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Results for "

hearing loss

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (1) Antibiotic (3) Apoptosis (7) Bacterial (3) Biochemical Assay Reagents (1) Calcium Channel (1) Caspase (6) Endogenous Metabolite (5) Ferroptosis (1) HSP (1) Isotope-Labeled Compounds (1) Neurokinin Receptor (1) Neurotensin Receptor (1) Phosphatase (1) Reactive Oxygen Species (5) Reference Standards (1) Sodium Channel (1) Src (1) TNF Receptor (1) γ-secretase (1)
By Research Areas:	Cancer (6) Infection (3) Inflammation/Immunology (1) Neurological Disease (10)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145250

NK1 receptor antagonist 2	Neurokinin Receptor	Neurological Disease
NK1 receptor antagonist 2 is a NK1 receptor antagonist. NK1 receptor antagonist 2 can be used for the research of tinnitus and hearing loss .

HY-B0739

Citicoline 3 Publications Verification Cytidine diphosphate-choline; CDP-Choline; Cytidine 5'-diphosphocholine	Apoptosis Endogenous Metabolite Reactive Oxygen Species Caspase	Neurological Disease Cancer
Citicoline is an endogenous intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes. Citicoline inhibits reactive oxygen species (ROS) and apoptosis. Citicoline can be used for neurological disease and hearing loss study .

HY-B0739A

Citicoline sodium 3 Publications Verification Cytidine diphosphate-choline sodium; CDP-Choline sodium; Cytidine 5'-diphosphocholine sodium	Endogenous Metabolite Apoptosis Reactive Oxygen Species Caspase	Neurological Disease Cancer
Citicoline sodium is an endogenous intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes. Citicoline sodium inhibits reactive oxygen species (ROS) and apoptosis. Citicoline sodium can be used for neurological disease and hearing loss study .

HY-B0019C

(R)-Azasetron besylate SENS-401	Phosphatase	Cancer
(R)-Azasetron besylate (SENS-401) is an orally active calcineurin inhibitor. (R)-Azasetron besylate reduces Cisplatin (HY-17394)-induced hearing loss and cochlear damage .

HY-18237

KX1-004	Src	Others
KX1-004 is a potent and non-ATP competitive Src-PTK inhibitor with an IC₅₀ of 40 μM. KX1-004 protects the cochlea from hazardous noise and prevents noise-induced hearing loss (NIHL) .

HY-148650A

(R)-Sortilin antagonist 1	Neurotensin Receptor	Neurological Disease
(R)-Sortilin antagonist 1 is a sortilin antagonist that blocks the sortilin mediated apoptosis pathway by interfering with the binding of sortilin to its ligand pro-neurotrophin. (R)-Sortilin antagonist 1 can be used in the study of hearing loss .

HY-171447

LPT99	Caspase Apoptosis	Others
LPT-99 is an antagonist of apoptotic protease activating factor 1 (APAF-1). LPT-99 suppresses the activation of procaspase-9. LPT99 suppresses Cisplatin (HY-17394)-induced apoptosis. LPT99 can effectively mitigate cisplatin-induced hearing loss in rats.

HY-B0739AR

Citicoline (sodium) (Standard)	Endogenous Metabolite Apoptosis Reactive Oxygen Species Caspase	Neurological Disease Cancer
Citicoline sodium (Standard) is the analytical standard of Citicoline sodium. This product is intended for research and analytical applications. Citicoline sodium is an endogenous intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes. Citicoline sodium inhibits reactive oxygen species (ROS) and apoptosis. Citicoline sodium can be used for neurological disease and hearing loss study.

HY-B0739R

Citicoline (Standard) Cytidine diphosphate-choline (Standard); CDP-Choline (Standard); Cytidine 5'-diphosphocholine (Standard)	Apoptosis Endogenous Metabolite Caspase Reactive Oxygen Species	Neurological Disease Cancer
Citicoline (Cytidine diphosphate-choline) (Standard) is the analytical standard of Citicoline. This product is intended for research and analytical applications. Citicoline is an endogenous intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes. Citicoline inhibits reactive oxygen species (ROS) and apoptosis. Citicoline can be used for neurological disease and hearing loss study.

HY-120726

BF844	HSP	Others
BF844 mitigate hearing loss associated with USH3 (usher syndrome type III) mutation CLRN1 (clarin-1) ^N48K. BF844 induces CLRN1 ^N48K transportes to the plasma membrane. BF844 shows significantly preserves hearing in vivo .

HY-B0739AS

Citicoline-d9 sodium Cytidine diphosphate-choline-d₉ sodium; CDP-Choline-d₉(sodium); Cytidine 5'-diphosphocholine-d₉ sodium	Isotope-Labeled Compounds Endogenous Metabolite Apoptosis Reactive Oxygen Species Caspase	Neurological Disease Cancer
Citicoline-d₉ (Cytidine diphosphate-choline-d₉) sodium is the deuterium labeled Citicoline sodium (HY-B0739A). Citicoline sodium is an endogenous intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes. Citicoline sodium inhibits reactive oxygen species (ROS) and apoptosis. Citicoline sodium can be used for neurological disease and hearing loss study .

HY-163506

Ebselen derivative 1	Apoptosis Ferroptosis	Others
Ebselen derivative 1 (Compound 19) is a glutathione peroxidase (GPx) mimic with oral activity. Ebselen derivative 1 demonstrates significant protective effects against cisplatin (HY-17394)-induced hair cell (HC) damage both in vitro and in vivo, effectively reducing oxidative stress, apoptosis, and ferroptosis in hair cells. Ebselen derivative 1 can be utilized in the research of cisplatin (HY-17394)-induced hearing loss .

HY-158012

LY3056480	γ-secretase	Others
LY3056480 is a gamma-secretase inhibitor (GSI) that inhibits Notch signaling. LY3056480 improves mild to moderate sensorineural hearing loss and is safe and tolerable. Intratympanic administration of LY3056480 induces hair cell regeneration and partial hearing recovery in mammals .

HY-B1241A

Dihydrostreptomycin DHSM	Antibiotic Bacterial	Infection
Dihydrostreptomycin (DHSM) is an aminoglycoside antibiotic with antibacterial effect against Gram-negative bacteria. Dihydrostreptomycin exhibits ototoxicity that causes irreversible damage in inner ear hair cells, leading to hearing loss .

HY-B0612B

(S)-Lercanidipine	Calcium Channel Sodium Channel	Neurological Disease
(S)-Lercanidipine is a calcium channel blocker with antihypertensive and neuroprotective activities. (S)-Lercanidipine reduces oxidative stress and protects auditory sensory hair cells from noise-induced damage. (S)-Lercanidipine showed significant protective effects on cell viability in in vitro experiments, especially at low concentrations. (S)-Lercanidipine has been found to effectively reduce the hearing threshold of mice after noise stimulation and protect the survival of outer hair cells. The antioxidant properties of (S)-Lercanidipine are reflected in its increased expression of antioxidant enzyme genes and decreased expression of oxidative enzyme genes. (S)-Lercanidipine administration is effective in reducing noise-induced hearing loss both before and after noise exposure. (S)-Lercanidipine may alleviate noise-induced hearing loss and protect the survival of outer hair cells through its antioxidant mechanism .

HY-B1241

Dihydrostreptomycin sulfate DHSM sulfate	Antibiotic Bacterial	Infection
Dihydrostreptomycin sulfate (DHSM sulfate) is the sulfate salt form of Dihydrostreptomycin (HY-B1241A). Dihydrostreptomycin sulfate is an aminoglycoside antibiotic with antibacterial effect against Gram-negative bacteria. Dihydrostreptomycin sulfate exhibits ototoxicity that causes irreversible damage in inner ear hair cells, leading to hearing loss .

HY-B1241R

Dihydrostreptomycin sulfate (Standard) DHSM sulfate (Standard)	Reference Standards Bacterial Antibiotic	Infection
Dihydrostreptomycin (sulfate) (Standard) is the analytical standard of Dihydrostreptomycin (sulfate) (HY-B1241). This product is intended for research and analytical applications. Dihydrostreptomycin sulfate (DHSM sulfate) is the sulfate salt form of Dihydrostreptomycin (HY-B1241A). Dihydrostreptomycin sulfate is an aminoglycoside antibiotic with antibacterial effect against Gram-negative bacteria. Dihydrostreptomycin sulfate exhibits ototoxicity that causes irreversible damage in inner ear hair cells, leading to hearing loss .

HY-18673

PROTO-1	Biochemical Assay Reagents	Others
PROTO-1 is a hair cell protector and can be used in studies of ototoxicity-induced hair cell death .

HY-128064

Adenosine amine congener ADAC	Adenosine Receptor	Neurological Disease Inflammation/Immunology
Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and Cisplatin-induced cochlear injury. Adenosine amine congener also has neuroprotective effects .

HY-121892

(Z)-KC02	TNF Receptor	Neurological Disease
(Z)-KC02 is an inhibitor of ABHD16A, the phosphatidylserine (PS) lipase that produces lyso-PS. Lysophosphatidylserine (lyso-PS) is a signaling lipid that regulates immune and neurological processes. It is associated with several neurological disorders such as retinitis pigmentosa and cataracts (PHARC). (Z)-KC02 depletes lyso-PS in lymphoblasts from PHARC subjects. (Z)-KC02 also reduces lyso-PS and lipopolysaccharide-induced cytokine production in macrophages and modulates lyso-PS metabolism in vivo .

Cat. No.	Product Name	Type

HY-121892

(Z)-KC02	Drug Delivery
(Z)-KC02 is an inhibitor of ABHD16A, the phosphatidylserine (PS) lipase that produces lyso-PS. Lysophosphatidylserine (lyso-PS) is a signaling lipid that regulates immune and neurological processes. It is associated with several neurological disorders such as retinitis pigmentosa and cataracts (PHARC). (Z)-KC02 depletes lyso-PS in lymphoblasts from PHARC subjects. (Z)-KC02 also reduces lyso-PS and lipopolysaccharide-induced cytokine production in macrophages and modulates lyso-PS metabolism in vivo .

(Z)-KC02

Drug Delivery

(Z)-KC02 is an inhibitor of ABHD16A, the phosphatidylserine (PS) lipase that produces lyso-PS. Lysophosphatidylserine (lyso-PS) is a signaling lipid that regulates immune and neurological processes. It is associated with several neurological disorders such as retinitis pigmentosa and cataracts (PHARC). (Z)-KC02 depletes lyso-PS in lymphoblasts from PHARC subjects. (Z)-KC02 also reduces lyso-PS and lipopolysaccharide-induced cytokine production in macrophages and modulates lyso-PS metabolism in vivo .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0739

Citicoline 3 Publications Verification Cytidine diphosphate-choline; CDP-Choline; Cytidine 5'-diphosphocholine	Alkaloids Structural Classification Human Gut Microbiota Metabolites Microorganisms other families Animals Other Alkaloids Source classification Plants Endogenous metabolite	Apoptosis Endogenous Metabolite Reactive Oxygen Species Caspase
Citicoline is an endogenous intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes. Citicoline inhibits reactive oxygen species (ROS) and apoptosis. Citicoline can be used for neurological disease and hearing loss study .

HY-B0739A

Citicoline sodium 3 Publications Verification Cytidine diphosphate-choline sodium; CDP-Choline sodium; Cytidine 5'-diphosphocholine sodium	Alkaloids Structural Classification Microorganisms other families Animals Other Alkaloids Source classification Plants Endogenous metabolite	Endogenous Metabolite Apoptosis Reactive Oxygen Species Caspase
Citicoline sodium is an endogenous intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes. Citicoline sodium inhibits reactive oxygen species (ROS) and apoptosis. Citicoline sodium can be used for neurological disease and hearing loss study .

HY-B0739AR

Citicoline (sodium) (Standard)	Alkaloids Structural Classification Microorganisms other families Animals Other Alkaloids Source classification Plants Endogenous metabolite	Endogenous Metabolite Apoptosis Reactive Oxygen Species Caspase
Citicoline sodium (Standard) is the analytical standard of Citicoline sodium. This product is intended for research and analytical applications. Citicoline sodium is an endogenous intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes. Citicoline sodium inhibits reactive oxygen species (ROS) and apoptosis. Citicoline sodium can be used for neurological disease and hearing loss study.

HY-B0739R

Citicoline (Standard) Cytidine diphosphate-choline (Standard); CDP-Choline (Standard); Cytidine 5'-diphosphocholine (Standard)	Alkaloids Structural Classification Human Gut Microbiota Metabolites Microorganisms other families Animals Other Alkaloids Source classification Plants Endogenous metabolite	Apoptosis Endogenous Metabolite Caspase Reactive Oxygen Species
Citicoline (Cytidine diphosphate-choline) (Standard) is the analytical standard of Citicoline. This product is intended for research and analytical applications. Citicoline is an endogenous intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes. Citicoline inhibits reactive oxygen species (ROS) and apoptosis. Citicoline can be used for neurological disease and hearing loss study.

Cat. No.	Product Name	Chemical Structure

HY-B0739AS

Citicoline-d9 sodium
Citicoline-d₉ (Cytidine diphosphate-choline-d₉) sodium is the deuterium labeled Citicoline sodium (HY-B0739A). Citicoline sodium is an endogenous intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes. Citicoline sodium inhibits reactive oxygen species (ROS) and apoptosis. Citicoline sodium can be used for neurological disease and hearing loss study .

Citicoline-d9 sodium

Citicoline-d₉ (Cytidine diphosphate-choline-d₉) sodium is the deuterium labeled Citicoline sodium (HY-B0739A). Citicoline sodium is an endogenous intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes. Citicoline sodium inhibits reactive oxygen species (ROS) and apoptosis. Citicoline sodium can be used for neurological disease and hearing loss study .

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