Search Result
Results for "
hetero-bifunctional
" in MedChemExpress (MCE) Product Catalog:
86
Biochemical Assay Reagents
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-D0975
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ADC Linker
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Cancer
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Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.
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- HY-138642
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ARV-471
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PROTACs
Estrogen Receptor/ERR
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Cancer
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Vepdegestrant (ARV-471) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of about 2 nM .
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- HY-W1049071H
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Biochemical Assay Reagents
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Others
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HO-PEG-SCM (MW 2000) is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
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- HY-W1049071C
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Biochemical Assay Reagents
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Others
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HO-PEG-SCM (MW 20000) is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
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- HY-W1049071A
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Biochemical Assay Reagents
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Others
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HO-PEG-SCM (MW 5000) is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
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- HY-W1049071I
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Biochemical Assay Reagents
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Others
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HO-PEG-SCM (MW 3400) is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
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- HY-W1049071D
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Biochemical Assay Reagents
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Others
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HO-PEG-SCM (MW 40000) is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
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- HY-W1049071B
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Biochemical Assay Reagents
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Others
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HO-PEG-SCM (MW 10000) is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
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- HY-W1049071E
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Biochemical Assay Reagents
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Others
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HO-PEG-SCM (MW 1000) is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
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- HY-138642A
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(Rac)-ARV-471
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Estrogen Receptor/ERR
PROTACs
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Cancer
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(Rac)-Vepdegestrant is the isomer of Vepdegestrant (HY-138642). Vepdegestrant ((R)-Lavandulol) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of about 2 nM .
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- HY-W1049061E
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Biochemical Assay Reagents
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Others
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Boc-NH-PEG-COOH (MW 1000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 1000) is an important cross-linker with PEG chains .
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- HY-W1049061D
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Biochemical Assay Reagents
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Others
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Boc-NH-PEG-COOH (MW 40000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 40000) is an important cross-linker with PEG chains .
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- HY-W1049061B
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Biochemical Assay Reagents
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Others
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Boc-NH-PEG-COOH (MW 10000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 10000) is an important cross-linker with PEG chains .
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- HY-W1049061
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Biochemical Assay Reagents
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Others
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Boc-NH-PEG-COOH (MW 2000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 2000) is an important cross-linker with PEG chains .
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- HY-W1049061A
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Biochemical Assay Reagents
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Others
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Boc-NH-PEG-COOH (MW 5000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 5000) is an important cross-linker with PEG chains .
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- HY-W1049061C
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Biochemical Assay Reagents
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Others
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Boc-NH-PEG-COOH (MW 20000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 20000) is an important cross-linker with PEG chains .
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- HY-W1049061H
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Biochemical Assay Reagents
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Others
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Boc-NH-PEG-COOH (MW 3400) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 3400) is an important cross-linker with PEG chains .
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- HY-W1048542A
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Biochemical Assay Reagents
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Others
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Fmoc-NH-PEG-COOH (MW 2000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 2000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
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- HY-W1048542D
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Biochemical Assay Reagents
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Others
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Fmoc-NH-PEG-COOH (MW 5000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 5000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
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- HY-W1048542I
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Biochemical Assay Reagents
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Others
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Fmoc-NH-PEG-COOH (MW 40000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 40000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
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- HY-W1048542E
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Biochemical Assay Reagents
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Others
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Fmoc-NH-PEG-COOH (MW 10000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 10000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
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- HY-W1048542C
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Biochemical Assay Reagents
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Others
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Fmoc-NH-PEG-COOH (MW 3400) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 3400) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
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- HY-W1048542H
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Biochemical Assay Reagents
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Others
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Fmoc-NH-PEG-COOH (MW 20000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 20000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
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- HY-140232A
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Boc-NH-PEG-Amine (MW 1000)
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Biochemical Assay Reagents
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Others
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BOC-NH-PEG-NH2 (MW 1000) (Boc-NH-PEG-Amine (MW 1000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 1000) is an important cross-linker with PEG chains .
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- HY-140232H
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Boc-NH-PEG-Amine (MW 20000)
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Biochemical Assay Reagents
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Others
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BOC-NH-PEG-NH2 (MW 20000) (Boc-NH-PEG-Amine (MW 20000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 20000) is an important cross-linker with PEG chains .
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- HY-140232I
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Boc-NH-PEG-Amine (MW 40000)
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Biochemical Assay Reagents
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Others
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BOC-NH-PEG-NH2 (MW 40000) (Boc-NH-PEG-Amine (MW 40000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 40000) is an important cross-linker with PEG chains .
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- HY-140232C
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Biochemical Assay Reagents
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Others
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BOC-NH-PEG-NH2 (MW 3400) (Boc-NH-PEG-Amine (MW 3400)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 3400) is an important cross-linker with PEG chains .
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- HY-140232D
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Biochemical Assay Reagents
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Others
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BOC-NH-PEG-NH2 (MW 5000) (Boc-NH-PEG-Amine (MW 5000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 5000) is an important cross-linker with PEG chains .
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- HY-140232E
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Boc-NH-PEG-Amine (MW 10000)
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Biochemical Assay Reagents
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Others
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BOC-NH-PEG-NH2 (MW 10000) (Boc-NH-PEG-Amine (MW 10000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 10000) is an important cross-linker with PEG chains .
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- HY-140232B
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Biochemical Assay Reagents
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Others
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BOC-NH-PEG-NH2 (MW 2000) (Boc-NH-PEG-Amine (MW 2000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 2000) is an important cross-linker with PEG chains .
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- HY-W1048555B
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Biochemical Assay Reagents
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Others
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Mal-PEG-SCM (MW 3400) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 3400) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
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- HY-W1048555A
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Biochemical Assay Reagents
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Others
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Mal-PEG-SCM (MW 2000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 2000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
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- HY-W1048555D
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Biochemical Assay Reagents
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Others
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Mal-PEG-SCM (MW 10000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 10000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
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- HY-W1048555H
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Biochemical Assay Reagents
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Others
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Mal-PEG-SCM (MW 40000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 40000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
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- HY-W1048555C
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Biochemical Assay Reagents
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Others
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Mal-PEG-SCM (MW 5000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 5000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
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- HY-W1048555E
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Biochemical Assay Reagents
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Others
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Mal-PEG-SCM (MW 20000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 20000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
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- HY-W1048555
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Biochemical Assay Reagents
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Others
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Mal-PEG-SCM (MW 1000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 1000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
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- HY-W1048572C
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Azide-PEG-Amine (MW 1000)
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Biochemical Assay Reagents
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Others
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N3-PEG-NH2 (MW 1000) (Azide-PEG-Amine (MW 1000)) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG-NH2 (MW 1000) is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
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- HY-W1048572H
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Azide-PEG-Amine (MW 10000)
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Biochemical Assay Reagents
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Others
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N3-PEG-NH2 (MW 10000) (Azide-PEG-Amine (MW 10000)) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG-NH2 (MW 10000) is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
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- HY-W1048572E
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Biochemical Assay Reagents
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Others
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N3-PEG-NH2 (MW 5000) (Azide-PEG-Amine (MW 5000)) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG-NH2 (MW 5000) is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
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- HY-W1048572I
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Azide-PEG-Amine (MW 20000)
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Biochemical Assay Reagents
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Others
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N3-PEG-NH2 (MW 20000) (Azide-PEG-Amine (MW 20000)) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG-NH2 (MW 20000) is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
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- HY-W1048572A
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Biochemical Assay Reagents
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Others
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N3-PEG-NH2 (MW 2000) (Azide-PEG-Amine (MW 2000)) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG-NH2 (MW 2000) is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
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- HY-W1048572D
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Azide-PEG-Amine (MW 3400)
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Biochemical Assay Reagents
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Others
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N3-PEG-NH2 (MW 3400) (Azide-PEG-Amine (MW 3400)) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG-NH2 (MW 3400) is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
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- HY-W1048572J
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Azide-PEG-Amine (MW 40000)
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Biochemical Assay Reagents
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Others
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N3-PEG-NH2 (MW 40000) (Azide-PEG-Amine (MW 40000)) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG-NH2 (MW 40000) is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
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- HY-129377
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ADC Linker
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Cancer
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Sulfo-SPP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
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- HY-129377A
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ADC Linker
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Cancer
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Sulfo-SPP sodium a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
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- HY-126495
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ADC Linker
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Cancer
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Sulfo-LC-SPDP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
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- HY-140339
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Biochemical Assay Reagents
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Others
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ANB-NOS is a heterobifunctional crosslinker that contain an amine-reactive Nhydroxysuccinimide (NHS) ester and a photoactivatable nitrophenyl azide .
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- HY-128925
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AMAS
1 Publications Verification
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ADC Linker
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Cancer
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AMAS is a nonclaevable heterobifunctional crosslinker with NHS ester and maleimide groups that allows covalent conjugation of amine- and sulfhydryl-containing molecules.
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- HY-W012166
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NHS-Bromoacetate
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Biochemical Assay Reagents
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Others
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N-Succinimidyl bromoacetate is a heterobifunctional cross-linking reagent can be used to prepare peptide-protein immunogens .
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- HY-164785
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Others
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Others
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TCO-PEG5-C2-Mal is a heterobifunctional linker that can be used for tetrazine ligation and sulfhydryl conjugation .
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- HY-78961
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EMCS
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ADC Linker
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Cancer
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6-Maleimidohexanoic acid N-hydroxysuccinimide ester (EMCS) is a heterobifunctional cross-linking reagent. EMCS is used as a unique and useful reagent for preparation of hapten conjugate and enzyme immunoconjugates .
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- HY-129655
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ADC Linker
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Cancer
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Sulfo-SMPB sodium is a non-cleavable, heterobifunctional chemical cross-linking reagent which contains N-hydroxysuccinimide (NHS) ester and maleimide groups, allowing covalent conjugation of amine- and sulfhydryl-containing molecules .
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- HY-W041994
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Biochemical Assay Reagents
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Others
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GMBS is a heterobifunctional cross-linker. GMBS can be used in chemical cross-linking of proteins coupled with mass spectrometry (CXMS) to study protein folding and to map the interfaces between interacting proteins .
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- HY-137251
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Biochemical Assay Reagents
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Others
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Sulfo-MBS sodium is a heterobifunctional crosslinker with a maleimide group and an N-hydroxysuccinimide (NHS) ester group, which can react with cysteine residues and lysine residues on proteins. Sulfo-MBS sodium be used for protein cross-linking studies .
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- HY-161095
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DNA/RNA Synthesis
Integrin
Topoisomerase
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Cancer
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iRGD-CPT is a conjugate of iRGD and camptothecin
that is covalently coupled through a heterobifunctional linker. iRGD-CPT has
anticancer activity in vitroandin vivo.
iRGD-CPT can be used for the study of colon cancer .
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- HY-145514A
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PROTACs
FKBP
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Cancer
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dTAGV-1-NEG is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1 is an FKBP12 F36V-selective degrader .
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- HY-W190796
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Biochemical Assay Reagents
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Others
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Mal-PEG3-NH2 is a linear heterobifunctional PEG reagent with a maleimide and an amine. Mal-PEG3-NH2 is a useful crosslinking reagent with a PEG spacer .
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- HY-W615173
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Biochemical Assay Reagents
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Others
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NHS ester-C2-NHCO-C2-NHS is a heterobifunctional PEG linker, featuring a terminal NHS ester that can be used to label amine compounds and maleimide group for reactions with thiol groups.
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- HY-147099
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PROTACs
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Cancer
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dTAG-47-NEG is an analog of dTAG-47 that cannot bind and recruit cereblon (CRBN). dTAG-47-NEG can be used as a heterobifunctional negative control of dTAG-47 .
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- HY-174364B
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Biochemical Assay Reagents
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Others
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Alkyne-PEG-COOH (MW 3400) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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- HY-145514B
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PROTACs
FKBP
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Cancer
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dTAGV-1-NEG TFA is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1-NEG TFA is an FKBP12 F36V-selective degrader .
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- HY-174364E
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Biochemical Assay Reagents
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Others
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Alkyne-PEG-COOH (MW 20000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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- HY-174364C
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Biochemical Assay Reagents
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Others
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Alkyne-PEG-COOH (MW 5000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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- HY-174364
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Biochemical Assay Reagents
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Others
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Alkyne-PEG-COOH (MW 1000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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- HY-138539
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- HY-174364H
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Biochemical Assay Reagents
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Others
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Alkyne-PEG-COOH (MW 40000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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- HY-174364D
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Biochemical Assay Reagents
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Others
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Alkyne-PEG-COOH (MW 10000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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- HY-174364A
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Biochemical Assay Reagents
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Others
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Alkyne-PEG-COOH (MW 2000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
|
-
- HY-172719
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Fmoc-PEG9-alcohol is a heterobifunctional PEG linker featuring a Fmoc-protected primary amine and an alcohol group. The hydroxy group is a versatile functionality while the Fmoc protecting group can be removed with base to reveal a primary amine.
|
-
- HY-W190786
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bromoacetamido-PEG2-azide is a heterobifunctional PEG linker containing a reactive bromoacetamido and a terminal azide.The bromoacetamidogroup is a very reactive group for nucleophilic substitution. The azide group can react with alkyne, BCN, DBCO via Click Chemistry.
|
-
- HY-W1048553D
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-NH2 TFA (MW 10000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-134592
-
-
- HY-W1048553C
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-NH2 TFA (MW 5000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W1048553H
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-NH2 TFA (MW 40000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W1048553A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-NH2 TFA (MW 2000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W1048553B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-NH2 TFA (MW 3400) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W1048553E
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-NH2 TFA (MW 20000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W1048553
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG-NH2 TFA (MW 1000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-134582
-
dCBP-1
3 Publications Verification
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP based on Cereblon ligand. dCBP-1 is exceptionally potent at killing multiple myeloma cells and ablates oncogenic enhancer activity driving MYC expression .
|
-
- HY-156301
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Methyltetrazine-amido-PEG8-amine Trifluoroacetate is a heterobifunctional linker containing a terminal methyltetrazine, which can react with TCO-containing compounds without the catalysis of Cu or elevated temperatures, and terminal amine, which reacts with NHS ester specifically and efficiently. The PEG spacer enhances water solubility.
|
-
- HY-W190925
-
|
|
Biochemical Assay Reagents
|
Others
|
|
APN-C3-biotin is a heterobifunctional linker containing an APN moiety with exquisite chemoselectivity for cysteine and Biotin. The superior stability of APN-cysteine conjugates in aqueous media, human plasma, and living cells makes this new thiol-click reaction a promising methodology for applications in bioconjugation.
|
-
- HY-W190796A
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG3-NH2 TFA is a linear heterobifunctional PEG crosslinker with Maleimide (HY-W007324) and amine. Mal-PEG3-NH2 TFA is a non-degradable (non-cleavable) PROTAC linker .
|
-
- HY-134591
-
-
- HY-161157
-
|
|
PROTACs
|
Cancer
|
|
dTAG-13-NEG is a negative control of dTAG-13. dTAG-13 (HY-114421), a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12 F36V with expression of FKBP12F36V in-frame with a protein of interest .
|
-
- HY-147098
-
|
|
PROTACs
FKBP
|
Cancer
|
|
dTAG-47, heterobifunctional dTAG molecule, targets mutant FKBP12 (FKBP12 F36V). FKBP12 F36V serves as a degradation tag (dTAG) and is fused to a protein of interest. dTAG-47 can be used for the research of basal-like breast cancers (BBC) .
|
-
- HY-176206C
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Biotin-PEG-COOH (MW 5000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 5000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
|
-
- HY-176206E
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Biotin-PEG-COOH (MW 20000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 20000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
|
-
- HY-176206D
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Biotin-PEG-COOH (MW 10000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 10000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
|
-
- HY-176206H
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Biotin-PEG-COOH (MW 40000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 401000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
|
-
- HY-168664
-
|
|
PROTACs
CDK
|
Cancer
|
|
CPD-39 is a potent and orally active CCND1 and CDK4 heterobifunctional PROTAC degrader. CPD-39 shows anti-proliferation. (Pink: ligand for target protein (HY-50767); black: linker (HY-20240); Blue: E3 ligase ligand (HY-168667)) .
|
-
- HY-176206
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Biotin-PEG-COOH (MW 1000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 1000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
|
-
- HY-176206A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Biotin-PEG-COOH (MW 2000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 2000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
|
-
- HY-176206B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Biotin-PEG-COOH (MW 3400) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 3400) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
|
-
- HY-W440951
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Azide-PEG-Silane, MW 5000 is a heterobifunctional polyPEG for surface grafting through reaction between hydroxyl and ethoxyl silane. The polymer through its azide moiety can react with a terminal alkyne via CuAAC or with a cyclooctyne (DBCO/BCN) via SPAAC to form a covalent triazole bond. Reagent grade, for research use only.
|
-
- HY-156820
-
|
|
Epigenetic Reader Domain
|
Cancer
|
|
HLDA-221 is a heterobifunctional small molecules called Regulated Induced Proximity Targeting Chimeras (RIPTACs). HLDA-221 elicits a stable ternary complex between a target protein selectively expressed in cancer tissue and a pan-expressed protein essential for cell survival, thus leading to cell death selectively in cells expressing the target protein .
|
-
- HY-W1048545I
-
|
|
Biochemical Assay Reagents
|
Others
|
|
H2N-PEG-SH (MW 3400) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 3400) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
-
- HY-W1048545A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
H2N-PEG-SH (MW 2000) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 2000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
-
- HY-W440954
-
|
|
Liposome
|
Others
|
|
Stearic acid-PEG-CH2CO2H, MW 2000 is a heterobifunctional polyPEG with 18-carbon aliphatic chain and carboxyl. The polymer has stearic acid as the hydrophobic tail and PEG as the hydrophilic chain, therefore it forms micelles in water. Carboxyl can react with amine in the presence of activator, such as HATU/EDC to generate a stable amide bond. Reagent grade, for research use only.
|
-
- HY-W1048545C
-
|
|
Biochemical Assay Reagents
|
Others
|
|
H2N-PEG-SH (MW 5000) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 5000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
-
- HY-114421
-
|
dTAG-13
|
PROTACs
FKBP
|
Cancer
|
|
FKBP12 PROTAC dTAG-13 (dTAG-13), a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12 F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 effectively engages FKBP12 F36V and CRBN, thereby selectively degrading FKBP12 F36V .
|
-
- HY-145232
-
|
|
Phosphatase
Tau Protein
|
Neurological Disease
Cancer
|
|
PhosTAC7 is a heterobifunctional molecule named as a Phosphorylation Targeting Chimera (PhosTAC). PhosTAC7 can dephosphorylate the PDCD4 protein, FOXO3a protein, and Tau protein by recruiting serine/threonine protein phosphatase 2A (PP2A). PhosTAC7 offers the advantage of selectively modulating the phosphorylation state of individual target proteins, making it a promising tool for research in cancer and tau protein-related neurodegenerative diseases .
|
-
- HY-176509D
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DSPE-PEG-CHO ammonium (MW 10000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 10000) can be used for drug delivery .
|
-
- HY-176509B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DSPE-PEG-CHO ammonium (MW 3400) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 3400) can be used for drug delivery .
|
-
- HY-176509C
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DSPE-PEG-CHO ammonium (MW 5000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 5000) can be used for drug delivery .
|
-
- HY-W1048545H
-
|
Amine-PEG-Thiol (MW 1000)
|
Biochemical Assay Reagents
|
Others
|
|
H2N-PEG-SH (MW 1000) (Amine-PEG-Thiol (MW 1000)) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 1000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
-
- HY-W1048545E
-
|
Amine-PEG-Thiol (MW 20000)
|
Biochemical Assay Reagents
|
Others
|
|
H2N-PEG-SH (MW 20000) (Amine-PEG-Thiol (MW 20000)) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 20000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
-
- HY-W1048545D
-
|
Amine-PEG-Thiol (MW 10000)
|
Biochemical Assay Reagents
|
Others
|
|
H2N-PEG-SH (MW 10000) (Amine-PEG-Thiol (MW 10000)) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 10000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
-
- HY-176509
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DSPE-PEG-CHO ammonium (MW 1000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 1000) can be used for drug delivery .
|
-
- HY-W1048545J
-
|
Amine-PEG-Thiol (MW 40000)
|
Biochemical Assay Reagents
|
Others
|
|
H2N-PEG-SH (MW 40000) (Amine-PEG-Thiol (MW 40000)) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 40000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
-
- HY-176509E
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DSPE-PEG-CHO ammonium (MW 20000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 20000) can be used for drug delivery .
|
-
- HY-176509H
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DSPE-PEG-CHO ammonium (MW 40000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 40000) can be used for drug delivery .
|
-
- HY-176509A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DSPE-PEG-CHO ammonium (MW 2000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 2000) can be used for drug delivery .
|
-
- HY-W1048547A
-
|
HOOC-PEG-Amine (MW 2000)
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG-NH2 (MW 2000) (HOOC-PEG-Amine (MW 2000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547J
-
|
HOOC-PEG-Amine (MW 40000)
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG-NH2 (MW 40000) (HOOC-PEG-Amine (MW 40000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547H
-
|
HOOC-PEG-Amine (MW 1000)
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG-NH2 (MW 1000) (HOOC-PEG-Amine (MW 1000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547E
-
|
HOOC-PEG-Amine (MW 20000)
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG-NH2 (MW 20000) (HOOC-PEG-Amine (MW 20000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-122653
-
|
|
PROTACs
|
Cancer
|
|
CCT367766 is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein .
|
-
- HY-W1048547I
-
|
HOOC-PEG-Amine (MW 3400)
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG-NH2 (MW 3400) (HOOC-PEG-Amine (MW 3400)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547C
-
|
HOOC-PEG-Amine (MW 5000)
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG-NH2 (MW 5000) (HOOC-PEG-Amine (MW 5000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547D
-
|
HOOC-PEG-Amine (MW 10000)
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG-NH2 (MW 10000) (HOOC-PEG-Amine (MW 10000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-163677
-
|
|
PROTACs
PI3K
Akt
|
Cancer
|
|
ARM165 is a heterobifunctional molecule. ARM165 degrades the PIK3CG proteins, inhibits PI3Kγ-Akt signaling pathway, and thus exhibits antileukemia efficacy. ARM165 inhibits proliferations of AML cells, with IC50 <1 μM. (Pink: ligand for target protein PI3Kγ inhibitor AZ2 (HY-111570); Black: linker; Blue: ligand for E3 ligase Pomalidomide (HY-10984))
|
-
- HY-W1005067
-
|
|
Molecular Glues
Hippo (MST)
Estrogen Receptor/ERR
|
Others
|
|
EN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol .
|
-
- HY-122653A
-
|
|
PROTACs
|
Cancer
|
|
CCT367766 formic is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 formic exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 formic reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 formic provides a potential chemical tool to study a largely unexplored protein .
|
-
- HY-134850
-
|
|
PROTACs
Tau Protein
|
Neurological Disease
|
|
QC-01-175 is a heterobifunctional molecule, which degrades aberrant tau. QC-01-175 reduces the levels of A152T and P301L mutant tau protein and protects neurons from tau-mediated toxicity and improve cell survival (Pink: ligand for target protein Aberrant tau ligand 1 (HY-W453397); Black: linker NH2-PEG3 (HY-W007545); Blue: ligand for E3 ligase Pomalidomide (HY-10984)) .
|
-
- HY-123941
-
|
dTAG-7
|
PROTACs
FKBP
Epigenetic Reader Domain
|
Others
|
|
FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional PROTAC degrader. FKBP12 PROTAC dTAG-7 targets FKBP12 F36V and BET BRD4. FKBP12 PROTAC dTAG-7 enables rapid and selective degradation of target proteins, and is suitable for cellular and in vivo studies to analyze protein functions and validate targets . (Pink: target protein ligand (HY-114420); Black: linker (HY-128844); Blue: CRBN Ligand (HY-103597); CRBN Ligand+linker: (HY-W722323))
|
-
- HY-176501
-
|
|
FKBP
|
Cancer
|
|
FKBP12 ligand-2 (compound d) is a high affinity ligand targeting FKBP12. FKBP12 ligand-2 can be used to selectively enhance the binding of heterobifunctional molecules to BRD4, enriching the drug intracellularly through the "CellTrap" effect to form a ternary complex of FKBP12-ligand-BRD4. This ternary complex has inhibitory activity against BRD4, thereby inhibiting the expression of BRD4 target genes (such as MYC) and inducing tumor cell death. FKBP12 ligand-2 can be used for selective cancer research based on differences in intracellular presenter protein levels .
|
-
- HY-161769
-
|
|
PROTACs
Epigenetic Reader Domain
Apoptosis
|
Cancer
|
|
HL435 is a heterobifunctional molecule that degrades BRD4 by linking to JQ1, with DC50 of 11.9 nM and 21.9 nM, in MDA-MB-231 and MCF-7 cells, respectively. HL435 inhibits the proliferation of MDA-MB-231, MCF-7, 22Rv1 and A549, arrests the cell cycle and induces apoptosis. HL435 exhibits antitumor activity in mouse model. (Pink: ligand for target protein JQ-1 (HY-78695); Black: linker (HY-W004640); blue: ligand for E3 ligase HL389 (HY-161770))
|
-
- HY-176502
-
|
|
FKBP
|
Cancer
|
|
FKBP12 ligand-3 (compound dj) is a high-affinity ligand targeting FKBP12. FKBP12 ligand-3 can be used to selectively enhance the binding of heterobifunctional molecules to BRD4, enriching the drug intracellularly through the "CellTrap" effect to form a ternary complex of FKBP12-ligand-BRD4. This ternary complex has inhibitory activity against BRD4, thereby inhibiting the expression of BRD4 target genes (such as MYC) and inducing tumor cell death. FKBP12 ligand-3 can be used for selective cancer research based on differences in intracellular presenter protein levels .
|
-
- HY-145925B
-
CFT8634
1 Publications Verification
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
CFT8634 is an orally bioavailable PROTAC BRD9 targeted degrader based on the E3 ubiquitin ligase CRBN mechanism. CFT8634 can be used for the study of synovial sarcoma and SMARCB1-deficient solid tumors (Pink: BRD9 ligand (HY-169988); Blue: E3 ligase ligand (HY-169989); Black: linker (HY-169991). CFT8634 is a heterobifunctional molecule that binds to BRD9 at one end and recruits CRBN at the other end, which can inhibit the growth of tumor cells that depend on BRD9. CFT8634 can be used for the study of SMARCB1-related cancers (such as synovial sarcoma and malignant rhabdoid tumor) .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-D0975
-
|
|
Biochemical Assay Reagents
|
|
Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.
|
-
- HY-W1049071H
-
|
|
Drug Delivery
|
|
HO-PEG-SCM (MW 2000) is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
|
-
- HY-W1049071C
-
|
|
Drug Delivery
|
|
HO-PEG-SCM (MW 20000) is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
|
-
- HY-W1049071A
-
|
|
Drug Delivery
|
|
HO-PEG-SCM (MW 5000) is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
|
-
- HY-W1049071I
-
|
|
Drug Delivery
|
|
HO-PEG-SCM (MW 3400) is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
|
-
- HY-W1049071D
-
|
|
Drug Delivery
|
|
HO-PEG-SCM (MW 40000) is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
|
-
- HY-W1049071B
-
|
|
Drug Delivery
|
|
HO-PEG-SCM (MW 10000) is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
|
-
- HY-W1049071E
-
|
|
Drug Delivery
|
|
HO-PEG-SCM (MW 1000) is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
|
-
- HY-W1049061E
-
|
|
Drug Delivery
|
|
Boc-NH-PEG-COOH (MW 1000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 1000) is an important cross-linker with PEG chains .
|
-
- HY-W1049061D
-
|
|
Drug Delivery
|
|
Boc-NH-PEG-COOH (MW 40000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 40000) is an important cross-linker with PEG chains .
|
-
- HY-W1049061B
-
|
|
Drug Delivery
|
|
Boc-NH-PEG-COOH (MW 10000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 10000) is an important cross-linker with PEG chains .
|
-
- HY-W1049061
-
|
|
Drug Delivery
|
|
Boc-NH-PEG-COOH (MW 2000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 2000) is an important cross-linker with PEG chains .
|
-
- HY-W1049061A
-
|
|
Drug Delivery
|
|
Boc-NH-PEG-COOH (MW 5000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 5000) is an important cross-linker with PEG chains .
|
-
- HY-W1049061C
-
|
|
Drug Delivery
|
|
Boc-NH-PEG-COOH (MW 20000) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 20000) is an important cross-linker with PEG chains .
|
-
- HY-W1049061H
-
|
|
Drug Delivery
|
|
Boc-NH-PEG-COOH (MW 3400) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG-COOH (MW 3400) is an important cross-linker with PEG chains .
|
-
- HY-W1048542A
-
|
|
Drug Delivery
|
|
Fmoc-NH-PEG-COOH (MW 2000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 2000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-W1048542D
-
|
|
Drug Delivery
|
|
Fmoc-NH-PEG-COOH (MW 5000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 5000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-W1048542I
-
|
|
Drug Delivery
|
|
Fmoc-NH-PEG-COOH (MW 40000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 40000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-W1048542E
-
|
|
Drug Delivery
|
|
Fmoc-NH-PEG-COOH (MW 10000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 10000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-W1048542C
-
|
|
Drug Delivery
|
|
Fmoc-NH-PEG-COOH (MW 3400) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 3400) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-W1048542H
-
|
|
Drug Delivery
|
|
Fmoc-NH-PEG-COOH (MW 20000) is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG-COOH (MW 20000) is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-140232A
-
|
Boc-NH-PEG-Amine (MW 1000)
|
Drug Delivery
|
|
BOC-NH-PEG-NH2 (MW 1000) (Boc-NH-PEG-Amine (MW 1000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 1000) is an important cross-linker with PEG chains .
|
-
- HY-140232H
-
|
Boc-NH-PEG-Amine (MW 20000)
|
Drug Delivery
|
|
BOC-NH-PEG-NH2 (MW 20000) (Boc-NH-PEG-Amine (MW 20000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 20000) is an important cross-linker with PEG chains .
|
-
- HY-140232I
-
|
Boc-NH-PEG-Amine (MW 40000)
|
Drug Delivery
|
|
BOC-NH-PEG-NH2 (MW 40000) (Boc-NH-PEG-Amine (MW 40000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 40000) is an important cross-linker with PEG chains .
|
-
- HY-140232C
-
|
|
Drug Delivery
|
|
BOC-NH-PEG-NH2 (MW 3400) (Boc-NH-PEG-Amine (MW 3400)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 3400) is an important cross-linker with PEG chains .
|
-
- HY-140232D
-
|
|
Drug Delivery
|
|
BOC-NH-PEG-NH2 (MW 5000) (Boc-NH-PEG-Amine (MW 5000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 5000) is an important cross-linker with PEG chains .
|
-
- HY-140232E
-
|
Boc-NH-PEG-Amine (MW 10000)
|
Drug Delivery
|
|
BOC-NH-PEG-NH2 (MW 10000) (Boc-NH-PEG-Amine (MW 10000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 10000) is an important cross-linker with PEG chains .
|
-
- HY-140232B
-
|
|
Drug Delivery
|
|
BOC-NH-PEG-NH2 (MW 2000) (Boc-NH-PEG-Amine (MW 2000)) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG-NH2 (MW 2000) is an important cross-linker with PEG chains .
|
-
- HY-W1048555B
-
|
|
Drug Delivery
|
|
Mal-PEG-SCM (MW 3400) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 3400) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
-
- HY-W1048555A
-
|
|
Drug Delivery
|
|
Mal-PEG-SCM (MW 2000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 2000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
-
- HY-W1048555D
-
|
|
Drug Delivery
|
|
Mal-PEG-SCM (MW 10000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 10000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
-
- HY-W1048555H
-
|
|
Drug Delivery
|
|
Mal-PEG-SCM (MW 40000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 40000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
-
- HY-W1048555C
-
|
|
Drug Delivery
|
|
Mal-PEG-SCM (MW 5000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 5000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
-
- HY-W1048555E
-
|
|
Drug Delivery
|
|
Mal-PEG-SCM (MW 20000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 20000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
-
- HY-W1048555
-
|
|
Drug Delivery
|
|
Mal-PEG-SCM (MW 1000) is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG-SCM (MW 1000) is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
-
- HY-W1048572C
-
|
Azide-PEG-Amine (MW 1000)
|
Drug Delivery
|
|
N3-PEG-NH2 (MW 1000) (Azide-PEG-Amine (MW 1000)) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG-NH2 (MW 1000) is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
|
-
- HY-W1048572H
-
|
Azide-PEG-Amine (MW 10000)
|
Drug Delivery
|
|
N3-PEG-NH2 (MW 10000) (Azide-PEG-Amine (MW 10000)) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG-NH2 (MW 10000) is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
|
-
- HY-W1048572E
-
|
|
Drug Delivery
|
|
N3-PEG-NH2 (MW 5000) (Azide-PEG-Amine (MW 5000)) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG-NH2 (MW 5000) is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
|
-
- HY-W1048572I
-
|
Azide-PEG-Amine (MW 20000)
|
Drug Delivery
|
|
N3-PEG-NH2 (MW 20000) (Azide-PEG-Amine (MW 20000)) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG-NH2 (MW 20000) is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
|
-
- HY-W1048572A
-
|
|
Drug Delivery
|
|
N3-PEG-NH2 (MW 2000) (Azide-PEG-Amine (MW 2000)) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG-NH2 (MW 2000) is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
|
-
- HY-W1048572D
-
|
Azide-PEG-Amine (MW 3400)
|
Drug Delivery
|
|
N3-PEG-NH2 (MW 3400) (Azide-PEG-Amine (MW 3400)) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG-NH2 (MW 3400) is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
|
-
- HY-W1048572J
-
|
Azide-PEG-Amine (MW 40000)
|
Drug Delivery
|
|
N3-PEG-NH2 (MW 40000) (Azide-PEG-Amine (MW 40000)) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG-NH2 (MW 40000) is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
|
-
- HY-77961
-
|
N-ε-Maleimidocaproic acid hydrazide TFA
|
Biochemical Assay Reagents
|
|
6-Maleimidocaproic acid hydrazide TFA is a carbonyl and sulfhydryl reactive heterobifunctional crosslinking reagent .
|
-
- HY-174364B
-
|
|
Drug Delivery
|
|
Alkyne-PEG-COOH (MW 3400) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
|
-
- HY-174364E
-
|
|
Drug Delivery
|
|
Alkyne-PEG-COOH (MW 20000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
|
-
- HY-174364C
-
|
|
Drug Delivery
|
|
Alkyne-PEG-COOH (MW 5000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
|
-
- HY-174364
-
|
|
Drug Delivery
|
|
Alkyne-PEG-COOH (MW 1000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
|
-
- HY-174364H
-
|
|
Drug Delivery
|
|
Alkyne-PEG-COOH (MW 40000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
|
-
- HY-174364D
-
|
|
Drug Delivery
|
|
Alkyne-PEG-COOH (MW 10000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
|
-
- HY-174364A
-
|
|
Drug Delivery
|
|
Alkyne-PEG-COOH (MW 2000) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
|
- HY-W1048553D
-
|
|
Drug Delivery
|
|
Mal-PEG-NH2 TFA (MW 10000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
- HY-W1048553C
-
|
|
Drug Delivery
|
|
Mal-PEG-NH2 TFA (MW 5000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
- HY-W1048553H
-
|
|
Drug Delivery
|
|
Mal-PEG-NH2 TFA (MW 40000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
- HY-W1048553A
-
|
|
Drug Delivery
|
|
Mal-PEG-NH2 TFA (MW 2000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
- HY-W1048553B
-
|
|
Drug Delivery
|
|
Mal-PEG-NH2 TFA (MW 3400) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
- HY-W1048553E
-
|
|
Drug Delivery
|
|
Mal-PEG-NH2 TFA (MW 20000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
- HY-W1048553
-
|
|
Drug Delivery
|
|
Mal-PEG-NH2 TFA (MW 1000) is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
- HY-176206C
-
|
|
Drug Delivery
|
|
Biotin-PEG-COOH (MW 5000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 5000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
|
- HY-176206E
-
|
|
Drug Delivery
|
|
Biotin-PEG-COOH (MW 20000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 20000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
|
- HY-176206D
-
|
|
Drug Delivery
|
|
Biotin-PEG-COOH (MW 10000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 10000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
|
- HY-176206H
-
|
|
Drug Delivery
|
|
Biotin-PEG-COOH (MW 40000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 401000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
|
- HY-176206
-
|
|
Drug Delivery
|
|
Biotin-PEG-COOH (MW 1000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 1000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
|
- HY-176206A
-
|
|
Drug Delivery
|
|
Biotin-PEG-COOH (MW 2000) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 2000) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
|
- HY-176206B
-
|
|
Drug Delivery
|
|
Biotin-PEG-COOH (MW 3400) is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG-COOH (MW 3400) can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
|
- HY-W440951
-
|
|
Drug Delivery
|
|
Azide-PEG-Silane, MW 5000 is a heterobifunctional polyPEG for surface grafting through reaction between hydroxyl and ethoxyl silane. The polymer through its azide moiety can react with a terminal alkyne via CuAAC or with a cyclooctyne (DBCO/BCN) via SPAAC to form a covalent triazole bond. Reagent grade, for research use only.
|
- HY-W1048545I
-
|
|
Drug Delivery
|
|
H2N-PEG-SH (MW 3400) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 3400) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
- HY-W1048545A
-
|
|
Drug Delivery
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H2N-PEG-SH (MW 2000) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 2000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
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- HY-W1048545C
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Drug Delivery
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H2N-PEG-SH (MW 5000) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 5000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
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- HY-176509D
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Drug Delivery
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DSPE-PEG-CHO ammonium (MW 10000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 10000) can be used for drug delivery .
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- HY-176509B
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Drug Delivery
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DSPE-PEG-CHO ammonium (MW 3400) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 3400) can be used for drug delivery .
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- HY-176509C
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Drug Delivery
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DSPE-PEG-CHO ammonium (MW 5000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 5000) can be used for drug delivery .
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- HY-W1048545H
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Amine-PEG-Thiol (MW 1000)
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Drug Delivery
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H2N-PEG-SH (MW 1000) (Amine-PEG-Thiol (MW 1000)) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 1000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
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- HY-W1048545E
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Amine-PEG-Thiol (MW 20000)
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Drug Delivery
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H2N-PEG-SH (MW 20000) (Amine-PEG-Thiol (MW 20000)) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 20000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
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- HY-W1048545D
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Amine-PEG-Thiol (MW 10000)
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Drug Delivery
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H2N-PEG-SH (MW 10000) (Amine-PEG-Thiol (MW 10000)) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 10000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
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- HY-176509
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Drug Delivery
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DSPE-PEG-CHO ammonium (MW 1000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 1000) can be used for drug delivery .
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- HY-W1048545J
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Amine-PEG-Thiol (MW 40000)
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Drug Delivery
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H2N-PEG-SH (MW 40000) (Amine-PEG-Thiol (MW 40000)) is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG-SH (MW 40000) is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
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- HY-176509E
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Drug Delivery
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DSPE-PEG-CHO ammonium (MW 20000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 20000) can be used for drug delivery .
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- HY-176509H
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Drug Delivery
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DSPE-PEG-CHO ammonium (MW 40000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 40000) can be used for drug delivery .
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- HY-176509A
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Drug Delivery
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DSPE-PEG-CHO ammonium (MW 2000) is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG-CHO ammonium (MW 2000) can be used for drug delivery .
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- HY-W1048547A
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HOOC-PEG-Amine (MW 2000)
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Drug Delivery
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HOOC-PEG-NH2 (MW 2000) (HOOC-PEG-Amine (MW 2000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
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- HY-W1048547J
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HOOC-PEG-Amine (MW 40000)
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Drug Delivery
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HOOC-PEG-NH2 (MW 40000) (HOOC-PEG-Amine (MW 40000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
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- HY-W1048547H
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HOOC-PEG-Amine (MW 1000)
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Drug Delivery
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HOOC-PEG-NH2 (MW 1000) (HOOC-PEG-Amine (MW 1000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
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- HY-W1048547E
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HOOC-PEG-Amine (MW 20000)
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Drug Delivery
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HOOC-PEG-NH2 (MW 20000) (HOOC-PEG-Amine (MW 20000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
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- HY-W1048547I
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HOOC-PEG-Amine (MW 3400)
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Drug Delivery
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HOOC-PEG-NH2 (MW 3400) (HOOC-PEG-Amine (MW 3400)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
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- HY-W1048547C
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HOOC-PEG-Amine (MW 5000)
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Drug Delivery
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HOOC-PEG-NH2 (MW 5000) (HOOC-PEG-Amine (MW 5000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
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- HY-W1048547D
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HOOC-PEG-Amine (MW 10000)
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Drug Delivery
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HOOC-PEG-NH2 (MW 10000) (HOOC-PEG-Amine (MW 10000)) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
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| Cat. No. |
Product Name |
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Classification |
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- HY-140339
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Azide
PROTAC Synthesis
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ANB-NOS is a heterobifunctional crosslinker that contain an amine-reactive Nhydroxysuccinimide (NHS) ester and a photoactivatable nitrophenyl azide .
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- HY-156301
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Tetrazine
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Methyltetrazine-amido-PEG8-amine Trifluoroacetate is a heterobifunctional linker containing a terminal methyltetrazine, which can react with TCO-containing compounds without the catalysis of Cu or elevated temperatures, and terminal amine, which reacts with NHS ester specifically and efficiently. The PEG spacer enhances water solubility.
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- HY-176501
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Alkynes
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FKBP12 ligand-2 (compound d) is a high affinity ligand targeting FKBP12. FKBP12 ligand-2 can be used to selectively enhance the binding of heterobifunctional molecules to BRD4, enriching the drug intracellularly through the "CellTrap" effect to form a ternary complex of FKBP12-ligand-BRD4. This ternary complex has inhibitory activity against BRD4, thereby inhibiting the expression of BRD4 target genes (such as MYC) and inducing tumor cell death. FKBP12 ligand-2 can be used for selective cancer research based on differences in intracellular presenter protein levels .
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- HY-176502
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Alkynes
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FKBP12 ligand-3 (compound dj) is a high-affinity ligand targeting FKBP12. FKBP12 ligand-3 can be used to selectively enhance the binding of heterobifunctional molecules to BRD4, enriching the drug intracellularly through the "CellTrap" effect to form a ternary complex of FKBP12-ligand-BRD4. This ternary complex has inhibitory activity against BRD4, thereby inhibiting the expression of BRD4 target genes (such as MYC) and inducing tumor cell death. FKBP12 ligand-3 can be used for selective cancer research based on differences in intracellular presenter protein levels .
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| Cat. No. |
Product Name |
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Classification |
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- HY-W440954
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Pegylated Lipids
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Stearic acid-PEG-CH2CO2H, MW 2000 is a heterobifunctional polyPEG with 18-carbon aliphatic chain and carboxyl. The polymer has stearic acid as the hydrophobic tail and PEG as the hydrophilic chain, therefore it forms micelles in water. Carboxyl can react with amine in the presence of activator, such as HATU/EDC to generate a stable amide bond. Reagent grade, for research use only.
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