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disc

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Androgen Receptor (2) Antibiotic (1) Apoptosis (3) Autophagy (1) Bacterial (4) Caspase (1) Endogenous Metabolite (2) Fluorescent Dye (2) FOXO (1) Fungal (1) Histone Acetyltransferase (2) Interleukin Related (3) JAK (1) Keap1-Nrf2 (1) Lipoxygenase (1) MMP (1) mTOR (1) nAChR (2) NF-κB (2) p38 MAPK (2) Parasite (1) PI3K (1) Pyroptosis (1) Reference Standards (2) Small Interfering RNA (siRNA) (3) STAT (1) Toll-like Receptor (TLR) (2) YTHDF (1)
By Research Areas:	Cancer (5) Endocrinology (2) Infection (7) Inflammation/Immunology (8) Metabolic Disease (1) Neurological Disease (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0085

DiSC3(5) Maximum Cited Publications 8 Publications Verification	Fluorescent Dye	Others
DiSC3(5) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3(5) is up to 622/670 nm. DiSC3(5) can inhibit the respiratory system associated with mitochondrial NAD, and the IC₅₀ value is 8 μM. DiSC3(5) in the presence of Na ⁺/K ⁺-ATPase inhibitor ouabain 2 can induce membrane hyperpolarization of Ehrlich ascites tumor cells .

HY-P990446

*Anti-IL-15 Antibody (DISC0280)* disc0280	Interleukin Related	Inflammation/Immunology
The Anti-IL-15 Antibody (DISC0280) is a CHO-expressed human antibody that targets IL-15. The Anti-IL-15 Antibody (DISC0280) has a huIgG1 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-IL-15 Antibody (DISC0280) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P10954

Link N peptide	p38 MAPK	Others
Link N peptide is a proteoglycan aggregates activator in the extracellular matrix. Link N peptide can selectively activate the p38 mitogen-activated protein kinase (MAPK) pathway to promote the expression of type I and II collagens in human intervertebral disc cells. Link N peptide is promising for research of intervertebral disc degeneration-related diseases .

HY-108909

Chymopapain	Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Chymopapain is a non-specific proteo-glycanase derived from the papaya plant. Chymopapain directly into the intervertebral disc caused disc narrowing due to dissolution of the extruded material. Chymopapain has the potential for the research of herniated lumbar discs .

HY-N9942

Physalin A 1 Publications Verification	Apoptosis Autophagy NF-κB p38 MAPK PI3K Akt mTOR STAT JAK	Inflammation/Immunology Cancer
Physalin A is a biologically active withanolide. Physalin A shows anti-inflammatory, antifibrotic and ameliorative effects on autophagy in models of disc degeneration. Physalin A has antitumor activity and can induce apoptosis, ROS production and G2/M phase cell cycle arrest. Besides. Physalin A can significantly increase the activity of quinone reductase and increase the expression of detoxifying enzymesc .

HY-D1626

DiSC18(3) 3,3'-Dioctadecylthiacarbocyanine perchlorate	Fluorescent Dye	Others
DiSC18(3) is a lipophilic carbocyanine dye for membrane labelling .

HY-RS03781

DISC1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DISC1 Human Pre-designed siRNA Set A contains three designed siRNAs for DISC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DISC1 Human Pre-designed siRNA Set A DISC1 Human Pre-designed siRNA Set A

HY-RS28073

Disc1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Disc1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Disc1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Disc1 Rat Pre-designed siRNA Set A Disc1 Rat Pre-designed siRNA Set A

HY-RS21555

Disc1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Disc1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Disc1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Disc1 Mouse Pre-designed siRNA Set A Disc1 Mouse Pre-designed siRNA Set A

HY-N11756

Linearmycin A	Bacterial	Infection
Linearmycin A is a polyene antibiotic that has been found in Streptomyces. It is active against the bacteria S. aureus and E. coli (MICs=3.1 and 1.6 μg/disc, respectively), the fungi S. cerevisiae and C. albicans (MICs=0.1 and 1.6 μg/disc, respectively), and the plant pathogenic fungus A. niger in disc assays (MIC=0.2 μg/disc). Linearmycin A induces lysis and degradation of B. subtilis as a component of Streptomyces Mg1 extract.

HY-121003

Aspyrone	Fungal Parasite	Infection
Aspyrone is a polyketide fungal metabolite that has been found in Aspergillus and has diverse biological activities. It is active against a panel of 13 fungi when used at a concentration of 20 μg/mL and a panel of 21 bacteria in a disc assay when used at a concentration of 100 μg per disc.1 Aspyrone (10-1,000 mg/L) is nematocidal against P. penetrans.

HY-129316

Dihydroaeruginoic Acid CGP 52547	Antibiotic	Infection
Dihydroaeruginoic acid is an antibiotic originally isolated from P. fluorescens. It has antimicrobial activity in a disc assay against R. solani, P. ultimum, B. cinera, S. rolfsii, C. gloeosporioide, F. oxysporum, and S. tritici fungi as well as B. subtilis, E. herbicola, and S. albus bacteria when used at a concentration of 200 μg/disc.

HY-N6812

Karacoline	NF-κB	Endocrinology
Karacoline, a diterpene alkaloid found in the plant Aconitum kusnezoffii, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway .

HY-113614

Tetrahydrobostrycin	Bacterial	Infection
Tetrahydrobostrycin is a secondary metabolite from Aspergillus sp., which exhibits a weak inhibitory activity against Staphylococcus aureus and Escherichia coli (100 mg/disc with the inhibition zones of 15 and 9.2 mm in diameter) .

HY-B1700A

Mivacurium dichloride	nAChR	Neurological Disease
Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell .

HY-P10326

Z-ATAD-FMK	Caspase Apoptosis	Cancer
Z-ATAD-FMK is an inhibitor of caspase-12. Z-ATAD-FMK is an inhibitor of caspase-12. Z-ATAD-FMK prevents endoplasmic reticulum stress-mediated apoptosis by inhibiting the activity of caspase-12 and reducing the activity of caspase-9 .

HY-N2292

Kinsenoside 4 Publications Verification	Keap1-Nrf2 Apoptosis	Inflammation/Immunology
Kinsenoside is the main active ingredient of the genus plant, and has various biological activities. Kinsenoside and Nrf2 depend on the protection of nuclear cells (NPCs), which significantly reduces their ability to survive. Kinsenoside Active NPC Medium AKT-ERK1/2-Nrf2 Signal passage, Prevent physical decline, aging, harmonious physical function impairment. Kinsenoside can improve the puncture guide model for intermediate vertebral wall discharge (IDD).

HY-N8296

Saccharocarcin A	Bacterial	Infection
Saccharocarcin A is an antibiotic originally isolated from S. aerocolonigenes subsp. antibiotica. It is active against M. luteus, S. aureus, E. coli, P. aeruginosa, and C. albicans in a disc assay. Saccharocarcin A inhibits C. trachomatis infection by 88% without inducing cytotoxicity in McCoy cells when used at a concentration of 0.5 μg/mL.

HY-B1700AR

Mivacurium dichloride (Standard)	Reference Standards nAChR	Neurological Disease
Mivacurium (dichloride) (Standard) is the analytical standard of Mivacurium (dichloride). This product is intended for research and analytical applications. Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell .

HY-133865

Diacetoxy-6-gingerdiol 1 Publications Verification	Interleukin Related	Metabolic Disease Inflammation/Immunology
Diacetoxy-6-gingerdiol is a gingerol isolated with anti-inflammatory and antioxidant effects, which is found in the dichloromethane extract of rhizomes of ginger (Zingiber officinale Roscoe). Diacetoxy-6-gingerdiol protects the extracellular matrix of nucleus pulposus cells and ameliorates intervertebral disc degeneration by inhibiting the IL-1β-mediated NLRP3 pathway .

HY-15091

Anisperimus LF-150195	Endogenous Metabolite	Neurological Disease
Anisperimus (LF-150195) is an immunosuppressant with the activity of enhancing activation-induced T cell death. Anisperimus enhances the sensitivity of T cells to anti-CD95 antibodies and other inducers by promoting the activation of caspase-8 and caspase-10 at the level of the death-inducing signaling complex (DISC). Anisperimus also promotes the development of Foxp3-expressing regulatory CD4 T cells, thereby preventing central nervous system autoimmunity .

HY-N2345

Procyanidin B3 1 Publications Verification	Histone Acetyltransferase Toll-like Receptor (TLR) Androgen Receptor	Inflammation/Immunology Cancer
Procyanidin B3 is a natural product with antioxidant activity and oral bioavailability, possessing good blood-brain barrier penetration. Procyanidin B3 is a selective inhibitor of histone acetyltransferase (HAT). By inhibiting p300 HAT-mediated acetylation of the androgen receptor (androgen receptor). Procyanidin B3 alleviates intervertebral disc degeneration (IVDD) by inhibiting the formation of the TLR4/MD-2 complex. Procyanidin B3 can be used in research on prostate cancer and arthritis .

HY-122980

Myxochelin A (S)-Myxochelin A	Lipoxygenase	Infection
Myxochelin A is a microbial metabolite that has been found in A. disciformis and has diverse biological activities. It is active against Gram-positive bacteria, including B. cereus, S. aureus, and M. luteus, but not Gram-negative bacteria or fungi in an agar diffusion assay when used at a concentration of 80 μg/disc. Myxochelin A inhibits 5-lipoxygenase (5-LO) activity with an IC₅₀ value of 1.9 μM for the recombinant human enzyme. It is cytotoxic to 26-L5 colon cancer cells when used at a concentration of 3 μg/mL.

HY-N2345R

Procyanidin B3 (Standard)	Reference Standards Histone Acetyltransferase Toll-like Receptor (TLR) Androgen Receptor	Inflammation/Immunology Cancer
Procyanidin B3 (Standard) is the analytical standard of Procyanidin B3. This product is intended for research and analytical applications. Procyanidin B3 is a natural product with antioxidant activity and oral bioavailability, possessing good blood-brain barrier penetration. Procyanidin B3 is a selective inhibitor of histone acetyltransferase (HAT). By inhibiting p300 HAT-mediated acetylation of the androgen receptor (androgen receptor). Procyanidin B3 alleviates intervertebral disc degeneration (IVDD) by inhibiting the formation of the TLR4/MD-2 complex. Procyanidin B3 can be used in research on prostate cancer and arthritis .

HY-154919

DC-Y13-27 4 Publications Verification	YTHDF FOXO MMP Pyroptosis Interleukin Related	Endocrinology Cancer
DC-Y13-27 is a DC-Y13 derivative and YTHDF2 inhibitor (K_D: 37.9 μM). DC-Y13-27 inhibits YTHDF2, restores FOXO3 and TIMP1 protein levels, and reduces MMP1/3/7/9 expression. DC-Y13-27 induces Pyroptosis and increases IL-1β secretion. DC-Y13-27 reduces intervertebral disc degeneration and enhances the response to radiotherapy in colon cancer and melanoma. DC-Y13-27 has antitumor activity against breast cancer .

HY-N15353

1-Palmitoyl-2-linoleoyl-sn-glycerol	Bacterial	Infection
1-Palmitoyl-2-linoleoyl-sn-glycerol is a diacylglycerol (DAG)-type lipid signaling molecule found in the coralloid roots of Cycas revoluta, and serves as a major active component of the plant-secreted hormogonium-inducing factor (HIF). At a concentration of 1 nmol/disc (approximately 0.6 µg), 1-palmitoyl-2-linoleoyl-sn-glycerol can significantly induce the differentiation of filamentous aggregates of Nostoc into motile hormogonia, thereby promoting chemotaxis toward host roots and the establishment of symbiosis. This compound holds significant research and application potential in areas such as plant–microbe interactions, rhizosphere signaling pathways, and nitrogen-fixing symbiosis .

Cat. No.	Product Name	Type

HY-D0085

DiSC3(5) 5+ Cited Publications	Fluorescent Dyes/Probes
DiSC3(5) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3(5) is up to 622/670 nm. DiSC3(5) can inhibit the respiratory system associated with mitochondrial NAD, and the IC₅₀ value is 8 μM. DiSC3(5) in the presence of Na ⁺/K ⁺-ATPase inhibitor ouabain 2 can induce membrane hyperpolarization of Ehrlich ascites tumor cells .

DiSC3(5)

5+ Cited Publications

Fluorescent Dyes/Probes

DiSC3(5) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3(5) is up to 622/670 nm. DiSC3(5) can inhibit the respiratory system associated with mitochondrial NAD, and the IC₅₀ value is 8 μM. DiSC3(5) in the presence of Na ⁺/K ⁺-ATPase inhibitor ouabain 2 can induce membrane hyperpolarization of Ehrlich ascites tumor cells .

HY-D1626

DiSC18(3) 3,3'-Dioctadecylthiacarbocyanine perchlorate	Fluorescent Dyes/Probes
DiSC18(3) is a lipophilic carbocyanine dye for membrane labelling .

Cat. No.	Product Name	Target	Research Area

HY-P10954

Link N peptide	p38 MAPK	Others
Link N peptide is a proteoglycan aggregates activator in the extracellular matrix. Link N peptide can selectively activate the p38 mitogen-activated protein kinase (MAPK) pathway to promote the expression of type I and II collagens in human intervertebral disc cells. Link N peptide is promising for research of intervertebral disc degeneration-related diseases .

HY-P10326

Z-ATAD-FMK	Caspase Apoptosis	Cancer
Z-ATAD-FMK is an inhibitor of caspase-12. Z-ATAD-FMK is an inhibitor of caspase-12. Z-ATAD-FMK prevents endoplasmic reticulum stress-mediated apoptosis by inhibiting the activity of caspase-12 and reducing the activity of caspase-9 .

Cat. No.	Product Name	Target	Research Area

HY-P990498

*Anti-RGMC/HFE2 Antibody (DISC-0974)* disc-0974	Inhibitory Antibodies	Inflammation/Immunology
The Anti-RGMC/HFE2 Antibody (DISC-0974) is a CHO-expressed human antibody that targets RGMC/HFE2. The Anti-RGMC/HFE2 Antibody (DISC-0974) features a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.66 kDa. For the isotype control of the Anti-RGMC/HFE2 Antibody (DISC-0974), please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990446

*Anti-IL-15 Antibody (DISC0280)* disc0280	Interleukin Related	Inflammation/Immunology
The Anti-IL-15 Antibody (DISC0280) is a CHO-expressed human antibody that targets IL-15. The Anti-IL-15 Antibody (DISC0280) has a huIgG1 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-IL-15 Antibody (DISC0280) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Chymopapain	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Chymopapain is a non-specific proteo-glycanase derived from the papaya plant. Chymopapain directly into the intervertebral disc caused disc narrowing due to dissolution of the extruded material. Chymopapain has the potential for the research of herniated lumbar discs .

Physalin A 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Alkekengi officinarum var. franchetii (Mast.) R.J.Wang Source classification Solanaceae Plants Disease Research Fields Cancer	Apoptosis Autophagy NF-κB p38 MAPK PI3K Akt mTOR STAT JAK
Physalin A is a biologically active withanolide. Physalin A shows anti-inflammatory, antifibrotic and ameliorative effects on autophagy in models of disc degeneration. Physalin A has antitumor activity and can induce apoptosis, ROS production and G2/M phase cell cycle arrest. Besides. Physalin A can significantly increase the activity of quinone reductase and increase the expression of detoxifying enzymesc .

Karacoline	Structural Classification Classification of Application Fields Terpenoids Source classification Ranunculaceae Diterpenoids Aconitum carmichaeli Debx. Plants Disease Research Fields Endocrinology	NF-κB
Karacoline, a diterpene alkaloid found in the plant Aconitum kusnezoffii, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway .

Kinsenoside 4 Publications Verification	Structural Classification Natural Products Classification of Application Fields Orchidaceae Plants Anoectochilus Inflammation/Immunology Disease Research Fields	Keap1-Nrf2 Apoptosis
Kinsenoside is the main active ingredient of the genus plant, and has various biological activities. Kinsenoside and Nrf2 depend on the protection of nuclear cells (NPCs), which significantly reduces their ability to survive. Kinsenoside Active NPC Medium AKT-ERK1/2-Nrf2 Signal passage, Prevent physical decline, aging, harmonious physical function impairment. Kinsenoside can improve the puncture guide model for intermediate vertebral wall discharge (IDD).

Diacetoxy-6-gingerdiol 1 Publications Verification	Zingiber officinale Roscoe Structural Classification Monophenols Classification of Application Fields Source classification Other Diseases Phenols Plants Disease Research Fields Zingiberaceae	Interleukin Related
Diacetoxy-6-gingerdiol is a gingerol isolated with anti-inflammatory and antioxidant effects, which is found in the dichloromethane extract of rhizomes of ginger (Zingiber officinale Roscoe). Diacetoxy-6-gingerdiol protects the extracellular matrix of nucleus pulposus cells and ameliorates intervertebral disc degeneration by inhibiting the IL-1β-mediated NLRP3 pathway .

Procyanidin B3 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Plants Flavonoids other families Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Disease Research Fields Cancer	Histone Acetyltransferase Toll-like Receptor (TLR) Androgen Receptor
Procyanidin B3 is a natural product with antioxidant activity and oral bioavailability, possessing good blood-brain barrier penetration. Procyanidin B3 is a selective inhibitor of histone acetyltransferase (HAT). By inhibiting p300 HAT-mediated acetylation of the androgen receptor (androgen receptor). Procyanidin B3 alleviates intervertebral disc degeneration (IVDD) by inhibiting the formation of the TLR4/MD-2 complex. Procyanidin B3 can be used in research on prostate cancer and arthritis .

Linearmycin A	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Bacterial
Linearmycin A is a polyene antibiotic that has been found in Streptomyces. It is active against the bacteria S. aureus and E. coli (MICs=3.1 and 1.6 μg/disc, respectively), the fungi S. cerevisiae and C. albicans (MICs=0.1 and 1.6 μg/disc, respectively), and the plant pathogenic fungus A. niger in disc assays (MIC=0.2 μg/disc). Linearmycin A induces lysis and degradation of B. subtilis as a component of Streptomyces Mg1 extract.

Tetrahydrobostrycin	Structural Classification Microorganisms Source classification Phenols Polyphenols	Bacterial
Tetrahydrobostrycin is a secondary metabolite from Aspergillus sp., which exhibits a weak inhibitory activity against Staphylococcus aureus and Escherichia coli (100 mg/disc with the inhibition zones of 15 and 9.2 mm in diameter) .

Procyanidin B3 (Standard)	Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants Biflavones	Reference Standards Histone Acetyltransferase Toll-like Receptor (TLR) Androgen Receptor
Procyanidin B3 (Standard) is the analytical standard of Procyanidin B3. This product is intended for research and analytical applications. Procyanidin B3 is a natural product with antioxidant activity and oral bioavailability, possessing good blood-brain barrier penetration. Procyanidin B3 is a selective inhibitor of histone acetyltransferase (HAT). By inhibiting p300 HAT-mediated acetylation of the androgen receptor (androgen receptor). Procyanidin B3 alleviates intervertebral disc degeneration (IVDD) by inhibiting the formation of the TLR4/MD-2 complex. Procyanidin B3 can be used in research on prostate cancer and arthritis .

1-Palmitoyl-2-linoleoyl-sn-glycerol	Structural Classification Natural Products Source classification Plants Cycadaceae Cycas revoluta Thunb.	Bacterial
1-Palmitoyl-2-linoleoyl-sn-glycerol is a diacylglycerol (DAG)-type lipid signaling molecule found in the coralloid roots of Cycas revoluta, and serves as a major active component of the plant-secreted hormogonium-inducing factor (HIF). At a concentration of 1 nmol/disc (approximately 0.6 µg), 1-palmitoyl-2-linoleoyl-sn-glycerol can significantly induce the differentiation of filamentous aggregates of Nostoc into motile hormogonia, thereby promoting chemotaxis toward host roots and the establishment of symbiosis. This compound holds significant research and application potential in areas such as plant–microbe interactions, rhizosphere signaling pathways, and nitrogen-fixing symbiosis .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82685

	DISC1 Antibody (YA2430) C1orf136; disc1; KIAA0457; RP4-730B13.1; SCZD9	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	DISC1 Antibody (YA2430) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2430), targeting DISC1, with a predicted molecular weight of 94 kDa (observed band size: 100 kDa). DISC1 Antibody (YA2430) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

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