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dynein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ceramidase (1) Endogenous Metabolite (1) Hedgehog (2)
By Research Areas:	Cancer (3) Inflammation/Immunology (1)

4

Inhibitors & Agonists

2

Recombinant Proteins

4

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Ciliobrevin D 4 Publications Verification	Hedgehog	Cancer
Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits *dynein*-dependent microtubule gliding and ATPase activity in vitro .

Dynarrestin 2 Publications Verification	Hedgehog	Cancer
Dynarrestin is a aminothiazole inhibitor of *cytoplasmic dyneins* 1 and 2*. Dynarrestin rapidly and reversibly inhibits dynein* 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells .

AZD4877 hydrochloride	Endogenous Metabolite	Cancer
AZD4877 hydrochloride is a synthetic dynein inhibitor with potential anti-tumor activity. AZD4877 selectively inhibits the microtubule dynein KSP (also known as kinesin-5 or Eg5), which may lead to inhibition of mitotic spindle assembly. The action of AZD4877 may activate the spindle assembly checkpoint, leading to cell cycle arrest at the mitotic stage. AZD4877 may induce cell death in actively dividing tumor cells. AZD4877 may be less likely to cause peripheral neuropathy associated with microtubule-targeted compounds as it is not involved in post-mitotic processes. AZD4877 is essential for the formation of bipolar spindles and the proper segregation of sister chromosomes .

Acid Ceramidase-IN-3	Ceramidase	Inflammation/Immunology
Acid Ceramidase-IN-3 is a acid ceramidase (aCDase) inhibitor. Acid Ceramidase-IN-3 inhibits the enzymatic activity of aCDase with a pIC ₅₀ of 8.5 in enzymatic assays and 6.8 in A375 melanoma cellular assays. Acid Ceramidase-IN-3 promotes HSC inactivation, as measured by a dose-dependent reduction in COL1A1 and ACTA2. Acid Ceramidase-IN-3 inhibits aCDase activity in HSCs, promotes HSC inactivation and suppresses YAP/TAZ nuclear localization. Acid Ceramidase-IN-3 increases Dynein/Kinesin (NDE1, NDEL1. KIF3B, KIF15) while decreases several proteins involved with signaling pathway (SARM1, RGAP1, PDGF-D,PDGFR-B). Acid Ceramidase-IN-3 can be used for the study of fibrotic diseases .

Species:	Human (2)
Tag:	His (2) SUMO (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

	PIN/DYNLL1 Protein, Human (His) rHudynein light chain 1, cytoplasmic/DYNLL1, His; dynein Light Chain 1 Cytoplasmic; 8 kDa dynein Light Chain; DLC8; dynein Light Chain LC8-Type 1; Protein Inhibitor of Neuronal Nitric Oxide Synthase; PIN; DYNLL1; DLC1; DNCL1; DNCLC1; HDLC1	Human	E. coli
	PIN/DYNLL1 acts as a non-catalytic accessory component in the cytoplasmic dynein 1 complex, connecting dynein to cargos and adapter proteins for dynein modulation. It functions as a motor for retrograde vesicle movement along microtubules, potentially influencing cytoskeletal structure. PIN/DYNLL1 enhances ESR1 transactivation and aids ESR1 nuclear localization. PIN/DYNLL1 Protein, Human (His) is the recombinant human-derived PIN/DYNLL1 protein, expressed by E. coli , with N-6*His labeled tag.

	DCTN1 Protein, Human (His-SUMO) 150kDa dynein associated polypeptide; 150kDa dynein-associated polypeptide; DAP 150; DAP-150; DAP150; DCTN 1; DCTN1; DCTN1_HUMAN; DP 150; DP-150; DP150; Dynactin 1 (p150 Glued (Drosophila) homolog); Dynactin 1 (p150 glued homolog Drosophila); Dynactin 1; Dynactin subunit 1; Dynactin1; HMN7B; p135; p150 Glued (Drosophila) homolog ; p150 glued; p150 glued homolog; p150(GLUED) DROSOPHILA HOMOLOG OF; p150-glued; p150glued	Human	E. coli
	The DCTN1 protein is a central player in intracellular trafficking within the dynein complex, guiding dynein-driven retrograde movement along microtubules. It recruits dynein to microtubules, enhancing vesicle and organelle transport. DCTN1 Protein, Human (His-SUMO) is the recombinant human-derived DCTN1 protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

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	Dynein Light Chain Tctex Type 1 Antibody (YA3263) CW-1; TCTEL1; tctex-1	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Dynein Light Chain Tctex Type 1 Antibody (YA3263) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dynein Light Chain Tctex Type 1.

	Dynein Intermediate Chain 1 Antibody (YA3374) DNAI1; ICS; Immotile cilia syndrome 1; ICS1; CILD1; PCD	WB	Human, Mouse, Rat
	Dynein Intermediate Chain 1 Antibody (YA3374) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dynein Intermediate Chain 1.

	Dynactin 1 Antibody (YA5119) DCTN1; Dynactin subunit 1; 150 kDa dynein-associated polypeptide; DAP-150; DP-150; p135; p150-glued	WB, ICC/IF	Human, Mouse, Bovine, Pig
	Dynactin 1 Antibody (YA5119) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Dynactin 1.

	Dynactin 1(N-term) Antibody (YA5180) 150 kDa dynein associated polypeptide; 150 kDa dynein-associated polypeptide; DAP 150; DAP-150; DAP150; DCTN 1; DCTN1; DCTN1_HUMAN; DP 150; DP-150; DP150; Dynactin 1; p150 Glued; Drosophila; homolog; dynactin 1; p150 glued homolog Drosophila; Dynactin 1; Dynactin subunit 1; Dynactin1; HMN7B; p135; p150 Glued; Drosophila; homolog; p150 glued; p150 glued homolog; p150; GLUED; DROSOPHILA HOMOLOG OF; p150-glued; p150glued.	WB, IP	Human
	Dynactin 1(N-term) Antibody (YA5180) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Dynactin 1(N-term).

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