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lipoic acid

" in MedChemExpress (MCE) Product Catalog:

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-18733
    Lipoic acid
    5+ Cited Publications

    (R)-(+)-α-lipoic acid; R-(+)-Thioctic acid

    		 Endogenous Metabolite Reactive Oxygen Species (ROS) Mitochondrial Metabolism Inflammation/Immunology Cancer
    Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.
    Lipoic acid
  • HY-18733R
    Lipoic acid (Standard)
    5+ Cited Publications

    (R)-(+)-α-lipoic acid(Standard); R-(+)-Thioctic acid (Standard)

    		 Reference Standards Mitochondrial Metabolism Endogenous Metabolite Reactive Oxygen Species (ROS) Inflammation/Immunology Cancer
    Lipoic acid (Standard) is the analytical standard of Lipoic acid. This product is intended for research and analytical applications. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.
    Lipoic acid (Standard)
  • HY-134633
    Alpha-lipoic acid choline ester chloride

    EV 06 chloride; UNR 844 chloride

    		 Others Others
    Alpha-lipoic acid choline ester (chloride) is a type of choline ester of alpha-lipoic acid. Alpha-lipoic acid choline ester (chloride) can reduce protein disulfides and increase the elasticity of mouse lenses, making it useful for research on presbyopia .
    Alpha-lipoic acid choline ester chloride
  • HY-N0492
    α-Lipoic Acid
    5+ Cited Publications

    Thioctic acid; (±)-α-lipoic acid; DL-α-lipoic acid

    		 NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis Infection Inflammation/Immunology Cancer
    α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .
    α-Lipoic Acid
  • HY-N0492A
    α-Lipoic Acid sodium
    5+ Cited Publications

    Thioctic acid sodium; (±)-α-lipoic acid sodium; DL-α-lipoic acid sodium

    		 NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis Infection Inflammation/Immunology Cancer
    α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .
    α-Lipoic Acid sodium
  • HY-N0492R
    α-Lipoic Acid (Standard)
    5+ Cited Publications

    Thioctic acid (Standard); (±)-α-lipoic acid (Standard); DL-α-lipoic acid (Standard)

    		 Reference Standards NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis Infection Inflammation/Immunology Cancer
    α-Lipoic Acid (Standard) is the analytical standard of α-Lipoic Acid. This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .
    α-Lipoic Acid (Standard)
  • HY-18733S
    Lipoic acid-d4

    (R)-(+)-α-lipoic acid-d4; R-(+)-Thioctic acid-d4

    		 Isotope-Labeled Compounds Endogenous Metabolite Mitochondrial Metabolism Reactive Oxygen Species (ROS) Inflammation/Immunology Cancer
    Lipoic acid-d4 ((R)-(+)-α-Lipoic acid-d4) is deuterium labeled Lipoic acid. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid .
    Lipoic acid-d4
  • HY-N15196
    Andrographolide-lipoic acid

    		NF-κB Metabolic Disease
    Andrographolide-lipoic acid is an Andrographolide (HY-N0191) analogue, which is formed by the coupling of Andrographolide and Lipoic acid (HY-18733). Andrographolide-lipoic acid inhibits NF-κB and has anti-diabetic and β-cell protective activities .
    Andrographolide-lipoic acid
  • HY-N0492AR
    α-Lipoic Acid sodium (Standard)

    Thioctic acid sodium (Standard); (±)-α-lipoic acid sodium (Standard); DL-α-lipoic acid sodium (Standard)

    		 Reference Standards NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis Infection Inflammation/Immunology Cancer
    α-Lipoic Acid (sodium) (Standard) is the analytical standard of α-Lipoic Acid (sodium). This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1.
    α-Lipoic Acid sodium (Standard)
  • HY-157175
    Mannosamine–lipoic acid adduct

    		Biochemical Assay Reagents Others
    Mannosamine-lipoic acid adduct is a hapten. Mannosamine-lipoic acid adduct with hsIgG conjugation significantly reduces the antibody immune response against hsIgG .
    Mannosamine–lipoic acid adduct
  • HY-N0492S
    α-Lipoic Acid-d5

    Thioctic acid-d5; (±)-α-lipoic acid-d5; DL-α-lipoic acid-d5

    		 Isotope-Labeled Compounds NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis Infection Inflammation/Immunology Cancer
    α-Lipoic Acid-d5 is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells .
    α-Lipoic Acid-d5
  • HY-120974
    α-lipoic acid derivative 1

    		GLUT Metabolic Disease
    α-Lipoic Acid Derivative 1 (Compound AN-7) is an α-lipoic acid derivative that enhances glucose transport in skeletal muscle by releasing active α-lipoic acid (LA), significantly improving glucose metabolism. In L6 skeletal muscle cells, α-Lipoic Acid Derivative 1 significantly increases glucose transport rates, approximately 12 times more potent than the parent compound α-lipoic acid (HY-N0492). In a mild diabetic mouse model, 10 mg/kg of α-Lipoic Acid Derivative 1 administered for two weeks significantly reduced blood glucose levels by 39%. α-Lipoic Acid Derivative 1 shows significant potential in research related to glucose metabolism in diabetes .
    α-lipoic acid derivative 1
  • HY-141336
    α-Lipoic acid-NHS
    3 Publications Verification

    DL-α-lipoic acid-NHS

    		 PROTAC Linkers Cancer
    α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
    α-Lipoic acid-NHS
  • HY-146133
    LA-Bac8c

    		Bacterial Antibiotic Infection
    LA-Bac8c is a Lipoic acid modified antimicrobial peptide with enhanced antimicrobial properties. LA-Bac8c inhibits S. aureus, MRSA, S. epidermidis, E. coli, and P. aeruginosa with MICs of 1, 4, 8, 8, and 8 μg/mL .
    LA-Bac8c
  • HY-119152
    CMX-2043

    		Insulin Receptor Tyrosinase Akt Others
    CMX-2043 is a novel analogue of α-Lipoic Acid (HY-N0492). CMX-2043 is effective in antioxidant effect, activation of insulin receptor kinase, soluble tyrosine kinase, and Akt phosphorylation. CMX-2043 shows protection against ischemia-reperfusion injury (IRI) in rat model .
    CMX-2043
  • HY-W014590
    (S)-Thioctic acid

    (S)-lipoic acid; (S)-5-(1,2-Dithiolan-3-yl)pentanoic acid

    		 Biochemical Assay Reagents Others
    (S)-Thioctic acid ((S)-lipoic acid; (S)-5-(1,2-Dithiolan-3-yl)pentanoic acid) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
    (S)-Thioctic acid
  • HY-15453
    Devimistat
    Maximum Cited Publications
    18 Publications Verification

    CPI-613

    		 Apoptosis Mitochondrial Metabolism Cancer
    Devimistat (CPI-613) is a mitochondrial metabolism inhibitor. Devimistat is a lipoic acid antagonist that abrogates mitochondrial energy metabolism to induce apoptosis in various cancer cells .
    Devimistat
  • HY-174910D
    6Arm-PEG-LA (MW 3400)

    		Biochemical Assay Reagents Others
    6Arm-PEG-LA (MW 3400) is a PEG derivative coupled with Lipoic acid (HY-18733) and can be used for drug delivery research .
    6Arm-PEG-LA (MW 3400)
  • HY-174910H
    6Arm-PEG-LA (MW 10000)

    		Biochemical Assay Reagents Others
    6Arm-PEG-LA (MW 10000) is a PEG derivative coupled with Lipoic acid (HY-18733) and can be used for drug delivery research .
    6Arm-PEG-LA (MW 10000)
  • HY-174910E
    6Arm-PEG-LA (MW 5000)

    		Biochemical Assay Reagents Others
    6Arm-PEG-LA (MW 5000) is a PEG derivative coupled with Lipoic acid (HY-18733) and can be used for drug delivery research .
    6Arm-PEG-LA (MW 5000)
  • HY-174910
    6Arm-PEG-LA (MW 400)

    		Biochemical Assay Reagents Others
    6Arm-PEG-LA (MW 400) is a PEG derivative coupled with Lipoic acid (HY-18733) and can be used for drug delivery research .
    6Arm-PEG-LA (MW 400)
  • HY-174910A
    6Arm-PEG-LA (MW 600)

    		Biochemical Assay Reagents Others
    6Arm-PEG-LA (MW 600) is a PEG derivative coupled with Lipoic acid (HY-18733) and can be used for drug delivery research .
    6Arm-PEG-LA (MW 600)
  • HY-174910C
    6Arm-PEG-LA (MW 2000)

    		Biochemical Assay Reagents Others
    6Arm-PEG-LA (MW 2000) is a PEG derivative coupled with Lipoic acid (HY-18733) and can be used for drug delivery research .
    6Arm-PEG-LA (MW 2000)
  • HY-174910B
    6Arm-PEG-LA (MW 1000)

    		Biochemical Assay Reagents Others
    6Arm-PEG-LA (MW 1000) is a PEG derivative coupled with Lipoic acid (HY-18733) and can be used for drug delivery research .
    6Arm-PEG-LA (MW 1000)
  • HY-147547
    SV5

    		Amyloid-β Neurological Disease
    SV5 is a potent anti-Alzheimer agent. SV5 can significantly protect SHSY-5Y cells against Aβ1-42-induced death. SV5 shows moderate antioxidant and good neuroprotective activities. SV5 shows the high stability in human plasma and the best pharmacological profile .
    SV5
  • HY-W014590R
    (S)-Thioctic acid (Standard)

    		Biochemical Assay Reagents Others
    (S)-Thioctic acid ((S)-lipoic acid; (S)-5-(1,2-Dithiolan-3-yl)pentanoic acid) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
    (S)-Thioctic acid (Standard)
  • HY-174912D
    DBCO-PEG-LA (MW 3400)

    		Biochemical Assay Reagents Others
    DBCO-PEG-LA (MW 3400) is a PEG derivative consisting of DBCO, PEG units, and Lipoic Acid (HY-18733). DBCO-PEG-LA (MW 3400) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
    DBCO-PEG-LA (MW 3400)
  • HY-174912B
    DBCO-PEG-LA (MW 1000)

    		Biochemical Assay Reagents Others
    DBCO-PEG-LA (MW 1000) is a PEG derivative consisting of DBCO, PEG units, and Lipoic Acid (HY-18733). DBCO-PEG-LA (MW 1000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
    DBCO-PEG-LA (MW 1000)
  • HY-174912
    DBCO-PEG-LA (MW 400)

    		Biochemical Assay Reagents Others
    DBCO-PEG-LA (MW 400) is a PEG derivative consisting of DBCO, PEG units, and Lipoic Acid (HY-18733). DBCO-PEG-LA (MW 400) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
    DBCO-PEG-LA (MW 400)
  • HY-174912A
    DBCO-PEG-LA (MW 600)

    		Biochemical Assay Reagents Others
    DBCO-PEG-LA (MW 600) is a PEG derivative consisting of DBCO, PEG units, and Lipoic Acid (HY-18733). DBCO-PEG-LA (MW 600) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
    DBCO-PEG-LA (MW 600)
  • HY-174912H
    DBCO-PEG-LA (MW 10000)

    		Biochemical Assay Reagents Others
    DBCO-PEG-LA (MW 10000) is a PEG derivative consisting of DBCO, PEG units, and Lipoic Acid (HY-18733). DBCO-PEG-LA (MW 10000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
    DBCO-PEG-LA (MW 10000)
  • HY-174912E
    DBCO-PEG-LA (MW 5000)

    		Biochemical Assay Reagents Others
    DBCO-PEG-LA (MW 5000) is a PEG derivative consisting of DBCO, PEG units, and Lipoic Acid (HY-18733). DBCO-PEG-LA (MW 5000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
    DBCO-PEG-LA (MW 5000)
  • HY-174912C
    DBCO-PEG-LA (MW 2000)

    		Biochemical Assay Reagents Others
    DBCO-PEG-LA (MW 2000) is a PEG derivative consisting of DBCO, PEG units, and Lipoic Acid (HY-18733). DBCO-PEG-LA (MW 2000) contains a DBCO group and can undergo a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with molecules containing an azide group .
    DBCO-PEG-LA (MW 2000)
  • HY-W015777
    4-Methoxybenzyl alcohol

    P-Methoxy-benzyl alcoho; (4-Methoxyphenyl)methanol

    		 Biochemical Assay Reagents Others
    4-Methoxybenzyl alcohol (P-Methoxy-benzyl alcohol; (4-Methoxyphenyl)methanol) is a Benzyl alcohol (HY-B0892) derivative, which is photocatalytically oxidized into p-anisaldehyde (PAA) in water. 4-Methoxybenzyl alcohol can undergo esterification reaction with α-lipoic acid .
    4-Methoxybenzyl alcohol
  • HY-B1142
    Lipoamide
    5+ Cited Publications

    (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide

    		 NO Synthase Others
    Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .
    Lipoamide
  • HY-151802
    CPUL1

    		TrxR Cancer
    CPUL1 is a TrxR inhibitor, which shows proliferation-inhibitory and anti-metastatic activity against A549 cells. CPUL1 influences EMT (epithelial-mesenchymal transition) via inducing ROS-mediated ERK/JNK signaling by inhibiting TrxR1 enzyme activity. CPUL1 in combination with α-Lipoic Acid (HY-N0492) or Dithiodipropionic acid (HY-W014395) is more effective .
    CPUL1
  • HY-W015777R
    4-Methoxybenzyl alcohol (Standard)

    P-Methoxy-benzyl alcoho (Standard); (4-Methoxyphenyl)methanol (Standard)

    		 Reference Standards Biochemical Assay Reagents Others
    4-Methoxybenzyl alcohol (Standard) is the analytical standard of 4-Methoxybenzyl alcohol. This product is intended for research and analytical applications. 4-Methoxybenzyl alcohol (P-Methoxy-benzyl alcohol; (4-Methoxyphenyl)methanol) is a Benzyl alcohol (HY-B0892) derivative, which is photocatalytically oxidized into p-anisaldehyde (PAA) in water. 4-Methoxybenzyl alcohol can undergo esterification reaction with α-lipoic acid .
    4-Methoxybenzyl alcohol (Standard)
  • HY-176817
    GPR109 receptor agonist-3

    		GPR109A Cardiovascular Disease Metabolic Disease
    GPR109 receptor agonist-3 is an orally active GPR109 receptor agonist, with an IC50 of 310 nM. GPR109 receptor agonist-3 retains the antioxidation and cytoprotection of Lipoic acid (HY-18733). GPR109 receptor agonist-3 reduces total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and increases high-density lipoprotein cholesterol (HDL-C) in high-fat diet-fed rats. GPR109 receptor agonist-3 can be used for the study of atherosclerosis .
    GPR109 receptor agonist-3
  • HY-151655
    11-Azidoundecanoic acid

    		ADC Linker Others
    11-Azidoundecanoic acid is a click chemistry reagent containing an azide group. 11-Azidoundecanoic acid acts as a hydrophobic bioconjugation linker that can be further modified at the azido-position using Staudinger ligation or Click-chemistry. 11-Azidoundecanoic acid is substrate of lipoic acid ligase (LpIA) for labeling . 11-Azidoundecanoic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    11-Azidoundecanoic acid

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