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Results for "

neuromodulator

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adrenergic Receptor (4) Apoptosis (4) Aryl Hydrocarbon Receptor (1) Autophagy (2) Cannabinoid Receptor (1) Drug Derivative (1) Endogenous Metabolite (18) Ferroptosis (2) Fluorescent Dye (1) GABA Receptor (2) iGluR (1) Isotope-Labeled Compounds (2) Neurokinin Receptor (6) Neuropeptide Y Receptor (3) Pyroptosis (2) Reference Standards (3) Sodium Channel (2) Trace Amine-associated Receptor (TAAR) (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (4) Endocrinology (6) Inflammation/Immunology (4) Metabolic Disease (3) Neurological Disease (33)

By Targets:

5-HT Receptor (1)

Adrenergic Receptor (4)

Apoptosis (4)

Aryl Hydrocarbon Receptor (1)

Autophagy (2)

Cannabinoid Receptor (1)

Drug Derivative (1)

Endogenous Metabolite (18)

Ferroptosis (2)

Fluorescent Dye (1)

GABA Receptor (2)

iGluR (1)

Isotope-Labeled Compounds (2)

Neurokinin Receptor (6)

Neuropeptide Y Receptor (3)

Pyroptosis (2)

Reference Standards (3)

Sodium Channel (2)

Trace Amine-associated Receptor (TAAR) (1)

By Research Areas:

Cancer (3)

Cardiovascular Disease (4)

Endocrinology (6)

Inflammation/Immunology (4)

Metabolic Disease (3)

Neurological Disease (33)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-30170

N-Methylphenethylamine	Endogenous Metabolite	Neurological Disease
N-Methylphenethylamine is a naturally occurring secondary amine *neuromodulator* and can be detected in human urine or plants .

HY-P1437

Neuropeptide S (mouse)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide S (mouse) is a bioactive peptide. Neuropeptide S (mouse), as a neurotransmitter/neuromodulator of 20 amino acids, can be used for the research of arousal, anxiety, locomotion, feeding behaviors, memory and agent addiction .

HY-B0528A

Octopamine hydrochloride 2 Publications Verification (±)-p-Octopamine hydrochloride	Adrenergic Receptor Endogenous Metabolite	Neurological Disease Endocrinology
Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .

HY-B0528AR

Octopamine hydrochloride (Standard) (±)-p-Octopamine hydrochloride (Standard)	Reference Standards Adrenergic Receptor Endogenous Metabolite	Neurological Disease Endocrinology
Octopamine (hydrochloride) (Standard) is the analytical standard of Octopamine (hydrochloride). This product is intended for research and analytical applications. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .

HY-114883A

Homocarnosine TFA 1 Publications Verification L-Homocarnosine TFA; γ-Aminobutyryl-L-histidine TFA	GABA Receptor Endogenous Metabolite	Neurological Disease
Homocarnosine TFA is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine TFA is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects . Homocarnosine TFA has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation .

HY-P1723

Spexin 1 Publications Verification Neuropeptide Q	Neuropeptide Y Receptor Apoptosis Ferroptosis Autophagy	Cardiovascular Disease Neurological Disease
Spexin (Neuropeptide Q) is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin can function through both central and peripheral actions. Spexin upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy .

HY-P0275

Proctolin 1 Publications Verification	Endogenous Metabolite	Neurological Disease
Proctolin is an endogenous pentapeptide that acts as an excitatory neuromodulator.

HY-103638A

3-Methoxytyramine 2 Publications Verification 3-O-methyl Dopamine	Endogenous Metabolite	Neurological Disease
3-Methoxytyramine, a well known extracellular metabolite of 3-hydroxytyramine/dopamine, is a neuromodulator.

HY-34713

N-Methylphenethylamine hydrochloride NMPEA hydrochloride	Trace Amine-associated Receptor (TAAR)	Neurological Disease
N-Methylphenethylamine (NMPEA) hydrochloride is a potent TAAR1 agonist. N-Methylphenethylamine hydrochloride also is a trace amine neuromodulator .

HY-B0681

Acamprosate	iGluR	Neurological Disease Metabolic Disease
Acamprosate is an orally active prototypic neuromodulator. Acamprosate can be used for the research of alcohol dependence and alcoholism .

HY-113356

m-Tyramine	Endogenous Metabolite	Neurological Disease
m-Tyramine is an endogenous trace amine neuromodulator. m-Tyramine has effects on the adrenergic and dopaminergic receptor ^{[1, 2]}.

HY-14948A

(R)-Carisbamate (R)-RWJ-333369	Others	Neurological Disease
(R)-Carisbamate ((R)-RWJ-333369) is the R-Enantiomer of Carisbamate (HY-14948). Carisbamate is an orally active neuromodulator .

HY-128975

m-Tyramine hydrobromide	Endogenous Metabolite	Neurological Disease
m-Tyramine hydrobromide is an endogenous trace amine neuromodulator. m-Tyramine hydrobromide has effects on the adrenergic and dopaminergic receptor ^{[1, 2]}.

HY-145475

Nervonoyl ethanolamide NEA	Cannabinoid Receptor	Neurological Disease Inflammation/Immunology
Nervonoyl ethanolamide (NEA) is an endogenous cannabinoid that can act as a presynaptic and postsynaptic neuromodulator. Nervonoyl ethanolamide can also be used in the research of inflammation .

HY-42068

(-)-Aspartic acid (R)-Aspartic acid; D-(-)-Aspartic acid	Pyroptosis	Neurological Disease
(-)-Aspartic acid is a pyroptosis inhibitor. (-)-Aspartic acid acts as a neurotransmitter and neuromodulator, participates in hormone synthesis and regulation, and plays a role in nervous system development and endocrine system .

HY-P3922

[Gly11] Substance P	Neurokinin Receptor	Neurological Disease
[Gly11] Substance P is an analog of Substance P (HY-P0201). Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS .

HY-B2132S

Tryptamine-d2 hydrochloride	Isotope-Labeled Compounds	Neurological Disease
Tryptamine-d₂ (hydrochloride) is a deuterium labeled Tryptamine hydrochloride. Tryptamine hydrochloride is a monoamine alkaloid, similar to other trace amines, is believed to play a role as a neuromodulator or neurotransmitter .

HY-P3925

[His11]Substance P	Neurokinin Receptor	Neurological Disease
[His11]Substance P is an analog of Substance P (HY-P0201). Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS .

HY-B2132R

Tryptamine (Standard) 1 Publications Verification 3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine (Standard)	Endogenous Metabolite	Others
Tryptamine (Standard) is the analytical standard of Tryptamine. This product is intended for research and analytical applications. Tryptamine is a monoamine alkaloid, similar to other trace amines, is believed to play a role as a neuromodulator or neurotransmitter.

HY-P0201

Substance P Maximum Cited Publications 21 Publications Verification Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Endocrinology Cancer
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

HY-103638AR

3-Methoxytyramine (Standard) 3-O-methyl Dopamine (Standard)	Reference Standards Endogenous Metabolite	Neurological Disease
3-Methoxytyramine (Standard) is the analytical standard of 3-Methoxytyramine. This product is intended for research and analytical applications. 3-Methoxytyramine, a well known extracellular metabolite of 3-hydroxytyramine/dopamine, is a neuromodulator.

HY-P0201A

Substance P TFA Maximum Cited Publications 21 Publications Verification Neurokinin P TFA	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Endocrinology Cancer
Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R) .

HY-172532

Acetylagmatine acetate N-Acetylagmatine acetate	Drug Derivative	Neurological Disease
Acetylagmatine (N-Acetylagmatine) acetate is a product formed by agmatine N-acetyltransferase (AgmNAT) catalyzing the reaction of acetyl-CoA and Agmatine (HY-101238). Agmatine is the product of arginine decarboxylation. Agmatine is a neurotransmitter and neuromodulator in mammalian brain .

HY-42068R

(-)-Aspartic acid (Standard) (R)-Aspartic acid (Standard); D-(-)-Aspartic acid (Standard)	Reference Standards Pyroptosis	Neurological Disease
(-)-Aspartic acid (Standard) is the analytical standard of (-)-Aspartic acid. This product is intended for research and analytical applications. (-)-Aspartic acid is a pyroptosis inhibitor. (-)-Aspartic acid acts as a neurotransmitter and neuromodulator, participates in hormone synthesis and regulation, and plays a role in nervous system development and endocrine system .

HY-128975R

m-Tyramine hydrobromide (Standard)	Endogenous Metabolite	Neurological Disease
m-Tyramine (hydrobromide) (Standard) is the analytical standard of m-Tyramine (hydrobromide). This product is intended for research and analytical applications. m-Tyramine hydrobromide is an endogenous trace amine neuromodulator. m-Tyramine hydrobromide has effects on the adrenergic and dopaminergic receptor[1, 2].

HY-P2546

Biotin-Substance P	Neurokinin Receptor	Neurological Disease
Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R) .

HY-P3927

[MePhe8,Sar9] Substance P [MePhe8-MeGly9] Substance P	Neurokinin Receptor	Neurological Disease
[MePhe8,Sar9] Substance P ([MePhe8-MeGly9] Substance P) is an analog of Substance P (HY-P0201). Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS .

HY-14948

Carisbamate 1 Publications Verification RWJ-333369	Sodium Channel	Neurological Disease
Carisbamate (RWJ-333369) is an orally active neuromodulator. Carisbamate prevents the development and production of epilep-like discharges and has a neuroprotective effect after in vitro epilepticus-like injury. Carisbamate has good antiepileptic activity in genetic models of generalized and nonconvulsive epilepsy .

HY-114883

Homocarnosine L-Homocarnosine; γ-Aminobutyryl-L-histidine	GABA Receptor Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects .Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation .

HY-P0201AF

Substance P, FAM-labeled TFA	Fluorescent Dye Endogenous Metabolite	Cancer
Substance P, FAM-labeled (TFA) is Substance P TFA (HY-P02101A) labeled with FAM fluorophore. Substance P TFA (Neurokinin P TFA) is a neuropeptide that acts as a neurotransmitter and neuromodulator in the central nervous system. The endogenous receptor of Substance P is neurokinin 1 receptor (NK1R) .

HY-B0528

Octopamine	Adrenergic Receptor Endogenous Metabolite	Neurological Disease Endocrinology
Octopamine is a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .

HY-113439

12-HETE 1 Publications Verification	Apoptosis	Cardiovascular Disease Inflammation/Immunology
12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway .12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .

HY-B0528AS

Octopamine-d4 hydrochloride (±)-p-Octopamine-d₄ hydrochloride	Adrenergic Receptor Endogenous Metabolite	Neurological Disease Endocrinology
Octopamine-d₄ (hydrochloride) is the deuterium labeled Octopamine hydrochloride. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .

HY-W707539

Carisbamate-d2,-15N RWJ-333369-d_215N	Isotope-Labeled Compounds Sodium Channel	Neurological Disease
Carisbamate-d₂,- ¹⁵N (RWJ-333369-d₂,- ¹⁵N) is the deuterium labeled Carisbamate (HY-14948). Carisbamate (RWJ-333369) is an orally active neuromodulator. Carisbamate prevents the development and production of epilep-like discharges and has a neuroprotective effect after in vitro epilepticus-like injury. Carisbamate has good antiepileptic activity in genetic models of generalized and nonconvulsive epilepsy .

HY-113439S

12-HETE-d8	Apoptosis	Cardiovascular Disease Inflammation/Immunology
12-HETE-d₈ is the deuterium labeled 12-HETE. 12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway .12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .

HY-B2132

Tryptamine 1 Publications Verification 3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine	Endogenous Metabolite 5-HT Receptor Aryl Hydrocarbon Receptor	Neurological Disease Metabolic Disease
Tryptamine is a selective, blood-brain-penetrating 5-HT4 receptor agonist (EC50=1-3 mM) and an endogenous ligand of the aryl hydrocarbon receptor (AHR) (Kd=10-50 nM). Tryptamine promotes intestinal anion secretion and fluid transport by activating G protein-coupled receptors (GPCRs) and accelerates gastrointestinal motility. Tryptamine regulates Th17/Treg balance to inhibit neuroinflammation, competitively binds to 5-HT receptors to regulate central nervous system activity, and participates in temperature regulation and spinal reflex regulation as a neuromodulator. Tryptamine can be used to study intestinal motility disorders such as functional constipation, and has shown significant efficacy in multiple sclerosis models .

HY-P1723A

Spexin TFA Neuropeptide Q TFA	Neuropeptide Y Receptor Apoptosis Ferroptosis Autophagy	Cardiovascular Disease Metabolic Disease
Spexin (Neuropeptide Q) TFA is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin TFA can function through both central and peripheral actions. Spexin TFA upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin TFA improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin TFA can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy .

Cat. No.	Product Name

HY-L212

Neuropeptide Library	109 compounds
Neuropeptides are small proteins produced and released by neurons through the regulation of secretory pathways, expressed in neurons and have transmitter or co-transmitter functions, and are used as nerve substrates. Neuropeptides are by far the largest and most diverse signaling molecules in the brain and have been implicated in the development of diseases and drugs. Neuropeptides are involved in inflammatory and immune diseases and have an impact on epithelial, vascular, and connective tissue cells proliferation and tissue repair. Studies have shown that neuropeptides are particularly important when the nervous system is challenged, such as stress, injury, or substance abuse. Substance P is a neuropeptide that acts as a neurotransmitter and neuromodulator in the central nervous system and is currently in clinical research and has been shown to be involved in inflammatory processes and pain. MCE can provide 109 neuropeptides that can be used for scientific research.

Neuropeptide Library

109 compounds

Neuropeptides are small proteins produced and released by neurons through the regulation of secretory pathways, expressed in neurons and have transmitter or co-transmitter functions, and are used as nerve substrates. Neuropeptides are by far the largest and most diverse signaling molecules in the brain and have been implicated in the development of diseases and drugs. Neuropeptides are involved in inflammatory and immune diseases and have an impact on epithelial, vascular, and connective tissue cells proliferation and tissue repair. Studies have shown that neuropeptides are particularly important when the nervous system is challenged, such as stress, injury, or substance abuse. Substance P is a neuropeptide that acts as a neurotransmitter and neuromodulator in the central nervous system and is currently in clinical research and has been shown to be involved in inflammatory processes and pain.

MCE can provide 109 neuropeptides that can be used for scientific research.

Cat. No.	Product Name	Target	Research Area

HY-P1437

Neuropeptide S (mouse)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide S (mouse) is a bioactive peptide. Neuropeptide S (mouse), as a neurotransmitter/neuromodulator of 20 amino acids, can be used for the research of arousal, anxiety, locomotion, feeding behaviors, memory and agent addiction .

HY-P1723

Spexin 1 Publications Verification Neuropeptide Q	Neuropeptide Y Receptor Apoptosis Ferroptosis Autophagy	Cardiovascular Disease Neurological Disease
Spexin (Neuropeptide Q) is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin can function through both central and peripheral actions. Spexin upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy .

HY-P0275

Proctolin 1 Publications Verification	Endogenous Metabolite	Neurological Disease
Proctolin is an endogenous pentapeptide that acts as an excitatory neuromodulator.

HY-P0201

Substance P Maximum Cited Publications 21 Publications Verification Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Endocrinology Cancer
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

HY-P0201A

Substance P TFA Maximum Cited Publications 21 Publications Verification Neurokinin P TFA	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Endocrinology Cancer
Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R) .

HY-P2546

Biotin-Substance P	Neurokinin Receptor	Neurological Disease
Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R) .

HY-P3922

[Gly11] Substance P	Neurokinin Receptor	Neurological Disease
[Gly11] Substance P is an analog of Substance P (HY-P0201). Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS .

HY-P3925

[His11]Substance P	Neurokinin Receptor	Neurological Disease
[His11]Substance P is an analog of Substance P (HY-P0201). Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS .

HY-P1761

Prepro VIP (111-122), human	Peptides	Neurological Disease
Prepro VIP (111-122), human is a prepro-vasoactive intestinal polypeptide (VIP)-derived peptide, corresponding to residues 111-122. VIP is present in the peripheral and the central nervous systems where it functions as a nonadrenergic, noncholinergic neurotransmitter or neuromodulator .

HY-P3927

[MePhe8,Sar9] Substance P [MePhe8-MeGly9] Substance P	Neurokinin Receptor	Neurological Disease
[MePhe8,Sar9] Substance P ([MePhe8-MeGly9] Substance P) is an analog of Substance P (HY-P0201). Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS .

HY-P0201AF

Substance P, FAM-labeled TFA	Fluorescent Dye Endogenous Metabolite	Cancer
Substance P, FAM-labeled (TFA) is Substance P TFA (HY-P02101A) labeled with FAM fluorophore. Substance P TFA (Neurokinin P TFA) is a neuropeptide that acts as a neurotransmitter and neuromodulator in the central nervous system. The endogenous receptor of Substance P is neurokinin 1 receptor (NK1R) .

HY-P1723A

Spexin TFA Neuropeptide Q TFA	Neuropeptide Y Receptor Apoptosis Ferroptosis Autophagy	Cardiovascular Disease Metabolic Disease
Spexin (Neuropeptide Q) TFA is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin TFA can function through both central and peripheral actions. Spexin TFA upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin TFA improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin TFA can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-30170

N-Methylphenethylamine	Structural Classification Natural Products other families Source classification Plants Endogenous metabolite	Endogenous Metabolite
N-Methylphenethylamine is a naturally occurring secondary amine *neuromodulator* and can be detected in human urine or plants .

HY-B0528A

Octopamine hydrochloride 2 Publications Verification (±)-p-Octopamine hydrochloride	Structural Classification Monophenols Neurological Disease Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .

HY-B0528AR

Octopamine hydrochloride (Standard) (±)-p-Octopamine hydrochloride (Standard)	Structural Classification Monophenols Source classification Phenols Endogenous metabolite	Reference Standards Adrenergic Receptor Endogenous Metabolite
Octopamine (hydrochloride) (Standard) is the analytical standard of Octopamine (hydrochloride). This product is intended for research and analytical applications. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .

HY-114883A

Homocarnosine TFA 1 Publications Verification L-Homocarnosine TFA; γ-Aminobutyryl-L-histidine TFA	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	GABA Receptor Endogenous Metabolite
Homocarnosine TFA is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine TFA is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects . Homocarnosine TFA has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation .

HY-P0275

Proctolin 1 Publications Verification	Structural Classification Natural Products Monophenols Animals Source classification Phenols	Endogenous Metabolite
Proctolin is an endogenous pentapeptide that acts as an excitatory neuromodulator.

HY-103638A

3-Methoxytyramine 2 Publications Verification 3-O-methyl Dopamine	Structural Classification Monophenols Disease markers Phenols Nervous System Disorder Endogenous metabolite	Endogenous Metabolite
3-Methoxytyramine, a well known extracellular metabolite of 3-hydroxytyramine/dopamine, is a neuromodulator.

HY-128975

m-Tyramine hydrobromide	Structural Classification Alkaloids Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
m-Tyramine hydrobromide is an endogenous trace amine neuromodulator. m-Tyramine hydrobromide has effects on the adrenergic and dopaminergic receptor ^{[1, 2]}.

HY-42068

(-)-Aspartic acid (R)-Aspartic acid; D-(-)-Aspartic acid	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Pyroptosis
(-)-Aspartic acid is a pyroptosis inhibitor. (-)-Aspartic acid acts as a neurotransmitter and neuromodulator, participates in hormone synthesis and regulation, and plays a role in nervous system development and endocrine system .

HY-B2132R

Tryptamine (Standard) 1 Publications Verification 3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine (Standard)	Structural Classification Alkaloids Microorganisms Source classification Endogenous metabolite Indole Alkaloids	Endogenous Metabolite
Tryptamine (Standard) is the analytical standard of Tryptamine. This product is intended for research and analytical applications. Tryptamine is a monoamine alkaloid, similar to other trace amines, is believed to play a role as a neuromodulator or neurotransmitter.

HY-113356

m-Tyramine	Monophenols Source classification Disease markers Phenols Endogenous metabolite Cardiovascular System Disorder	Endogenous Metabolite
m-Tyramine is an endogenous trace amine neuromodulator. m-Tyramine has effects on the adrenergic and dopaminergic receptor ^{[1, 2]}.

HY-P0201

Substance P Maximum Cited Publications 21 Publications Verification Neurokinin P	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology	Neurokinin Receptor Endogenous Metabolite
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

HY-103638AR

3-Methoxytyramine (Standard) 3-O-methyl Dopamine (Standard)	Structural Classification Monophenols Disease markers Phenols Nervous System Disorder Endogenous metabolite	Reference Standards Endogenous Metabolite
3-Methoxytyramine (Standard) is the analytical standard of 3-Methoxytyramine. This product is intended for research and analytical applications. 3-Methoxytyramine, a well known extracellular metabolite of 3-hydroxytyramine/dopamine, is a neuromodulator.

HY-42068R

(-)-Aspartic acid (Standard) (R)-Aspartic acid (Standard); D-(-)-Aspartic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Pyroptosis
(-)-Aspartic acid (Standard) is the analytical standard of (-)-Aspartic acid. This product is intended for research and analytical applications. (-)-Aspartic acid is a pyroptosis inhibitor. (-)-Aspartic acid acts as a neurotransmitter and neuromodulator, participates in hormone synthesis and regulation, and plays a role in nervous system development and endocrine system .

HY-128975R

m-Tyramine hydrobromide (Standard)	Structural Classification Alkaloids Monophenols Other Alkaloids Source classification Phenols Endogenous metabolite	Endogenous Metabolite
m-Tyramine (hydrobromide) (Standard) is the analytical standard of m-Tyramine (hydrobromide). This product is intended for research and analytical applications. m-Tyramine hydrobromide is an endogenous trace amine neuromodulator. m-Tyramine hydrobromide has effects on the adrenergic and dopaminergic receptor[1, 2].

HY-114883

Homocarnosine L-Homocarnosine; γ-Aminobutyryl-L-histidine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	GABA Receptor Endogenous Metabolite
Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects .Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation .

HY-B0528

Octopamine	Structural Classification Monophenols Microorganisms Source classification Phenols	Adrenergic Receptor Endogenous Metabolite
Octopamine is a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .

HY-113439

12-HETE 1 Publications Verification	Microorganisms Source classification	Apoptosis
12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway .12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .

HY-B2132

Tryptamine 1 Publications Verification 3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine	Alkaloids Structural Classification Microorganisms Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Indole Alkaloids	Endogenous Metabolite 5-HT Receptor Aryl Hydrocarbon Receptor
Tryptamine is a selective, blood-brain-penetrating 5-HT4 receptor agonist (EC50=1-3 mM) and an endogenous ligand of the aryl hydrocarbon receptor (AHR) (Kd=10-50 nM). Tryptamine promotes intestinal anion secretion and fluid transport by activating G protein-coupled receptors (GPCRs) and accelerates gastrointestinal motility. Tryptamine regulates Th17/Treg balance to inhibit neuroinflammation, competitively binds to 5-HT receptors to regulate central nervous system activity, and participates in temperature regulation and spinal reflex regulation as a neuromodulator. Tryptamine can be used to study intestinal motility disorders such as functional constipation, and has shown significant efficacy in multiple sclerosis models .

Cat. No.	Product Name	Chemical Structure

HY-B2132S1

Tryptamine-d4 hydrochloride
Tryptamine-d₄ (hydrochloride) is the deuterium labeled Tryptamine hydrochloride. Tryptamine hydrochloride, a monoamine alkaloid, similar to other trace amines, is believed to play a role as a neuromodulator or neurotransmitter .

HY-B0528AS

Octopamine-d4 hydrochloride

Octopamine-d₄ (hydrochloride) is the deuterium labeled Octopamine hydrochloride. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .

HY-113439S

12-HETE-d8
12-HETE-d₈ is the deuterium labeled 12-HETE. 12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway .12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .

HY-B2132S

Tryptamine-d2 hydrochloride
Tryptamine-d₂ (hydrochloride) is a deuterium labeled Tryptamine hydrochloride. Tryptamine hydrochloride is a monoamine alkaloid, similar to other trace amines, is believed to play a role as a neuromodulator or neurotransmitter .

HY-W707539

Carisbamate-d2,-15N

Carisbamate-d₂,- ¹⁵N (RWJ-333369-d₂,- ¹⁵N) is the deuterium labeled Carisbamate (HY-14948). Carisbamate (RWJ-333369) is an orally active neuromodulator. Carisbamate prevents the development and production of epilep-like discharges and has a neuroprotective effect after in vitro epilepticus-like injury. Carisbamate has good antiepileptic activity in genetic models of generalized and nonconvulsive epilepsy .

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