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9-PAHPA is a fatty acid esters of hydroxyfatty acid (FAHFA). FAHFAs are a new family of endogenous lipids, have antidiabetic and anti-inflammatory effects .
13-OAHSA is one of fatty acid esters of hydroxyfattyacids (FAHFAs). 13-OAHSA increases glucose-stimulated insulin secretion (GSIS) at a high glucose concentration .
13-POHSA is one of fatty acid esters of hydroxyfattyacids (FAHFAs). 13-POHSA increases glucose-stimulated insulin secretion (GSIS) at a high glucose concentration .
10-OAHSA is one of fatty acid esters of hydroxyfattyacids (FAHFAs). 10-POHSA increases glucose-stimulated insulin secretion (GSIS) at a high glucose concentration. 10-OAHSA reduces LPS (HY-D1056)-induced Tnf-α secretion in bone marrow-derived dendritic cells (BMDCs) .
16-Hydroxyhexadecanoic acid (Juniperic acid) is one of the main monomers of cutin in Vicia faba flower petals. 16-Hydroxyhexadecanoic acid can be used as an internal standard for the measurement of hydroxy and hydroperoxy fattyacids in plasma .
12-POHSA is one of fatty acid esters of hydroxyfattyacids (FAHFAs). 12-POHSA increases glucose-stimulated insulin secretion (GSIS) at a high glucose concentration .
1-Palmitoyl-2-10-pahsa-3-oleoyl-sn-glycerol (16:0-10-Pahsa-18:1-TG) is a triacylglycerol that contains Palmitic acid (HY-N08307), the fatty acid ester of hydroxyfatty acid (FAHFA) 10-PAHSA, and Oleic acid (HY-N1446) .
Eliglustat (Standard) is the analytical standard of Eliglustat. This product is intended for research and analytical applications. Eliglustat is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC50 of 24 nM.
16-Hydroxy-9-hexadecenoic acid is a minor hydroxyfatty acid component. 16-Hydroxy-9-hexadecenoic acid can form ester bonds with terpenoid acids to form monoester or polyester structures in cordyceps .
3-Hydroxy-3-methylhexanoic acid-d5 is the deuterium labeled 3-Hydroxy-3-methylhexanoic acid (HY-W041195). 3-Hydroxy-3-methylhexanoic acid is a fatty acid that is one of the metabolic products of leukocytes .
(9Z)-16-Hydroxy-9-hexadecenoic acid is an unsaturated hydroxyfatty acid. (9Z)-16-Hydroxy-9-hexadecenoic acid can be produced by the fermentation of Methyl palmitoleate (HY-W011688) using the yeast Torulopsis apicola .
9-SAHSA is a fatty acid ester of hydroxyfattyacids (FAHFAs). 9-SAHSA is a protective molecule to prevent colon carcinoma cells
from apoptotic cell death .
(±)-10-Hydroxy-12(Z),15(Z)-octadecadienoic acid is a fatty acid derivative. (±)-10-Hydroxy-12(Z),15(Z)-octadecadienoic acid can be used in the food, cosmetic and pharmaceutical industries, such as starting materials for biodegradable polymers, lubricants, emulsifiers, drugs and fragrances .
10-POHSA is a newly identified endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxyfattyacids (FAHFAs). 10-POHSA may be a bioactive lipid with roles in metabolic syndrome and inflammation.
10-Hydroxy-2-decenoic acid (10-HDA) is an orally active unsaturated medium-chain fatty acid with various physiological activities. 10-Hydroxy-2-decenoic acid induces ROS-mediated apoptosis in A549 cells. 10-Hydroxy-2-decenoic acid inhibits VEGF-induced angiogenesis in human venous endothelial cells. 10-Hydroxy-2-decenoic acid alleviates non-alcoholic fatty liver disease (NAFLD) by activating the AMPK-α signaling pathway. 10-Hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4. 10-Hydroxy-2-decenoic acid is an antibiotic against many bacteria and fungi, such as Neurospora sitophila, molds and Staphylococcus aureus. 10-Hydroxy-2-decenoic acid has longevity-promoting effects in C. elegans. 10-Hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence .
(R)-3-Hydroxyvaleryl-CoA ((3R)-Hydroxyvaleryl-coenzyme A) is a 3-hydroxyfatty acyl-CoA resulting from the formal condensation of the thiol group of coenzyme A with the carboxy group of (R)-3-hydroxypentanoic acid.
JJH260 is AIG1inhibitor, and inhibit the fluorophosphonate reactivity and fatty acid esters of hydroxyfatty acid (FAHFA) hydrolysis activity of AIG1in HEK293T cells, with IC50 values of 0.50 μM and 0.57 μM, respectively .
9-POHSA is a fatty acid ester of hydroxyfattyacids (FAHFAs). 9-POHSA shows anti-inflammatory effects via inhibiting cytokine production and reduces IL-1β and IL-6 expression .
10-Hydroxy-2-decenoic acid (Standard) is an analytical standard for 10-Hydroxy-2-decenoic acid (HY-W592871). This product is intended for research and analytical applications.10-Hydroxy-2-decenoic acid (10-HDA) is an orally active unsaturated medium-chain fatty acid with various physiological activities. 10-Hydroxy-2-decenoic acid induces ROS-mediated apoptosis in A549 cells. 10-Hydroxy-2-decenoic acid inhibits VEGF-induced angiogenesis in human venous endothelial cells. 10-Hydroxy-2-decenoic acid alleviates non-alcoholic fatty liver disease (NAFLD) by activating the AMPK-α signaling pathway. 10-Hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4. 10-Hydroxy-2-decenoic acid is an antibiotic against many bacteria and fungi, such as Neurospora sitophila, molds and Staphylococcus aureus. 10-Hydroxy-2-decenoic acid has longevity-promoting effects in C. elegans. 10-Hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence .
(R)-3-Hydroxytetradecanoyl-CoA ((R)-3-Hydroxytetradecanoyl-coenzyme A) is a 3-hydroxyfatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (R)-3-hydroxytetradecanoic acid.
Methyl pentadecanoate is a fatty acid ester, can be isolated from L. wallichi extracts. Methyl pentadecanoate is obtained by condensation of the carboxy group of pentadecanoic acid with the hydroxy group of methanol .
Methyl pentadecanoate is a fatty acid ester, can be isolated from L. wallichi extracts. Methyl pentadecanoate is obtained by condensation of the carboxy group of pentadecanoic acid with the hydroxy group of methanol .
ABC34 is an inactive control compound of JJH260. ABC34 does not inhibit the fluorophosphonate reactivity or fatty acid esters of hydroxyfatty acid (FAHFA) hydrolysis activity of AIG1. ABC34 can inhibit both ABHD6 and PPT122 .
Hydroxy tipelukast (Compound MN-002), the metabolite of Compound MN-001, is an orally active phenoxyalkylcarboxylic acid. Hydroxy tipelukast inhibits liver steatosis, lobular inflammation, hepatic ballooning, and hepatic scarring, and reduces liver hydroxyproline levels. Hydroxy tipelukast is promising for research of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) .
Ceramides Mixture is an endogenous ceramide and consists of hydroxy and non-hydroxyfatty acid-containing ceramides. Ceramides Mixture is a main lipid component of the permeability barrier in epidermis. Ceramides Mixture is involved in the regulation of growth inhibition, cell cycle arrest, and modulation of telomerase activity .
(S)-3-Hydroxy-2-palmitamidopropanoic acid (sodium) (Compound C16Ser) is a serinate surfactants. (S)-3-Hydroxy-2-palmitamidopropanoic acid (sodium) can be used to study the effect of fatty acyl chain length on the foam properties. (S)-3-Hydroxy-2-palmitamidopropanoic acid (sodium) has the longer acyl chain, which enhances the intermolecular interaction, thereby facilitating a compact adsorption film at the interface. (S)-3-Hydroxy-2-palmitamidopropanoic acid (sodium) exhibits higher interfacial activity and forms more stable interfacial films under stronger intermolecular interaction .
(3S)-3-Hydroxyoleoyl-CoA ((3S)-3-Hydroxyoleoyl-coenzyme A) is a 3-hydroxyfatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (3S)-3-hydroxyoleic acid.
2-Hydroxytetradecanoic acid is a hydroxyfatty acid that inhibits cleavage between the enterovirus capsid proteins VP4 and VP2. 2-Hydroxytetradecanoic Acid has anti-virus activity .
2-Hydroxytetradecanoic acid is a hydroxyfatty acid that inhibits cleavage between the enterovirus capsid proteins VP4 and VP2. 2-Hydroxytetradecanoic Acid has anti-virus activity .
1-Palmitoyl-2-hydroxy-sn-glycero-3-PE is a naturally occurring choline phospholipid that can be synthesized from phosphatidylcholine and fattyacids. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PE is used as a structure-related lipid control .
Ricinelaidic acid, a 12-hydroxyfatty acid，is a leukotriene B4 (LTB4) receptor antagonist with the Ki of 2 μM in porcine neutrophil membranes. Ricinelaidic acid inhibits chemotaxis and calcium flux induced by LTB4 in isolated human neutrophils (IC50=10 and 7 μM, respectively). Ricinelaidic acid inhibits bronchoconstriction induced by LTB4 in rats .
4-hydroxy Nonenal Mercapturic Acid (4-HNE) is generated by the peroxidation of common ω-6 polyunsaturated fattyacids (PUFAs) such as linoleic acid, DGLA, and arachidonic acid. 4-hydroxy Nonenal Mercapturic Acid is rapidly cleared from plasma and enters the enterohepatic circulation in rats as a glutathione conjugate. Approximately two-thirds of 4-hydroxy Nonenal Mercapturic Acid is excreted in the urine within 48 hours, primarily as mercapturic acid conjugates. Approximately half of the metabolites are C-1 aldehydes of 4-hydroxy Nonenal Mercapturic Acid that are reduced to alcohols. The remainder are C-1 aldehydes or have been oxidized to C-1 carboxylic acids. These aldehydes and carboxylic acids can also form gamma-lactols and gamma-lactones, respectively, resulting in at least four or five final urinary metabolites of 4-HNE in vivo.
9-OAHSA is a fatty acid ester of hydroxyfattyacids (FAHFAs). 9-OAHSA shows anti-inflammatory effects via inhibiting cytokine production and reduces IL-1β and IL-6 expression. 9-OAHSA is also a protective molecule to prevent colon carcinoma cells from apoptotic cell death .
(S)-3-Hydroxyoctanoyl-CoA ((S)-3-Hydroxyoctanoyl-Coenzyme A) is a hydroxyfatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (S)-3-hydroxyoctanoic acid.
(S)-3-Hydroxylauroyl-CoA ((S)-3-Hydroxylauroyl-coenzyme A) is a hydroxyfatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (S)-3-hydroxydodecanoic acid.
N-Boc-erythro-sphingosine is composed of t-butyl ester protected N-acetylsphingosine with a fatty acid tail. The hydroxy group enables further derivatization or replacement with other reactive functional groups. The t-butyl group can be deprotected under mild acidic conditions.
(3R,19Z,22Z,25Z,28Z)-3-Hydroxytetratriacontatetraenoyl-CoA ((3R,19Z,22Z,25Z,28Z)-3-Hydroxytetratriacontatetraenoyl-coenzyme A) is a 3-hydroxyfatty acyl-CoA.
10-Hydroxyhexadecanoic acid is a hydroxyfatty acid found in Camembert cheese. 10-Hydroxyhexadecanoic acid can promote cholesterol efflux from ABCA1 and ABCG1, preventing the accumulation of excess cholesterol in cells. 10-Hydroxyhexadecanoic acid can be used in anti-atherosclerosis research .
NITD-916, a 4-hydroxy-2-pyridone derivative, is an orally active mycobacterial enoyl reductase InhA inhibitor with an IC50 of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to block access to the fatty acyl substrate binding pocket. NITD-916 inhibition of InhA reduces the synthesis of mycolic acids and results in cell death. NITD-916 has potent anti-tuberculosis effects .
2-Hydroxyvaleric acid is a medium chain α-hydroxyfatty acid. 2-Hydroxyvaleric acid is an activator in fat metabolism of palmitic acid-1-C 14. 2-hydroxyvaleric acid is also used as a staining agent for measuring tissue-specific Lactate dehydrogenase activity and elevated levels of 2-hydroxyvaleric acid induces lactic acidosis .
(R)-Leucic acid (D-α-Hydroxyisocaproic acid) is an orally active D-isomer of the α-hydroxy analogue of Leucine (HY-N0486). (R)-Leucic acid is a metabolite of Lactobacillus and can promote intestinal fatty acid absorption by upregulating CD36 expression. (R)-Leucic acid can be used to study microbe-host interactions and the regulation of lipid metabolism by probiotics .
2-Hydroxystearic acid is an alpha-hydroxyfatty acid commonly used in a variety of personal care products, especially cosmetic and skin care formulations. 2-Hydroxystearic acid has unique chemical properties that make it an effective emulsifier and stabilizer, improving the texture and shelf life of cosmetic products. It also has a potential physiological role in improving skin hydration and elasticity, although its biological function is not fully understood.
(R)-Leucic acid (Standard) is the analytical standard of (R)-Leucic acid (HY-30216). This product is intended for research and analytical applications. (R)-Leucic acid (D-α-Hydroxyisocaproic acid) is the D-isomer of the α-hydroxy analogue of Leucine (HY-N0486). (R)-Leucic acid is a metabolite of Lactobacillus and can promote intestinal fatty acid absorption by upregulating CD36 expression. (R)-Leucic acid can be used to study microbe-host interactions and the regulation of lipid metabolism by probiotics.
Ricinoleic acid (purity≥99%), a hydroxyfatty acid, is an attractive feedstock for the production of high-performance lubricants, cosmetics, polymers, surfactants, and coatings. Ricinoleic acid is the main active ingredient of Castor oil (HY-107799). Ricinoleic acid is the agonist for prostaglandin EP3 receptor (EP3 receptor) (EC50 in MEG-01 is 0.5 μM), that causes laxative effects and uterine contraction. Ricinoleic acid exhibits antianxiety-like, anti-inflammatory and pro-inflammatory properties .
Ricinoleic acid (purity≥85%), a hydroxyfatty acid, is an attractive feedstock for the production of high-performance lubricants, cosmetics, polymers, surfactants, and coatings. Ricinoleic acid is the main active ingredient of Castor oil (HY-107799). Ricinoleic acid is the agonist for prostaglandin EP3 receptor (EP3 receptor) (EC50 in MEG-01 is 0.5 μM), that causes laxative effects and uterine contraction. Ricinoleic acid exhibits antianxiety-like, anti-inflammatory and pro-inflammatory properties .
Ricinoleic acid (purity≥99%) (Standard) is the analytical standard of Ricinoleic acid (purity≥99%). This product is intended for research and analytical applications. Ricinoleic acid (purity≥99%), a hydroxyfatty acid, is an attractive feedstock for the production of high-performance lubricants, cosmetics, polymers, surfactants, and coatings. Ricinoleic acid is the main active ingredient of Castor oil (HY-107799). Ricinoleic acid is the agonist for prostaglandin EP3 receptor (EP3 receptor) (EC50 in MEG-01 is 0.5 μM), that causes laxative effects and uterine contraction. Ricinoleic acid exhibits antianxiety-like, anti-inflammatory and pro-inflammatory properties .
EOP (t18:0/30:0/18:2) (C48:2 EOP (t18:0/30:0w18:2 (9Z,12Z)); N-(30-Linoleoyloxy-triacontanoyl)-phytosphingosine) is a plant ceramide-based EOS analog. EOP (t18:0/30:0/18:2) is formed by esterifying an ω-hydroxy very long chain ceramide (C28-36) with the essential fatty acid linoleic acid. EOP (t18:0/30:0/18:2) has been used as a component of a model stratum corneum lipid mixture .
Lysophosphatidylethanolamine (LPE) is a naturally-occurring lysophospholipid that can be generated via deacylation of phosphatidylethanolamine by phospholipase A2 (PLA2). It increases the phosphorylation of ERK1/2 in PC12 cells, an effect that can be blocked by the MEK inhibitors U-0126 (HY-12031A) and PD 98059 (HY-12028) and the EGFR inhibitor AG-1478 (HY-13524).1 LPE also increases neurite outgrowth and expression of neurofilament M in PC12 cells. LPE inhibits the activity of phospholipase D (PLD) partially purified from cabbage.3 This product contains lysophosphatidylethanolamine molecular species with variable fatty acyl chain lengths at the sn-1 position and a hydroxy group at the sn-2 position.
10-Hydroxydecanoic acid (10-HDAA) is a saturated fatty acid derived from 10-hydroxy-trans-2-decenoic acid, which can be isolated from royal jelly. 10-Hydroxydecanoic acid exhibits various biological activities, including anti-inflammatory, insecticidal, anti-malarial, and anti-Leishmania properties, as well as enhancing antigen-specific immune responses. The anti-inflammatory effects of 10-Hydroxydecanoic acid are primarily mediated by inhibiting the activation of NF-κB and the translation of interferon regulatory factor 1 (IRF-1), which reduces the production of interleukin 6 (IL-6) and nitric oxide (NO) in inflammatory cells. Additionally, 10-Hydroxydecanoic acid alleviates neuroinflammatory responses through the p53-autophagy pathway and the p53-NLRP3 pathway. Finally, 10-Hydroxydecanoic acid enhances antigen-specific immune responses by promoting the effective uptake of antigens by microfold cells .
10-Hydroxydecanoic acid (Standard) is the analytical standard of 10-Hydroxydecanoic acid. This product is intended for research and analytical applications. 10-Hydroxydecanoic acid (10-HDAA) is a saturated fatty acid derived from 10-hydroxy-trans-2-decenoic acid, which can be isolated from royal jelly. 10-Hydroxydecanoic acid exhibits various biological activities, including anti-inflammatory, insecticidal, anti-malarial, and anti-Leishmania properties, as well as enhancing antigen-specific immune responses. The anti-inflammatory effects of 10-Hydroxydecanoic acid are primarily mediated by inhibiting the activation of NF-κB and the translation of interferon regulatory factor 1 (IRF-1), which reduces the production of interleukin 6 (IL-6) and nitric oxide (NO) in inflammatory cells. Additionally, 10-Hydroxydecanoic acid alleviates neuroinflammatory responses through the p53-autophagy pathway and the p53-NLRP3 pathway. Finally, 10-Hydroxydecanoic acid enhances antigen-specific immune responses by promoting the effective uptake of antigens by microfold cells[1][2][3][4][5].
13-POHSA is one of fatty acid esters of hydroxyfattyacids (FAHFAs). 13-POHSA increases glucose-stimulated insulin secretion (GSIS) at a high glucose concentration .
2-Hydroxystearic acid is an alpha-hydroxyfatty acid commonly used in a variety of personal care products, especially cosmetic and skin care formulations. 2-Hydroxystearic acid has unique chemical properties that make it an effective emulsifier and stabilizer, improving the texture and shelf life of cosmetic products. It also has a potential physiological role in improving skin hydration and elasticity, although its biological function is not fully understood.
9-PAHPA is a fatty acid esters of hydroxyfatty acid (FAHFA). FAHFAs are a new family of endogenous lipids, have antidiabetic and anti-inflammatory effects .
10-Hydroxy-2-decenoic acid (10-HDA) is an orally active unsaturated medium-chain fatty acid with various physiological activities. 10-Hydroxy-2-decenoic acid induces ROS-mediated apoptosis in A549 cells. 10-Hydroxy-2-decenoic acid inhibits VEGF-induced angiogenesis in human venous endothelial cells. 10-Hydroxy-2-decenoic acid alleviates non-alcoholic fatty liver disease (NAFLD) by activating the AMPK-α signaling pathway. 10-Hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4. 10-Hydroxy-2-decenoic acid is an antibiotic against many bacteria and fungi, such as Neurospora sitophila, molds and Staphylococcus aureus. 10-Hydroxy-2-decenoic acid has longevity-promoting effects in C. elegans. 10-Hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence .
Methyl pentadecanoate is a fatty acid ester, can be isolated from L. wallichi extracts. Methyl pentadecanoate is obtained by condensation of the carboxy group of pentadecanoic acid with the hydroxy group of methanol .
Eliglustat (Standard) is the analytical standard of Eliglustat. This product is intended for research and analytical applications. Eliglustat is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC50 of 24 nM.
16-Hydroxy-9-hexadecenoic acid is a minor hydroxyfatty acid component. 16-Hydroxy-9-hexadecenoic acid can form ester bonds with terpenoid acids to form monoester or polyester structures in cordyceps .
10-Hydroxy-2-decenoic acid (Standard) is an analytical standard for 10-Hydroxy-2-decenoic acid (HY-W592871). This product is intended for research and analytical applications.10-Hydroxy-2-decenoic acid (10-HDA) is an orally active unsaturated medium-chain fatty acid with various physiological activities. 10-Hydroxy-2-decenoic acid induces ROS-mediated apoptosis in A549 cells. 10-Hydroxy-2-decenoic acid inhibits VEGF-induced angiogenesis in human venous endothelial cells. 10-Hydroxy-2-decenoic acid alleviates non-alcoholic fatty liver disease (NAFLD) by activating the AMPK-α signaling pathway. 10-Hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4. 10-Hydroxy-2-decenoic acid is an antibiotic against many bacteria and fungi, such as Neurospora sitophila, molds and Staphylococcus aureus. 10-Hydroxy-2-decenoic acid has longevity-promoting effects in C. elegans. 10-Hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence .
Methyl pentadecanoate is a fatty acid ester, can be isolated from L. wallichi extracts. Methyl pentadecanoate is obtained by condensation of the carboxy group of pentadecanoic acid with the hydroxy group of methanol .
2-Hydroxyvaleric acid is a medium chain α-hydroxyfatty acid. 2-Hydroxyvaleric acid is an activator in fat metabolism of palmitic acid-1-C 14. 2-hydroxyvaleric acid is also used as a staining agent for measuring tissue-specific Lactate dehydrogenase activity and elevated levels of 2-hydroxyvaleric acid induces lactic acidosis .
(R)-Leucic acid (D-α-Hydroxyisocaproic acid) is an orally active D-isomer of the α-hydroxy analogue of Leucine (HY-N0486). (R)-Leucic acid is a metabolite of Lactobacillus and can promote intestinal fatty acid absorption by upregulating CD36 expression. (R)-Leucic acid can be used to study microbe-host interactions and the regulation of lipid metabolism by probiotics .
(R)-Leucic acid (Standard) is the analytical standard of (R)-Leucic acid (HY-30216). This product is intended for research and analytical applications. (R)-Leucic acid (D-α-Hydroxyisocaproic acid) is the D-isomer of the α-hydroxy analogue of Leucine (HY-N0486). (R)-Leucic acid is a metabolite of Lactobacillus and can promote intestinal fatty acid absorption by upregulating CD36 expression. (R)-Leucic acid can be used to study microbe-host interactions and the regulation of lipid metabolism by probiotics.
Ricinoleic acid (purity≥85%), a hydroxyfatty acid, is an attractive feedstock for the production of high-performance lubricants, cosmetics, polymers, surfactants, and coatings. Ricinoleic acid is the main active ingredient of Castor oil (HY-107799). Ricinoleic acid is the agonist for prostaglandin EP3 receptor (EP3 receptor) (EC50 in MEG-01 is 0.5 μM), that causes laxative effects and uterine contraction. Ricinoleic acid exhibits antianxiety-like, anti-inflammatory and pro-inflammatory properties .
10-Hydroxydecanoic acid (10-HDAA) is a saturated fatty acid derived from 10-hydroxy-trans-2-decenoic acid, which can be isolated from royal jelly. 10-Hydroxydecanoic acid exhibits various biological activities, including anti-inflammatory, insecticidal, anti-malarial, and anti-Leishmania properties, as well as enhancing antigen-specific immune responses. The anti-inflammatory effects of 10-Hydroxydecanoic acid are primarily mediated by inhibiting the activation of NF-κB and the translation of interferon regulatory factor 1 (IRF-1), which reduces the production of interleukin 6 (IL-6) and nitric oxide (NO) in inflammatory cells. Additionally, 10-Hydroxydecanoic acid alleviates neuroinflammatory responses through the p53-autophagy pathway and the p53-NLRP3 pathway. Finally, 10-Hydroxydecanoic acid enhances antigen-specific immune responses by promoting the effective uptake of antigens by microfold cells .
10-Hydroxydecanoic acid (Standard) is the analytical standard of 10-Hydroxydecanoic acid. This product is intended for research and analytical applications. 10-Hydroxydecanoic acid (10-HDAA) is a saturated fatty acid derived from 10-hydroxy-trans-2-decenoic acid, which can be isolated from royal jelly. 10-Hydroxydecanoic acid exhibits various biological activities, including anti-inflammatory, insecticidal, anti-malarial, and anti-Leishmania properties, as well as enhancing antigen-specific immune responses. The anti-inflammatory effects of 10-Hydroxydecanoic acid are primarily mediated by inhibiting the activation of NF-κB and the translation of interferon regulatory factor 1 (IRF-1), which reduces the production of interleukin 6 (IL-6) and nitric oxide (NO) in inflammatory cells. Additionally, 10-Hydroxydecanoic acid alleviates neuroinflammatory responses through the p53-autophagy pathway and the p53-NLRP3 pathway. Finally, 10-Hydroxydecanoic acid enhances antigen-specific immune responses by promoting the effective uptake of antigens by microfold cells[1][2][3][4][5].
ADTRP protein exhibits specialized enzymatic activity, specifically hydrolyzing bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), with a notable preference for branched FAHFAs. This unique function distinguishes ADTRP, as it does not hydrolyze other major lipid classes. Moreover, ADTRP regulates endothelial cells, influencing TFPI expression and cell-associated anticoagulant activity, observed in in vitro settings. ADTRP Protein, Human (Cell-Free, His, Myc) is the recombinant human-derived ADTRP protein, expressed by E. coli Cell-free , with N-10*His, C-Myc labeled tag.
3-Hydroxy-3-methylhexanoic acid-d5 is the deuterium labeled 3-Hydroxy-3-methylhexanoic acid (HY-W041195). 3-Hydroxy-3-methylhexanoic acid is a fatty acid that is one of the metabolic products of leukocytes .
1-Palmitoyl-2-hydroxy-sn-glycero-3-PE is a naturally occurring choline phospholipid that can be synthesized from phosphatidylcholine and fattyacids. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PE is used as a structure-related lipid control .
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