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  5. DISC1 Antibody (YA2430)

DISC1 Antibody (YA2430)

Cat. No.: HY-P82685
COA
SDS
User Guide for Antibodies Technical Support

DISC1 Antibody (YA2430) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DISC1.

For research use only. We do not sell to patients.

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10 μL In-stock
50 μL In-stock
100 μL In-stock
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

DISC1 Antibody (YA2430) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DISC1.
Background

DISC1 is a protein involved in regulating multiple aspects of embryonic and adult neurogenesis. It promotes neural progenitor proliferation in the embryonic ventricular/subventricular zone and the adult hippocampal dentate gyrus (by similar). As a positive regulator of Wnt-mediated neural progenitor proliferation, DISC1 modulates GSK3B activity and CTNNB1 abundance (PubMed:19303846). It also acts as a modulator of the AKT-mTOR signaling pathway, influencing the integration of newborn neurons, including neuron positioning, dendritic development, and synapse formation (by similar). DISC1 inhibits AKT-mTOR signaling activation upon interaction with CCDC88A (by similar). During hippocampal development, it regulates the migration of early-born granule cell precursors toward the dentate gyrus (PubMed:19502360). Additionally, DISC1 inhibits ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA-binding (by similar). Together with PCNT, it plays a role in microtubule network formation (PubMed:18955030).
Gene ID
SwissProt ID
Synonyms
C1orf136; DISC1; KIAA0457; RP4-730B13.1; SCZD9
Molecular Weight

Predicted band size: 94 kDa; Observed band size: 100 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Neuroscience
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1:500-1:1000; IHC: 1:50-1:100; IF: 1:50-1:200; IP: 1:50; FC: 1:50-1:100
Application

WB, IHC-P, ICC/IF, IP, FC
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthesized peptide derived from human DISC1
Database

Entrez Gene: 1620 Human ; 56710 Mouse ; 140610 Rat

SwissProt: O60477 Human ; Q920P3 Mouse ; Q925T8 Rat

OMIM: 602865 Human

Documentation
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

DISC1 Antibody (YA2430) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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DISC1 Antibody (YA2430)
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