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globin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Bcl-2 Family (4) Biochemical Assay Reagents (2) GLP Receptor (1) Histone Acetyltransferase (1) Histone Methyltransferase (3) Isotope-Labeled Compounds (3) Ligands for E3 Ligase (1) Molecular Glues (1) Platelet-activating Factor Receptor (PAFR) (2) Reference Standards (1) TGF-beta/Smad (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (7) Inflammation/Immunology (2) Metabolic Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y1620

3-(3,4-Dimethoxyphenyl)propanoic acid	Biochemical Assay Reagents	Cardiovascular Disease
3-(3,4-Dimethoxyphenyl)propanoic acid is an orally active short-chain fatty acids (SCFAs). 3-(3,4-Dimethoxyphenyl)propanoic acid stimulates γ globin gene expression, erythropoiesis in vivo and is used for the β hemoglobinopathies and other anemias .

HY-108634

Apafant 3 Publications Verification WEB 2086	Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
Apafant (WEB 2086), a chemical probe, is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a K_i of 9.9 nM. Apafant increases the gene expression of PAF-r, α-globin, β-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit .

HY-W015881

Dimebutic acid NSC-16045; NSC-741804	Bcl-2 Family	Cardiovascular Disease
Dimebutic acid is an orally active short-chain fatty acid. Dimebutic acid stimulates fetal *globin* production and alters the balance of Bcl family proteins. Dimebutic acid prolongs red blood cell survival. Dimebutic acid exhibits toxicity in rats. Dimebutic acid can be used in the study of β-thalassemia and sickle cell disease .

HY-152775

RK-701	Histone Methyltransferase	Cancer
RK-701 is an highly selective and non-genotoxic inhibitor of G9a with IC₅₀ value of 23-27 nM. RK-701 selectively up-regulates HbF, γ- Globin, BGLT3 expression, down-regulates H3K9me2 expression. RK-701 also has inhibition for BCL11A and ZBTB7A .

HY-Y1620S

3-(3,4-Dimethoxyphenyl)propanoic acid-d10	Isotope-Labeled Compounds	Cardiovascular Disease
3-(3,4-Dimethoxyphenyl)propanoic acid-d₁₀ is the deuterium labeled 3-(3,4-Dimethoxyphenyl)propanoic acid. 3-(3,4-Dimethoxyphenyl)propanoic acid is an orally active short-chain fatty acids (SCFAs). 3-(3,4-Dimethoxyphenyl)propanoic acid stimulates γ globin gene expression, erythropoiesis in vivo and is used for the β hemoglobinopathies and other anemias .

HY-108634S

Apafant-d8	Isotope-Labeled Compounds Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
Apafant-d₈ is the deuterium labeled Apafant. Apafant (WEB 2086) is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a K_iof 9.9 nM. Apafant increases the gene expression of PAF-r, α-globin, β-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit .

HY-NP007A

Myoglobin (human)	Biochemical Assay Reagents	Metabolic Disease
Myoglobin (human) is a small molecular pigment protein formed by binding globin to Heme, which can be reversibly bound to oxygen to form MbO2, MbO2 is called oxymyoglobin, and Mb is called deoxymyoglobin. Myoglobin has the role of transporting and storing oxygen in muscle cells .

HY-W015881A

Dimebutic acid sodium NSC-16045 sodium; NSC-741804 sodium	Bcl-2 Family	Cardiovascular Disease
Dimebutic acid sodium is an orally active short-chain fatty acid. Dimebutic acid sodium stimulates fetal *globin* production and alters the balance of Bcl family proteins. Dimebutic acid sodium prolongs red blood cell survival. Dimebutic acid sodium exhibits toxicity in rats. Dimebutic acid sodium can be used in the study of β-thalassemia and sickle cell disease .

HY-170831

DS79932728	Histone Methyltransferase GLP Receptor	Others
DS79932728 is an orally active inhibitor for G9a and GLP with IC₅₀ of 12.6 nM and 75.7 nM. DS79932728 induces the production of γ-globin, thereby increasing the level of fetal hemoglobin (HbF). DS79932728 increases F-reticulocytes (F-rets) proportion and exhibits good oral absorption characteristics in cynomolgus monkey models .

HY-175742

BMS-986470	Ligands for E3 Ligase Molecular Glues Histone Acetyltransferase	Cardiovascular Disease
BMS-986470, a HbF-activating CRBN E3 ligase modulator (CELMoD), is an orally active dual molecular glue degrader targeting ZBTB7A and WIZ. BMS-986470 has potent γ-globin induction activity. BMS-986470 can be used for sickle cell disease (SCD) research .

HY-W015881R

Dimebutic acid (Standard) NSC-16045 (Standard); NSC-741804 (Standard)	Reference Standards Bcl-2 Family	Cardiovascular Disease
Dimebutic acid (Standard) is an analytical standard of Dimebutic acid (HY-W015881). This product is intended for research and analytical applications. Dimebutic acid is an orally active short-chain fatty acid. Dimebutic acid stimulates fetal *globin* production and alters the balance of Bcl family proteins. Dimebutic acid prolongs red blood cell survival. Dimebutic acid exhibits toxicity in rats. Dimebutic acid can be used in the study of β-thalassemia and sickle cell disease .

HY-161787

G9a-IN-2	Histone Methyltransferase	Others
G9a-IN-2 (Compound 7i) is an inhibitor for histone methyltransferases G9a with IC₅₀ of 0.024 μM. G9a-IN-2 reduces H3K9me2 levels and induces the mRNA expression of γ-globin mRNA. G9a-IN-2 shows the potential in ameliorating sickle cell disease (SCD) .

HY-113427A

cis-Vaccenic acid	Antibiotic	Cancer
cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate , acts a potential fetal hemoglobin inducer .

HY-P99720A

Luspatercept (mIgG2a) RAP-536	TGF-beta/Smad	Metabolic Disease
Luspatercept (mIgG2a) (RAP-536) is a fusion protein, consisting of a modified extracellular domain of human ActRIIB linked to the murine IgG2a Fc domain. Luspatercept (mIgG2a) inhibits Smad2/3 signaling, promotes differentiation of late-stage erythroid precursors and mitigates ineffective erythropoiesis (IE) in murine β-thalassemia. Luspatercept (mIgG2a) reduces anemia, α-globin aggregates, hemolysis, and disease complications of IE such as iron overload, splenomegaly, and bone defects .

HY-W699526

Dimebutic acid-d6 NSC-16045-d₆; NSC-741804-d₆	Isotope-Labeled Compounds Bcl-2 Family	Cardiovascular Disease
Dimebutic acid-d₆ (NSC-16045-d₆; NSC-741804-d₆) is the deuterium labeled Dimebutic acid (HY-W015881). Dimebutic acid is a fatty acid derivative. Dimebutic acid is an orally active short-chain fatty acid. Dimebutic acid stimulates fetal *globin* production and alters the balance of Bcl family proteins. Dimebutic acid prolongs red blood cell survival. Dimebutic acid exhibits toxicity in rats. Dimebutic acid is used in the study of β-thalassemia and sickle cell disease .

Cat. No.	Product Name	Type

HY-NP007

Myoglobin	Native Proteins
Myoglobin is a small molecular pigment protein formed by binding globin to Heme, which can be reversibly bound to oxygen to form MbO₂, MbO₂ is called oxymyoglobin, and Mb is called deoxymyoglobin. Myoglobin has the role of transporting and storing oxygen in muscle cells .

HY-NP007A

Myoglobin (human)	Native Proteins
Myoglobin (human) is a small molecular pigment protein formed by binding globin to Heme, which can be reversibly bound to oxygen to form MbO2, MbO2 is called oxymyoglobin, and Mb is called deoxymyoglobin. Myoglobin has the role of transporting and storing oxygen in muscle cells .

Cat. No.	Product Name	Target	Research Area

HY-P99720A

Luspatercept (mIgG2a) RAP-536	TGF-beta/Smad	Metabolic Disease
Luspatercept (mIgG2a) (RAP-536) is a fusion protein, consisting of a modified extracellular domain of human ActRIIB linked to the murine IgG2a Fc domain. Luspatercept (mIgG2a) inhibits Smad2/3 signaling, promotes differentiation of late-stage erythroid precursors and mitigates ineffective erythropoiesis (IE) in murine β-thalassemia. Luspatercept (mIgG2a) reduces anemia, α-globin aggregates, hemolysis, and disease complications of IE such as iron overload, splenomegaly, and bone defects .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113427A

cis-Vaccenic acid	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	Antibiotic
cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate , acts a potential fetal hemoglobin inducer .

Species:	Human (3)
Tag:	His (3)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P70242

	Hemoglobin subunit zeta/HBAZ Protein, Human (His) rHuHemoglobin subunit zeta/HBAZ, His; Hemoglobin Subunit Zeta; HBAZ; Hemoglobin Zeta Chain; Zeta-globin; HBZ; HBZ2	Human	E. coli
	The hemoglobin zeta subunit (HBAZ) protein acts as an α-type chain in mammalian embryonic hemoglobin. It contributes to the formation of heterotetramers and is involved in various developmental stages. Hemoglobin subunit zeta/HBAZ Protein, Human (His) is the recombinant human-derived Hemoglobin subunit zeta/HBAZ protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70397

	Hemoglobin subunit alpha/HBA1 Protein, Human (His) rHuHemoglobin subunit alpha/HBA1, His; Hemoglobin subunit alpha; Alpha-globin; Hemoglobin alpha chain; HBA1; HBH; HBA-T3	Human	E. coli
	Hemoglobin subunit alpha/HBA1 protein plays a crucial role in oxygen transport and gas exchange within the human body. It also acts as a regulator in the cannabinoid receptor pathway by interacting with hemopressin, a CNR1 antagonist. This dual functionality highlights the multifaceted significance of HBA1, contributing not only to vital oxygen transport but also to the modulation of cannabinoid receptor-mediated processes. Hemoglobin subunit alpha/HBA1 Protein, Human (His) is the recombinant human-derived Hemoglobin subunit alpha/HBA1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70272

	Hemoglobin subunit theta-1/HBQ1 Protein, Human (His) rHuHemoglobin subunit theta-1, His; Hemoglobin subunit theta-1; Hemoglobin theta-1 chain; Theta-1-globin; HBQ1	Human	E. coli
	Hemoglobin subunit theta-1 (HBQ1) is a protein belonging to the globin family. Globulin is a group of proteins involved in oxygen transport and storage. Hemoglobin subunit theta-1/HBQ1 Protein, Human (His) is the recombinant human-derived Hemoglobin subunit theta-1/HBQ1 protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-Y1620S

3-(3,4-Dimethoxyphenyl)propanoic acid-d10
3-(3,4-Dimethoxyphenyl)propanoic acid-d₁₀ is the deuterium labeled 3-(3,4-Dimethoxyphenyl)propanoic acid. 3-(3,4-Dimethoxyphenyl)propanoic acid is an orally active short-chain fatty acids (SCFAs). 3-(3,4-Dimethoxyphenyl)propanoic acid stimulates γ globin gene expression, erythropoiesis in vivo and is used for the β hemoglobinopathies and other anemias .

HY-108634S

Apafant-d8
Apafant-d₈ is the deuterium labeled Apafant. Apafant (WEB 2086) is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a K_iof 9.9 nM. Apafant increases the gene expression of PAF-r, α-globin, β-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit .

HY-W699526

Dimebutic acid-d6
Dimebutic acid-d₆ (NSC-16045-d₆; NSC-741804-d₆) is the deuterium labeled Dimebutic acid (HY-W015881). Dimebutic acid is a fatty acid derivative. Dimebutic acid is an orally active short-chain fatty acid. Dimebutic acid stimulates fetal *globin* production and alters the balance of Bcl family proteins. Dimebutic acid prolongs red blood cell survival. Dimebutic acid exhibits toxicity in rats. Dimebutic acid is used in the study of β-thalassemia and sickle cell disease .

Dimebutic acid-d6

Dimebutic acid-d₆ (NSC-16045-d₆; NSC-741804-d₆) is the deuterium labeled Dimebutic acid (HY-W015881). Dimebutic acid is a fatty acid derivative. Dimebutic acid is an orally active short-chain fatty acid. Dimebutic acid stimulates fetal globin production and alters the balance of Bcl family proteins. Dimebutic acid prolongs red blood cell survival. Dimebutic acid exhibits toxicity in rats. Dimebutic acid is used in the study of β-thalassemia and sickle cell disease .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82819

	Fetal Hemoglobin Antibody (YA2564) Gamma 1 globin; Gamma 2 globin; Gamma A hemoglobin; Gamma globin; Hb F Agamma; Hb F Ggamma; HBG1; HBG2; HBGA; HBGR	WB	Human
	Fetal Hemoglobin Antibody (YA2564) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Fetal Hemoglobin.

HY-P81428

	Hemoglobin subunit alpha Antibody (YA1173) HBA1; HBA2; Hemoglobin subunit alpha; Alpha-globin; Hemoglobin alpha chain; Hemopressin	IHC-P	Human
	Hemoglobin subunit alpha Antibody (YA1173) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hemoglobin subunit alpha.