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Isoforms Recommended:	Lck

Results for "

p56-Lck

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Fungal (1) p38 MAPK (2) PKC (2) Small Interfering RNA (siRNA) (3) Src (5)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

8

Inhibitors & Agonists

2

Natural
Products

1

Recombinant Proteins

5

Antibodies

3

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

SB 220025	p38 MAPK Src PKC	Inflammation/Immunology
SB 220025 is a reversible, orally active, cell-permeable, ATP-competitive and selective human p38 MAPK inhibitor (IC₅₀ = 60 nM). SB 220025 also inhibits p56 ^Lck and PKC with IC₅₀ values of 3.5 and 2.89 µM, respectively. SB 220025 inhibits the expression of IL-8 gene in response to globular adiponectin (gAd), reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 effectively prevents the progression of arthritis in a chronic inflammatory disease model and can be used in the study of inflammation .

Damnacanthal	Src Apoptosis Fungal	Infection Inflammation/Immunology Cancer
Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56 ^lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 ^lck autophosphorylation and phosphorylation of exogenous substrates with IC₅₀s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against *Candida albicans* .

SB 220025 (tri(hydrochloride))	p38 MAPK Src PKC	Inflammation/Immunology
SB 220025 trihydrochloride is a reversible, orally active, cell-permeable, ATP-competitive and selective human p38 MAPK inhibitor (IC₅₀ = 60 nM). SB 220025 trihydrochloride also inhibits p56 ^Lck and PKC with IC₅₀ values of 3.5 and 2.89 μM, respectively. SB 220025 trihydrochloride inhibits the expression of IL-8 gene in response to globular adiponectin (gAd), reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 trihydrochloride effectively prevents the progression of arthritis in a chronic inflammatory disease model and can be used in the study of inflammation .

BMS-243117	Src	Cancer
BMS-243117 is a potent, and selective benzothiazole based p56 ^Lck inhibitor with an IC₅₀ of 4 nM. BMS-243117 inhibits anti-CD3/anti-CD28 induced PBL (human peripheral blood T-cells) proliferation with an IC₅₀ of 1.1 μM. BMS-243117 binds in an extended conformation to the ATP-binding site of Lck .

2,3,4,6,8-Pentahydroxy-1-methylxanthone	Src	Cardiovascular Disease
2,3,4,6,8-Pentahydroxy-1-methylxanthone is a xanthone derivative of Wardomyces anomalus. 2,3,4,6,8-Pentahydroxy-1-methylxanthone shows significant antioxidant activities. 2,3,4,6,8-Pentahydroxy-1-methylxanthone is inhibitors of p56 ^lck tyrosine kinase. 2,3,4,6,8-Pentahydroxy-1-methylxanthone can be used to treat cardiovascular disease .

Lck Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lck Rat Pre-designed siRNA Set A contains three designed siRNAs for Lck gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lck Rat Pre-designed siRNA Set A Lck Rat Pre-designed siRNA Set A

LCK Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LCK Human Pre-designed siRNA Set A contains three designed siRNAs for LCK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LCK Human Pre-designed siRNA Set A LCK Human Pre-designed siRNA Set A

Lck Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lck Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lck gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lck Mouse Pre-designed siRNA Set A Lck Mouse Pre-designed siRNA Set A

Cat. No.	Compare	Product Name	Species	Source

	Lck Protein, Human (sf9, GST) Tyrosine-protein kinase Lck; LSK; Lck; Hck-3	Human	Sf9 insect cells
	The Lck protein is a non-receptor tyrosine protein kinase that is essential for T cell development and function. Lck is constitutively associated with CD4 and CD8 receptors and is recruited to the TCR/CD3 complex following TCR interaction with MHC. Lck Protein, Human (sf9, GST) is the recombinant human-derived Lck protein, expressed by Sf9 insect cells , with N-GST labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

	Lck Antibody (YA712) Lck; Tyrosine-protein kinase Lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-Lck	WB	Human
	Lck Antibody (YA712) is a non-conjugated and Mouse origined monoclonal antibody about 58 kDa, targeting to Lck (3E5). It can be used for WB assays with tag free, in the background of Human.

	Lck Antibody (YA3667) YT16; p56Lck; pp58Lck	WB, ELISA	Human
	Lck Antibody (YA3667) is a mouse-derived and non-conjugated IgG2a antibody, targeting to Lck. It can be applicated for WB, ELISA assays, in the background of human.

	LCK Antibody (YA5247) Lck; Lck p56; Lck_HUMAN; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell specific protein tyrosine kinase; Lymphocyte cell-specific protein-tyrosine kinase; Lymphocyte Specific Protein Tyrosine Kinase; Membrane associated protein tyrosine kinase; Oncogene Lck; p56 Lck; p56; LSTRA; protein tyrosine kinase; p56-Lck; p56Lck; pp58 Lck; pp58Lck; Protein YT16; Proto oncogene tyrosine protein kinase Lck; Proto-oncogene Lck; Protooncogene tyrosine protein kinase Lck; T cell specific protein tyrosine kinase; T cell-specific protein-tyrosine kinase; T lymphocyte specific protein tyrosine kinase p56Lck; Tyrosine-protein kinase Lck; YT 16; YT16.	WB	Human
	LCK Antibody (YA5247) is a mouse-derived and non-conjugated monoclonal antibody, targeting to LCK. It can be applicated for WB assays, in the background of human.

	Lck Antibody (YA4947) Lck; Tyrosine-protein kinase Lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-Lck	WB, ELISA	Human
	Lck Antibody (YA4947) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Lck. It can be applicated for WB, ELISA assays, in the background of human.

	Lck Antibody (YA6169) Lck; Tyrosine-protein kinase Lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-Lck	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Lck Antibody (YA6169) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lck. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

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Cat. No.	Product Name		Classification

Lck Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Lck Rat Pre-designed siRNA Set A contains three designed siRNAs for Lck gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

LCK Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
LCK Human Pre-designed siRNA Set A contains three designed siRNAs for LCK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lck Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Lck Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lck gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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