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donor substrate

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43

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8

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W012145
    TMPD dihydrochloride

    		Others Metabolic Disease
    TMPD dihydrochloride, a readily oxidizable compound, is an enzymatically convert redox active substrate molecule. TMPD dihydrochloride is also an electron donor and serves as a reducing cosubstrate for heme peroxidases . TMPD dihydrochloride is also a complex IV substrate .
    TMPD dihydrochloride
  • HY-N7389A
    GDP-D-mannose disodium

    		Endogenous Metabolite Metabolic Disease
    GDP-D-mannose disodium contains GDP-α-D-mannose (HY-N7389B) and GDP-β-D-mannose. GDP-α-D-mannose is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM) .
    GDP-D-mannose disodium
  • HY-N10573
    UDP-rhamnose
    1 Publications Verification

    		 Endogenous Metabolite Others
    UDP-rhamnose is one of the substrates for pectin synthesis in cell wall. UDP-rhamnose can be identified in fungi. UDP-rhamnose is one of the most common sugar donors in plants. UDP-rhamnose synthesis requires recombinant enzymes. UDP-rhamnose can be synthesized from UDP-glucose through the consecutive three-step reaction catalyzed by a single structure enzyme in plants .
    UDP-rhamnose
  • HY-112174
    UDP-GlcNAc disodium
    5 Publications Verification

    UDP-α-D-N-Acetylglucosamine disodium

    		 OGT Metabolic Disease
    UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (OGT).
    UDP-GlcNAc disodium
  • HY-W250153
    Adenosine 3'-phosphate 5'-phosphosulfate lithium

    		Biochemical Assay Reagents Others
    Adenosine 3'-phosphate 5'-phosphosulfate lithium is a co-substrate used for the sulfonation of glycans. Adenosine 3'-phosphate 5'-phosphosulfate lithium can be used for Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays, which as donor substrate to transfer a sulfonate group .
    Adenosine 3'-phosphate 5'-phosphosulfate lithium
  • HY-P6959
    N3AcAAPF-glycolate-FG-amide

    		Biochemical Assay Reagents Others
    N3AcAAPF-glycolate-FG-amide is an ester donor subtiligase substrate. subtiligase contains azide .
    N3AcAAPF-glycolate-FG-amide
  • HY-D1079
    EDANS sodium

    		DNA Stain Others
    EDANS sodium is a potent fluorogenic substrates. EDANS sodium is a donor for FRET-based nucleic acid probes and protease substrates. EDANS sodium is often paired with DABCYL or DABSYL. The optimal absorbance and emission wavelengths of EDANS sodium are λabs = 336 nm and λem = 490 nm respectively .
    EDANS sodium
  • HY-137802
    SAHO2

    S-Adenosyl-L-homocysteine sulfone

    		 Amino Acid Derivatives Others
    SAHO2 is the sulfone form of the methyl donor S-(5'-adenosyl)-L-methionine chloride (SAM) and serves as a substrate for radical SAM enzymes .
    SAHO2
  • HY-148869A
    Hexanoyl-Coenzyme A triammonium

    06:0 Coenzyme A

    		 Biochemical Assay Reagents Metabolic Disease
    Hexanoyl-Coenzyme A triammonium (06:0 Coenzyme A) is a medium-chain fatty acyl CoA that is an acyl donor substrate for ghrelin O-acyltransferase (GOAT) .
    Hexanoyl-Coenzyme A triammonium
  • HY-P10922
    Cathepsin E substrate e

    		Cathepsin Others
    Cathepsin E substrate e is a substrate of Cathepsin E. Cathepsin E substrate e was designed in such a way that due to the close proximity of a Mca-donor and a Dnp-acceptor, a near complete intramolecular quenching effect was achieved in its intact state. After the proteolytic cleavage of the hydrophobic motif of the peptide substrate, both Mca and Dnp would be further apart, resulting in bright fluorescence .
    Cathepsin E substrate e
  • HY-112169
    10-Formyltetrahydrofolic acid

    		Endogenous Metabolite Metabolic Disease
    10-Formyltetrahydrofolic acid is a form of tetrahydrofolic acid that acts as a donor of formyl groups in anabolism. 10-Formyltetrahydrofolic acid can be used as a substrate for formyltransferase reactions and is involved in the biosynthesis of purines .
    10-Formyltetrahydrofolic acid
  • HY-112169A
    10-Formyltetrahydrofolic acid disodium

    		Endogenous Metabolite Metabolic Disease
    10-Formyltetrahydrofolic acid disodium is a form of tetrahydrofolic acid that acts as a donor of formyl groups in anabolism. 10-Formyltetrahydrofolic acid disodium can be used as a substrate for formyltransferase reactions and is involved in the biosynthesis of purines .
    10-Formyltetrahydrofolic acid disodium
  • HY-D0845
    Nitrosoglutathione
    4 Publications Verification

    GSNO; RVC-588; S-Nitroso-L-glutathione

    		 Endogenous Metabolite Angiotensin Receptor Cardiovascular Disease Inflammation/Immunology
    Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses .
    Nitrosoglutathione
  • HY-W250153A
    Adenosine 3'-phosphate 5'-phosphosulfate lithium, hydrate

    		Biochemical Assay Reagents Others
    Adenosine 3'-phosphate 5'-phosphosulfate lithium is a co-substrate used for the sulfonation of glycans. Adenosine 3'-phosphate 5'-phosphosulfate lithium can be used for Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays, which as donor substrate to transfer a sulfonate group .
    Adenosine 3'-phosphate 5'-phosphosulfate lithium, hydrate
  • HY-E70191
    β-1,4-Galactosyltransferase 2

    EC:2.4.1.22; B4GALT2

    		 Glycosyltransferase Others
    β-1,4-Galactosyltransferase 2 catal exclusive specificity for the donor substrate UDP-galactose and all transfer galactosein a beta1,4 linkage .
    β-1,4-Galactosyltransferase 2
  • HY-112174S
    UDP-GlcNAc-13C disodium

    UDP-α-D-N-Acetylglucosamine-13C disodium

    		 Isotope-Labeled Compounds Metabolic Disease
    UDP-GlcNAc- 13C (disodium) is the 13C labeled UDP-GlcNAc Disodium Salt. UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (O .
    UDP-GlcNAc-13C disodium
  • HY-N11287
    UDP-xylose

    		Endogenous Metabolite Others
    UDP-xylose is an endogenous sugar nucleotide and a catalytic substrate of UDP-xylose synthase (UXS). UDP-xylose is a sugar donor for the synthesis of glycoproteins, polysaccharides, various metabolites and oligosaccharides in plants, vertebrates and fungi, and participates in the synthesis of proteoglycans as a glycosyl donor. UDP-xylose participates in the regulation of the synthesis of extracellular matrix components and can be used to study the mechanism of proteoglycan biosynthesis in glycobiology and related diseases (such as connective tissue diseases)[1][2].
    UDP-xylose
  • HY-E70024
    CMP-sialic acid synthetase (NmCSS)

    		Sialyltransferase Others
    CMP-sialic acid synthetase (NmCSS) is an essential enzyme involved in the biosynthesis of carbohydrates and glycoconjugates containing sialic acids. CMP-sialic acid synthetase (NmCSS) activates free Sia, converting it to CMP-Sia, which is the only donor substrate for all sialyltransferases .
    CMP-sialic acid synthetase (NmCSS)
  • HY-18743
    Coelenterazine
    5 Publications Verification

    		 Reactive Oxygen Species (ROS) Cancer
    Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite (Ex/Em = 429/466 nm) .
    Coelenterazine
  • HY-114365
    UDP-GalNAc disodium

    UDP-N-acetyl-D-galactosamine disodium

    		 Endogenous Metabolite Metabolic Disease
    UDP-GalNAc (UDP-N-acetyl-D-galactosamine) disodium is a sugar nucleotide and a substrate of EpsC115. EpsC115 is an exopolymeric substances (EPS) N-terminal deletion mutant with the residue 1-115 deletion. UDP-GalNAc UDP-GalNAc is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GalNAc from the nucleotide sugar to a saccharide or peptide acceptor .
    UDP-GalNAc disodium
  • HY-N11287A
    UDP-xylose disodium

    		Endogenous Metabolite Others
    UDP-xylose disodium is an endogenous sugar nucleotide and a catalytic substrate of UDP-xylose disodium synthase (UXS). UDP-xylose disodium is a sugar donor for the synthesis of glycoproteins, polysaccharides, various metabolites and oligosaccharides in plants, vertebrates and fungi, and participates in the synthesis of proteoglycans as a glycosyl donor. UDP-xylose disodium participates in the regulation of the synthesis of extracellular matrix components and can be used to study the mechanism of proteoglycan biosynthesis in glycobiology and related diseases (such as connective tissue diseases)[1][2].
    UDP-xylose disodium
  • HY-E70138
    β-1,4-Galactosyltransferase 7

    EC:2.4.1.133; B4GALT7

    		 Glycosyltransferase Others
    β-1,4-Galactosyltransferase 7 has exclusive specificity for the donor substrate UDP-galactose and all transfer galactose in a β-1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. .
    β-1,4-Galactosyltransferase 7
  • HY-P10172
    Abz-SDK(Dnp)P-OH

    		Angiotensin-converting Enzyme (ACE) Neurological Disease
    Abz-SDK(Dnp)P-OH is a fluorescence peptide. Abz-SDK(Dnp)P-OH is the substrate of angiotensin I-converting enzyme (ACE). Abz-SDK(Dnp)P-OH has fluorescent donor-acceptor pair Abz and Dnp (2,4-dinitrophenyl) .
    Abz-SDK(Dnp)P-OH
  • HY-N7389B
    GDP-α-D-mannose disodium

    		Endogenous Metabolite Metabolic Disease
    GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM) .
    GDP-α-D-mannose disodium
  • HY-E70286
    N-Acetylglucosaminyltransferase V

    MGAT4B

    		 Biochemical Assay Reagents Cancer
    N-Acetylglucosaminyltransferase V (MGAT4B) is the enzyme that catalyzes the formation of the β1,6-GlcNAc branch of N-glycans in the Golgi apparatus using UDP-GlcNAc as the donor substrate. N-Acetylglucosaminyltransferase V is involved in cancer malignancy and autoimmune disease etiology .
    N-Acetylglucosaminyltransferase V
  • HY-D0845R
    Nitrosoglutathione (Standard)

    GSNO (Standard); RVC-588 (Standard); S-Nitroso-L-glutathione (Standard)

    		 Reference Standards Endogenous Metabolite Angiotensin Receptor Cardiovascular Disease Inflammation/Immunology
    Nitrosoglutathione (Standard) (GSNO (Standard)) is the analytical standard of Nitrosoglutathione (HY-D0845). This product is intended for research and analytical applications. Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses. x
    Nitrosoglutathione (Standard)
  • HY-162654
    FXIIIa-IN-1

    		Factor VIII Cardiovascular Disease
    FXIIIa-IN-1 (Compound 16) is a potent and selective FXIIIa (Factor XIIIa) inhibitor with an IC50 value of 2.4 μM. FXIIIa-IN-1 inhibits FXIIIa by competing with the Gln-donor protein substrate (dimethylcasein). FXIIIa-IN-1 holds promise for the development of effective and safe novel anticoagulants .
    FXIIIa-IN-1
  • HY-W076543
    5-(Biotinamido)pentylamine

    		Transglutaminase Others
    5-(Biotinamido)pentylamine is an amine donor substrate for transglutaminase. 5-(Biotinamido)pentylamine can be used as a biotin-labeled probe to specifically participate in the calcium-dependent reaction catalyzed by TG, bind to the γ-carboxamide group of the glutamine residue in the protein, introduce the biotin tag into the target protein, and form a biotinylated protein product. 5-(Biotinamido)pentylamine can be used for the labeling, separation, and detection of TG amine receptor protein substrates .
    5-(Biotinamido)pentylamine
  • HY-134393
    6-Me-ATP

    N6-Methyl-ATP

    		 GSK-3 Others
    6-Me-ATP (N6-Methyl-ATP) is a N 6-modified ATP derivative. 6-Me-ATP shows excellent binding affinity to GSK3, serving as the phosphate group donor for GSK3β-catalyzed phosphorylation of its substrate peptide .
    6-Me-ATP
  • HY-134393B
    6-Me-ATP (trisodium) solution (100mM)

    N6-Methyl-ATP (trisodium) solution (100mM)

    		 GSK-3 Others
    6-Me-ATP (N6-Methyl-ATP) trisodium solution (100mM) is a N 6-modified ATP derivative. 6-Me-ATP trisodium shows excellent binding affinity to GSK3, serving as the phosphate group donor for GSK3β-catalyzed phosphorylation of its substrate peptide .
    6-Me-ATP (trisodium) solution (100mM)
  • HY-E70132
    Endo-β-N-acetylglucosaminidase D

    Endo D

    		 Glycosidase Metabolic Disease
    Endo-β-N-acetylglucosaminidase D (Endo D), isolated from Streptococcus pneumoniae. Endo-β-N-acetylglucosaminidase D hydrolyzes Fc N-glycan of intact IgG antibodies after sequential removal of the sialic acid, galactose, and internal GlcNAc residues in the N-glycan. Endo-β-N-acetylglucosaminidase D possesses transglycosylation activity with sugar oxazoline as the donor substrate .
    Endo-β-N-acetylglucosaminidase D
  • HY-110196
    (S)-PFI-2 hydrochloride

    		Histone Methyltransferase Others
    (S)-PFI-2 hydrochloride is an inhibitor of lysine methyltransferase SETD7 and is approximately 500-fold more active than its enantiomer (R)-PFI-2. (R)-PFI-2 is a cofactor-dependent and substrate-competitive inhibitor. (R)-PFI-2 can occupy the substrate peptide binding groove of SETD7 (including the catalytic lysine binding channel) and interact with the cofactor The donor methyl group is in direct contact. However, (S)-PFI-2 was not observed to have the same interaction as (R)-PFI-2 .
    (S)-PFI-2 hydrochloride
  • HY-P2888A
    Bilirubin oxidase, bacillus cereus

    BOD, bacillus cereus

    		 Endogenous Metabolite Metabolic Disease
    Bilirubin oxidase, bacillus cereus is a multi-copper oxidase that catalyzes the oxidation of bilirubin into biliverdin, as well as other tetrapyrroles, phenols, and aryl diamines. Bilirubin oxidase, bacillus cereus can serve as a single-enzyme deoxygenator, catalyzing the direct reduction of oxygen to water in the presence of electron donor substrates, without releasing hydrogen peroxide. Bilirubin oxidase, bacillus cereus can be used to develop enzyme-based biosensors .
    Bilirubin oxidase, bacillus cereus
  • HY-P2888C
    Bilirubin oxidase, Bacillus pumilus

    BOD, Bacillus pumilus

    		 Endogenous Metabolite Metabolic Disease
    Bilirubin oxidase (BOD), Bacillus pumilus is a multicopper oxidase that catalyzes the oxidation of bilirubin to biliverdin, as well as other tetrapyrrole, phenols, and aryl diamines. Bilirubin oxidase, Bacillus pumilus can serve as a single-enzyme deoxygenator, catalyzing the direct reduction of oxygen to water in the presence of electron donor substrates, without releasing hydrogen peroxide. Bilirubin oxidase, Bacillus pumilus can be used to develop enzyme-based biosensors .
    Bilirubin oxidase, Bacillus pumilus
  • HY-125954A
    Uridine diphosphate glucuronic acid ammonium

    UDP-α-D-glucuronic acid ammonium

    		 Endogenous Metabolite Metabolic Disease
    Uridine diphosphate glucuronic acid (UDP-GlcA) ammonium is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase. Uridine diphosphate glucuronic acid (ammonium) is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Uridine diphosphate glucuronic acid (ammonium), as a glucuronic acid donor, can be used for for the research of the conjugation of bilirubin in the endoplasmic recticulum .
    Uridine diphosphate glucuronic acid ammonium
  • HY-125954
    Uridine diphosphate glucuronic acid

    UDP-α-D-glucuronic acid

    		 Endogenous Metabolite Metabolic Disease
    Uridine diphosphate glucuronic acid (UDP-α-D-glucuronic acid) is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase. Uridine diphosphate glucuronic acid is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Uridine diphosphate glucuronic acid as a glucuronic acid donor, can be used for for the research of the conjugation of bilirubin in the endoplasmic recticulum .
    Uridine diphosphate glucuronic acid
  • HY-112942A
    CMP-Sialic acid sodium salt
    2 Publications Verification

    CMP-Neu5Ac sodium salt

    		 Endogenous Metabolite Metabolic Disease
    CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium salt is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .
    CMP-Sialic acid sodium salt
  • HY-112942
    CMP-Sialic acid

    CMP-Neu5Ac

    		 Endogenous Metabolite Metabolic Disease
    CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .
    CMP-Sialic acid
  • HY-112942AR
    CMP-Sialic acid sodium salt (Standard)

    		Endogenous Metabolite Metabolic Disease
    CMP-Sialic acid (sodium salt) (Standard) is the analytical standard of CMP-Sialic acid (sodium salt). This product is intended for research and analytical applications. CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium salt is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .
    CMP-Sialic acid sodium salt (Standard)
  • HY-145934A
    UDP-GlcNAz disodium

    		OGT Biochemical Assay Reagents Glycosidase Metabolic Disease
    UDP-GlcNAz disodium (UDP-N-azidoacetylgalactosamine disodium) is the analogue of UDP-GlcNAc (HY-112174). UDP-GlcNAc is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GlcNAc from the nucleotide sugar to a saccharide or peptide acceptor . UDP-GlcNAc (disodium) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    UDP-GlcNAz disodium
  • HY-145934
    UDP-GalNAz disodium

    UDP-N-azidoacetylgalactosamine disodium

    		 Biochemical Assay Reagents OGT Glycosidase Metabolic Disease
    UDP-GalNAz (UDP-N-azidoacetylgalactosamine) disodium is the analogue of UDP-GalNAc (HY-114365). UDP-GalNAc is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GalNAc from the nucleotide sugar to a saccharide or peptide acceptor . UDP-GalNAz (disodium) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    UDP-GalNAz disodium
  • HY-125954S
    Uridine diphosphate glucuronic acid-13C,15N2

    UDP-α-D-glucuronic acid-13C,15N2

    		 Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    Uridine diphosphate glucuronic acid- 13C, 15N2 (UDP-α-D-glucuronic acid- 13C, 15N2) is the 13C- and 15N-labeled Uridine diphosphate glucuronic acid (HY-125954). Uridine diphosphate glucuronic acid (UDP-α-D-glucuronic acid) is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase. Uridine diphosphate glucuronic acid is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Uridine diphosphate glucuronic acid as a glucuronic acid donor, can be used for for the research of the conjugation of bilirubin in the endoplasmic recticulum .
    Uridine diphosphate glucuronic acid-13C,15N2
  • HY-113324
    NADPH
    Maximum Cited Publications
    11 Publications Verification

    		 Endogenous Metabolite Cancer
    NADPH is a coenzyme of glutathione reductase (GR), thioredoxin reductase (TrxR) and NADPH oxidase (NOX), and participates in redox reactions as a hydrogen donor. NADPH has the characteristic of selectively participating in the regulation of cellular redox homeostasis. NADPH exerts antioxidant activity and resists reactive oxygen species (ROS) damage by providing reducing equivalents for the regeneration of glutathione (GSH) and thioredoxin (Trx); at the same time, it acts as a substrate of NOX to generate superoxide anions, mediating oxidative stress and immune response. NADPH participates in maintaining the intracellular reducing environment, biosynthesis and regulating gene expression (such as the Nrf2 pathway), and is mainly used in the study of oxidative stress-related diseases (such as cardiovascular diseases, neurodegenerative diseases, cancer) and immune regulation mechanisms .
    NADPH

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