG-Mal (MW 3400) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-W012898

Dimethylglyoxime Biacetyl dioxime	Biochemical Assay Reagents
Dimethylglyoxime (Biacetyl dioxime) belongs to the class of oximes and consists of two acetyl groups attached to a nitrogen atom, which in turn is attached to another nitrogen atom through a diimine bond. Dimethylglyoxime is a specific chelator of Ni that inhibits or slows the aggregation of Aβ peptides in vitro .

HY-174809B

6-Arm-PEG-Mal (MW 1000)	Drug Delivery
6-Arm-PEG-Mal (MW 1000) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-W591618D

4-Arm-PEG-Maleimide (MW 3400) 4-Arm-PEG-Mal (MW 3400)	Drug Delivery
4-Arm-PEG-Maleimide (MW 3400) (4-Arm-PEG-Mal (MW 3400)) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-W591618B

4-Arm-PEG-Maleimide (MW 600) 4-Arm-PEG-Mal (MW 600)	Drug Delivery
4-Arm-PEG-Maleimide (MW 600) (4-Arm-PEG-Mal (MW 600)) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-W591465

4-Arm-PEG-Maleimide (MW 2000) 4-Arm-PEG-Mal (MW 2000)	Drug Delivery
4-Arm-PEG-Maleimide (MW 2000) (4-Arm-PEG-Mal (MW 2000)) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-W591618A

4-Arm-PEG-Maleimide (MW 400) 4-Arm-PEG-Mal (MW 400)	Drug Delivery
4-Arm-PEG-Maleimide (MW 400) (4-Arm-PEG-Mal (MW 400)) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-W591618C

4-Arm-PEG-Maleimide (MW 1000) 4-Arm-PEG-Mal (MW 1000)	Drug Delivery
4-Arm-PEG-Maleimide (MW 1000) (4-Arm-PEG-Mal (MW 1000)) is a PEG derivative modified with Maleimide (HY-W007324), which forms a stable thioether bond with sulfhydryl (-SH). PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-79647

Fmoc-OSu

N-(Fmoc-oxy)succinimide

Biochemical Assay Reagents

Fmoc-OSu (N-(Fmoc-oxy)succinimide) is an acylating agent that targets amino groups (-NH2). It can selectively protect the amino groups of amino acids by covalently binding with primary or secondary amines through nucleophilic substitution reactions. Fmoc-OSu forms a stable amide bond with the amino group to avoid side reactions of the amino group in peptide synthesis. It can also be used as a fluorescent labeling reagent to react with glycosylamines for efficient labeling of N-sugar chains. Fmoc-OSu can be used as an Fmoc protection strategy in peptide synthesis, and as a fluorescent labeling and analysis method for N-sugar chains .

HY-W440901

DSPE-PEG-SPDP (MW 5000)

Drug Delivery

DSPE-PEG-SPDP, MW 5000 is an amphiphilic polyPEG which forms lipid bilayer in water. It can be used to encapsualte therapeutic agents. The core can encapsulate hydrophilic nutrients, such as protein/peptide and mRNA/DNA/siRNA etc. while the lipid bilayer can solubilize hydrophobic drugs, such as doxorubicin, curcumin etc. The SPDP moiety can react with thiol molecule to form a disulfide bond. Reagent grade, for research use only.

HY-174961C

Fmoc-PEG-Maleimide (MW 5000)

Fmoc-NH-PEG-Mal (MW 5000)

Drug Delivery

Fmoc-PEG-Maleimide (MW 5000) (Fmoc-NH-PEG-Mal (MW 5000)) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-174961B

Fmoc-PEG-Maleimide (MW 3400)

Fmoc-NH-PEG-Mal (MW 3400)

Drug Delivery

Fmoc-PEG-Maleimide (MW 3400) (Fmoc-NH-PEG-Mal (MW 3400)) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-174961

Fmoc-PEG-Maleimide (MW 1000)

Fmoc-NH-PEG-Mal (MW 1000)

Drug Delivery

Fmoc-PEG-Maleimide (MW 1000) (Fmoc-NH-PEG-Mal (MW 1000)) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-174961A

Fmoc-PEG-Maleimide (MW 2000)

Fmoc-NH-PEG-Mal (MW 2000)

Drug Delivery

Fmoc-PEG-Maleimide (MW 2000) (Fmoc-NH-PEG-Mal (MW 2000)) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .

HY-Y0623

N-Hydroxysuccinimide

1 Publications Verification

HOSu; 1-Hydroxy-2,5-pyrrolidinedione

Biochemical Assay Reagents

N-Hydroxysuccinimide (HOSu; 1-Hydroxy-2,5-pyrrolidinedione) is a covalent crosslinker commonly used in bioconjugation technology with a primary amine group. N-Hydroxysuccinimide reacts with amino groups (-NH2) to form a stable amide bond, which can modify amino-containing biomolecules. N-Hydroxysuccinimide can be used, for example, for protein labeling with fluorescent dyes and enzymes, surface activation of chromatography supports, microbeads, nanoparticles and microarray slides, and chemical synthesis of peptides. N-Hydroxysuccinimide has a wide range of applications in biomaterial synthesis (such as collagen, chitosan crosslinking), drug delivery systems (such as hydrogel preparation) and tissue engineering .

Cat. No.	Product Name	Target	Research Area

HY-131092A

H-Asn-Arg-OH diTFA	Drug Intermediate	Others
H-Asn-Arg-OH diTFA is a dipeptide formed by the connection of asparagine and arginine via a peptide bond, which can be used in polypeptide synthesis.

HY-A0162

Quinupristin 1 Publications Verification	Bacterial	Infection
Quinupristin is a streptogramin antibiotic. Quinupristin blocks peptide bond synthesis to prevent the extension of polypeptide chains and promote the detachment of incomplete protein chains in the bacterial ribosomal subunits .

HY-41121

Boc-L-Ala-OH 1 Publications Verification Boc-Ala-OH	Amino Acid Derivatives	Others
Boc-L-Ala-OH (Boc-Ala-OH) shows excellent affinity with ATP. Boc-L-Ala-OH contains an amino acid moiety, and an acylamide bond like that of the peptide and protein .

HY-W843885

H-Glu-Thr-OH L-α-Glutamyl-L-threonine	CaSR	Others
H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide made up of two amino acids—glutamic acid (Glu) and threonine (Thr)—connected by a peptide bond, and it acts as an agonist for the extracellular calcium-sensing receptor (CaSR) .

HY-P4615

Cyclo(-Glu-Glu)	Peptides	Others
Cyclo(-Glu-Glu) is a cyclic peptide, a cyclic structure formed by linking two glutamic acid residues through a peptide bond .

HY-131092

H-Asn-Arg-OH	Drug Intermediate	Others
H-Asn-Arg-OH is a dipeptide formed by the connection of asparagine and arginine via a peptide bond, which can be used in polypeptide synthesis.

HY-P4597

(H-Cys-Phe-OH)2 (disulfide bond)	Peptides	Others
(H-Cys-Phe-OH)2 (disulfide bond) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-A0162A

Quinupristin mesylate	Bacterial	Infection
Quinupristin mesylate is a streptogramin antibiotic. Quinupristin mesylate blocks peptide bond synthesis to prevent the extension of polypeptide chains and promote the detachment of incomplete protein chains in the bacterial ribosomal subunits .

HY-P2054

Mvt-101	HIV Protease	Infection
Mvt-101 is a hexapeptide-based inhibitor of HIV-1 protease. Mvt-101 is also reduced-peptide-bond inhibitor. Mvt-101 inhibits reproduction of the HIV virus by blocking protease action .

HY-P6023

D-Leu-Pro-Arg-Rh110-D-Pro	Factor Xa	Cardiovascular Disease
D-Leu-Pro-Arg-Rh110-D-Pro is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro can be used to detect FXIa activity .

HY-P6023B

D-Leu-Pro-Arg-Rh110-D-Pro acetate	Factor Xa	Cardiovascular Disease
D-Leu-Pro-Arg-Rh110-D-Pro acetate is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro acetate consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro acetate can be used to detect FXIa activity .

HY-P5510

Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-ψ-(COO)Ala-Ser-Lys(DABCYL)-NH2 HCV NS3 protease substrate	Peptides	Others
Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-ψ-(COO)Ala-Ser-Lys(DABCYL)-NH2 (HCV NS3 protease substrate) is a biological active peptide. (This peptide is a HCV protease substrate incorporating an ester bond between residues P1 and P1. Due to ready transesterification of the scissile bond to the acyl-enzyme intermediate, this substrate shows very high kcat/Km values, enabling detection of activity with subnanomolar nonstructural protein 3 (NS3 protease) concentrations. It is widely used for the continuous assay of NS3 protease activity. Substrate cleavage is proportional to the enzyme concentration with a detection limit for NS3 between 1 nM and 250 pM.

HY-P5439

Epsilon-V1-2, Cys-conjugated	PKC MARCKS	Others
Epsilon-V1-2, Cys-conjugated is a biological active peptide. (This peptide is the εPKC specific inhibitor. Its inhibitory activity is based on εPKC translocation and MARCKS phosphorylation. This peptide interferes with εPKC interaction with the anchoring protein εRACK. This peptide contains a cysteine residue added to the C-terminus for potential S-S bond formation with a carrier protein.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

HY-P6023A

D-Leu-Pro-Arg-Rh110-D-Pro TFA	Factor Xa	Cardiovascular Disease
D-Leu-Pro-Arg-Rh110-D-Pro TFA is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro TFA consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro TFA can be used to detect FXIa activity .

HY-P5481

DABCYL-LPETG-EDANS	Peptides	Others
DABCYL-LPETG-EDANS is a biological active peptide. (This 5-amino acid peptide is a sortase substrate, C-terminal sorting signal. Sortase cleaves surface proteins at the LPXTG motif and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Sortases are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer. Cleavage of this FRET substrate by sortase reveals the fluorescent signal, Abs/Em = 340/490 nm.)

HY-P5461

CHRG01	Bacterial	Others
CHRG01 is a biological active peptide. (CHRG01 is derived from human b-defensin 3 (hBD3) C-terminal amino acids 54 to 67, with all Cys residues substituted with Ser. This substitution removes all disulfide bond linkages within the sequence. CHRG01, like hBD3, displays electrostatic-dependent antimicrobial properties.)

HY-P1883

Bacterial Sortase Substrate III, Abz/DNP	Fluorescent Dye	Infection
Bacterial Sortase Substrate III, Abz/DNP is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.

HY-P3123

Dnp-RPLALWRS	Fluorescent Dye	Others
Dnp-RPLALWRS is a fluorescent peptide substrate designed for human matrilysin (MMP-7). After enzymatic cleavage of Dnp-RPLALWRS at the alanine-leucine bond, the release of the Dnp group alleviates fluorescence quenching, thereby enabling real-time quantitative analysis of MMP-7 activity by increasing tryptophan emission. Dnp-RPLALWRS provides a sensitive and efficient detection method for kinetic studies and inhibitor screenin .

HY-P3123A

Dnp-RPLALWRS TFA	Fluorescent Dye	Others
Dnp-RPLALWRS TFA is a fluorescent peptide substrate designed for human matrilysin (MMP-7). After enzymatic cleavage of Dnp-RPLALWRS TFA at the alanine-leucine bond, the release of the Dnp group alleviates fluorescence quenching, thereby enabling real-time quantitative analysis of MMP-7 activity by increasing tryptophan emission. Dnp-RPLALWRS TFA provides a sensitive and efficient detection method for kinetic studies and inhibitor screenin .

HY-P1883A

Bacterial Sortase Substrate III, Abz/DNP TFA	Fluorescent Dye	Infection
Bacterial Sortase Substrate III, Abz/DNP TFA is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Cleavage of this substrate can be monitored at Ex/Em=320 nm/420 nm.

HY-P5377

Abz-HPGGPQ-EDDnp Cathepsin K substrate	Ser/Thr Protease	Others
Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2, 4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.)

HY-P10968

KT2	Bacterial Antibiotic	Infection
KT2 is a cationic amphipathic antibacterial peptide. KT2 can completely kill cells of E. coli O157:H7. KT2 has potent anti-biofilm activity and prevents biofilm formation of E. coli O157:H7. KT2 significantly binds to bacterial surface LPS and interacts with the lipids of liposomes with great penetration capability into bacterial cells, followed by bond to DNA and other cytoplasmic membrane .

HY-P5601

Thanatin	Bacterial Fungal	Infection
Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .

HY-P5601A

Thanatin TFA	Bacterial Fungal	Infection
Thanatin TFA is an inducible cationic antimicrobial peptide. Thanatin TFA s a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin TFA displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin TFA has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .

HY-P5415

DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS	HIV	Others
DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is a biological active peptide. (DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is also called HIV protease substrate I in some literature. It is widely used for the continuous assay for HIV protease activity. The 11-kD protease (PR) encoded by the human immunodeficiency virus 1 (HIV-1) is essential for the correct processing of viral polyproteins and the maturation of infectious virus, and is therefore a target for the design of selective acquired immunodeficiency syndrome (AIDS) therapeutics. The FRET-based fluorogenic substrate is derived from a natural processing site for HIV-1 PR. Incubation of recombinant HIV-1 PR with the fluorogenic substrate resulted in specific cleavage at the Tyr-Pro bond and a time-dependent increase in fluorescence intensity that is linearly related to the extent of substrate hydrolysis. The fluorescence quantum yields of the HIV-1 PR substrate in the FRET assay increased by 40.0- and 34.4-fold, respectively, per mole of substrate cleaved. Because of its simplicity and precision in the determination of reaction rates required for kinetic analysis, this substrate offers many advantages over the commonly used HPLC or electrophoresis-based assays for peptide substrate hydrolysis by retroviral PRs. Abs/Em = 340nm/490nm.)

Cat. No.	Product Name

HY-K1054

Blasticidin S, Sterile 1 Publications Verification
Blasticidin S is a peptidyl nucleoside antibiotic isolated from Streptomyces griseochromogenes. It acts by blocking hydrolysis of peptidyl-tRNA induced by release factors and inhibits peptide bond formation.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6680

Virginiamycin S1	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields	Bacterial Antibiotic
Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic, inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. Virginiamycin S1 belongs to the type B compounds in the streptogramin family and is produced by Streptomyces virginiae, shows a strong bactericidal activity against a wide range of Gram-positive bacteria. Virginiamycin S1 together with virginiamycin M1 is more effective in treat multidrug-resistant bacterial infections ^[1][2].

HY-118593

A2315A Madumycin II; Antibiotic A 2315A	Structural Classification Natural Products Microorganisms Source classification	Antibiotic
A2315A (Madumycin II) is an alanine-containing streptogramin A antibiotic. A2315A is a potent peptidyl transferase center (PTC) inhibitor. A2315A inhibits the ribosome prior to the first cycle of peptide bond formation .

HY-N6680R

Virginiamycin S1 (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification Antibacterial Disease Research	Reference Standards Bacterial Antibiotic
Virginiamycin S1 (Standard) is the analytical standard of Virginiamycin S1. This product is intended for research and analytical applications. Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic, inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. Virginiamycin S1 belongs to the type B compounds in the streptogramin family and is produced by Streptomyces virginiae, shows a strong bactericidal activity against a wide range of Gram-positive bacteria. Virginiamycin S1 together with virginiamycin M1 is more effective in treat multidrug-resistant bacterial infections .

Cat. No.	Product Name	Chemical Structure

HY-176305S

Neurofilament, U-15N
Neurofilament, U- ¹⁵N is the ¹⁵N-labeled Neurofilament.

HY-B0239S3

Chloramphenicol-d4
Chloramphenicol-d₄ is deuterium labeled Chloramphenicol. Chloramphenicol, a broad-spectrum antibiotic, acts as a potent inhibitor of bacterial protein biosynthesis . Chloramphenicol acts primarily on the 50S subunit of bacterial 70S rihosomes and inhibits peptide bond formation by suppressing peptidyl transferase activity .

HY-41121S1

Boc-L-Ala-OH-3-13C
Boc-L-Ala-OH-3- ¹³C is a ¹³C-labeled Boc-L-Ala-OH (HY-41121). Boc-L-Ala-OH (Boc-Ala-OH) shows excellent affinity with ATP. Boc-L-Ala-OH contains an amino acid moiety, and an acylamide bond like that of the peptide and protein .

HY-41121S2

Boc-L-Ala-OH-2-13C
Boc-L-Ala-OH-2- ¹³C is a ¹³C-labeled Boc-L-Ala-OH (HY-41121). Boc-L-Ala-OH (Boc-Ala-OH) shows excellent affinity with ATP. Boc-L-Ala-OH contains an amino acid moiety, and an acylamide bond like that of the peptide and protein .

Cat. No.	Product Name		Classification

HY-151738

Fmoc-Aeg(N3)-OH		Azide
Fmoc-Aeg(N3)-OH is a click chemistry reagent containing an Azide. Alkylating the Nitrogen of an amide bond results in peptoid structures, which leads to conformational restrains, like N-methylation and allows backbone derivatisation. Altering cytotoxicity, bacterial cell selectivity and receptor pharmacology through formation of peptoid derivatives have been published for Cilengitide, Piscidin 1, and MC3, MC4 and MC5 receptor agonist. This building block enables design of macrocycles through intermolecular crosslinking or backbone stabilization through intermolecular ring-closure. This compound is a potential building block for the construction of (customized) peptide nucleic acids (PNAs) and for peptoid synthesis . Fmoc-Aeg(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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