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Results for "

glucokinase (GK)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Glucokinase (14) Insulin Receptor (1) Reference Standards (1) Sodium Channel (1)
By Research Areas:	Metabolic Disease (15)

15

Inhibitors & Agonists

1

Natural
Products

Targets Recommended: Glucokinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Cadisegliatin TTP-399	Glucokinase	Metabolic Disease
Cadisegliatin (TTP-399) is a potential, orally active liver-selective glucokinase *(GK)* activator. Cadisegliatin has antihyperglycaemic activity. Cadisegliatin can be used for the research of type 2 diabetes .

AMG-3969 1 Publications Verification	Glucokinase	Metabolic Disease
AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC₅₀ of 4 nM.

AM-2394	Glucokinase	Metabolic Disease
AM-2394 is a structurally distinct *glucokinase* activator (GKA). AM-2394 activates glucokinase (GK) with an EC₅₀ of 60 nM.

AMG-1694	Glucokinase	Metabolic Disease
AMG-1694 is a potent **glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC₅₀** of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals .

Glucokinase activator 3	Glucokinase Sodium Channel	Metabolic Disease
Glucokinase activator 3 is an orally active *Glucokinase* (GK) activator with an AC₅₀ of 38 nM. Glucokinase activator 3 inhibits hERG channel and sodium channel in patch clamp assays. Glucokinase activator 3 exhibits high efficacy in reducing blood glucose in diet-induced obese (DIO) mice. Glucokinase activator 3 has the potential for the research of type 2 diabetes .

Dorzagliatin 2 Publications Verification HMS5552	Glucokinase	Metabolic Disease
Dorzagliatin (HMS5552), a dual-acting **glucokinase (GK)** activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes .

RO-28-1675 3 Publications Verification	Glucokinase	Metabolic Disease
RO-28-1675 is a potent allosteric **glucokinase (GK) activator with an EC₅₀** of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes .

PSN-GK1	Glucokinase	Metabolic Disease
PSN-GK1 is a potent *glucokinase* activator with an EC₅₀ of 0.13 μM.

PF-04279405	Glucokinase	Metabolic Disease
PF-04279405 is a potent and full-acting glucokinase (GK) agonist (EC₅₀=23 nM). Glucokinase (GK) is an enzyme responsible for the conversion of glucose to glucose-6-phosphate and plays a key role in maintaining blood glucose homeostasis. PF-04279405 can be used in the research of type 2 diabetes .

AZD1092	Glucokinase	Metabolic Disease
AZD1092 is an orally active glucokinase *(GK)* activator with an EC₅₀ value of 0.03 μM. AZD1092 can be used for the research of Type 2 Diabetes (T2D) .

BMS-820132	Glucokinase	Metabolic Disease
BMS-820132 is an orally active and partial *glucokinase* (GK) activator with a AC₅₀ of 29 nM. BMS-820132 decreases the glucose levels in glucose tolerance test (OGTT) model in normal rats, but not Zucker diabetic fatty (ZDF) rats. BMS-820132 exhibits pharmacological toxicity secondary to strong GK activation .

Dorzagliatin (Standard) HMS5552 (Standard)	Reference Standards Glucokinase	Metabolic Disease
Dorzagliatin (Standard) is the analytical standard of Dorzagliatin. This product is intended for research and analytical applications. Dorzagliatin (HMS5552), a dual-acting **glucokinase (GK)** activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes .

LCZ960 NVP-LCZ960	Glucokinase	Metabolic Disease
LCZ960 is an orally active *glucokinase* (GK) activator. LCZ960 stimulates GK activity in hepatocytes in vitro and stimulates glucose uptake in vivo through hepatic GK activation. LCZ960 lowers blood glucose in mice with diet-induced obesity (DIO). LCZ960 maintains normoglycemia and improves glucose tolerance in DIO mice and rats. LCZ960 stimulates glycogen synthase flux and increases hepatic glycogen turnover in rats. LCZ960 induces increased hepatic glycogen recycling. LCZ960 can be used to study high-fat diet-induced obesity and type 2 diabetes .

Globalagliatin 1 Publications Verification LY2608204; SY-004	Glucokinase	Metabolic Disease
Globalagliatin (LY2608204) is an orally active glucokinase (GK) activator with an EC₅₀ of 42 nM. Globalagliatin also stimulates glucose metabolism in rat insulinoma INS1-E cells with an EC₅₀ of 579 nM. Globalagliatin targets both pancreatic β-cells and hepatocytes. Globalagliatin is promising for research of type 2 diabetes .

Peonidin 3-O-glucoside chloride 1 Publications Verification	Insulin Receptor	Metabolic Disease
Peonidin 3-O-glucoside chloride is an agonist of the free fatty acid receptor FFAR1 and Glucokinase. Peonidin 3-O-glucoside chloride enhances insulin secretion of pancreatic beta cells and increases glucose uptake by liver cells. Peonidin 3-O-glucoside chloride activates FFAR1, promotes the phosphorylation of related proteins in the insulin secretion pathway, and increases the expression of FFAR1. In liver cells, Peonidin 3-O-glucoside chloride activates GK and regulates proteins associated with carbohydrate metabolism. Peonidin 3-O-glucoside chloride can be used in diabetes research .

Cat. No.	Product Name	Category	Target	Chemical Structure

Peonidin 3-O-glucoside chloride 1 Publications Verification	Anthocyans Flavonoids Classification of Application Fields Source classification Vitis vinifera cv. Zalema Metabolic Disease Plants Vitaceae Disease Research Fields	Insulin Receptor
Peonidin 3-O-glucoside chloride is an agonist of the free fatty acid receptor FFAR1 and Glucokinase. Peonidin 3-O-glucoside chloride enhances insulin secretion of pancreatic beta cells and increases glucose uptake by liver cells. Peonidin 3-O-glucoside chloride activates FFAR1, promotes the phosphorylation of related proteins in the insulin secretion pathway, and increases the expression of FFAR1. In liver cells, Peonidin 3-O-glucoside chloride activates GK and regulates proteins associated with carbohydrate metabolism. Peonidin 3-O-glucoside chloride can be used in diabetes research .

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