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Results for "

extracellular matrix (ECM)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Anaplastic lymphoma kinase (ALK) (1) Biochemical Assay Reagents (5) Integrin (1) Isotope-Labeled Compounds (1) NF-κB (1) Phosphodiesterase (PDE) (1) PI3K (2) Reactive Oxygen Species (1) TGF-beta/Smad (1) TGF-β Receptor (1)
By Research Areas:	Cancer (1) Endocrinology (2) Inflammation/Immunology (5) Metabolic Disease (2)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: MMP ERK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W005379

DGM	TGF-beta/Smad	Inflammation/Immunology
DGM is an inhibitor of the TGF-β1/Smad signaling pathway with significant antifibrotic effects. DGM inhibits the epithelial-mesenchymal transition (EMT) process in alveolar epithelial cells and slows the progression of pulmonary fibrosis in vivo by reducing lung inflammation, improving lung function, and decreasing extracellular matrix (ECM) remodeling. DGM can be used in research on idiopathic pulmonary fibrosis (IPF) and EMT-related diseases .

HY-N6812

Karacoline	NF-κB	Endocrinology
Karacoline, a diterpene alkaloid found in the plant Aconitum kusnezoffii, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway .

HY-136651

BNTA	Reactive Oxygen Species	Inflammation/Immunology
BNTA, a potent **extracellular matrix (ECM) modulator, facilitates cartilage structural molecule synthesis on chondrocytes by activating superoxide dismutase 3 (SOD3)**. BNTA shows a promising potential for osteoarthritis alleviation by modulating cartilage generation .

HY-158220

Hyaluronic acid Methacryloyl (MW 400 kDa) HAMA (MW 400 kDa)	Biochemical Assay Reagents	Others
Hyaluronic acid Methacryloyl (HAMA) is methacrylated hyaluronic acid that is biocompatible. Hyaluronic acid Methacryloyl is also used as a 3D printing hydrogel ink, which has the characteristics of fast photosensitive response, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl can quickly induce gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under UV irradiation. The combination of Hyaluronic acid Methacryloyl and tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) will become an important source material for organoid culture .

HY-158220A

Hyaluronic acid Methacryloyl (MW 150 kDa) HAMA (MW 150 kDa)	Biochemical Assay Reagents	Others
Hyaluronic acid Methacryloyl (HAMA) MW 150 kDa is methacrylated hyaluronic acid that is biocompatible. Hyaluronic acid Methacryloyl is also used as a 3D printing hydrogel ink, which has the characteristics of fast photosensitive response, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl can quickly induce gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under UV irradiation. The combination of Hyaluronic acid Methacryloyl and tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) will become an important source material for organoid culture .

HY-13306

Pyrintegrin 4 Publications Verification	Integrin	Metabolic Disease
Pyrintegrin is an β1-integrin agonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival. Pyrintegrin enhances cell-extracellular matrix (ECM) adhesion-mediated integrin signaling. Pyrintegrin can be used as a podocyte-protective agent and has robustly adipogenic .

HY-159621

Endosidine 5 ES5	Others	Endocrinology
Endosidine 5 (ES5) inhibits EPS (extracellular polymeric substance) secretion and cell wall expansion. Endosidine 5 alters secretion of ECM (extracellular matrix) material in Penium margaritaceum by affecting the Golgi apparatus. Endosidine 5 interferes with recycling endosomes through Annexin A6, thereby promoting the release and expression of mRNA into the cytoplasm .

HY-E70369

Collagenase H (Recombinant)	Biochemical Assay Reagents	Others
Collagenase H Recombinant is able to digest and break down collagen (especially collagen III) in the extracellular matrix (ECM). Collagenase H Recombinant is important in the isolation and function of rat pancreatic islets. Collagenase H Recombinant can be used in tissue engineering and cell culture .

HY-NP156

Type I Collagen, for cell culture, from Bovine	Biochemical Assay Reagents	Others
Type I Collagen, for cell culture, from Bovine plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, for cell culture, from Bovine can mimic the extracellular matrix (ECM) and is suitable for 2D/3D cell culture .

HY-NP156A

Type I Collagen, for cell culture, from Porcine	Biochemical Assay Reagents	Others
Type I Collagen, for cell culture, from Porcine plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, for cell culture, from Porcine can mimic the extracellular matrix (ECM) and is suitable for 2D/3D cell culture .

HY-121246

Fluorofenidone 1 Publications Verification AKF-PD	PI3K Akt	Inflammation/Immunology
Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway .

HY-163507

ALK5-IN-79	Anaplastic lymphoma kinase (ALK)	Cancer
ALK5-IN-79 (compound 57) is an ALK inhibitor with anticancer activity, by blocking TGF-β1/SMAD signaling pathway. ALK5-IN-79 attenuates the production of extracellular matrix (ECM) and deposition of collagen. ALK5-IN-79 exhibits adequate pharmacokinetic (PK) properties and good in vivo tolerance.

HY-121246S

Fluorofenidone-d3 AKF-PD-d₃	Isotope-Labeled Compounds Akt PI3K	Inflammation/Immunology
Fluorofenidone-d₃ is deuterium labeled Fluorofenidone. Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway[1][2].

HY-170227

Autotaxin-IN-7	Phosphodiesterase (PDE) TGF-β Receptor	Inflammation/Immunology
Autotaxin-IN-7 (45), a pyridine-2-carboxylic derivative, demonstrates subnanomolar ATX inhibition (IC₅₀ = 0.086 nM), with a favorable heart safety profile (hERG > 30 μM) and minimal fibroblast toxicity. Autotaxin-IN-7 (45) suppresses the TGF-β/Smad signaling pathway, downregulating α-smooth muscle actin (α-SMA) and extracellular matrix components (ECM). Autotaxin-IN-7 (45) is used in the research for pulmonary fibrosis .

Cat. No.	Product Name

HY-L185

Anti-Fibrosis Compound Library	2,000 compounds
Fibrosis is a kind of repair response to long-term tissue damage, which is mainly manifested by excessive deposition of extracellular matrix (ECM) and scar formation. Myofibroblasts are the main generating cells of extracellular matrix, and their activation process is related to various pathological mechanisms including Oxidative stress, chronic inflammation and cytokine secretion. Fibrosis can occur in many organs, such as kidneys, liver, heart, lungs, etc. Continuous fibrosis can lead to the destruction of the normal structure of tissues and organs, and if not controlled in time, may cause organ failure or even life-threatening. MCE contains 2,000 compounds targeting ant-fibrosis targets such as TGF-β, PI3K, Wnt, MMP, etc. These compounds have clear or potential anti-fibrosis activity and can be used for mechanism research and drug screening of fibrosis diseases.

Anti-Fibrosis Compound Library

2,000 compounds

Fibrosis is a kind of repair response to long-term tissue damage, which is mainly manifested by excessive deposition of extracellular matrix (ECM) and scar formation. Myofibroblasts are the main generating cells of extracellular matrix, and their activation process is related to various pathological mechanisms including Oxidative stress, chronic inflammation and cytokine secretion. Fibrosis can occur in many organs, such as kidneys, liver, heart, lungs, etc. Continuous fibrosis can lead to the destruction of the normal structure of tissues and organs, and if not controlled in time, may cause organ failure or even life-threatening.

MCE contains 2,000 compounds targeting ant-fibrosis targets such as TGF-β, PI3K, Wnt, MMP, etc. These compounds have clear or potential anti-fibrosis activity and can be used for mechanism research and drug screening of fibrosis diseases.

Cat. No.	Product Name	Type

HY-158220

Hyaluronic acid Methacryloyl (MW 400 kDa) HAMA (MW 400 kDa)	3D Bioprinting
Hyaluronic acid Methacryloyl (HAMA) is methacrylated hyaluronic acid that is biocompatible. Hyaluronic acid Methacryloyl is also used as a 3D printing hydrogel ink, which has the characteristics of fast photosensitive response, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl can quickly induce gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under UV irradiation. The combination of Hyaluronic acid Methacryloyl and tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) will become an important source material for organoid culture .

Hyaluronic acid Methacryloyl (MW 400 kDa)

HAMA (MW 400 kDa)

3D Bioprinting

Hyaluronic acid Methacryloyl (HAMA) is methacrylated hyaluronic acid that is biocompatible. Hyaluronic acid Methacryloyl is also used as a 3D printing hydrogel ink, which has the characteristics of fast photosensitive response, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl can quickly induce gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under UV irradiation. The combination of Hyaluronic acid Methacryloyl and tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) will become an important source material for organoid culture .

HY-158220A

Hyaluronic acid Methacryloyl (MW 150 kDa) HAMA (MW 150 kDa)	3D Bioprinting
Hyaluronic acid Methacryloyl (HAMA) MW 150 kDa is methacrylated hyaluronic acid that is biocompatible. Hyaluronic acid Methacryloyl is also used as a 3D printing hydrogel ink, which has the characteristics of fast photosensitive response, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl can quickly induce gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under UV irradiation. The combination of Hyaluronic acid Methacryloyl and tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) will become an important source material for organoid culture .

Hyaluronic acid Methacryloyl (MW 150 kDa)

HAMA (MW 150 kDa)

3D Bioprinting

Hyaluronic acid Methacryloyl (HAMA) MW 150 kDa is methacrylated hyaluronic acid that is biocompatible. Hyaluronic acid Methacryloyl is also used as a 3D printing hydrogel ink, which has the characteristics of fast photosensitive response, fast gelation speed and stable hydrogel performance. Hyaluronic acid Methacryloyl can quickly induce gelation with lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) under UV irradiation. The combination of Hyaluronic acid Methacryloyl and tissue-specific extracellular matrix (ECM) materials (such as pancreatic extracellular matrix (pECM)) will become an important source material for organoid culture .

HY-NP156

Type I Collagen, for cell culture, from Bovine	Native Proteins
Type I Collagen, for cell culture, from Bovine plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, for cell culture, from Bovine can mimic the extracellular matrix (ECM) and is suitable for 2D/3D cell culture .

HY-NP156A

Type I Collagen, for cell culture, from Porcine	Native Proteins
Type I Collagen, for cell culture, from Porcine plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, for cell culture, from Porcine can mimic the extracellular matrix (ECM) and is suitable for 2D/3D cell culture .

Cat. No.	Product Name	Target	Research Area

HY-W129161

Acetyl tetrapeptide-3	Peptides	Metabolic Disease
Acetyl tetrapeptide-3 combined with Biochanin A (HY-14595) and Acetyl tetrapeptide-3, can stimulate dermal papilla extracellular matrix (ECM) proteins by increasing hydroxyproline, Collagen Type 3, and laminin, yielding a significant improvement in hair follicle size and hair anchoring .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6812

Karacoline	Structural Classification Classification of Application Fields Terpenoids Source classification Ranunculaceae Diterpenoids Aconitum carmichaeli Debx. Plants Disease Research Fields Endocrinology	NF-κB
Karacoline, a diterpene alkaloid found in the plant Aconitum kusnezoffii, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway .

Species:	Human (1) Rat (1) Mouse (3)
Tag:	His (5)
Source:	HEK293 (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P75264

	ECM1 Protein, Rat (HEK293, His) extracellular matrix protein 1; Secretory component p85; Ecm1	Rat	HEK293
	The ECM1 protein is a multifaceted player that negatively regulates bone mineralization and affects endochondral bone formation. In addition to bone biology, it stimulates endothelial cell proliferation and angiogenesis and exerts regulatory control on MMP9 proteolytic activity. ECM1 Protein, Rat (HEK293, His) is the recombinant rat-derived ECM1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P75265

	ECM1 Protein, Mouse (HEK293, His) extracellular matrix protein 1; Secretory component p85; Ecm1	Mouse	HEK293
	ECM1 Protein, an extracellular matrix protein, is involved in various biological processes, including skin development, wound healing, and angiogenesis. It supports cell adhesion and migration, and regulates the structure and function of the extracellular matrix. Understanding the functions of ECM1 Protein is important for studying tissue remodeling and developing therapeutic strategies for ECM1-related disorders and diseases. ECM1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ECM1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P704031

	ECM1 Protein, Human (HEK293, His) extracellular matrix protein 1; Secretory component p85	Human	HEK293

HY-P76651

	SPARCL1 Protein, Mouse (650a.a, HEK293, His) SPARC-like protein 1; extracellular matrix protein 2; matrix glycoprotein Sc1; ECM2, SC1	Mouse	HEK293
	SPARCL1 protein has important functions such as calcium ion, collagen and extracellular matrix binding. SPARCL1 mainly plays a role in glutamatergic synaptic membrane adhesion. SPARCL1 Protein, Mouse (650a.a, HEK293, His) is the recombinant mouse-derived SPARCL1 protein, expressed by HEK293 , with C-His, C-10*His labeled tag.

HY-P76652

	SPARCL1 Protein, Mouse (283a.a, HEK293, His) SPARC-like protein 1; extracellular matrix protein 2; matrix glycoprotein Sc1; ECM2, SC1	Mouse	HEK293
	SPARCL1 protein has important functions such as calcium ion, collagen and extracellular matrix binding. SPARCL1 mainly plays a role in glutamatergic synaptic membrane adhesion. SPARCL1 Protein, Mouse (283a.a, HEK293, His) is the recombinant mouse-derived SPARCL1 protein, expressed by HEK293 , with N-His labeled tag.

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