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Results for "

marine-derived

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Akt (1) Antibiotic (1) Apoptosis (4) Bacterial (3) Bcl-2 Family (1) COX (1) Endogenous Metabolite (6) Fungal (1) GLUT (1) Interleukin Related (1) NF-κB (1) NO Synthase (1) P-glycoprotein (1) Parasite (1) Phosphatase (1) Reactive Oxygen Species (1) TNF Receptor (1)
By Research Areas:	Cancer (10) Endocrinology (1) Infection (3) Inflammation/Immunology (4) Metabolic Disease (1)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Targets Recommended: PDGFR GDNF Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113972

Methyl mycophenolate	Others	Inflammation/Immunology
Methyl mycophenolate is a methyl ester of mycophenolic acid and is also found in marine-derived fungus Phaeosphaeria spartinae .

HY-125538

Deoxybrevianamide E	Endogenous Metabolite	Inflammation/Immunology
Deoxybrevianamide E, an indole alkaloid, is a biosynthetic precursor for advanced metabolites isolated from the marine-derived Aspergillus sp. .

HY-N8571

6-Methoxyflavonol	Others	Others
6-Methoxyflavonol (Compound 15) is a natural flavone isolated from the marine-derived fungus Aspergillus candidus .

HY-136293

Mechercharmycin A	Apoptosis	Cancer
Mechercharmycin A is a cytotoxic substance isolated from marine-derived Thermoactinomyces sp. YM3-251. Mechercharmycin A exhibits relatively strong antitumor activity .

HY-N10203

Rostratin A	Endogenous Metabolite	Cancer
Rostratin A is a cytotoxic disulfide found in the marine-derived fungus Exserohilum rostratum. Rostratin A shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with an IC₅₀ of 8.5 μg/mL .

HY-N12165

1,3,5,6-Tetrahydroxy-8-methylxanthone	Others	Others
1,3,5,6-Tetrahydroxy-8-methylxanthone (compound 8) is a dimeric 1,4-benzoquinone derivative isolated from the marine-derived fungus Penicillium genus .

HY-116479

Citromycetin	Bacterial	Others
Citromycetin is an aromatic polyketide compound from Australian marine-derived and terrestrial Penicillium spp .

HY-120551

Fructigenine A	Others	Others
Fructigenine A (compound 4) is a active product that can be isolated from marine-derived Penicillium sp. .

HY-121133

(-)-Cyclopenol	Endogenous Metabolite	Others
(-)-Cyclopenol is a fungal metabolite isolated from an Australian marine-derived isolate of Aspergillus versicolor (MST-MF495) .

HY-N6181

Terrelumamide A	Others	Endocrinology
Terrelumamide A is a lumazine-containing peptide. Terrelumamide A is isolated from the culture broth of the marine-derived fungus Aspergillus terreus. Terrelumamide A exhibits pharmacological activity by improving insulin sensitivity. Terrelumamide A has the potential in the application of DNA sequence recognition .

HY-W167769

(±)-Mellein	Endogenous Metabolite	Others
(±)-Mellein, a marine-derived natural product, is known for its presence in Helicascus kanaloanus, exhibiting the chemical structure of 8-hydroxy-3-methyl-3,4-dihydroisochromen-1-one.

HY-167926

3-Bromo-4,5-dihydroxybenzoic acid methyl ester	Others	Inflammation/Immunology
3-Bromo-4,5-dihydroxybenzoic acid methyl ester is a marine-derived natural product known for its biological activity, specifically showcasing antioxidant properties and potential therapeutic applications against oxidative stress-related diseases.

HY-N8908

2α,9α,11-Trihydroxy-6-oxodrim-7-ene	Others	Infection
2α,9α,11-Trihydroxy-6-oxodrim-7-ene is a natural product that can be isolated from the culture medium of the marine-derived fungus Aspergillus insuetus .

HY-172659

6-Epi-ophiobolin G MHO7	Fungal Akt Apoptosis	Cancer
6-Epi-ophiobolin G (MHO7), a Marine-derived fungal metabolite, is a blood-brain barrier penetrated and orally active Akt inhibitor. 6-Epi-ophiobolin G (MHO7) inhibits GBM cell proliferation and promotes apoptosis. 6-Epi-ophiobolin G (MHO7) can be used in the research for glioblastoma .

HY-N10208

Aspericin C	Endogenous Metabolite	Cancer
Aspericin C is a pyran derivative found in the marine-derived fungus Rhizopus sp. 2-PDA-61. Aspericin C shows cytotoxic activities against P388, A549, HL-60, and BEL-7420 cell lines (IC₅₀=14.6, 7.1, 61.4, and 24.2 μM, respectively) .

HY-W052289

Methyl 6-bromo-1H-indole-3-carboxylate	Endogenous Metabolite	Cancer
Methyl 6-bromo-1H-indole-3-carboxylate is a marine-derived natural product with antitumor activity. Methyl 6-bromo-1H-indole-3-carboxylate showed growth inhibition against Staphylococcus epidermidis, exhibiting weak or moderate minimum inhibitory concentrations (MICs) .

HY-N13869

Asperlin	Antibiotic Bacterial Apoptosis Reactive Oxygen Species Bcl-2 Family NO Synthase COX TNF Receptor Interleukin Related	Infection Metabolic Disease Inflammation/Immunology Cancer
Asperlin is an orally active marine-derived antibiotic with antifungal, anticancer, anti-inflammatory and anti-atherosclerotic activities. Asperlin induces apoptosis. Asperlin increases reactive oxygen species (ROS)- and DNA damage-associated G2/M phase arrest and ATM phosphorylation. Asperlin is effective in preventing HFD-induced obesity and modulating gut microbiota .

HY-133541

Glucopiericidin A	GLUT ADC Cytotoxin Apoptosis	Cancer
Glucopiericidin A is a natural piericidin compound obtained from a marine-derived Streptomyces strain. Glucopiericidin A serves as a glucose transporter (GLUT) chemical probe and suppresses glycolysis. Glucopiericidin A inhibits ATP-dependent filopodia protrusion with Piericidin A (PA; HY-114936) and has no effect alone. Glucopiericidin A induces cell apoptosis through reducing the reactive oxygen species (ROS) level by increasing PRDX1 and exhibits potent antitumor efficacy in ACHN mice xenografts .

HY-W003793

Ethyl 6-bromo-1H-indole-3-carboxylate	Others	Cancer
Ethyl 6-bromo-1H-indole-3-carboxylate is a marine-derived natural product with anti-tumor activity. Ethyl 6-bromo-1H-indole-3-carboxylate was isolated from the sponge Iotrochota purpurea collected in Indonesia. The structure of Ethyl 6-bromo-1H-indole-3-carboxylate was confirmed by spectroscopic methods and accurate mass measurements .

HY-137990

Questin	Bacterial Parasite Phosphatase	Infection Cancer
Questin is an anthraquinone compound and antibacterial agent. Questin can be isolated from marine-derived fungi and plants. Questin inhibits Cdc25B phosphatase. Questin exhibits antibacterial activity against V. harveyi, V. anguillarum, V. cholerae, and V. parahemolyticus with MIC values of 31.25 µg/mL, 62.5 µg/mL, 62.5 µg/mL, and 125 µg/mL. Questin displays antiprotozoal activity against the animal protozoan pathogen Tritrichomonas foetus, with a MIC of 12.5 µg/mL. Questin has anticancer activity against lung and colon cancer .

HY-N12604

Penicisteck acid F	NF-κB	Others
Penicisteck acid F (Compound 2) is a Marine derived tanzanic acid derivative that is a NF-κB inhibitor. Penicisteck acid F inhibits osteoclast expression by decreasing RANKL-induced IκBα degradation, NF-κB p65 nuclear translocation, NFATc1 activation and nuclear translocation, and related mRNA expression. Penicisteck acid F can be used in osteoporosis research .

HY-N144114

P-gp inhibitor 2	P-glycoprotein	Cancer
P-gp inhibitor 2 is a potent P-gp inhibitor. P-gp inhibitor 2 shows reverse Doxorubicin resistance (IC₅₀=0.22 µM) in P-gp overexpressing human colorectal carcinoma cells (SW600 Ad300) .

Cat. No.	Product Name

HY-L143

Marine-Sourced Natural Product Library	61 compounds
Oceans cover more than 70% of the Earth’s surface and host a huge species diversity. Marine organisms are considered the most recent source of bioactive natural products after terrestrial plants and nonmarine microorganisms. Marine biological sources are taxonomically diverse and include sponges, tunicates, corals, mollusks, fungi, and sediment-derived bacteria. Marine organisms can produce a plethora of small molecules with novel chemical structures and potent biological properties, being a rich source for the discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Ziconotide, a peptide originally discovered in a tropical cone snail, was the first marine-derived compound to be approved in the United States in December 2004 for the treatment of pain. Then, in October 2007, Trabectedin became the first marine anticancer drug to be approved in the European Union. MCE offers a unique collection of 61 marine-sourced natural products which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE marine-sourced natural product library is an important source for drug discovery and development.

Marine-Sourced Natural Product Library

61 compounds

Oceans cover more than 70% of the Earth’s surface and host a huge species diversity. Marine organisms are considered the most recent source of bioactive natural products after terrestrial plants and nonmarine microorganisms. Marine biological sources are taxonomically diverse and include sponges, tunicates, corals, mollusks, fungi, and sediment-derived bacteria.

Marine organisms can produce a plethora of small molecules with novel chemical structures and potent biological properties, being a rich source for the discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Ziconotide, a peptide originally discovered in a tropical cone snail, was the first marine-derived compound to be approved in the United States in December 2004 for the treatment of pain. Then, in October 2007, Trabectedin became the first marine anticancer drug to be approved in the European Union.

MCE offers a unique collection of 61 marine-sourced natural products which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE marine-sourced natural product library is an important source for drug discovery and development.

Cat. No.	Product Name	Target	Research Area

HY-133801

Unguisin A	Peptides	Others
Unguisin A s a cyclic peptides that can be isolated from the marine-derived fungus Emericella unguis .

HY-125488

Unguisin B	Peptides	Others
Unguisin B s a cyclic peptides that can be isolated from the marine-derived fungus Emericella unguis .

Methyl mycophenolate	Structural Classification Monophenols Microorganisms Classification of Application Fields Marine natural products Phenols Inflammation/Immunology Disease Research Fields Marine microorganism	Others
Methyl mycophenolate is a methyl ester of mycophenolic acid and is also found in marine-derived fungus Phaeosphaeria spartinae .

Deoxybrevianamide E	Alkaloids Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Marine natural products Endogenous metabolite Inflammation/Immunology Disease Research Fields Marine microorganism Indole Alkaloids	Endogenous Metabolite
Deoxybrevianamide E, an indole alkaloid, is a biosynthetic precursor for advanced metabolites isolated from the marine-derived Aspergillus sp. .

6-Methoxyflavonol	Structural Classification Flavonols Flavonoids Microorganisms Source classification	Others
6-Methoxyflavonol (Compound 15) is a natural flavone isolated from the marine-derived fungus Aspergillus candidus .

Mechercharmycin A	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Marine natural products Disease Research Fields Marine microorganism Cancer	Apoptosis
Mechercharmycin A is a cytotoxic substance isolated from marine-derived Thermoactinomyces sp. YM3-251. Mechercharmycin A exhibits relatively strong antitumor activity .

Rostratin A	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Marine natural products Disease Research Fields Marine microorganism Cancer	Endogenous Metabolite
Rostratin A is a cytotoxic disulfide found in the marine-derived fungus Exserohilum rostratum. Rostratin A shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with an IC₅₀ of 8.5 μg/mL .

1,3,5,6-Tetrahydroxy-8-methylxanthone	Structural Classification Flavonoids Microorganisms Xanthones Source classification Phenols Other Flavonoids	Others
1,3,5,6-Tetrahydroxy-8-methylxanthone (compound 8) is a dimeric 1,4-benzoquinone derivative isolated from the marine-derived fungus Penicillium genus .

Citromycetin	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Marine natural products Source classification Other Diseases Phenols Polyphenols Marine microorganism Disease Research Fields	Bacterial
Citromycetin is an aromatic polyketide compound from Australian marine-derived and terrestrial Penicillium spp .

Fructigenine A	Structural Classification Natural Products Microorganisms Source classification	Others
Fructigenine A (compound 4) is a active product that can be isolated from marine-derived Penicillium sp. .

(-)-Cyclopenol	Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Marine natural products Other Diseases Disease Research Fields Marine microorganism	Endogenous Metabolite
(-)-Cyclopenol is a fungal metabolite isolated from an Australian marine-derived isolate of Aspergillus versicolor (MST-MF495) .

Terrelumamide A	Alkaloids Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Marine natural products Endogenous metabolite Disease Research Fields Marine microorganism Endocrinology	Others
Terrelumamide A is a lumazine-containing peptide. Terrelumamide A is isolated from the culture broth of the marine-derived fungus Aspergillus terreus. Terrelumamide A exhibits pharmacological activity by improving insulin sensitivity. Terrelumamide A has the potential in the application of DNA sequence recognition .

3-Bromo-4,5-dihydroxybenzoic acid methyl ester	Structural Classification Microorganisms Source classification Phenols Polyphenols	Others
3-Bromo-4,5-dihydroxybenzoic acid methyl ester is a marine-derived natural product known for its biological activity, specifically showcasing antioxidant properties and potential therapeutic applications against oxidative stress-related diseases.

2α,9α,11-Trihydroxy-6-oxodrim-7-ene	Other Terpenoids Structural Classification Microorganisms Terpenoids Source classification	Others
2α,9α,11-Trihydroxy-6-oxodrim-7-ene is a natural product that can be isolated from the culture medium of the marine-derived fungus Aspergillus insuetus .

Aspericin C	Natural Products Microorganisms Classification of Application Fields Source classification Marine natural products Disease Research Fields Marine microorganism Cancer	Endogenous Metabolite
Aspericin C is a pyran derivative found in the marine-derived fungus Rhizopus sp. 2-PDA-61. Aspericin C shows cytotoxic activities against P388, A549, HL-60, and BEL-7420 cell lines (IC₅₀=14.6, 7.1, 61.4, and 24.2 μM, respectively) .

Methyl 6-bromo-1H-indole-3-carboxylate	Structural Classification Alkaloids Marine natural products Source classification Sponge Indole Alkaloids	Endogenous Metabolite
Methyl 6-bromo-1H-indole-3-carboxylate is a marine-derived natural product with antitumor activity. Methyl 6-bromo-1H-indole-3-carboxylate showed growth inhibition against Staphylococcus epidermidis, exhibiting weak or moderate minimum inhibitory concentrations (MICs) .

Asperlin	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial Apoptosis Reactive Oxygen Species Bcl-2 Family NO Synthase COX TNF Receptor Interleukin Related
Asperlin is an orally active marine-derived antibiotic with antifungal, anticancer, anti-inflammatory and anti-atherosclerotic activities. Asperlin induces apoptosis. Asperlin increases reactive oxygen species (ROS)- and DNA damage-associated G2/M phase arrest and ATM phosphorylation. Asperlin is effective in preventing HFD-induced obesity and modulating gut microbiota .

Glucopiericidin A	Classification of Application Fields Disease Research Fields Cancer	GLUT ADC Cytotoxin Apoptosis
Glucopiericidin A is a natural piericidin compound obtained from a marine-derived Streptomyces strain. Glucopiericidin A serves as a glucose transporter (GLUT) chemical probe and suppresses glycolysis. Glucopiericidin A inhibits ATP-dependent filopodia protrusion with Piericidin A (PA; HY-114936) and has no effect alone. Glucopiericidin A induces cell apoptosis through reducing the reactive oxygen species (ROS) level by increasing PRDX1 and exhibits potent antitumor efficacy in ACHN mice xenografts .

Ethyl 6-bromo-1H-indole-3-carboxylate	Structural Classification Ketones, Aldehydes, Acids Marine natural products Source classification	Others
Ethyl 6-bromo-1H-indole-3-carboxylate is a marine-derived natural product with anti-tumor activity. Ethyl 6-bromo-1H-indole-3-carboxylate was isolated from the sponge Iotrochota purpurea collected in Indonesia. The structure of Ethyl 6-bromo-1H-indole-3-carboxylate was confirmed by spectroscopic methods and accurate mass measurements .

Questin	Structural Classification Classification of Application Fields Marine natural products Source classification Endogenous metabolite Infection Quinones Human Gut Microbiota Metabolites Microorganisms Anthraquinones Phenols Polyphenols Marine microorganism Disease Research Fields	Bacterial Parasite Phosphatase
Questin is an anthraquinone compound and antibacterial agent. Questin can be isolated from marine-derived fungi and plants. Questin inhibits Cdc25B phosphatase. Questin exhibits antibacterial activity against V. harveyi, V. anguillarum, V. cholerae, and V. parahemolyticus with MIC values of 31.25 µg/mL, 62.5 µg/mL, 62.5 µg/mL, and 125 µg/mL. Questin displays antiprotozoal activity against the animal protozoan pathogen Tritrichomonas foetus, with a MIC of 12.5 µg/mL. Questin has anticancer activity against lung and colon cancer .

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