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Results for "

fluorinated

" in MedChemExpress (MCE) Product Catalog:

44

Inhibitors & Agonists

1

Fluorescent Dye

6

Biochemical Assay Reagents

2

Peptides

1

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0069
    Fludarabine
    Maximum Cited Publications
    70 Publications Verification

    F-ara-A; NSC 118218

    		 Nucleoside Antimetabolite/Analog DNA/RNA Synthesis STAT Apoptosis Cancer
    Fludarabine (NSC 118218) is a DNA synthesis inhibitor and a fluorinated purine analogue with antineoplastic activity in lymphoproliferative malignancies. Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes .
    Fludarabine
  • HY-32126
    1-Fluoronaphthalene

    		Drug Intermediate Others
    1-Fluoronaphthalene is an organofluorine compound derived from naphthalene derivatives and fluorinated aromatics. 1-Fluoronaphthalene can be used to synthesize LY248686, a potent inhibitor of serotonin and noradrenaline uptake .
    1-Fluoronaphthalene
  • HY-W075766
    Nickel(II) fluoride

    Nickel difluoride

    		 Biochemical Assay Reagents Others
    Nickel(II) fluoride (Nickel difluoride) is a fluorinating agent and catalyst suitable for surface treatment of aluminum profiles and the production of inks, fluorescent lamps, and organic synthesis. Nickel(II) fluoride is a kind of biological materials or organic compounds that are widely used in life science research .
    Nickel(II) fluoride
  • HY-124472
    2,4-Difluororesorcinol

    		Drug Intermediate Others
    2,4-Difluororesorcinol is a fluorinated building block .
    2,4-Difluororesorcinol
  • HY-40421
    (R)-3-Fluoropyrrolidine hydrochloride

    		Biochemical Assay Reagents Others
    (R)-3-Fluoropyrrolidine hydrochloride is a derivative of fluorinated pyrrolidines. The amide series of fluorinated pyrrolidines are inhibitors of dipeptidyl peptidase DP-IV. Novel α4β2 receptor ligands characterized by a 3-Fluoropyrrolidine core .
    (R)-3-Fluoropyrrolidine hydrochloride
  • HY-79171
    3,4-Difluorophenylalanine

    		Biochemical Assay Reagents Others
    3,4-Difluorophenylalanine is a fluorinated peptide with gelation ability .
    3,4-Difluorophenylalanine
  • HY-B0628
    Vinflunine

    		Microtubule/Tubulin Mitosis Cancer
    Vinflunine is a type of fluorinated vinca alkaloid that has the ability to block mitosis and interact with tubulin .
    Vinflunine
  • HY-B0069R
    Fludarabine (Standard)

    F-ara-A (Standard); NSC 118218 (Standard)

    		 Nucleoside Antimetabolite/Analog DNA/RNA Synthesis STAT Apoptosis Cancer
    Fludarabine (Standard) is the analytical standard of Fludarabine. This product is intended for research and analytical applications. Fludarabine (NSC 118218) is a DNA synthesis inhibitor and a fluorinated purine analogue with antineoplastic activity in lymphoproliferative malignancies. Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes .
    Fludarabine (Standard)
  • HY-32126R
    1-Fluoronaphthalene (Standard)

    		Adrenergic Receptor Serotonin Transporter Others
    1-Fluoronaphthalene (Standard) is the analytical standard of 1-Fluoronaphthalene. This product is intended for research and analytical applications. 1-Fluoronaphthalene is an organofluorine compound derived from naphthalene derivatives and fluorinated aromatics. 1-Fluoronaphthalene can be used to synthesize LY248686, a potent inhibitor of serotonin and noradrenaline uptake .
    1-Fluoronaphthalene (Standard)
  • HY-158882
    FLAC6

    		Biochemical Assay Reagents Adenosine Receptor Others
    FLAC6 is a potent fluorinated detergent that can be used to solubilize membrane proteins (the native adenosine receptor A2AR, a G protein-coupled receptor, and two native transporters AcrB and BmrA). FLAC6 can maintain the structural and functional integrity of different membrane proteins .
    FLAC6
  • HY-65254
    5-Amino-2-fluoropyridine

    		Biochemical Assay Reagents Drug Intermediate Others
    5-Amino-2-fluoropyridine is a fluorinated heterocyclic compound, which can be used for the synthesis of other active compounds .
    5-Amino-2-fluoropyridine
  • HY-163474
    MAO-B-IN-32

    		Monoamine Oxidase Neurological Disease
    MAO-B-IN-32 is an inhibitor of MAO-B (IC50 = 16 nM).MAO-B-IN-32 increases dopamine concentration in the brain by inhibiting MAO-B activity .
    MAO-B-IN-32
  • HY-115859
    SCH 25393

    		Bacterial Infection
    SCH 25393 is a potent antibacterial agent .
    SCH 25393
  • HY-32887
    3,5-Difluorophenylboronic acid

    		Biochemical Assay Reagents Drug Intermediate Others
    3,5-Difluorophenylboronic acid is a fluorinated arylboronic acid compound. As an important intermediate, 3,5-difluorophenylboronic acid can be used in the synthesis of other active compounds .
    3,5-Difluorophenylboronic acid
  • HY-W576868
    Thalidomide-4,5-F

    		Ligands for E3 Ligase Cancer
    Thalidomide-4,5-F is a fluorinated Thalidomide analogue. Thalidomide promotes the ubiquitinylation of proteins. The structure may be further derivatized via substitution at its fluorines.
    Thalidomide-4,5-F
  • HY-113938
    AZD4694

    NAV4694

    		 Amyloid-β Cardiovascular Disease
    AZD4694 (NAV4694), a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils (Kd = 2.3 nM) .
    AZD4694
  • HY-111343
    ONC212
    4 Publications Verification

    		 Apoptosis Endocrinology Cancer
    ONC212, a fluorinated-ONC201 analogue, is a promising anti-cancer agent and also a selective agonist of GPR132. ONC212 also induces apoptosis .
    ONC212
  • HY-155869
    5-fluoro-dCTP

    5-Fluoro-2′-deoxycytidine 5′-triphosphate

    		 DNA/RNA Synthesis Others
    5-fluoro-dCTP is a fluorinated pyrimidine dNTP that can be used as a substrate for the incorporation of fluorine modification into specific DNA sequences by primer extension (PEX) catalyzed by Pwo polymerase .
    5-fluoro-dCTP
  • HY-155869A
    5-fluoro-dCTP sodium

    5-Fluoro-2′-deoxycytidine 5′-triphosphate sodium

    		 DNA/RNA Synthesis Others
    5-fluoro-dCTP sodium is a fluorinated pyrimidine dNTP that can be used as a substrate for the incorporation of fluorine modification into specific DNA sequences by primer extension (PEX) catalyzed by Pwo polymerase .
    5-fluoro-dCTP sodium
  • HY-173387
    4F-Docetaxel

    4FDT

    		 Others Cancer
    4F-Docetaxel (4FDT) is a fluorinated docetaxel analog. 4F-Docetaxel has anti-hepatoma activity and can be used for research of hepatocellular carcinoma (HCC) .
    4F-Docetaxel
  • HY-172295
    Tetrafluoro-thalidomide

    		Ligands for E3 Ligase Cancer
    Tetrafluoro-thalidomide is a fluorinated Thalidomide analogue. Tetrafluoro-thalidomide is an activator of E3 ligase, which ubiquitinylates proteins for later proteolysis. The structure may be further derivatized via substitution at its fluorines.
    Tetrafluoro-thalidomide
  • HY-P2496
    Endothelin 1 (swine, human), Alexa Fluor 488-labeled

    		Endothelin Receptor Cardiovascular Disease
    Endothelin 1 (swine, human), Alexa Fluor 488-labeled is a synthetic Endothelin 1 peptide labled with Alexa Fluor 488. Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB .
    Endothelin 1 (swine, human), Alexa Fluor 488-labeled
  • HY-W050049
    2-Deoxy-2,2-difluoro-D-erythro-pentonic acid γ-Lactone 3,5-dibenzoate

    		Biochemical Assay Reagents Others
    2-Deoxy-2,2-difluoro-D-erythro-pentonic acid γ-Lactone 3,5-dibenzoate is a chemically synthesized fluorinated carbohydrate derivative that can be used in glycobiology research .
    2-Deoxy-2,2-difluoro-D-erythro-pentonic acid γ-Lactone 3,5-dibenzoate
  • HY-113719
    VM4-037

    		Carbonic Anhydrase Cancer
    VM4-037 can be used for the synthesis of VM4-037(18F). VM4-037(18F) is a fluorinated PET imaging agent for carbonic anhydrase IX .
    VM4-037
  • HY-132978
    SulfoxFluor

    		Biochemical Assay Reagents Others
    SulfoxFluor is a fluorinated sulfoximine compound that can be used in the rapid deoxyfluorination and selective deoxyazidation reactions of various alcohols. SulfoxFluor is characterized by high reactivity, rapid reaction, simple operation, easy scale-up, and high selectivity .
    SulfoxFluor
  • HY-162453
    Anticancer agent 204

    		Apoptosis MMP Cancer
    Anticancer agent 204 (Compound 6), a cinnamide fluorinated derivative, possesses anticancer activity. Anticancer agent 204 can arrest the cell cycle of HepG2 cells in the G1 phase and induce apoptosis by reducing the level of mitochondrial membrane polarization (MMP) .
    Anticancer agent 204
  • HY-B0248
    Desonide
    2 Publications Verification

    		 Glucocorticoid Receptor Huntingtin Apoptosis Neurological Disease Inflammation/Immunology
    Desonide is a non-fluorinated corticosteroid anti-inflammatory agent that acts on the glucocorticoid receptor. Desonide can also specifically bind to the mutant huntingtin protein (mHTT), reducing the level and toxicity of mHTT. Desonide can be used in the research of Huntington's disease and inflammatory diseases such as atopic dermatitis .
    Desonide
  • HY-139211
    Difluorinated Curcumin

    3,4-Difluorobenzylidene curcumin

    		 Reactive Oxygen Species (ROS) Cancer
    Difluorinated Curcumin (3,4-Difluorobenzylidene curcumin) is a fluorinated curcumin analog with high bioavailability and anticancer activity. Difluorinated Curcumin inhibits the self-renewal ability of tumor stem/stem-like cells, clonogenicity, invasiveness and angiogenesis of tumor cells. Difluorinated Curcumin also increases cell sensitivity to chemotherapy .
    Difluorinated Curcumin
  • HY-B0139
    Flucytosine
    2 Publications Verification

    5-Fluorocytosine; NSC 103805; Ro 2-9915

    		 Fungal Antibiotic Infection Cancer
    Flucytosine (5-Fluorocytosine) is an antifungal compound with oral activity. Flucytosine is a widely used cytotoxic drug that, after further metabolism, produces fluorinated ribonucleotides and deoxyribonucleotides, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida neoplasm infection and producies cytotoxicity to cancer cells .
    Flucytosine
  • HY-136595
    3,5-Difluoro-L-tyrosine

    		Phosphatase Others
    3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine. 3,5-Difluoro-L-tyrosine can be used to analyze the substrate specificity of protein tyrosine phosphatases (PTPs) .
    3,5-Difluoro-L-tyrosine
  • HY-143330
    MAO-B-IN-4

    		Monoamine Oxidase Neurological Disease
    MAO-B-IN-4 (Compound 26) is an orally active and reversible MAO-B inhibitor with an IC50 of 9 nM. MAO-B-IN-4 has good metabolic stability, safety profile and brain permeability. MAO-B-IN-4 shows antidepressant activity in rats and mice. MAO-B-IN-4 can be used in studies related to Alzheimer's disease .
    MAO-B-IN-4
  • HY-106218
    Flurocitabine

    5-Fluorocyclocytidine; 5'-Fluorocyclocytidine

    		 Nucleoside Antimetabolite/Analog Cancer
    Flurocitabine (5-Fluorocyclocytidine) is a fluorinated anlydride analog of cytosine arabinoside, partially hydrolysecl in vivo into two active antitumor substances (arabinosyl-tluorocytosine (ara-FC) and arabinosyl-fluorouracil (ara-FU)). Flurocitabine (5-Fluorocyclocytidine) has antitumor activity during phase I studies in acute leukemia and solid tumors .
    Flurocitabine
  • HY-B0248R
    Desonide (Standard)

    		Glucocorticoid Receptor Huntingtin Apoptosis Neurological Disease Inflammation/Immunology
    Desonide (Standard) is the analytical standard of Desonide. This product is intended for research and analytical applications. Desonide is a non-fluorinated corticosteroid anti-inflammatory agent that acts on the glucocorticoid receptor. Desonide can also specifically bind to the mutant huntingtin protein (mHTT), reducing the level and toxicity of mHTT. Desonide can be used in the research of Huntington's disease and inflammatory diseases such as atopic dermatitis.
    Desonide (Standard)
  • HY-W422400
    Fluoroglutamine (2S,4R)

    		Biochemical Assay Reagents Others Cancer
    Fluoroglutamine (2S,4R) is a fluorinated derivative of glutamine. As a substrate for various aminotransferases, Fluoroglutamine (2S,4R) can be used as a tracer for positron emission tomography (PET) imaging. Fluoroglutamine (2S,4R) is applied in the research fields of tumor metabolism and imaging .
    Fluoroglutamine (2S,4R)
  • HY-B0139R
    Flucytosine (Standard)

    5-Fluorocytosine (Standard); NSC 103805 (Standard); Ro 2-9915 (Standard)

    		 Fungal Antibiotic Infection Cancer
    Flucytosine (Standard) is the analytical standard of Flucytosine. This product is intended for research and analytical applications. Flucytosine (5-Fluorocytosine) is an antifungal compound with oral activity. Flucytosine is a widely used cytotoxic drug that, after further metabolism, produces fluorinated ribonucleotides and deoxyribonucleotides, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida neoplasm infection and producies cytotoxicity to cancer cells .
    Flucytosine (Standard)
  • HY-W577257
    Thalidomide-1-Me,5-F

    		Ligands for E3 Ligase Cancer
    5-Fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione is a fluorinated E3 ligase activator. Thalidomide-1-Me,5-F may be used for further derivitization by SNAr.
    Thalidomide-1-Me,5-F
  • HY-W653989
    Desonide-13C3

    		Isotope-Labeled Compounds Others
    Desonide- 13C3 is the 13C labeled isotope of Desonide (HY-B0248). Desonide is a non-fluorinated corticosteroid anti-inflammatory agent that acts on the glucocorticoid receptor. Desonide can also specifically bind to the mutant huntingtin protein (mHTT), reducing the level and toxicity of mHTT. Desonide can be used in the research of Huntington's disease and inflammatory diseases such as atopic dermatitis .
    Desonide-13C3
  • HY-149558
    CXCR4-IN-2

    		Apoptosis CXCR Cancer
    CXCR4-IN-2 (compound A1) is a bifunctional fluorinated small molecule that is a potent CXCR4 inhibitor with anticancer activity. CXCR4-IN-2 has cytotoxic (IC50: 60 μg/mL; 72 h) and antiproliferative effects on mouse colorectal cancer (CRC) cells. CXCR4-IN-2 induces cell arrest in the G2/M phase and induces apoptosis .
    CXCR4-IN-2
  • HY-15234
    Fluticasone furoate

    		Glucocorticoid Receptor Inflammation/Immunology
    Fluticasone furoate is a topical, intranasal, enhanced-affinity synthetic trifluorinated corticosteroid with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflamatory and anti-asthmatic activity, and low systemic exposure. Fluticasone furoate has the potential for allergic rhinitis treatment .
    Fluticasone furoate
  • HY-15234R
    Fluticasone furoate (Standard)

    		Glucocorticoid Receptor Inflammation/Immunology
    Fluticasone furoate (Standard) is the analytical standard of Fluticasone furoate. This product is intended for research and analytical applications. Fluticasone furoate is a topical, intranasal, enhanced-affinity synthetic trifluorinated corticosteroid with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflamatory and anti-asthmatic activity, and low systemic exposure. Fluticasone furoate has the potential for allergic rhinitis treatment .
    Fluticasone furoate (Standard)
  • HY-W095635
    Tetramethylammonium fluoride tetrahydrate

    		Biochemical Assay Reagents Others
    Tetramethylammonium fluoride tetrahydrate (TMAF) is a quaternary ammonium salt. TMAF is commonly used as a weak base and a source of fluoride ions in various organic reactions, including nucleophilic substitution, functional group deprotection, and ring-opening polymerization. Unlike other fluoride sources, TMAF is compatible with many functional groups, making it a versatile tool in synthetic chemistry. Functional reagents, In addition, TMAF has been used as a fluorinating agent in medicinal chemistry, for the preparation of radiotracers and protein modification in biochemistry, and the tetrahydrate form of TMAF is more stable and easier to handle than the anhydrous form.
    Tetramethylammonium fluoride tetrahydrate
  • HY-164576
    NCS-MP-NODA

    NODA-Bz-SCN

    		 Radionuclide-Drug Conjugates (RDCs) Cancer
    NCS-MP-NODA (NODA-Bz-SCN) is a bifunctional chelator that can be used to bind to the labeled peptide DK222 with high specificity for PD-L1. The corresponding fluorinated radioactive is synthesized by the aluminum fluoride method, and NCS-MP-NODA targets DK222 to obtain the radioactive analog [18/19F]DK222. [18F]DK222 can quantify PD-L1 in vivo via PET tracking in xenograft models of multiple cancer types.
    NCS-MP-NODA
  • HY-D1447
    Fluo-3FF pentapotassium

    		Fluorescent Dye Others
    Fluo-3FF pentapotassium is a cell-permeable acetoxy-methyl ester of Fluo-3FF, a fluorescent calcium indicator. Fluo-3FF is a di-fluorinated analog of Fluo-3 with a 100-fold lower affinity than Fluo-3 for calcium (Kds=42 and 0.4 碌M, respectively). For its low affinity, Fluo-3FF is used for studying compartments with high concentrations of calcium, such as endoplasmic reticulum, where high affinity dyes will be insensitive to luminal fluctuations.
    Fluo-3FF pentapotassium
  • HY-172728
    Difluorocarboxyfluorescein NHS Ester, 6-isomer

    		Fluorescent Dye Others
    Difluorocarboxyfluorescein NHS Ester, 6-isomer is an amine-reactive fluorinated analog of fluorescein that overcomes some of the key limitations of fluorescein, including greater photostability and a lower pKa (pKa ~ 4.7 versus 6.4 for fluorescein), making its fluorescence essentially pH insensitive in the physiological pH range. Although the mixed isomers of Difluorocarboxyfluorescein NHS Ester, is a preferred, routinely used fluorescent dye for labeling proteins, peptides and nucleotides, purification of peptide and nucleotides labeled with 5(6) isomers might be troublesome due to significant signal broadening in HPLC purification. Peptides and nucleotides labeled with a single isomer usually give better resolution in HPLC purification that is often required in the conjugation processes.
    Difluorocarboxyfluorescein NHS Ester, 6-isomer

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