exotoxin

By Targets:	Apoptosis (1) Bacterial (5) CD22 (1) CD28 (2) Endogenous Metabolite (3) Interleukin Related (1) PGE synthase (1)
By Research Areas:	Cancer (4) Infection (8) Inflammation/Immunology (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1028

Hexa-D-arginine 5 Publications Verification Furin Inhibitor II	Bacterial	Infection
Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with K_i values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo .

HY-P1028A

Hexa-D-arginine TFA 5 Publications Verification Furin Inhibitor II TFA	Bacterial	Infection
Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with K_i values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo .

HY-135416

Streptolysin O 1 Publications Verification	Endogenous Metabolite	Infection
Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state .

HY-135416A

Streptolysin O (≥1000000 units/mg)	Endogenous Metabolite	Infection
Streptolysin O (≥1000000 units/mg) is a ≥1000000 units/mg Streptolysin O (HY-135416). Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state .

HY-P1698

Reltecimod AB-103	Bacterial CD28	Infection Inflammation/Immunology Cancer
Reltecimod (AB-103) is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod has beneficial effects against different bacterial infections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, without inhibiting it. Reltecimod can be used to research necrotizing soft-tissue infections (NSTIs) .

HY-P2455

LLO (91-99) Listeriolysin O (91-99)	Bacterial	Infection Inflammation/Immunology
LLO (91-99) (Listeriolysin O (91-99)) is an exotoxin and class I MHC-restricted T-cell epitope of listeriolysin (LLO). LLO (91-99) is processed by antigen-presenting cells, binds to MHC class I molecules and is presented to the cell surface. LLO (91-99) induces CTL responses and effectively eliminates Listeria from infected cells. LLO (91-99) can be used in the research of Listeria infections (e.g., listeriosis) .

HY-P1698B

Reltecimod TFA AB-103 TFA	Bacterial CD28	Infection Inflammation/Immunology Cancer
Reltecimod (AB-103) TFA is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod TFA has beneficial effects against different bacterial infections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod TFA modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, without inhibiting it. Reltecimod TFA can be used to research necrotizing soft-tissue infections (NSTIs) .

HY-P990708

Bizaxofusp MDNA55; NBI-3001; PRX-321	Interleukin Related Apoptosis	Inflammation/Immunology Cancer
Bizaxofusp (MDNA55) is a fusion protein formed by the linkage of IL-4 and a truncated Pseudomonas exotoxin. Bizaxofusp can bind to IL-4 receptors on the surface of tumor cells and be internalized, and its exotoxin moiety can inhibit protein synthesis and induce tumor cell apoptosis. Bizaxofusp can be used in the study of cancer .

HY-112779

Pertussis Toxin	Endogenous Metabolite	Infection
Pertussis Toxin is a protein-based AB₅-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. Pertussis Toxin inhibits G protein-coupled receptor (GPR) signaling through Gi proteins .

HY-P991550

RFB4	CD22	Cancer
RFB4 is a anti-CD22 monoclonal antibody. RFB4 can construct recombinant immunotoxins by fusing with copper green pseudomonas exotoxin (PE38) through disulfide bonds such as RFB4(dsFv)-PE38. RFB4 can be used for research on cancer such as lymphoma .

HY-169430

AGU654	PGE synthase
AGU654 (Compound 44) is a selective mPGES-1 inhibitor with an IC₅₀ of 2.9 nM against mPGES-1. AGU654 inhibits mPGES-1 to block the pathway converting arachidonic acid into prostaglandin E2 (PGE2) by COX-1/2, thereby alleviating inflammatory responses, pain, and fever. In activated human monocyte-derived macrophages and human whole blood models, AGU654 selectively suppresses bacterial exotoxin-induced PGE2 production while preserving the production of other prostaglandins. In guinea pig models, AGU654 significantly alleviates fever, inflammation, and inflammatory pain, exhibiting excellent anti-inflammatory, analgesic, and antipyretic effects. AGU654 holds promise as a strategy for studying inflammatory diseases and pain .

Cat. No.	Product Name	Target	Research Area

HY-P1028

Hexa-D-arginine 5 Publications Verification Furin Inhibitor II	Bacterial	Infection
Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with K_i values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo .

HY-P1028A

Hexa-D-arginine TFA 5 Publications Verification Furin Inhibitor II TFA	Bacterial	Infection
Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with K_i values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo .

HY-P1698

Reltecimod AB-103	Bacterial CD28	Infection Inflammation/Immunology Cancer
Reltecimod (AB-103) is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod has beneficial effects against different bacterial infections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, without inhibiting it. Reltecimod can be used to research necrotizing soft-tissue infections (NSTIs) .

HY-P2455

LLO (91-99) Listeriolysin O (91-99)	Bacterial	Infection Inflammation/Immunology
LLO (91-99) (Listeriolysin O (91-99)) is an exotoxin and class I MHC-restricted T-cell epitope of listeriolysin (LLO). LLO (91-99) is processed by antigen-presenting cells, binds to MHC class I molecules and is presented to the cell surface. LLO (91-99) induces CTL responses and effectively eliminates Listeria from infected cells. LLO (91-99) can be used in the research of Listeria infections (e.g., listeriosis) .

HY-P1698B

Reltecimod TFA AB-103 TFA	Bacterial CD28	Infection Inflammation/Immunology Cancer
Reltecimod (AB-103) TFA is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod TFA has beneficial effects against different bacterial infections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod TFA modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, without inhibiting it. Reltecimod TFA can be used to research necrotizing soft-tissue infections (NSTIs) .

Cat. No.	Product Name	Target	Research Area

HY-P990708

Bizaxofusp MDNA55; NBI-3001; PRX-321	Interleukin Related Apoptosis	Inflammation/Immunology Cancer
Bizaxofusp (MDNA55) is a fusion protein formed by the linkage of IL-4 and a truncated Pseudomonas exotoxin. Bizaxofusp can bind to IL-4 receptors on the surface of tumor cells and be internalized, and its exotoxin moiety can inhibit protein synthesis and induce tumor cell apoptosis. Bizaxofusp can be used in the study of cancer .

HY-P991550

RFB4	CD22	Cancer
RFB4 is a anti-CD22 monoclonal antibody. RFB4 can construct recombinant immunotoxins by fusing with copper green pseudomonas exotoxin (PE38) through disulfide bonds such as RFB4(dsFv)-PE38. RFB4 can be used for research on cancer such as lymphoma .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-135416

Streptolysin O 1 Publications Verification	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state .

HY-135416A

Streptolysin O (≥1000000 units/mg)	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Streptolysin O (≥1000000 units/mg) is a ≥1000000 units/mg Streptolysin O (HY-135416). Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state .

Cat. No.	Compare	Product Name	Species	Source

HY-P704245

	SPEB Protein, Streptococcus pyogenes (His-SUMO) speB; Streptopain; EC 3.4.22.10; exotoxin type B; SPE B; Streptococcal cysteine proteinase; Streptococcus peptidase A; SPP	Others	E. coli
	SPEB Protein, Streptococcus pyogenes (His-SUMO) is the recombinant SPEB protein, expressed by E. coli, with N-6*His & N-SUMO tag.

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