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mouth

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By Targets:	Antibiotic (2) Apoptosis (1) Autophagy (2) Bacterial (6) Dopamine Receptor (3) Enterovirus (1) Histone Methyltransferase (2) HIV (2) Influenza Virus (2) Integrin (1) mAChR (4) Necroptosis (1) Reference Standards (1) SARS-CoV (2) Virus Protease (1) VSV (2)
By Research Areas:	Cancer (7) Infection (12) Inflammation/Immunology (4) Neurological Disease (7)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1223

Anethole trithione 2 Publications Verification	mAChR	Neurological Disease Cancer
Anethole trithione, a sulfur heterocyclic choleretic, is a bile secretion-stimulating agent. Anethole trithione enhances salivary secretion and increases mAChRs, and can be used for dry mouth research .

HY-W039454

2,4-Dichlorobenzyl alcohol	Bacterial SARS-CoV	Infection
2,4-Dichlorobenzyl alcohol is an orally active mild antiseptic, with a broad spectrum for bacterial and virus associated with mouth and throat infections. 2,4-Dichlorobenzyl alcohol exhibits prenatal developmental toxicity.2,4-Dichlorobenzyl alcohol can be used in the study of SARS-CoV .

HY-B1597

Cetalkonium chloride Benzyldimethylhexadecylammonium chloride	Bacterial	Infection Inflammation/Immunology
Cetalkonium chloride is an ammonium antiseptic agent used in many topical agents for infections of mouth, throat and eye. Cetalkonium chloride acts as anti-inflammatory amphiphilic agent. Cetalkonium chloride is a cationic surfactant, that improves the precorneal residence time and bioavailability of drugs. Cetalkonium chloride interacts with the negative charges on the bacterial cell membrane, disrupts the integrity of the cell membrane, causes leakage of cell contents and ultimately leading to bacterial death .

HY-131554

Tibezonium iodide	Bacterial Antibiotic	Infection
Tibezonium iodide, an oropharyngeal disinfectant, has antibacterial activity for the prevention of mouth infections .

HY-B1597R

Cetalkonium chloride (Standard) Benzyldimethylhexadecylammonium chloride (Standard)	Bacterial	Infection Inflammation/Immunology
Cetalkonium (chloride) (Standard) is the analytical standard of Cetalkonium (chloride). This product is intended for research and analytical applications. Cetalkonium chloride is an ammonium antiseptic agent used in many topical agents for infections of mouth, throat and eye. Cetalkonium chloride acts as anti-inflammatory amphiphilic agent. Cetalkonium chloride is a cationic surfactant, that improves the precorneal residence time and bioavailability of drugs. Cetalkonium chloride interacts with the negative charges on the bacterial cell membrane, disrupts the integrity of the cell membrane, causes leakage of cell contents and ultimately leading to bacterial death .

HY-P2015A

Diacetylsplenopentin hydrochloride BCH 069 hydrochloride	HIV	Infection Inflammation/Immunology
Diacetylsplenopentin (BCH 069) hydrochloride is an antiviral agent, and protects guinea pigs from foot-and-mouth disease (FMD) infection. Berlopentin has immunostimulatory properties .

HY-P2015

Diacetylsplenopentine BCH 069	HIV	Infection Inflammation/Immunology
Diacetylsplenopentine (BCH 069) is an antiviral agent, and protects guinea pigs from foot-and-mouth disease (FMD) infection. Berlopentin has immunostimulatory properties .

HY-161352

NPI52	Virus Protease	Infection
NPI52 (Compound E1) is a foot-and-mouth disease virus 3C protease (FMDV 3Cpro) inhibitor, with IC₅₀ values of 0.05 and 0.11 µM in FRET and cell-based assay, respectively .

HY-157082

ZHSI-1	Enterovirus	Infection
ZHSI-1 is an EV71 (Enterovirus 71) inhibitor that inhibits EV71/CVA16 replication and virus-induced pyroptosis associated with viral pathogenesis. ZHSI-1 effectively prevents EV71 infection in neonatal and young mice in animal models. ZHSI-1 can be used to study viral infections such as hand, foot and mouth disease (HFMD) .

HY-W039454R

2,4-Dichlorobenzyl alcohol (Standard)	Reference Standards Bacterial SARS-CoV	Infection
2,4-Dichlorobenzyl alcohol (Standard) is the analytical standard of 2,4-Dichlorobenzyl alcohol (HY-W039454). This product is intended for research and analytical applications. 2,4-Dichlorobenzyl alcohol is an orally active mild antiseptic, with a broad spectrum for bacterial and virus associated with mouth and throat infections. 2,4-Dichlorobenzyl alcohol exhibits prenatal developmental toxicity.2,4-Dichlorobenzyl alcohol can be used in the study of SARS-CoV .

HY-P1654

A20FMDV2	Integrin	Cancer
A20FMDV2 is a selective αvβ6 integrin inhibitor (IC₅₀: 3 nM), with an activity 1,000-fold more selective for αvβ6 than for other RGD-directed integrins (αvβ3, αvβ5, and α5β1). A20FMDV2 can be derived from the foot-and-mouth disease virus. A20FMDV2 can be radiolabeled for the PET imaging of αvβ6 integrin-positive tumors .

HY-110093

UNC0638 hydrate	VSV Histone Methyltransferase Autophagy Influenza Virus	Infection Cancer
UNC0638 hydrate selectively inhibits G9a and GLP histone methyltransferases with IC₅₀ of 15 nM and 19 nM, respectively. UNC0638 hydrate inhibits TNBC cell invasion and migration in vitro. UNC0638 hydrate is also an inhibitor of EHMT1/2 and induces fetal hemoglobin (HbF) expression in human erythroid progenitor cell culture. In addition, UNC0638 hydrate has anti-FMDV (foot-and-mouth disease virus) and anti-VSV (vesicular stomatitis virus) activities, with excellent potency and selectivity against multiple epigenetic and non-epigenetic targets .

HY-15273

UNC0638 5+ Cited Publications	VSV Histone Methyltransferase Autophagy Influenza Virus	Infection Cancer
UNC0638 selectively inhibits G9a and GLP histone methyltransferases with IC₅₀ of 15 nM and 19 nM, respectively. UNC0638 inhibits TNBC cell invasion and migration in vitro. UNC0638 is also an inhibitor of EHMT1/2 and induces fetal hemoglobin (HbF) expression in human erythroid progenitor cell culture. In addition, UNC0638 has anti-FMDV (foot-and-mouth disease virus) and anti-VSV (vesicular stomatitis virus) activities, with excellent potency and selectivity against multiple epigenetic and non-epigenetic targets .

HY-70020B

Cevimeline hydrochloride AF102B hydrochloride	mAChR	Neurological Disease Cancer
Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia . Cevimeline hydrochloride can cross the blood-brain barrier (BBB) .

HY-70020

Cevimeline AF102B	mAChR	Neurological Disease Cancer
Cevimeline (AF-102B) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia . Cevimeline can cross the blood-brain barrier (BBB) .

HY-B0608

Chlorhexidine digluconate (20% in water) Maximum Cited Publications 11 Publications Verification	Antibiotic Bacterial Necroptosis Apoptosis	Infection
Chlorhexidine digluconate (20% in water) is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine digluconate (20% in water) binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine digluconate (20% in water) has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine digluconate (20% in water) can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) .

HY-76772

Cevimeline hydrochloride hemihydrate SNI-2011; AF102B hydrochloride hemihydrate	mAChR	Neurological Disease Cancer
Cevimeline hydrochloride hemihydrate (SNI-2011) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride hemihydrate stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia . Cevimeline hydrochloride hemihydrate can cross the blood-brain barrier (BBB) .

HY-B1904R

Fluphenazine decanoate (Standard)	Dopamine Receptor	Neurological Disease
Fluphenazine decanoate (Standard) is the analytical standard of Fluphenazine decanoate. This product is intended for research and analytical applications. Fluphenazine decanoate is a dopamine D2 receptor inhibitor, is a long-acting phenothiazine neuroleptic. Fluphenazine can be used for schizophrenia research .

HY-B1904

Fluphenazine decanoate	Dopamine Receptor	Neurological Disease
Fluphenazine decanoate is a dopamine D₂ receptor inhibitor, is a long-acting phenothiazine neuroleptic. Fluphenazine can be used for schizophrenia research .

HY-B1904A

Fluphenazine decanoate dihydrochloride	Dopamine Receptor	Neurological Disease
Fluphenazine decanoate dihydrochloride is a dopamine D₂ receptor inhibitor, is a long-acting phenothiazine neuroleptic. Fluphenazine can be used for schizophrenia research .

Cat. No.	Product Name	Target	Research Area

HY-P1654

A20FMDV2	Integrin	Cancer
A20FMDV2 is a selective αvβ6 integrin inhibitor (IC₅₀: 3 nM), with an activity 1,000-fold more selective for αvβ6 than for other RGD-directed integrins (αvβ3, αvβ5, and α5β1). A20FMDV2 can be derived from the foot-and-mouth disease virus. A20FMDV2 can be radiolabeled for the PET imaging of αvβ6 integrin-positive tumors .

HY-P2015

Diacetylsplenopentine BCH 069	HIV	Infection Inflammation/Immunology
Diacetylsplenopentine (BCH 069) is an antiviral agent, and protects guinea pigs from foot-and-mouth disease (FMD) infection. Berlopentin has immunostimulatory properties .

Anethole trithione 2 Publications Verification	Structural Classification Natural Products Leguminosae Source classification Sophora alopecuroides L Plants	mAChR
Anethole trithione, a sulfur heterocyclic choleretic, is a bile secretion-stimulating agent. Anethole trithione enhances salivary secretion and increases mAChRs, and can be used for dry mouth research .

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