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glutathione peroxidase 4 (GPX4)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Glutathione Peroxidase (10) Autophagy (1) Cannabinoid Receptor (1) Drug Isomer (1) Ferroptosis (11) Mitochondrial Metabolism (1) p62 (1) PROTACs (1) Reactive Oxygen Species (ROS) (2) STING (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (1) Inflammation/Immunology (1) Neurological Disease (1)

12

Inhibitors & Agonists

2

Recombinant Proteins

2

Antibodies

Targets Recommended: Glutathione Peroxidase Peroxidase Enzyme Glutathione Reductase (GR) Glutathione S-transferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

GPX4-IN-3 2 Publications Verification	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-3 (26a) is a potent **glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis** inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM .

GPX4-IN-9	Glutathione Peroxidase Ferroptosis	Cancer
GPX4-IN-9 (Compound A16) is a glutathione peroxidase 4 (GPX4) inhibitor that specifically targets *GPX4* under both in vitro and in vivo conditions, inducing ferroptosis. GPX4-IN-9 exhibits cytotoxicity against pancreatic cancer cells and can be used in cancer research .

ML-210 15+ Cited Publications	Glutathione Peroxidase Ferroptosis	Cancer
ML-210 is a selective and covalent **glutathione peroxidase 4 (GPX4) inhibitor with an EC₅₀** of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity .

ML162 10+ Cited Publications	Glutathione Peroxidase Ferroptosis	Cancer
ML162 is a covalent **glutathione peroxidase 4 (GPX4)** inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines

PKUMDL-LC-101-D04 5 Publications Verification GPX4-Activator-1d4	Glutathione Peroxidase	Inflammation/Immunology
PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a glutathione peroxidase 4 *(GPX4)* allosteric activator (pEC₅₀=4.7). PKUMDL-LC-101-D04 can inhibit ferroptosis and inflammation .

RSL3 Maximum Cited Publications 394 Publications Verification (1S,3R)-RSL3	p62 Glutathione Peroxidase Ferroptosis Reactive Oxygen Species (ROS)	Cancer
RSL3 ((1S,3R)-RSL3) is an inhibitor of **glutathione peroxidase 4 (GPX4) (ferroptosis** activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .

JKE-1674 5 Publications Verification	Glutathione Peroxidase Ferroptosis	Cancer
JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and an active metabolite of *GPX4* inhibitor ML-210. JKE-1674, an analog of ML-210 in which the nitroisoxazole ring is replaced with an α-nitroketoxime. JKE-1674 can convert into a nitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in a manner that is equipotent to ML-210 and is completely rescued by ferroptosis inhibitors .

(1R,3R)-RSL3 3 Publications Verification	Drug Isomer Ferroptosis	Cancer
(1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of **glutathione peroxidase 4 (GPX4) (ferroptosis** activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .

PROTAC GPX4 degrader-2	Ferroptosis PROTACs Glutathione Peroxidase	Cancer
PROTAC GPX4 degrader-2 (compound 18a) is a proteolysis targeting chimeras (PROTACs) that can degrade **glutathione peroxidase** 4 (GPX4), with the DC_{50, 48h} value of 1.68 μM. PROTAC GPX4 degrader-2 induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. PROTAC GPX4 degrader-2 has anti-proliferative effect .

GPX4-IN-18	Glutathione Peroxidase Reactive Oxygen Species (ROS) Cannabinoid Receptor Ferroptosis	Cancer
GPX4-IN-18 (Compound 17) is a ferrocene-containing inhibitor of glutathione peroxidase 4 (GPX4). GPX4-IN-18 is also an inducer of ferroptosis. GPX4-IN-18 can increase the production of ROS and malondialdehyde (MDA) levels in OS-RC-2 clear cell renal cell carcinoma cells. GPX4-IN-18 induces ferroptosis in HT-1080 cells with IC₅₀s of 0.007 μM (absence of ferrostatin-1) and 1.486 μM (presence of ferrostatin-1). GPX4-IN-18 reduces in vivo tumor volume and intratumoral GPX4 levels in OS-RC-2 xenograft murine model .

Ferroptosis-IN-17	Ferroptosis Glutathione Peroxidase	Cardiovascular Disease Neurological Disease Cancer
Ferroptosis-IN-17 (Compound 18) is a ferroptosis (Ferroptosis) inhibitor with an EC₅₀ value of 0.57 μM. Ferroptosis-IN-17 reduces intracellular ferrous ion accumulation, lipid peroxidation, and effectively restores the levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4). Ferroptosis-IN-17 shows good solubility and significant metabolic stability in rat plasma. Ferroptosis-IN-17 is promising for research in tumor suppression, neurodegenerative diseases, and cardiovascular diseases .

NA-Ir	Ferroptosis Mitochondrial Metabolism STING Autophagy	Cancer
NA-Ir is a Ferroptosis inducer. NA-Ir targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to induce ferritinophagy (Autophagy), while also generating reactive oxygen species (ROS) through photodynamic therapy (PDT), depleting glutathione (GSH), and downregulating glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and Ferroptosis. NA-Ir exhibits higher anticancer activity under light exposure and selectively inhibits cancer cells with high H₂S levels .

Species:	Human (2)
Tag:	His (1) Flag (1)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	GPX4 Protein, Human (U73S, His) PHGPx; glutathione peroxidase 4; GPx-4; GSHPx-4	Human	E. coli
	GPX4 Protein, Human (U73S, His) is the recombinant human-derived GPX4, expressed by E. coli , with N-6*His labeled tag. ,

	GPX4 Protein, Human (HEK293, Flag) Phospholipid hydroperoxide glutathione peroxidase; PHGPx; glutathione peroxidase 4; GPx-4; GSHPx-4	Human	HEK293
	GPX4 Protein, Human (HEK293, Flag) is the recombinant human-derived GPX4 protein, expressed by HEK293, with N-Flag tag.

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	GPX4 Antibody 2 Publications Verification Phospholipid hydroperoxide glutathione peroxidase; mitochondrial; PHGPx; EC 1.11.1.12; glutathione peroxidase 4; GPx-4; GSHPx-4	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	GPX4 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to GPX4.

	GPX4 Antibody (YA5931) Phospholipid hydroperoxide glutathione peroxidase, mitochondrial; PHGPx; glutathione peroxidase 4; GPx-4; GSHPx-4;	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	GPX4 Antibody (YA5931) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GPX4.

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