2. Induced Disease Models Products Antibody-drug Conjugate/ADC Related
  3. Immunology and Inflammatory Disease Models ADC Linker
  4. Hapten
  5. 6-Maleimidohexanoic acid N-hydroxysuccinimide ester

6-Maleimidohexanoic acid N-hydroxysuccinimide ester  (Synonyms: EMCS)

Cat. No.: HY-78961 Purity: 99.81%
COA
SDS
Handling Instructions Technical Support

6-Maleimidohexanoic acid N-hydroxysuccinimide ester (EMCS) is a heterobifunctional cross-linking reagent. EMCS is used as a unique and useful reagent for preparation of hapten conjugate and enzyme immunoconjugates.

For research use only. We do not sell to patients.

6-Maleimidohexanoic acid N-hydroxysuccinimide ester

6-Maleimidohexanoic acid N-hydroxysuccinimide ester Chemical Structure

CAS No. : 55750-63-5

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Based on 1 publication(s) in Google Scholar

6-Maleimidohexanoic acid N-hydroxysuccinimide ester Related Antibodies

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Description

6-Maleimidohexanoic acid N-hydroxysuccinimide ester (EMCS) is a heterobifunctional cross-linking reagent. EMCS is used as a unique and useful reagent for preparation of hapten conjugate and enzyme immunoconjugates[1].

IC50 & Target

Non-cleavable Linker

 

In Vitro

6-Maleimidohexanoic acid N-hydroxysuccinimide ester is coupled to the peptides, and then conjugated to the Adenovirus vector containing luciferase gene as adenovirus vector carrier[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6-Maleimidohexanoic acid N-hydroxysuccinimide ester Related Antibodies
Molecular Weight

308.29

Formula

C14H16N2O6
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C=C1)N(CCCCCC(ON2C(CCC2=O)=O)=O)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (324.37 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2437 mL 16.2185 mL 32.4370 mL
5 mM 0.6487 mL 3.2437 mL 6.4874 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.94%

SDS (419 KB)

COA (249 KB) HNMR (132 KB) RP-HPLC (87 KB) LCMS (338 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2437 mL 16.2185 mL 32.4370 mL 81.0925 mL
5 mM 0.6487 mL 3.2437 mL 6.4874 mL 16.2185 mL
10 mM 0.3244 mL 1.6218 mL 3.2437 mL 8.1092 mL
15 mM 0.2162 mL 1.0812 mL 2.1625 mL 5.4062 mL
20 mM 0.1622 mL 0.8109 mL 1.6218 mL 4.0546 mL
25 mM 0.1297 mL 0.6487 mL 1.2975 mL 3.2437 mL
30 mM 0.1081 mL 0.5406 mL 1.0812 mL 2.7031 mL
40 mM 0.0811 mL 0.4055 mL 0.8109 mL 2.0273 mL
50 mM 0.0649 mL 0.3244 mL 0.6487 mL 1.6218 mL
60 mM 0.0541 mL 0.2703 mL 0.5406 mL 1.3515 mL
80 mM 0.0405 mL 0.2027 mL 0.4055 mL 1.0137 mL
100 mM 0.0324 mL 0.1622 mL 0.3244 mL 0.8109 mL
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6-Maleimidohexanoic acid N-hydroxysuccinimide ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Maleimidohexanoic acid N-hydroxysuccinimide ester55750-63-5EMCSADC LinkerAntibody-drug conjugates linkeraminosulfhydrylgroupscross-linkingreagentenzymeimmunoconjugateshaptenconjugateInhibitorinhibitorinhibit

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