2. Signaling Pathways
  3. Repulsive guidance molecule

Repulsive guidance molecule

RGM

Repulsive guidance molecule (RGM) is a membrane-associated glycoprotein found in most vertebrate species. The RGM family is formed by three members: RGMa, RGMb, and RGMc. RGMa and RGMb (also called Dragon) are expressed in the developing and adult CNS, but with different expression patterns. RGMc (also called HJV, HFE2, or DL-M) is expressed in the liver and the striated muscle but not in the nervous system and is involved in the regulation of iron metabolism. The three proteins, RGMa, RGMb and RGMc, products of distinct single-copy genes that arose early in vertebrate evolution, are ~40-50%identical to each other in primary amino acid sequence. All three RGM proteins appear capable of binding selected BMPs (bone morphogenetic proteins), and interactions with BMPs mediate at least some of the biological effects of RGMc on iron metabolism.

Repulsive guidance molecule Related Products (1):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P991716
    Selcodebart
    		Inhibitor
    Selcodebart is a humanized IgG1κ monoclonal antibody inhibitor targeting Repulsive Guidance Molecule C (RGMC/HFE2). Selcodebart has antianaemic activity. Abdakibart can be used for CNS disorders like Alzheimer’s disease and stroke, brain tumors and anemia research.
    Selcodebart