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Results for "

hybrid molecules

" in MedChemExpress (MCE) Product Catalog:

15

Inhibitors & Agonists

2

Peptides

1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-19738
    NQTrp

    		Tau Protein Neurological Disease
    NQTrp, an aromatic naphthoquinone-tryptophan hybrid molecule, an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects. NQTrp inhibits the in vitro aggregation of hexapeptide ( 41GCWMLY 46 within the N-terminus of γD-crystallin) as well as full-length γD-crystallin .
    NQTrp
  • HY-15035
    S-Diclofenac

    ACS 15; ATB-337

    		 MDM-2/p53 JNK SOD Cardiovascular Disease Inflammation/Immunology
    S-Diclofenac (ACS 15) is a hybrid molecule of an H2S donor and the NSAID diclofenac. S-Diclofenac activates the p53 signaling pathway, and inhibits the activation of JNK. S-Diclofenac exhibits antioxidant and anti-inflammatory activities .
    S-Diclofenac
  • HY-131678
    Palmitoyl serotonin

    PA-5HT

    		 FAAH Neurological Disease
    Palmitoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin, antagonist of FAAH. Palmitoyl serotonin inhibits L-3,4-dihydroxyphenylalanine (HY-N0304) induced abnormal involuntary movements. Palmitoyl serotonin has the potential for the research of parkinson's disease (PD) .
    Palmitoyl serotonin
  • HY-18003
    Oleanolic acid derivative 2

    		Drug Derivative Inflammation/Immunology
    Oleanolic acid derivative 2 is an oleanolic acid derivative, which is a novel triterpenoid-steroid hybrid molecule.
    Oleanolic acid derivative 2
  • HY-18002
    Oleanolic acid derivative 1

    		Others Inflammation/Immunology
    Oleanolic acid derivative 1 is an oleanolic acid derivative, which is a novel triterpenoid-steroid hybrid molecule.
    Oleanolic acid derivative 1
  • HY-P5768
    WSHPQFEKWSHPQFEK

    		Biochemical Assay Reagents Others
    WSHPQFEKWSHPQFEK is an oligopeptide that can link proteins and dsDNA molecules in an efficient, rapid and specific manner. WSHPQFEKWSHPQFEK can be used to construct DNA-protein hybrids .
    WSHPQFEKWSHPQFEK
  • HY-163451
    Apoptosis inducer 17

    		Apoptosis Cancer
    Apoptosis inducer 17 is a Curcumin-Piperlongumine hybrid molecule that increases cell cycle arrest and apoptosis through activating JNK signaling pathway in lung cancer cells .
    Apoptosis inducer 17
  • HY-P5768A
    WSHPQFEKWSHPQFEK TFA

    		Biochemical Assay Reagents Cancer
    WSHPQFEKWSHPQFEK TFA is an oligopeptide that can link proteins and dsDNA molecules in an efficient, rapid and specific manner. WSHPQFEKWSHPQFEK TFA can be used to construct DNA-protein hybrids .
    WSHPQFEKWSHPQFEK TFA
  • HY-117429
    Se-Aspirin

    Selenium-acetylsalicylic acid

    		 NF-κB Inflammation/Immunology
    Se-Aspirin is a hybrid molecule of selenium and Aspirin (HY-14654). Se-Aspirin reduces the viability of cancer cell lines, particularly colorectal cancer cells .
    Se-Aspirin
  • HY-151872
    HDAC-IN-48

    		HDAC Ferroptosis Cancer
    HDAC-IN-48 is a potent HDAC inhibitor. HDAC-IN-48 is a hybrid molecule with great cytotoxic profile (GI50~20 nM). HDAC-IN-48 consists of harmacophores of SAHA and CETZOLE molecules. HDAC-IN-48 induces ferroptosis and inhibits HDAC proteins . HDAC-IN-48 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    HDAC-IN-48
  • HY-15035R
    S-Diclofenac (Standard)

    		MDM-2/p53 JNK SOD Cardiovascular Disease Inflammation/Immunology
    S-Diclofenac (Standard) is the analytical standard of S-Diclofenac. This product is intended for research and analytical applications. S-Diclofenac (ACS 15) is a hybrid molecule of an H2S donor and the NSAID diclofenac. S-Diclofenac activates the p53 signaling pathway, and inhibits the activation of JNK. S-Diclofenac exhibits antioxidant and anti-inflammatory activities .
    S-Diclofenac (Standard)
  • HY-P2929C
    PNGase F (Lyophilized)

    		Glycosidase Cancer
    PNGase F (Lyophilized) is a glycosidase expressed by recombinant E. coli. PNGase F (Lyophilized) can selectively hydrolyze all N-glycans linked to Asn in proteins except those containing α1-3 fucosidic bonds. The cleavage site is the glycosidic bond between Asn and the innermost GIcNAc, which releases sugar molecules linked to asparagine from glycoproteins and converts asparagine to aspartic acid. The cleaved glycoforms include high mannose, hybrid and complex oligosaccharides .
    PNGase F (Lyophilized)
  • HY-162856
    TRPV1-IN-2

    		TRP Channel Neurological Disease
    TRPV1-IN-2 ((R)-32) is a TRPV1 inhibitor. TRPV1-IN-2 has protective effects on ED epilepsy models .
    TRPV1-IN-2
  • HY-162805
    iNOS/TopoI-IN-1

    		NO Synthase Topoisomerase Apoptosis NF-κB Inflammation/Immunology Cancer
    iNOS/TopoI-IN-1 (compound AuL9) is a multi-target hybrid molecule with anti-tumor, anti-inflammatory and antioxidant activities. iNOS/TopoI-IN-1 inhibits the growth of breast cancer cells MCF-7 and MDA MB-231 in vitro with IC50 of 3.5 μM and 6.3 μM, respectively, and induces DNA damage and apoptosis of breast cancer cells by inhibiting human topoisomerase I (TopoI) (Ki=2.72 μM). In addition, NOS/TopoI-IN-1 inhibits the expression of iNOS by inhibiting the activation of NF-kB (Ki=1.49 μM) .
    iNOS/TopoI-IN-1
  • HY-121465
    Stearoyl Serotonin

    		Endogenous Metabolite Metabolic Disease
    Stearoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin. Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase (FAAH) and the transient receptor potential vanilloid-type 1 (TRPV1) channel, reducing both acute and chronic peripheral pain. The effects of replacing the arachidonoyl portion with the saturated 18-carbon stearoyl moiety have not been studied. However, replacement of arachidonate with saturated 11- or 12-carbon fatty acids produces compounds that potently inhibit capsaicin-induced TRPV1 channel activation (IC50=0.76 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 μM).
    Stearoyl Serotonin

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